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1. 发明授权

KR101364624B1 온도감응성 하이드로젤 내에서의 중간엽 줄기세포의 신경분화 및 신경분화용 조성물 有权
标题翻译：间充质干细胞对热敏水凝胶的神经发生和神经分化的组成
公开(公告)号：KR101364624B1
公开(公告)日：2014-02-19
申请号：KR1020120013054
申请日：2012-02-09
申请人： 아주대학교산학협력단
发明人： 권진선 , 김다연 , 김문석
IPC分类号： C12N11/04 , C12N5/0793 , A61K35/30 , A61K9/00
CPC分类号： C12N11/04 , A61K35/30 , C12N5/0619 , C12N2501/065 , C12N2501/115 , C12N2506/1346 , C12N2533/72 , C12N2539/10
摘要： 본 발명은 온도 감응성 하이드로젤 내에서의 중간엽 줄기세포의 신경분화 유도 및, 신경세포로의 분화 유도에 필요한 신경분화용 조성물에 관한 것이다. 보다 구체적으로는 온도감응성 하이드로젤에서 중간엽 줄기세포의 배양과 신경세포로의 분화 유도를 통하여 주사제형 세포전달체를 제공하기 위한 것이다.

2. 发明公开

KR1020050071520A 프로그램 가능한 스캐폴드 및 이의 제조 및 이용 방법 无效
标题翻译：可编程的SCAFFOLD及其制造和使用方法
公开(公告)号：KR1020050071520A
公开(公告)日：2005-07-07
申请号：KR1020057005328
申请日：2003-09-30
申请人： 벡톤 디킨슨 앤드 컴퍼니
发明人： 로울리존 , 헤이드아란모하메드
IPC分类号： C12N5/00 , C12N5/02 , C12N5/071 , G01N33/50
CPC分类号： C12N5/0068 , A61K35/12 , A61L27/38 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/414 , A61L2300/604 , C12M25/14 , C12N2501/998 , C12N2533/30 , C12N2533/54 , C12N2533/72 , C12N2533/74 , C12N2533/80 , C12N2533/90
摘要： The present invention relates to a programmable scaffold, which is a three-dimensional scaffold having interconnected pores and biologically active molecules physically entrapped therein. The scaffold is a lyophilized hydrogel of a polymer. The scaffold can be used in an array on a platform and loaded with various combinations of biologically active molecules for high throughput and parallel screening, as well as tissue engineering. The present invention also relates to methods for making and modifying the scaffolds.
摘要翻译：本发明涉及一种可编程支架，其是具有物理截留在其中的互连孔和生物活性分子的三维支架。支架是聚合物的冻干水凝胶。支架可用于平台上的阵列中，并加载生物活性分子的各种组合，用于高通量和平行筛选以及组织工程。本发明还涉及制备和修饰支架的方法。

3. 发明公开

KR1020040053133A 세포의 활성화 및 증식 无效
标题翻译：细胞的活化和增殖
公开(公告)号：KR1020040053133A
公开(公告)日：2004-06-23
申请号：KR1020047004089
申请日：2002-09-04
申请人： 싸이트 테라피스 인코포레이티드
发明人： 베렌슨로날드 , 라우체 , 보니하디마크 , 사운드나린더 , 크레이그스튜어트 , 하드윅알란알 , 칼라마츠데일 , 맥밀런데이비드 , 차나하르진더싱그
IPC分类号： C12N5/00 , C12N5/02 , C12M3/00 , C12N5/07
CPC分类号： A61L27/3804 , A61K2035/124 , A61K2039/5158 , A61K2039/57 , C07K16/2803 , C07K16/2806 , C07K16/2809 , C07K16/2812 , C07K16/2815 , C07K16/2818 , C07K16/2821 , C07K16/2827 , C07K16/2833 , C07K16/2845 , C07K16/2854 , C07K16/2866 , C07K16/2875 , C07K16/2878 , C07K16/289 , C07K16/2896 , C12N5/0635 , C12N5/0636 , C12N5/0647 , C12N2500/32 , C12N2501/23 , C12N2501/51 , C12N2501/515 , C12N2501/53 , C12N2501/59 , C12N2533/12 , C12N2533/14 , C12N2533/18 , C12N2533/30 , C12N2533/40 , C12N2533/54 , C12N2533/70 , C12N2533/72 , C12N2533/90
摘要： 본 발명은 일반적으로 세포를 활성화시키고 증시시키는 방법 및 보다 특히, 세포의 증식을 최대화하여 급격하게 고밀도가 되도록 세포를 활성화시키고/시키거나 자극시키기 위한 신규 방법에 관한 것이다. 다양한 양태에서, 세포는 단기간내에 활성화되고 매우 고밀도로 증식한다. 특정 양태에서, 세포는 단기간내에 매우 높은 수의 세포로 활성화되고 증식된다. 본 발명은 추가로 본원의 방법에 의해 활성화되고 증식된 세포의 조성물을 제공한다.

4. 发明授权

KR101886114B1 조작된 구조체의 신경분포 有权
公开(公告)号：KR101886114B1
公开(公告)日：2018-08-07
申请号：KR1020147024303
申请日：2013-01-31
申请人： 웨이크 포리스트 유니버시티 헬스 사이언시즈
发明人： 비타,칼릴
IPC分类号： A61F2/08 , A61L27/38 , A61L27/56
CPC分类号： A61K35/34 , A61F2/04 , A61F2/08 , A61F2002/045 , A61L27/20 , A61L27/3826 , A61L27/3873 , A61L27/50 , A61L2430/30 , C12N5/0068 , C12N5/0623 , C12N5/0661 , C12N2501/999 , C12N2533/54 , C12N2533/72 , C08L5/08
摘要： 신경분포된근육구조체와조직복원및 재생을위한생체조작된구조체를발생시키는방법이개시되었다. 이방법은평활근세포와 뉴런전구세포의개체군을수득하고, 세포들을함께매트릭스물질에심은후 방향성있게지향된평활근세포의신경분포된평활근세포구조체를형성하기위해심어진세포를배양하는단계들을포함한다. 하나의실시예에서, 신경전구세포는우선신경구로서생체적합성용액( 콜라겐/라미닌용액)에심어지고젤에도허용된다. 다음, 두번째평활근세포의현탁액은분리된층으로서증착될수 있다. 다중층구조교착근육또는신경구성요소의다중충구조물은이러한방식으로제조될수 있다. 신경전구세포의분화는뉴로베이살 A 배지(Neurobasal A medium) 에대한노출및 또는분화제 (B-27 보조제)에대한노출에의해유발될수 있다. 신경배치된근육구조체는원형스캐폴드주위(예를들면키토산을포함하는튜브) 배치될수 있고, 더배양되어튜브모양의, 생체조작구조체를형성할수 있다. 두개또는그 이상의신경분포된근육구조체는연장된합성구조체를형성하기위해서로연결될수 있다.

5. 发明公开

KR1020100080924A 조직공학, 세포 배양 및 세포 운반용 다공성 스캐폴드의 제조방법 有权
标题翻译：制备用于组织工程，细胞培养和细胞递送的多孔切片的方法
公开(公告)号：KR1020100080924A
公开(公告)日：2010-07-13
申请号：KR1020107009937
申请日：2008-10-10
申请人： 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) , 유니베르시떼 파리스 7- 데니스 디데롯
发明人： 르비쟈쥐,까뜨린느 , 르뚜르너르,디디에
IPC分类号： A61L27/52 , A61L27/20 , A61L27/56 , C12N5/07
CPC分类号： A61L27/20 , A61L27/3804 , A61L27/3834 , A61L27/3847 , A61L27/3852 , A61L27/507 , A61L27/52 , A61L27/54 , A61L27/56 , C08B37/0018 , C08B37/0021 , C08B37/003 , C08B37/0039 , C08B37/0054 , C08B37/0063 , C08B37/0072 , C08B37/0075 , C08B37/0084 , C08J9/08 , C08J9/28 , C08J9/283 , C08J2201/026 , C08J2201/0484 , C08J2201/0504 , C08J2205/022 , C08J2207/10 , C08J2305/00 , C08J2305/02 , C08J2305/04 , C08J2305/08 , C08J2305/10 , C08J2305/12 , C12N5/0068 , C12N2533/70 , C12N2533/72 , C12N2533/74
摘要： The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprises the steps consisting of: a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide, an amount of a cross-linking agent and an amount of a porogen agent b) transforming the solution into a hydrogel by placing said solution at a temperature from about 4°C to about 80°C for a sufficient time to allow the cross-linking of said amount of polysaccharide and c) submerging said hydrogel into an aqueous solution d) washing the porous scaffold obtained at step c).
摘要翻译：本发明涉及一种用于组织工程的多孔支架的制备方法。本发明的另一个目的是提供可通过上述方法获得的多孔支架及其在组织工程，细胞培养和细胞递送中的应用。本发明的方法包括以下步骤：a）制备包含一定量的多糖，一定量的交联剂和一定量的致孔剂的碱性水溶液b）将溶液转化成水凝胶通过将所述溶液置于约4℃至约80℃的温度下足够的时间以允许所述量的多糖的交联，和c）将所述水凝胶浸入水溶液中d）洗涤在步骤c）。

6. 发明授权

KR100375422B1 다공성 키토산 구슬 및 그의 제조 방법 失效
标题翻译： 다공성키토산구슬및그의제조방법
公开(公告)号：KR100375422B1
公开(公告)日：2003-03-10
申请号：KR1019990060034
申请日：1999-12-21
申请人： 한국과학기술연구원
发明人： 정서영 , 배은희 , 권익찬 , 최귀원
IPC分类号： C12N1/00
CPC分类号： C08J9/28 , C08B37/003 , C08J2201/0484 , C08J2305/08 , C08L5/08 , C12N5/0075 , C12N2533/72
摘要： The present invention relates to macroporous chitosan beads having 5-200 mum in size of relatively large and uniform pores that are distributed from surface to core region, and a preparation method thereof compring the following steps; by dropping chitosan solution, aqueous chitosan solution or their mixture into the low-temperature of organic solvent or liquid nitrogen; and by regulating pore size by phase separation method via temperature difference. The macroporous chitosan beads of the present invention make cell culture more efficient than the previous substrate, since cell can attach to them efficiently due to their large surface area, it is easy for cell to be injected into them and cell attached to them can exist longer due to their three-dimensional structure, therefore they can be used for a study about production of protein, abtibiotics, anticancer agent, polysaccharide, physiologically active agent, animal hormone, or plant hormone as well as a study about substitution of metabolic organs, cartilage or bone.
摘要翻译：本发明涉及一种大孔径壳聚糖珠粒及其制备方法，所述大孔隙大小为5-200μm，具有较大且均匀的从表面到中心区域的孔隙，其制备方法包括以下步骤：将壳聚糖溶液，壳聚糖水溶液或其混合物滴入低温有机溶剂或液氮中; 并通过温度差通过相分离法调节孔径。本发明的大孔脱乙酰壳多糖珠粒使细胞培养比先前的基质更有效，因为细胞由于它们的大表面积而可以有效地附着到它们上，细胞很容易注入它们并且细胞附着在它们上的时间可以更长由于它们的三维结构，因此它们可以用于研究蛋白质，抗生素，抗癌剂，多糖，生理活性剂，动物激素或植物激素的产生，以及关于代谢器官，软骨替代的研究或骨头。

7. 发明授权

KR101647793B1 온도 감응성 글리콜 키토산 유도체를 이용한 스페로이드 형성용 배양 용기 및 이를 이용한 스페로이드 형성 방법 有权
标题翻译：细胞培养容器用于形成SPHEROID使用温敏甘露糖胺衍生物和使用其的SPHEROID形成方法
公开(公告)号：KR101647793B1
公开(公告)日：2016-08-12
申请号：KR1020140116020
申请日：2014-09-02
申请人： 충남대학교산학협력단 , 한국화학연구원
发明人： 허강무 , 강선웅 , 강한창 , 심혜은 , 조익성 , 조명옥
IPC分类号： C12M3/00 , C08B37/08
CPC分类号： C12N5/0068 , C12M23/10 , C12M23/20 , C12N2533/72
摘要： 온도감응성글리콜키토산유도체를이용한스페로이드형성용배양용기및 이를이용한스페로이드형성방법이개시된다. 개시된스페로이드형성용배양용기는온도에따라가역적인졸-겔전이특성을갖는글리콜키토산유도체가배양공간의표면에코팅된다.

8. 发明公开

KR1020140117293A 하이드록시아파타이트, 키토산 또는 이의 유도체, 및 카테콜 또는 이의 유도체를 함유하는 복합체 및 그 용도 有权
标题翻译：包含羟基磷灰石，壳多糖或其衍生物的复合材料及其衍生物及其用途
公开(公告)号：KR1020140117293A
公开(公告)日：2014-10-07
申请号：KR1020140034299
申请日：2014-03-24
申请人： 포항공과대학교 산학협력단
发明人： 황동수 , 오동엽 , 프라자테리스티아에카비안티 , 이진우 , 예영진
IPC分类号： A61L27/12 , A61L27/26
CPC分类号： A61L27/12 , A61F2002/5093 , A61L2430/10 , C12N2501/815 , C12N2533/72
摘要： The present invention relates to a composite including hydroxyapatite, chitosan, chitin, or a derivative of the same, and catechol or a derivative of the same; an organic reinforcing material composition including the composite, a product manufactured with the organic reinforcing material composition, and a method to manufacture the composite. The composite provided in the present invention is a material with catechol or an added catechol derivative, which has characteristics of being harmless to a human body, shows strong mechanical strength to be used as various biomaterials such as an artificial sinew, an artificial ligament, and an artificial dental material; and is useful for various kinds of required materials, without limitations.
摘要翻译：本发明涉及包含羟基磷灰石，壳聚糖，壳多糖或其衍生物的复合材料，以及儿茶酚或其衍生物; 包含所述复合材料的有机增强材料组合物，使用所述有机增强材料组合物制造的产品以及所述复合材料的制造方法。本发明提供的复合材料是具有儿茶酚衍生物或添加的儿茶酚衍生物的材料，具有对人体无害的特性，显示出很强的机械强度，可用作各种生物材料如人造丝，人造韧带和人造牙科材料; 并且对于各种所需材料是有用的，没有限制。

9. 发明公开

KR1020130091818A 온도감응성 하이드로젤 내에서의 중간엽 줄기세포의 신경분화 및 신경분화용 조성물 有权
标题翻译：热敏水凝胶中的细胞干细胞的神经元细胞和神经元分化的组成
公开(公告)号：KR1020130091818A
公开(公告)日：2013-08-20
申请号：KR1020120013054
申请日：2012-02-09
申请人： 아주대학교산학협력단
发明人： 권진선 , 김다연 , 김문석
IPC分类号： C12N11/04 , C12N5/0793 , A61K35/30 , A61K9/00
CPC分类号： C12N11/04 , A61K35/30 , C12N5/0619 , C12N2501/065 , C12N2501/115 , C12N2506/1346 , C12N2533/72 , C12N2539/10 , A61K9/0019
摘要： PURPOSE: Neuronal differentiation of the mesenchyme stem cells is provided to be simply induced by using culture medium of the suitable composition and increase the mesenchyme stem cells without affecting the induction of being developed into the nerve cell. CONSTITUTION: Thermo-sensitivity supporter for the neural cell differentiation of the mesenchyme stem cell comprises a cell culture substrate; and thermo-sensitivity hydrogel which coated on the cell culture substrate. An obtaining method of nerve cell using the thermo-sensitivity hydrogel comprises a step of leading the thermo-sensitivity hydrogel as gel; a step of sowing the mesenchyme stem cells to the thermo-sensitivity hydrogel and developing it into neural progenitor cell; and a step of inducing the neural progenitor cell to the nerve cell. Composition for treatment of neurological disease comprises thermo-sensitivity hydrogel and nerve cell obtained by the attaining method.
摘要翻译：目的：提供间充质干细胞的神经元分化是通过使用合适组合物的培养基简单诱导，并增加间充质干细胞，而不影响被发育成神经细胞的诱导。构成：间充质干细胞的神经细胞分化的热敏感性支持体包含细胞培养基质; 和热敏性水凝胶，其涂覆在细胞培养基质上。使用热敏水凝胶的神经细胞的获得方法包括将热敏水凝胶引导为凝胶的步骤; 将间充质干细胞播种到热敏水凝胶并将其发育成神经祖细胞的步骤; 以及将神经祖细胞诱导至神经细胞的步骤。用于治疗神经疾病的组合物包括通过获得方法获得的热敏水凝胶和神经细胞。

10. 发明公开

KR20070099187A METHOD OF DETACHING CELLS FROM THE SURFACE WHICH THE CELLS ADHERE TO 审中-公开
标题翻译：从细胞粘附的表面分离细胞的方法
公开(公告)号：KR20070099187A
公开(公告)日：2007-10-09
申请号：KR20060030250
申请日：2006-04-03
申请人： SAMSUNG ELECTRONICS CO LTD
发明人： HONG SUNG WOO , KIM BYUNG CHUL , KIM SOOK YOUNG
IPC分类号： C12Q1/24 , C12N5/00
CPC分类号： C12N5/0606 , C12N5/0068 , C12N5/0696 , C12N2509/00 , C12N2509/10 , C12N2533/72
摘要： A method for detaching cells from attached surface with high yield is provided to separate the cells from the surface without the damage of the cells without using an enzyme such as trypsin by introducing chitosan with the characteristic of being depolymerized in a weak acidic range into the inner surface of a cell culture container. A method comprises the steps of: (a) after filling a liquid culture medium in a cell culture container in which a chitosan coating film is formed inside, adhesion-culturing cells on the chitosan coating film; (b) adding an acid such as sulfuric acid, nitric acid and phosphoric acid to the liquid culture medium to adjust the pH of the medium into 4.5-6.0 to depolymerize the chitosan; and (c) isolating the cells from the cell cultured material including the depolymerized chitosan through centrifugation.
摘要翻译：提供以高产率从附着表面分离细胞的方法，以将细胞从表面分离而不用细胞损伤，而不使用酶如胰蛋白酶，通过引入具有在弱酸性范围内解聚的特征的壳聚糖进入内部细胞培养容器的表面。一种方法包括以下步骤：（a）在将液体培养基填充到其中形成壳聚糖涂膜的细胞培养容器中之后，在壳聚糖涂膜上粘附培养细胞; （b）向液体培养基中加入硫酸，硝酸，磷酸等酸，将培养基的pH调节为4.5〜6.0，使壳聚糖解聚; 和（c）通过离心从包括解聚的壳聚糖的细胞培养物质中分离细胞。

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