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    • 2. 发明公开
    • 수산화아파타이트 나노 결정의 표면 개질 방법
    • 羟基磷灰石纳米晶体表面改性方法
    • KR1020080069799A
    • 2008-07-29
    • KR1020070007473
    • 2007-01-24
    • 한국산업기술평가원(관리부서:요업기술원)
    • 이상천김경자이홍재최형우황호찬김진영송석범강계원
    • B82B3/00C01B25/32B82Y40/00
    • C01B25/327B82Y40/00C08F292/00C08J2207/10C08J2300/16
    • A modification method of the surface of hydroxyapatite nano-crystal is provided to obtain hydroxyapatite nano-crystal having excellent dispersibility and improved mechanical property by grafting polymerization of biodegradable polymer on the nano-crystal through modulating the reactivity of the hydroxyl group on the surface of the hydroxyapatite nano-crystal. A modification method of the surface of hydroxyapatite nano-crystal comprises a step of introducing a primary alcohol group to the hydroxyl group on the surface of the hydroxyl group on the surface of the hydroxyapatite nano-crystal for the grafting polymerization of a biodegradable polymer. The hydroxyl group is the hydroxyl group introduced by ethylene glycol in a one-pot reaction of hexamethylenediisocyanate and ethylene glycol. The biodegradable polymer is selected from a group consisting of polylactide, polyglycolide, polycaprolactone, polytrimethylene carbonate, and combinations thereof. The amount of the biodegradable polymer is 20-30wt%. Further, a weight average molecular weight of the biodegradable polymer is 10000 to 100000 g/mol.
    • 提供羟基磷灰石纳米晶体表面的改性方法,通过调节纳米晶体表面羟基的反应性,得到具有优异分散性和改善机械性能的羟基磷灰石纳米晶体, 羟基磷灰石纳米晶体。 羟基磷灰石纳米晶体表面的改性方法包括将羟基磷灰石纳米晶体表面的羟基表面上的羟基引入到生物可降解聚合物的接枝聚合中的步骤。 羟基是在六甲基二异氰酸酯和乙二醇的一锅反应中由乙二醇引入的羟基。 生物可降解聚合物选自聚丙交酯,聚乙交酯,聚己酸内酯,聚三亚甲基碳酸酯及其组合。 可生物降解聚合物的量为20-30重量%。 此外,生物降解性聚合物的重均分子量为10000〜100000g / mol。
    • 3. 发明授权
    • 인산칼슘계 수산화아파타이트 나노결정의 표면개질 방법
    • 羟基磷酸钙纳米晶体表面改性方法
    • KR100845560B1
    • 2008-07-10
    • KR1020070009573
    • 2007-01-30
    • 한국산업기술평가원(관리부서:요업기술원)
    • 이상천김경자이홍재최형우황호찬김진영송석범강계원
    • B82B3/00C01B25/32B82Y40/00
    • C01B25/327B82Y40/00C08F292/00C08J2207/10C08J2300/16
    • A method for modifying the surface of hydroxyapatite calcium phosphate nanocrystal is provided to produce the hydroxyapatite calcium phosphate nanocrystal having excellent dispersion stability in an aqueous solution. A method for modifying the surface of hydroxyapatite calcium phosphate nanocrystal includes the steps of: (1) reacting calcium hydroxide, phosphoric acid, and 3-mercaptopropionic acid in-situ to prepare hydroxyapatite nanocrystal containing both hydroxyl groups and thiol groups on the surface of the hydroxyapatite nanocrystal; and (2) graft-polymerizing a vinyl group-containing polymer on the thiol groups present on the surface of the hydroxyapatite nanocrystal containing both hydroxyl groups and thiol groups through a radical chain transfer reaction to modify the surface of the hydroxyapatite nanocrystal. Further, a weight average molecular weight of the vinyl group-containing polymer is 10000 to 100000 g/mol.
    • 提供羟基磷灰石磷酸钙纳米晶体的表面改性方法,制备在水溶液中具有优异的分散稳定性的羟基磷灰石磷酸钙纳米晶体。 一种改性羟基磷灰石磷酸钙纳米晶体表面的方法包括以下步骤:(1)将氢氧化钙,磷酸和3-巯基丙酸原位反应,制备含有羟基磷灰石纳米晶体的羟基和硫醇基的表面上的羟基磷灰石纳米晶体 羟基磷灰石纳米晶体 和(2)通过自由基链转移反应将存在于含有羟基和硫醇基的羟基磷灰石纳米晶体的表面上的硫醇基上的含乙烯基聚合物接枝聚合,以改性羟基磷灰石纳米晶体的表面。 此外,含乙烯基聚合物的重均分子量为10000〜100000g / mol。