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1. 发明公开

KR1020070018501A 고순도 및 고용량으로 ＤＮＡ를 분리 정제할 수 있는아미노 치환기를 가지는 실리카 코팅 자성나노입자와 그의제조방법 无效
标题翻译：具有能够以高纯度和大规模分离和纯化DNA的氨基取代基的二氧化硅包覆磁铁矿及其制备方法
公开(公告)号：KR1020070018501A
公开(公告)日：2007-02-14
申请号：KR1020050073260
申请日：2005-08-10
申请人： 한국산업기술평가원(관리부서:요업기술원) , 코아바이오시스템 주식회사
发明人： 김경자 , 장정호 , 박무언 , 박용원 , 이진성
IPC分类号： B82B3/00 , B82Y25/00
CPC分类号： C01B33/12 , C01P2004/64 , C01P2006/42 , C12N15/1013 , C12Q1/6806
摘要： 본 발명은 고순도 및 고용량으로 DNA를 분리 정제할 수 있는 아미노 치환기를 가지는 실리카 코팅 자성나노입자와 그의 제조방법에 관한 것으로, 더욱 상세하게는 DNA에 특이적으로 결합할 수 있도록 실리카 코팅된 자성나노입자에 모노아민기 또는 다이아민기가 치환되어 DNA를 고순도 및 고용량으로 분리, 정제할 수 있는 기능성 자성나노입자에 관한 것이다.
본 발명에 따른 아미노기가 치환된 자성나노입자는 종래의 자성입자 보다 다양한 크기로 제조될 수 있어서 크기별로는 플라스미드 DNA, 게놈 DNA, PCR 등에 다양하게 적용할 수 있다. 또한, 종래의 자성입자 보다 목적 DNA에 대한 결합성 및 DNA의 수득율이 높아 단위 시간당 필요한 시료 DNA를 많이 확보할 수 있으며, 목적 분자의 특성에 따라 자성나노입자를 가공하면 DNA를 고순도로 정제할 수 있으므로 기존의 HPLC, FPLC, 전기영동 등과 같은 시간 소모가 많은 생화학적 방법의 속도를 획기적으로 개선할 수 있다.
자성나노입자, DNA 분리정제, 실리카 코팅 자성나노입자

2. 发明授权

KR100845560B1 인산칼슘계 수산화아파타이트 나노결정의 표면개질 방법 有权
标题翻译：羟基磷酸钙纳米晶体表面改性方法
公开(公告)号：KR100845560B1
公开(公告)日：2008-07-10
申请号：KR1020070009573
申请日：2007-01-30
申请人： 한국산업기술평가원(관리부서:요업기술원)
发明人： 이상천 , 김경자 , 이홍재 , 최형우 , 황호찬 , 김진영 , 송석범 , 강계원
IPC分类号： B82B3/00 , C01B25/32 , B82Y40/00
CPC分类号： C01B25/327 , B82Y40/00 , C08F292/00 , C08J2207/10 , C08J2300/16
摘要： A method for modifying the surface of hydroxyapatite calcium phosphate nanocrystal is provided to produce the hydroxyapatite calcium phosphate nanocrystal having excellent dispersion stability in an aqueous solution. A method for modifying the surface of hydroxyapatite calcium phosphate nanocrystal includes the steps of: (1) reacting calcium hydroxide, phosphoric acid, and 3-mercaptopropionic acid in-situ to prepare hydroxyapatite nanocrystal containing both hydroxyl groups and thiol groups on the surface of the hydroxyapatite nanocrystal; and (2) graft-polymerizing a vinyl group-containing polymer on the thiol groups present on the surface of the hydroxyapatite nanocrystal containing both hydroxyl groups and thiol groups through a radical chain transfer reaction to modify the surface of the hydroxyapatite nanocrystal. Further, a weight average molecular weight of the vinyl group-containing polymer is 10000 to 100000 g/mol.
摘要翻译：提供羟基磷灰石磷酸钙纳米晶体的表面改性方法，制备在水溶液中具有优异的分散稳定性的羟基磷灰石磷酸钙纳米晶体。一种改性羟基磷灰石磷酸钙纳米晶体表面的方法包括以下步骤：（1）将氢氧化钙，磷酸和3-巯基丙酸原位反应，制备含有羟基磷灰石纳米晶体的羟基和硫醇基的表面上的羟基磷灰石纳米晶体羟基磷灰石纳米晶体和（2）通过自由基链转移反应将存在于含有羟基和硫醇基的羟基磷灰石纳米晶体的表面上的硫醇基上的含乙烯基聚合物接枝聚合，以改性羟基磷灰石纳米晶体的表面。此外，含乙烯基聚合物的重均分子量为10000〜100000g / mol。

3. 发明授权

KR100776252B1 탄소재 상에 내산화성 다층코팅을 형성하는 방법 有权
标题翻译：在碳表面上形成多层耐氧化涂层的方法
公开(公告)号：KR100776252B1
公开(公告)日：2007-11-13
申请号：KR1020060057785
申请日：2006-06-27
申请人： 한국산업기술평가원(관리부서:요업기술원)
发明人： 류도형 , 김경자 , 김영희 , 조광연 , 정영근 , 홍현정 , 허승헌
IPC分类号： C23C28/00 , C23C16/00 , C04B41/50
摘要： A method for forming oxidation resistant multi-coating on carbon material is provided to manufacture the multi-coating having superior airtight property by coating a surface after a CVR process with carbosilane polymer. A method for forming anti-oxidative multi-coating on carbon material comprises a step of allowing carbon material to react with silicon gas or silicon oxidation gas, which is provided by pack power containing carbide, to deposit a first coating layer containing SiC on the surface of the carbon material. The carbon material having the first coating layer is coated with polycarbosilane solution to form a second coating layer. The carbon material is subject to a heat treatment process in order to form carbide by thermally decomposing the second coating layer. The polycarbosilane comprises at least one selected from the group consisting of polymethylcarbosilane, polymethylphenylcarbosilane, polyvinylcarbosilane and polymethylsilane.
摘要翻译：提供了一种在碳材料上形成耐氧化多层涂层的方法，以通过在碳氢硅烷聚合物进行CVR处理之后涂覆表面来制造具有优异气密性的多层涂层。用于在碳材料上形成抗氧化多层涂层的方法包括使碳材料与包含碳化物的包装电力提供的硅气体或硅氧化气体反应的步骤，以在表面上沉积含有SiC的第一涂层的碳材料。具有第一涂层的碳材料涂覆有聚碳硅烷溶液以形成第二涂层。碳材料经受热处理工艺，以通过热分解第二涂层形成碳化物。聚碳硅烷包括选自聚甲基碳硅烷，聚甲基苯基碳硅烷，聚乙烯基碳硅烷和聚甲基硅烷中的至少一种。

4. 发明授权

KR100760684B1 아미노기가 치환된 기능성 메조포러스 실리카를 이용한핵산 및 단백질의 선택적 분리 정제 방법 有权
标题翻译：用氨基官能化自组装的多孔硅选择性纯化核酸和蛋白质
公开(公告)号：KR100760684B1
公开(公告)日：2007-10-04
申请号：KR1020060097650
申请日：2006-10-04
申请人： 한국산업기술평가원(관리부서:요업기술원)
发明人： 장정호 , 조민애 , 김경자
IPC分类号： C07K1/14 , C12N15/10
摘要： A method for preparing an amino group-substituted mesoporous silica is provided to obtain a functional mesoporous silica by substituting the mesoporous silica with a mono-amine, a di-amine or a tri-amine group, which is able to purify DNA with high purity, thereby capable of significantly improving the speed of a time-consuming biochemical method such as HPLC, FPLC, and electrophoresis. A method for preparing a functional mesoporous silica comprises the steps of: (a) preparing a mesoporous silica; (b) adding at least one compound selected from the group consisting of 3-aminopropyltriethoxy silane, N-[3-(trimethoxysilyl)propyl]ethylene diamine and N'-[3-(trimethoxysilyl)propyl]diethylene triamine to the mesoporous silica solution; (c) increasing the temperature of the mixture to 100-130 deg.C and then refluxing the mixture with agitating; and (d) washing the mixture after finishing the reaction and drying the obtained powder at room temperature. The method for purifying nucleic acid or protein comprises the steps of: (a) absorbing the nucleic acid or protein using the functional mesoporous silica; and (b) isolating the mesoporous silica and the nucleic acid or protein from the absorbed material.
摘要翻译：提供了制备氨基取代的介孔二氧化硅的方法，通过用能够以高纯度纯化DNA的单胺，二胺或三胺基取代介孔二氧化硅来获得功能介孔二氧化硅从而能够显着地提高诸如HPLC，FPLC和电泳之类的耗时生化方法的速度。制备功能介孔二氧化硅的方法包括以下步骤：（a）制备介孔二氧化硅; （b）向介孔二氧化硅溶液中加入至少一种选自3-氨基丙基三乙氧基硅烷，N- [3-（三甲氧基甲硅烷基）丙基]乙二胺和N' - [3-（三甲氧基甲硅烷基）丙基]二亚乙基三胺的化合物 ; （c）将混合物的温度升至100-130℃，然后搅拌回流混合物; 和（d）在反应完成后洗涤混合物，并在室温下干燥得到的粉末。纯化核酸或蛋白质的方法包括以下步骤：（a）使用功能性介孔二氧化硅吸收核酸或蛋白质; 和（b）从吸收的材料中分离介孔二氧化硅和核酸或蛋白质。

5. 发明授权

KR100675986B1 파이로인산을 이용하여 흑연재의 내산화성을 증진시키기위한 코팅 방법 失效
标题翻译：使用我们的产品和服务，我们将为您提供最优质的产品和服务。
公开(公告)号：KR100675986B1
公开(公告)日：2007-01-30
申请号：KR1020050124853
申请日：2005-12-16
申请人： 한국산업기술평가원(관리부서:요업기술원)
发明人： 장정호 , 김경자 , 조광연 , 서규식
IPC分类号： B05D1/16 , B05D7/00
摘要： A coating method for improving oxidation resistance of graphite by pyrophosphoric acid is provided to secure the stability of graphite even at high temperature and to extend the life time by forming an oxidation resistance layer by coating the graphite with pyrophosphoric acid. The coating method for improving oxidation resistance of graphite by pyrophosphoric acid comprises the steps of: impregnating the graphite with alcohol and then drying the graphite; dipping the dried graphite in a pyrophosphoric acid aqueous solution, dispersing ultrasonic wave, and then drying the graphite; and thermally treating the graphite at high temperature. The concentration of the pyrophosphoric acid aqueous solution is in a range of 0.1~3mol/L. The graphite is vacuum-pressurized in the pyrophosphoric acid aqueous solution at the same time in dispersing ultrasonic wave.
摘要翻译：提供一种通过焦磷酸提高石墨抗氧化性的涂覆方法，以确保即使在高温下石墨的稳定性，并通过用焦磷酸涂覆石墨形成抗氧化层来延长寿命。用焦磷酸改善石墨抗氧化性的涂覆方法包括以下步骤：用酒精浸渍石墨，然后干燥石墨; 将干燥的石墨浸入焦磷酸水溶液中，分散超声波，然后干燥石墨; 并在高温下热处理石墨。焦磷酸水溶液的浓度在0.1〜3mol / L的范围内。在分散超声波的同时，在焦磷酸水溶液中对石墨进行真空加压。

6. 发明授权

KR100588555B1 온도-감응성 폴리머로 개질된 실리카 약물전달체 失效
标题翻译：热敏聚合物改性二氧化硅的药物输送系统及其制备方法
公开(公告)号：KR100588555B1
公开(公告)日：2006-06-14
申请号：KR1020040003614
申请日：2004-01-17
申请人： 한국산업기술평가원(관리부서:요업기술원)
发明人： 장정호 , 김경자 , 심창한 , 김범중 , 김영희 , 조광연 , 박윤현 , 정수철
IPC分类号： A61K47/48
摘要： 본 발명은 온도-감응성 폴리머로 개질된 나노다공성 실리카에 약물을 담지시킨 약물전달체 및 이의 제조방법에 관한 것이다.
온도-감응성 폴리머, 나노다공성, 실리카, 약물전달체, 폴리(N-이소프로필아크릴아미드)(PNIPAm)

7. 发明公开

KR1020040109982A 탄소재 저온 발열체 제조방법 失效
标题翻译：从作为前驱体的PITCH制备碳材料的低温加热元件的方法
公开(公告)号：KR1020040109982A
公开(公告)日：2004-12-29
申请号：KR1020030039631
申请日：2003-06-19
申请人： 장승조 , 한국산업기술평가원(관리부서:요업기술원)
发明人： 장승조 , 김경자 , 조광연
IPC分类号： C10C3/00
摘要： PURPOSE: Provided is a cost-efficient method for preparation of low temperature heating element of carbon material starting from pitch precursor. CONSTITUTION: The method comprises the steps of providing a pitch precursor; the first heat treatment of the pitch precursor to prepare mesophase pitch; shaping the pitch into the desired shape; the second heat treatment of the shaped pitch under oxidizing atmosphere to stabilize; and the third heat treatment for carbonizing the shaped pitch. Alternatively, the method further comprises the step of mixing coke into the pitch after the first heat treatment. The first heat treatment is carried out under inert atmosphere at the temperature of about 400 to about 550 deg.C and the second heat treatment is carried out at the temperature of about 150 to about 200 deg.C. In the step of mixing, the ratio of the thermally treated pitch and coke is 100:0.1 to 100:40.
摘要翻译：目的：提供从沥青前体制备碳材料的低温加热元件的成本有效的方法。构成：该方法包括提供沥青前体的步骤; 首先对沥青前体进行热处理以制备中间相沥青; 将节距成形为所需的形状; 在氧化气氛下对成形沥青的第二次热处理稳定; 以及用于碳化成形节距的第三热处理。或者，该方法还包括在第一热处理之后将焦炭混入沥青中的步骤。第一热处理在惰性气氛下在约400至约550℃的温度下进行，第二次热处理在约150至约200℃的温度下进行。在混合工序中，热处理沥青与焦炭的比例为100:0.1〜100:40。

8. 发明公开

KR1020040044659A 수용해성 유리를 이용한 3차원 연결 다공체의 제조방법 有权
标题翻译：使用水溶性玻璃的具有三维网络结构的多孔陶瓷的生产方法
公开(公告)号：KR1020040044659A
公开(公告)日：2004-05-31
申请号：KR1020020072760
申请日：2002-11-21
申请人： 한국산업기술평가원(관리부서:요업기술원)
发明人： 현부성 , 정수철 , 김경자 , 김수룡 , 김영희
IPC分类号： C03B37/15
摘要： PURPOSE: A production method of three dimensional porous ceramic structures is provided to control pore size and shape, and porosity easily by using water soluble glass. The method is also applied to the production of porous metal or resin structures. CONSTITUTION: The porous ceramic structures are produced by the following steps of: (i) forming molten soluble glass to a shape of fiber(50-100micrometer of diameter) or sphere, wherein the molten soluble glass is prepared by grinding soluble glass based on Li2O-SiO2, K2O-SiO2, MgO-P2O5, CaO-P2O5, etc., melting ground soluble glass in a Pt crucible at 1450deg.C for 2hrs, and cooling; (ii) bonding glass fibers(or spheres) by heat-treating at 600-810deg.C for 5-10min or autoclave-treating for 1-5min under 1-3atm to form three dimensional network structures; (iii) filling pores of the structures with matrix through vacuuming or centrifuging, and then hardening; (iv) removing glass from the hardened structures by soaking matrix-filled structures in water or applying vapor pressure to structures. In the step (i), the glass fibers are obtained by drawing prepared glass with a burner and the glass spheres are obtained by grinding prepared glass, mixing with graphite which is an ideal mixing material in manufacturing glass, heating a mixture at 650-800deg.C for 1-10min in a furnace and washing the mixture with alcohol to separate graphite from glass.
摘要翻译：目的：提供三维多孔陶瓷结构的制造方法，通过使用水溶性玻璃容易地控制孔径，形状和孔隙度。该方法也适用于生产多孔金属或树脂结构。构成：通过以下步骤制备多孔陶瓷结构：（i）将熔融可溶玻璃形成为纤维（直径为50-100微米）或球形的形状，其中熔融可溶性玻璃通过研磨基于Li 2 O的可溶性玻璃制备 -SiO 2，K 2 O-SiO 2，MgO-P 2 O 5，CaO-P 2 O 5等，在Pt坩埚中将熔融的可溶性玻璃在1450℃下熔融2小时，并冷却; （ii）通过在600-810℃下热处理5-10分钟或1-3atm下高压釜处理1-5分钟将玻璃纤维（或球体）粘结形成三维网状结构; （iii）通过抽真空或离心将基质的孔结构填充，然后硬化; （iv）通过将基体填充的结构浸入水中或对结构施加蒸气压来从硬化结构中除去玻璃。在步骤（i）中，通过用燃烧器拉制制备的玻璃来获得玻璃纤维，并且通过研磨制备的玻璃，与在制造玻璃中的理想的混合材料的石墨混合获得玻璃球，将混合物加热至650-800deg 在炉中加热1-10分钟，用乙醇洗涤混合物，将石墨与玻璃分离。

9. 发明授权

KR100418047B1 수지결합질 탄소재 조성물 및 그 제조방법 有权
标题翻译： 수지결합질탄소재조성물및그제조방법
公开(公告)号：KR100418047B1
公开(公告)日：2004-02-11
申请号：KR1020010056574
申请日：2001-09-13
申请人： 극동씰테크 주식회사 , 한국산업기술평가원(관리부서:요업기술원)
发明人： 김경자 , 조광연 , 고재식
IPC分类号： C08K9/06
摘要： PURPOSE: Provided is a resin bonded carbon composition excellent in compatibility between a filler and a binder and wettability, thereby injection-molding resin bonded carbon articles having excellent properties. CONSTITUTION: The resin bonded carbon composition is produced by a process comprising the steps of: surface-treating a part or whole of a carbon filler with a silane-based coupling agent such as gamma-amino alkyl trialkoxy silane; mixing the carbon filler and a polymer resin as the binder and curing the mixture; grinding the cured mixture.
摘要翻译：目的：提供一种填料和粘合剂之间的相容性和润湿性优异的树脂粘合碳组合物，由此注射成型具有优异性能的树脂粘合碳制品。构成：树脂结合碳组合物通过包括以下步骤的方法生产：用硅烷基偶联剂如γ-氨基烷基三烷氧基硅烷对一部分或全部碳填料进行表面处理; 混合碳填料和作为粘合剂的聚合物树脂并固化混合物; 研磨固化的混合物。

10. 发明公开

KR1020090002946A 상호침투성 가교구조를 갖는 온도감응성 고분자하이드로겔, 이의 제조방법 및 이를 포함하는 주사제형약물전달체 无效
标题翻译：具有互聚聚合物网络结构的热敏聚合物水凝胶，其制备方法和包含其的可注射的药物递送系统
公开(公告)号：KR1020090002946A
公开(公告)日：2009-01-09
申请号：KR1020070067371
申请日：2007-07-05
申请人： 한국산업기술평가원(관리부서:요업기술원)
发明人： 김소연 , 이상천 , 김경자 , 황호찬 , 강계원 , 송석범 , 서석진 , 김진영
IPC分类号： A61K47/30 , A61K47/34 , A61K47/48
CPC分类号： A61K47/6903 , A61K9/0019 , A61K38/385 , A61K47/595 , A61K47/605
摘要： A temperature sensitive polymer P(NIPAAm-co-VPAc) hydrogel, a method for preparing the polymer hydrogel, and a drug delivery system for injection containing the polymer hydrogel are provided to control the releasing velocity of drug by controlling the crosslinked structure of a hydrogel. A temperature sensitive polymer P(NIPAAm-co-VPAc) hydrogel comprises poly(N-isopropylacrylamide) (PNIPAA) and poly(vinyl phosphonic acid). (PVPAc) and has an interpenetrating crosslinked structure. Preferably the ratio of PNIPAA and PVPAc is 90:10 to 99:1. Preferably the polymer hydrogel has a low critical solution temperature (LCST) of 33-36 deg.C.
摘要翻译：提供温度敏感性聚合物P（NIPAAm-co-VPAc）水凝胶，制备聚合物水凝胶的方法和含有聚合物水凝胶的注射药物递送系统，以通过控制水凝胶的交联结构来控制药物的释放速度。温度敏感性聚合物P（NIPAAm-co-VPAc）水凝胶包含聚（N-异丙基丙烯酰胺）（PNIPAA）和聚（乙烯基膦酸）。（PVPAc），并具有互穿交联结构。优选地，PNIPAA和PVPAc的比例为90:10至99:1。优选地，聚合物水凝胶具有33-36℃的低临界溶解温度（LCST）。

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