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1. 发明公开

KR1020080027259A 생리 활성 물질 ＮＫ13650Ｐ3, 그 제조법 및 용도 无效
标题翻译：生理活性物质NK13650P3，其生产方法及其用途
公开(公告)号：KR1020080027259A
公开(公告)日：2008-03-26
申请号：KR1020077029414
申请日：2006-06-26
申请人： 니폰 가야꾸 가부시끼가이샤
发明人： 도무라아리히로 , 오다나카쥰코 , 니시모토마사카즈
IPC分类号： C07D521/00 , C07G99/00 , C12N1/14 , A61K36/06
CPC分类号： A61K36/06 , C07G17/00 , C12N1/14 , C12R1/80
摘要： A physiologically active substance NK13650P3 having the following physicochemical properties or a pharmacologically acceptable salt thereof. 1) Appearance: pale yellow powder 2) Molecular formula: C29 H37O15 3) Molecular weight: 723 4) Hydrogen nuclear magnetic resonance spectrum: spectrum measured at 600 MHz in heavy water contains the following signals: chemical shift value H ppm: 7.05(1H,s), 7. 00(1H, d), 6.96(1H, d), 6.83(1H, s), etc. 5) Carbon nuclear magnetic resonance spectrum: spectrum measured at 150 MHz in heavy water contains the following signals: chemical shift value H ppm: 181.5(s), 181.4(s), 179.9(s), 179.2(s), 174.5(s), 174.3(s), 171.5(s), 165.4(s), etc. 6) Ultraviolet light spectrum: spectrum measured in aqueous solution contains the following UV absorption bands: Umax(MeOH):196.5 nm, 224.5 nm, 322.5 nm 7) Solubility: highly soluble in water but insoluble in methanol, acetone, ethyl acetate, chloroform and dimethyl sulfoxide. 8) Coloration reaction: positive to phosphomolybdic acid/ sulfuric acid reaction and Rydon-Smith reaction. ® KIPO & WIPO 2008
摘要翻译：具有以下物理化学性质的生理活性物质NK13650P3或其药理学上可接受的盐。 1）外观：浅黄色粉末2）分子式：C29 H37O15 3）分子量：723 4）氢核磁共振谱：重水中在600MHz测得的光谱含有以下信号：化学位移值H ppm：7.05（1H ，s），7.00（1H，d），6.96（1H，d），6.83（1H，s）等。5）碳核磁共振谱：在150MHz在重水中测量的光谱包含以下信号：化学位移值H ppm：181.5（s），181.4（s），179.9（s），179.2（s），174.5（s），174.3（s），171.5（s），165.4（s）紫外线光谱：在水溶液中测定的光谱含有以下UV吸收带：Umax（MeOH）：196.5nm，224.5nm，322.5nm 7）溶解度：高溶于水但不溶于甲醇，丙酮，乙酸乙酯，氯仿和二甲基亚砜。 8）着色反应：对磷钼酸/硫酸反应呈阳性，Rydon-Smith反应。 ®KIPO＆WIPO 2008

2. 发明公开

KR1020150086242A 황화 알킬-치환된 히드록시방향족 조성물의 염을 제조하기 위한 용매 추출 审中-实审
标题翻译：用于制备硫化烷基取代羟基芳族化合物的盐的溶剂萃取
公开(公告)号：KR1020150086242A
公开(公告)日：2015-07-27
申请号：KR1020157010631
申请日：2013-11-15
申请人： 셰브런 오로나이트 컴퍼니 엘엘씨
发明人： 마히에욱스,세드릭 , 두따,리차드프랜 , 캠벨,커티스베이 , 짚,벤자민데이비드
IPC分类号： C10M135/02 , C10M177/00
CPC分类号： C10M135/02 , C07G17/00 , C10M177/00 , C10M2219/02 , C10M2219/089 , C10N2230/64 , C10N2270/00
摘要： 감소된함량의비황화(unsulfurized) 알킬-치환된히드록시방향족화합물및 그의비황화금속염을갖는황화(sulfurized) 알킬-치환된히드록시방향족조성물의염을제조하는방법이본원에개시되어있다. 상기방법은적어도하기단계를포함한다: (a) (i) 황화알킬-치환된히드록시방향족화합물의염; (ⅱ) 비황화알킬-치환된히드록시방향족화합물; 및 (iii) 알킬-치환된히드록시방향족화합물의비황화금속염을포함하는조성물을제공하는단계로서; 여기서, 상기알킬-치환된히드록시방향족화합물은프로필렌, 부틸렌, 또는이들의혼합물로부터선택된모노머의 C내지 C올리고머를포함하는하나이상의올레핀과히드록시방향족화합물의알킬화로부터유래되는단계; 및 (b) 감소된함량의비황화알킬-치환된히드록시방향족화합물및 그의비황화금속염을갖는황화알킬-치환된히드록시방향족조성물의염을제공하기에충분한추출조건하에서, 단계 (a)의조성물로부터상기비황화알킬-치환된히드록시방향족화합물및 그의비황화금속염을, 상기비황화알킬-치환된히드록시방향족화합물및 그의비황화금속염을용해시킬수 있는하나이상의용매로추출하는단계.

3. 发明公开

KR1020090093964A 식물에서 유래하는 생분해성 천연 소재 无效
标题翻译：植物衍生的天然生物可降解材料
公开(公告)号：KR1020090093964A
公开(公告)日：2009-09-02
申请号：KR1020097010850
申请日：2007-11-26
申请人： 사토, 세이코
发明人： 사토,세이코
IPC分类号： C12P1/04 , C08L3/02 , C08G65/00 , C07G99/00
CPC分类号： C07G17/00 , C08L3/02 , C12N3/00 , C12P1/04 , C12P7/02 , C12P19/04 , Y10T428/1352
摘要： It is intended to provide a natural biodegradable material which has both properties of biodegradability and mechanical strength; a biodegradable film or container produced from the natural biodegradable material; a binder for producing the biodegradable material; and a method for producing the same. A cereal starch such as kaoliang starch is used as a raw material for culture, a microorganism belonging to the genus Bacillus is added to the raw material and cultured, and a viscous polymeric substance is collected, whereby a natural polymeric substance having a property like cellulose with a hydroxy group which is not present in a petroleum-derived polymeric compound, and also having a structure like polypropylene is obtained. The natural polymeric substance is used as a binder and a starch and/or shell powder are/is mixed with the binder, whereby a biodegradable material having biodegradability comparable to cellulose and also having a mechanical strength with a property of polypropylene can be obtained. A film or container produced using this biodegradable material has excellent properties of both biodegradability and mechanical strength.
摘要翻译：旨在提供具有生物降解性和机械强度两者性质的天然可生物降解材料; 由天然生物降解材料生产的可生物降解的薄膜或容器; 用于生产可生物降解材料的粘合剂; 及其制造方法。使用高岭淀粉等谷物淀粉作为培养原料，向原料中加入属于芽孢杆菌属的微生物，进行培养，收集粘性聚合物，得到具有纤维素性质的天然高分子物质具有不存在于石油衍生的聚合物中的羟基，并且还具有如聚丙烯的结构。将天然高分子物质用作粘合剂，并将淀粉和/或壳粉末与粘合剂混合，从而可获得具有与纤维素相当的生物降解性并具有聚丙烯性能的机械强度的可生物降解材料。使用该可生物降解材料制造的薄膜或容器具有优异的生物降解性和机械强度的性质。

4. 发明授权

KR100594915B1 잔류 연료 오일을 위한 오버베이스된 마그네슘 침착 억제첨가제 失效
标题翻译：用于残余燃料油的高碱性镁沉积物控制添加剂
公开(公告)号：KR100594915B1
公开(公告)日：2006-07-03
申请号：KR1019997011219
申请日：1999-02-25
申请人： 켐츄라 코포레이션
发明人： 뮈어,로날드,제이. , 엘리아데스,테오,아이.
IPC分类号： C10L1/10
CPC分类号： C10L1/1828 , C07C51/414 , C07F3/003 , C07G17/00 , C10L1/10 , C10L1/1233 , C10L1/125 , C10L1/1616 , C10L1/1824 , C10L1/1855 , C10L1/1881 , C10L1/1883 , C10L1/189 , C10L1/19 , C10L1/198 , C10L1/202 , C10L1/205 , C10L1/2225 , C10L1/2437 , C10L10/04
摘要： 잔류 연료 오일 및 터빈 연료를 위한 오버베이스된 마그네슘 조성물 침착 억제 첨가제는 마그네슘을 14 중량% 내지 약 18 중량% 포함하고 숙신산 무수물 및 저급 카르복실산 보조촉진제 반응 생성물을 포함하는 오버베이스된 마그네슘 술포네이트, 카르복실레이트 또는 페네이트, 또는 이들의 혼합물이다. 많은 아스팔텐을 포함하는 잔류 연료 오일과 같은 연료 오일에 첨가제를 첨가하면 마그네슘/아스팔텐 침착물 또는 앙금 및 결과적인 필터의 막힘이 제거 또는 감소된다. 첨가제는 또한 터빈에서 바나듐에 의한 부식을 제거 또는 감소시킨다. 본 발명은 또한 오버베이스 반응이 보조촉진제로서 저급 카르복실산, 바람직하게는 아세트산 및 숙신산 무수물, 바람직하게는 도데세닐 숙신산 무수물(DDSA)의 배합을 포함하는, 오버베이스된 조성물 또는 침착 억제 첨가제의 제조 방법에 관한 것이다.
오버베이스된 마그네슘 침착 억제 첨가제, 연료 오일, 이산화 탄소

5. 发明公开

KR1020000016110A 과염기화된금속함유세제 失效
标题翻译：超重金属含有洗涤剂
公开(公告)号：KR1020000016110A
公开(公告)日：2000-03-25
申请号：KR1019980709677
申请日：1997-05-16
申请人： 엑손모빌 케미칼 패턴츠 인코포레이티드
发明人： 스키너필립 , 레나크알라인
IPC分类号： C10M159/22 , C10G17/00 , C10M159/20
CPC分类号： C07G17/00 , C10M159/22
摘要： PURPOSE: A detergent containing overbased metal is provided which is useful as a lubricating additive, especially for marine engines. CONSTITUTION: Phenate/salicylate overbased detergents with high proportions of phenate and salicylate surfactants in the surfactant system and with TBN; % surfactant ratios of 11 or more are useful marine diesel lubricant additives. For an example, 540g toluene, 276g methanol and 22g diluted oil(150N) are maintained at about 20°C, added with 145g calcium hydroxide and heated at 40°C in stirring. Obtained slurry is added with 375g phenate, 42g sulfonate and 83g salicylate surfactant, and 100g toluene. The mixture is neutralized with calcium hydroxide, cooled to about 28°C, poured with carbon dioxide, heated to 60°C for 60 min, cooled to 28°C for 30 min, added with 127g calcium hydroxide and 62g carbon dioxide, heated to 90°C for 60 min, and added with 267g diluted oil. The product has percent surfactant ratios of 18 and a filtration grade of 0.51.
摘要翻译：目的：提供含有高碱性金属的洗涤剂，可用作润滑添加剂，尤其适用于船用发动机。构成：在表面活性剂体系和TBN中具有高比例酚盐和水杨酸盐表面活性剂的苯酸盐/水杨酸盐过碱洗涤剂; 11％以上的表面活性剂比例是有用的船用柴油润滑剂添加剂。例如，将540g甲苯，276g甲醇和22g稀释油（150N）保持在约20℃，加入145g氢氧化钙，并在40℃下在搅拌下加热。加入375g酚盐，42g磺酸盐和83g水杨酸盐表面活性剂，100g甲苯。将混合物用氢氧化钙中和，冷却至约28℃，倒入二氧化碳，加热至60℃60分钟，冷却至28℃30分钟，加入127g氢氧化钙和62g二氧化碳，加热至 90℃60分钟，加入267克稀释油。产品的表面活性剂比例为18，过滤度为0.51。

6. 发明公开

KR1020000016109A 과염기화된금속함유세제 失效
标题翻译：含金属含量大的洗涤剂
公开(公告)号：KR1020000016109A
公开(公告)日：2000-03-25
申请号：KR1019980709676
申请日：1997-05-16
申请人： 엑손모빌 케미칼 패턴츠 인코포레이티드
发明人： 스키너필립 , 레나크알라인
IPC分类号： C10M159/22 , C07G99/00
CPC分类号： C10M159/24 , C07G17/00 , C10M159/20 , C10M159/22
摘要： PURPOSE: A calcium overbased detergent is provided to be suitable for being used as a lubricant oil additive for a ship engine. CONSTITUTION: Phenate overbased detergents with high TBN:% surfactant ratios are useful lubricant additives. Therefore, the detergent can be induced from more than two surfactant while supplying a calcium overbased detergent including the induced surfactant system. Therefore, the ratio of phenol in the measured surfactant system is over 15 mass%, and the overbased detergent has over 21 TBN:% of surfactant ratio.
摘要翻译：目的：提供钙高碱性洗涤剂，适用于作为船用发动机的润滑油添加剂。构成：具有高TBN的苯甲酸高碱性清洁剂：表面活性剂比例是有用的润滑剂添加剂。因此，洗涤剂可以由多于两种表面活性剂诱导，同时供应包含诱导表面活性剂体系的钙高碱性洗涤剂。因此，所测量的表面活性剂体系中苯酚的比例超过15质量％，高碱性洗涤剂的表面活性剂比例为21 TBN％以上。

7. 发明授权

KR101176758B1 화합물 ＷＳ727713 失效
标题翻译：化合物WS727713
公开(公告)号：KR101176758B1
公开(公告)日：2012-08-23
申请号：KR1020117016590
申请日：2005-03-22
申请人： 아스테라스 세이야쿠 가부시키가이샤
发明人： 오츠카,다카나오 , 우에다,히로츠구 , 후지에,게이코 , 무라마츠,히데유키 , 하시모토,미치자네 , 다카세,시게히로
IPC分类号： C07D259/00 , C12P13/00 , C12N1/20
CPC分类号： C12R1/01 , A61K8/99 , A61K35/74 , A61K2800/85 , A61Q5/065 , A61Q19/00 , C07G17/00 , C12P1/06
摘要： 본 발명은 멜라노코르틴 수용체 조절제로서 유용한 신규한 화합물에 관한 것이다. 특히, 본 발명은 화합물 WS727713, 슈도노카르디아에 속하는 WS727713-생산균주를 배양 배지에서 배양하는 단계 및 배양액으로부터 상기 화합물을 회수하는 단계에 의한 화합물의 제조 방법, 상기 화합물을 포함하는 약학적 조성물, 멜라노코르틴 수용체 조절용 약제 또는 화장품 제조를 위한 상기 화합물의 용도, 허혈/재관류 손상, 뇌 및 신장 염증 질환, 간염, 패혈증/패혈증 쇼크, 저산소 쇼크, 급성 호흡 곤란 증후군 (ARDS), 류마티스성 관절염 (RA), 통풍성 관절염, 대동맥판 역류 (AR), 연소기 만성 관절염, 골관절염, 신염, 내성 유도, 접촉과민증, 염증성 장질환 (IBD), 성기능 장애, 이식, 통증, HIV 질환 진행, 염증후 색소침착저하증, 전풍, 특발성 적상 저색소증, 발열, 기능성 장 질환, 비만, 포만 효과, 당뇨병, 피부 외분비 기능의 변형, 백모증(국한성 백모증), 백발, 췌장염, 섬유성 장애(비대성 반흔, 켈로이드, 국소성 경피증, 전신 경화증, 피부의 경피성 이식편대숙주질환, 간경화, 특발성 및 블레오마이신 유도 폐 섬유증, 시클로스포린 유도 신병증), 포도막증(특히 베체트 증후군 및 유육종증 내), 혈관염, 미생물 감염, 셀리악병, 외음부 전정염 증후군, 흑색종 침습 또는 식욕부진 등의 치료 또는 예방용 약제 또는 화장품 제조에 있어서 상기 화합물의 용도에 관한 것이다.

8. 发明公开

KR1020100051751A 화합물 ＷＳ727713 失效
标题翻译：化合物WS727713
公开(公告)号：KR1020100051751A
公开(公告)日：2010-05-17
申请号：KR1020107008864
申请日：2005-03-22
申请人： 아스테라스 세이야쿠 가부시키가이샤
发明人： 오츠카,다카나오 , 우에다,히로츠구 , 후지에,게이코 , 무라마츠,히데유키 , 하시모토,미치자네 , 다카세,시게히로
IPC分类号： C12N1/20 , C07D259/00
CPC分类号： C12R1/01 , A61K8/99 , A61K35/74 , A61K2800/85 , A61Q5/065 , A61Q19/00 , C07G17/00 , C12P1/06
摘要： The present invention relates to a new compound useful as a modulator of melanocortin receptors. In particular, the present invention relates to a compound WS727713, a process for production of the compound by culturing, in a culture medium, a WS727713-producing strain belonging to Pseudonocardia and recovering the compound from a culture broth, a pharmaceutical composition containing the compound, a use of the compound for manufacture of a medicament or a cosmetic for melanocortin receptor modulation, a use of the compound for manufacture of a medicament or a cosmetic for treating or preventing ishemia/reperfusion injury, brain and renal infammatory diseases, hepatitis, sepsis/septic shock, hypoxic shock, acute respiratory distress syndrome (ARDS), rheumatic arthritis (RA), gouty arthritis, aortic regurgitation (AR), juvenile chronic arthritis, osteoarthritis, nephritis, induction of tolerance, contact hypersensitivity, inflammatory bowel disease (IBD), sexual dysfuntion, transplantation, pain, disease progression of HIV, postinflammatory hypopigmentation, tinea versicolor, idiopathic guttate hypomelanosis, fever, functional bowel disease, obesity, satiety effect, diabetes mellitus, modulation of dermal exocrine function, canities (canities circumscripta), gray hair, pancreatitis, fibrotic disorders (hypertrophic scars, keloids, localized scleroderma, systematic sclerosis, sclerodermic graft versus host disease of the skin, cirrhosis of the liver, idiopathic and bleomycin induced lung fibrosis, cyclosporin induced nephropathy), uveitis (especially in Behcet's syndrome and sarcoidosis), vasculitis, microbial infections, celiac disease, vulvar vestibulitis syndrome, melonoma invasion, anorexia or the like.
摘要翻译：本发明涉及可用作黑皮质素受体调节剂的新化合物。特别地，本发明涉及化合物WS727713，该化合物的生产方法是在培养基中培养属于假诺卡氏菌属的WS727713生产菌株并从培养液中回收该化合物，含有该化合物的药物组合物，该化合物用于制造用于黑皮质素受体调节的药物或化妆品的用途，该化合物用于制备用于治疗或预防缺血/再灌注损伤，脑和肾脏炎症性疾病，肝炎，败血症的药物或化妆品的用途 /脓毒性休克，缺氧休克，急性呼吸窘迫综合征（ARDS），风湿性关节炎（RA），痛风性关节炎，主动脉瓣反流（AR），青少年慢性关节炎，骨关节炎，肾炎，耐受诱导，接触性超敏反应，炎症性肠病），性功能障碍，移植，疼痛，艾滋病病毒进展，炎性色素沉着减轻，花斑癣，特发性肥胖症，饱腹感，糖尿病，皮肤外分泌功能的调节，阴毛（canence circumscripta），灰白色，胰腺炎，纤维化疾病（肥大性瘢痕，瘢痕疙瘩，局部硬皮病，系统性硬化症，硬皮病皮肤移植物抗宿主病，肝硬化，特发性和博来霉素引起的肺纤维化，环孢菌素诱导的肾病），葡萄膜炎（特别是Behcet综合征和结节病），血管炎，微生物感染，乳糜泻，外阴前庭炎综合征，美黄酮侵袭，厌食症等。

9. 发明公开

KR1020090121281A 리간드 개질 폴리 옥소-히드록시 금속 이온 물질, 이의 용도 및 이의 제조 방법 有权
标题翻译： LIGAND改性聚氧化羟基金属离子材料及其制备及其制备方法
公开(公告)号：KR1020090121281A
公开(公告)日：2009-11-25
申请号：KR1020097016904
申请日：2008-02-06
申请人： 메디칼 리서취 카운실
发明人： 파웰조나단조셉 , 부루가라버실뱅프랑소와즈알린 , 파리아누노조지로드리게스 , 페레이라도라이자벨아마랄
IPC分类号： C07F15/02 , A61K31/295
CPC分类号： C07F15/025 , C07G17/00
摘要： Ligand-modified poly oxo-hydroxy metal ion materials and their uses are disclosed, in particular for nutritional, medical, cosmetic or biologically related applications for example for the treatment of a deficiency related to a component of the material or for the removal of an endogenous substance capable of binding to the material. The present invention further relates to processes for preparing the materials and optimising their physicochemical properties and their medical uses.
摘要翻译：公开了配体改性的聚氧代 - 羟基金属离子材料及其用途，特别是用于营养，医学，化妆品或生物相关应用，例如用于治疗与材料组分相关的缺陷或用于去除内源性能够结合材料的物质。本发明还涉及制备材料和优化其物理化学性质及其医疗用途的方法。

10. 发明公开

KR1020070008682A 화합물 ＷＳ727713 无效
标题翻译：化合物WS727713
公开(公告)号：KR1020070008682A
公开(公告)日：2007-01-17
申请号：KR1020067023115
申请日：2005-03-22
申请人： 아스테라스 세이야쿠 가부시키가이샤
发明人： 오츠카,다카나오 , 우에다,히로츠구 , 후지에,게이코 , 무라마츠,히데유키 , 하시모토,미치자네 , 다카세,시게히로
IPC分类号： C07D259/00 , C12N1/20
CPC分类号： C12R1/01 , A61K8/99 , A61K35/74 , A61K2800/85 , A61Q5/065 , A61Q19/00 , C07G17/00 , C12P1/06
摘要： The present invention relates to a new compound useful as a modulator of melanocortin receptors. In particular, the present invention relates to a compound WS727713, a process for production of the compound by culturing, in a culture medium, a WS727713-producing strain belonging to Pseudonocardia and recovering the compound from a culture broth, a pharmaceutical composition containing the compound, a use of the compound for manufacture of a medicament or a cosmetic for melanocortin receptor modulation, a use of the compound for manufacture of a medicament or a cosmetic for treating or preventing ishemia/reperfusion injury, brain and renal infammatory diseases, hepatitis, sepsis/septic shock, hypoxic shock, acute respiratory distress syndrome (ARDS), rheumatic arthritis (RA), gouty arthritis, aortic regurgitation (AR), juvenile chronic arthritis, osteoarthritis, nephritis, induction of tolerance, contact hypersensitivity, inflammatory bowel disease (IBD), sexual dysfuntion, transplantation, pain, disease progression of HIV, postinflammatory hypopigmentation, tinea versicolor, idiopathic guttate hypomelanosis, fever, functional bowel disease, obesity, satiety effect, diabetes mellitus, modulation of dermal exocrine function, canities (canities circumscripta), gray hair, pancreatitis, fibrotic disorders (hypertrophic scars, keloids, localized scleroderma, systematic sclerosis, sclerodermic graft versus host disease of the skin, cirrhosis of the liver, idiopathic and bleomycin induced lung fibrosis, cyclosporin induced nephropathy), uveitis (especially in Behcet's syndrome and sarcoidosis), vasculitis, microbial infections, celiac disease, vulvar vestibulitis syndrome, melonoma invasion, anorexia or the like. ® KIPO & WIPO 2007
摘要翻译：本发明涉及可用作黑皮质素受体调节剂的新化合物。特别地，本发明涉及化合物WS727713，该化合物的生产方法是在培养基中培养属于假诺卡氏菌属的WS727713生产菌株并从培养液中回收该化合物，含有该化合物的药物组合物，该化合物用于制造用于黑皮质素受体调节的药物或化妆品的用途，该化合物用于制备用于治疗或预防缺血/再灌注损伤，脑和肾脏炎症性疾病，肝炎，败血症的药物或化妆品的用途 /脓毒性休克，缺氧休克，急性呼吸窘迫综合征（ARDS），风湿性关节炎（RA），痛风性关节炎，主动脉瓣反流（AR），青少年慢性关节炎，骨关节炎，肾炎，耐受诱导，接触性超敏反应，炎症性肠病），性功能障碍，移植，疼痛，艾滋病病毒进展，炎性色素沉着减轻，花斑癣，特发性肥胖症，饱腹感，糖尿病，皮肤外分泌功能的调节，阴毛（canence circumscripta），灰白色，胰腺炎，纤维化疾病（肥大性瘢痕，瘢痕疙瘩，局部硬皮病，系统性硬化症，硬皮病皮肤移植物抗宿主病，肝硬化，特发性和博来霉素引起的肺纤维化，环孢菌素诱导的肾病），葡萄膜炎（特别是Behcet综合征和结节病），血管炎，微生物感染，乳糜泻，外阴前庭炎综合征，美黄酮侵袭，厌食症等。 ®KIPO＆WIPO 2007

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