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1. 发明授权

KR100845560B1 인산칼슘계 수산화아파타이트 나노결정의 표면개질 방법 有权
标题翻译：羟基磷酸钙纳米晶体表面改性方法
公开(公告)号：KR100845560B1
公开(公告)日：2008-07-10
申请号：KR1020070009573
申请日：2007-01-30
申请人： 한국산업기술평가원(관리부서:요업기술원)
发明人： 이상천 , 김경자 , 이홍재 , 최형우 , 황호찬 , 김진영 , 송석범 , 강계원
IPC分类号： B82B3/00 , C01B25/32 , B82Y40/00
CPC分类号： C01B25/327 , B82Y40/00 , C08F292/00 , C08J2207/10 , C08J2300/16
摘要： A method for modifying the surface of hydroxyapatite calcium phosphate nanocrystal is provided to produce the hydroxyapatite calcium phosphate nanocrystal having excellent dispersion stability in an aqueous solution. A method for modifying the surface of hydroxyapatite calcium phosphate nanocrystal includes the steps of: (1) reacting calcium hydroxide, phosphoric acid, and 3-mercaptopropionic acid in-situ to prepare hydroxyapatite nanocrystal containing both hydroxyl groups and thiol groups on the surface of the hydroxyapatite nanocrystal; and (2) graft-polymerizing a vinyl group-containing polymer on the thiol groups present on the surface of the hydroxyapatite nanocrystal containing both hydroxyl groups and thiol groups through a radical chain transfer reaction to modify the surface of the hydroxyapatite nanocrystal. Further, a weight average molecular weight of the vinyl group-containing polymer is 10000 to 100000 g/mol.
摘要翻译：提供羟基磷灰石磷酸钙纳米晶体的表面改性方法，制备在水溶液中具有优异的分散稳定性的羟基磷灰石磷酸钙纳米晶体。一种改性羟基磷灰石磷酸钙纳米晶体表面的方法包括以下步骤：（1）将氢氧化钙，磷酸和3-巯基丙酸原位反应，制备含有羟基磷灰石纳米晶体的羟基和硫醇基的表面上的羟基磷灰石纳米晶体羟基磷灰石纳米晶体和（2）通过自由基链转移反应将存在于含有羟基和硫醇基的羟基磷灰石纳米晶体的表面上的硫醇基上的含乙烯基聚合物接枝聚合，以改性羟基磷灰石纳米晶体的表面。此外，含乙烯基聚合物的重均分子量为10000〜100000g / mol。

2. 发明公开

KR1020090002946A 상호침투성 가교구조를 갖는 온도감응성 고분자하이드로겔, 이의 제조방법 및 이를 포함하는 주사제형약물전달체 无效
标题翻译：具有互聚聚合物网络结构的热敏聚合物水凝胶，其制备方法和包含其的可注射的药物递送系统
公开(公告)号：KR1020090002946A
公开(公告)日：2009-01-09
申请号：KR1020070067371
申请日：2007-07-05
申请人： 한국산업기술평가원(관리부서:요업기술원)
发明人： 김소연 , 이상천 , 김경자 , 황호찬 , 강계원 , 송석범 , 서석진 , 김진영
IPC分类号： A61K47/30 , A61K47/34 , A61K47/48
CPC分类号： A61K47/6903 , A61K9/0019 , A61K38/385 , A61K47/595 , A61K47/605
摘要： A temperature sensitive polymer P(NIPAAm-co-VPAc) hydrogel, a method for preparing the polymer hydrogel, and a drug delivery system for injection containing the polymer hydrogel are provided to control the releasing velocity of drug by controlling the crosslinked structure of a hydrogel. A temperature sensitive polymer P(NIPAAm-co-VPAc) hydrogel comprises poly(N-isopropylacrylamide) (PNIPAA) and poly(vinyl phosphonic acid). (PVPAc) and has an interpenetrating crosslinked structure. Preferably the ratio of PNIPAA and PVPAc is 90:10 to 99:1. Preferably the polymer hydrogel has a low critical solution temperature (LCST) of 33-36 deg.C.
摘要翻译：提供温度敏感性聚合物P（NIPAAm-co-VPAc）水凝胶，制备聚合物水凝胶的方法和含有聚合物水凝胶的注射药物递送系统，以通过控制水凝胶的交联结构来控制药物的释放速度。温度敏感性聚合物P（NIPAAm-co-VPAc）水凝胶包含聚（N-异丙基丙烯酰胺）（PNIPAA）和聚（乙烯基膦酸）。（PVPAc），并具有互穿交联结构。优选地，PNIPAA和PVPAc的比例为90:10至99:1。优选地，聚合物水凝胶具有33-36℃的低临界溶解温度（LCST）。

3. 发明公开

KR1020080069799A 수산화아파타이트 나노 결정의 표면 개질 방법 无效
标题翻译：羟基磷灰石纳米晶体表面改性方法
公开(公告)号：KR1020080069799A
公开(公告)日：2008-07-29
申请号：KR1020070007473
申请日：2007-01-24
申请人： 한국산업기술평가원(관리부서:요업기술원)
发明人： 이상천 , 김경자 , 이홍재 , 최형우 , 황호찬 , 김진영 , 송석범 , 강계원
IPC分类号： B82B3/00 , C01B25/32 , B82Y40/00
CPC分类号： C01B25/327 , B82Y40/00 , C08F292/00 , C08J2207/10 , C08J2300/16
摘要： A modification method of the surface of hydroxyapatite nano-crystal is provided to obtain hydroxyapatite nano-crystal having excellent dispersibility and improved mechanical property by grafting polymerization of biodegradable polymer on the nano-crystal through modulating the reactivity of the hydroxyl group on the surface of the hydroxyapatite nano-crystal. A modification method of the surface of hydroxyapatite nano-crystal comprises a step of introducing a primary alcohol group to the hydroxyl group on the surface of the hydroxyl group on the surface of the hydroxyapatite nano-crystal for the grafting polymerization of a biodegradable polymer. The hydroxyl group is the hydroxyl group introduced by ethylene glycol in a one-pot reaction of hexamethylenediisocyanate and ethylene glycol. The biodegradable polymer is selected from a group consisting of polylactide, polyglycolide, polycaprolactone, polytrimethylene carbonate, and combinations thereof. The amount of the biodegradable polymer is 20-30wt%. Further, a weight average molecular weight of the biodegradable polymer is 10000 to 100000 g/mol.
摘要翻译：提供羟基磷灰石纳米晶体表面的改性方法，通过调节纳米晶体表面羟基的反应性，得到具有优异分散性和改善机械性能的羟基磷灰石纳米晶体，羟基磷灰石纳米晶体。羟基磷灰石纳米晶体表面的改性方法包括将羟基磷灰石纳米晶体表面的羟基表面上的羟基引入到生物可降解聚合物的接枝聚合中的步骤。羟基是在六甲基二异氰酸酯和乙二醇的一锅反应中由乙二醇引入的羟基。生物可降解聚合物选自聚丙交酯，聚乙交酯，聚己酸内酯，聚三亚甲基碳酸酯及其组合。可生物降解聚合物的量为20-30重量％。此外，生物降解性聚合物的重均分子量为10000〜100000g / mol。

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