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    • 3. 发明公开
    • 소형 정제의 제조방법 및 그 제조장치
    • 制作微型薄片的方法和装置
    • KR1020050037555A
    • 2005-04-22
    • KR1020057001053
    • 2003-07-21
    • 에스엠아이 인코퍼레이티드
    • 법게리
    • A61J3/06A61J3/10
    • A61K9/2072B29C43/08B29C43/361B29C2043/3272B29C2043/3288B29C2043/3618B29C2043/3689B29C2043/3692B30B11/08
    • The present invention relates to a method and system for forming a miniature tablet (12) using a predetermined compression force in a rotary tablet press (10). The predetermined compression force can be in the range of about 50 to about 2,000 Newtons, preferably less than about 500 Newtons. In one embodiment, the predetermined compression force is applied using an adjustable ramp (86) for moving a lower punch (28) upwardly towards a downwardly moving upper punch (68). The height of the adjustable ramp (86) is accurately controlled to precisely provide the predetermined compression force for forming the miniature tablet (12). It has also been found that breakage of punch stems (38, 80) formed on the lower punch can be reduced by providing a reinforced portion of the punch stem (38) formed on the lower punch (28) can be reduced by providing a reinforced portion of the punch stem below the slender portion (36) of the punch stem (38) which enters a bore (44) of the die (40) wherein the miniature tablet (12) is formed.
    • 本发明涉及一种在旋转式压片机(10)中使用预定压缩力形成小型片剂(12)的方法和系统。 预定的压缩力可以在约50至约2,000牛顿的范围内,优选小于约500牛顿。 在一个实施例中,使用可调斜面(86)来施加预定的压缩力,用于向下移动下冲头(28)朝向下移动的上冲头(68)。 精确地控制可调节斜坡(86)的高度以精确地提供用于形成小型压片(12)的预定压缩力。 还发现通过提供形成在下冲头(28)上的冲头杆(38)的加强部分可以减少形成在下冲头上的冲杆(38,80)的破损,可以通过提供加强件 所述冲头杆部分位于所述冲头杆(38)的细长部分(36)下方,所述冲头杆(38)进入所述模具(40)的孔(44),其中形成所述微型薄片(12)。