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    • 1. 发明公开
    • 위장관, 말초신경, 또는 혈관 기원의 중간엽줄기세포의 배양방법 및 그 용도
    • 培养来自胃肠组织,神经组织或血管的细胞干细胞的方法及其用途
    • KR1020130124074A
    • 2013-11-13
    • KR1020120047700
    • 2012-05-04
    • 인제대학교 산학협력단이화여자대학교 산학협력단
    • 양영일이승진최민영김종태김형인최창수
    • C12N5/071C12N11/04
    • C12N5/068C12N11/04C12N2533/54
    • The present invention relates to a method for culturing mesenchymal stem cells, the mesenchymal stem cells obtained by the same, and a cell therapeutic agent using the mesenchymal stem cells. More particularly, the present invention provides a method for culturing mesenchymal stem cells and the mesenchymal stem cells culture by the method. The method comprises the steps of: impregnating one or more tissues selected among gastrointestinal submucous tissues, peripheral nerve outer tissues, and blood vessel outer tissues into hydrogel and culturing the tissues; decomposing the hydrogel and collecting mesenchymal stem cells transferred and grown in the hydrogel from the tissues selected among gastrointestinal submucous tissues, peripheral nerve outer tissues, and blood vessel outer tissues. The mesenchymal stem cells have self-replication ability and pluripotency, thereby being used as a cell therapeutic agent for tissue or organ regeneration.
    • 本发明涉及培养间充质干细胞的方法,由其获得的间充质干细胞和使用间充质干细胞的细胞治疗剂。 更具体地,本发明提供了通过该方法培养间充质干细胞和间充质干细胞培养的方法。 该方法包括以下步骤:将选自胃肠​​粘膜下组织,周围神经外组织和血管外组织中的一种或多种组织浸渍到水凝胶中并培养组织; 分解水凝胶并收集从选自胃肠粘膜下组织,外周神经外组织和血管外组织中的组织转移并生长在水凝胶中的间充质干细胞。 间充质干细胞具有自我复制能力和多能性,从而被用作组织或器官再生的细胞治疗剂。
    • 4. 发明公开
    • 심장전구세포의 배양방법 및 그 용도
    • 心脏细胞培养细胞培养方法及其用途
    • KR1020130124075A
    • 2013-11-13
    • KR1020120047701
    • 2012-05-04
    • 인제대학교 산학협력단이화여자대학교 산학협력단
    • 양영일이승진김형인김종태정순호
    • C12N5/00C12N11/04
    • A61K35/34C12N5/0657C12N5/0692C12N2501/999C12N2533/52C12N5/00C12N11/04C12N2506/1315
    • The present invention relates to a method for culturing myocardium-derived cardiac progenitor cells; the cardiac progenitor cells culture by the method; a differentiation method; and a cell therapeutic agent and a therapeutic agent for treating heart diseases, containing the cardiac progenitor cells. The method for culturing the cardiac progenitor cells comprise the step of impregnating myocardium tissues into hydrogel and culturing; and decomposing the hydrogel and collecting cardiac progenitor cells transferred and grown in the hydrogel from the myocardium tissues. The cardiac progenitor cells have superior pluripotency into cardiomyocytes, osteoblasts, adipocytes, chondrocytes, vascular endothelial cells, smooth muscle cells, or skeletal muscle cells and are spontaneously differentiated into cardiomyocytes without a special differentiation factor, thereby being applied to producing a novel drug such as a cell therapeutic agent and a tissue engineering therapeutic agent.
    • 本发明涉及培养心肌来源的心脏祖细胞的方法; 心脏祖细胞培养方法; 分化方法; 以及含有心脏祖细胞的细胞治疗剂和治疗心脏病的治疗剂。 培养心脏祖细胞的方法包括将心肌组织浸渍到水凝胶中并培养的步骤; 并分解水凝胶并收集从心肌组织转移和生长在水凝胶中的心脏祖细胞。 心脏祖细胞对心肌细胞,成骨细胞,脂肪细胞,软骨细胞,血管内皮细胞,平滑肌细胞或骨骼肌细胞具有优异的多能性,并且自发分化成没有特殊分化因子的心肌细胞,从而适用于产生新药 细胞治疗剂和组织工程治疗剂。
    • 6. 发明公开
    • 신경능선줄기세포의 배양방법 및 그 용도
    • 用于培养神经干细胞的方法及其用途
    • KR1020130124076A
    • 2013-11-13
    • KR1020120047702
    • 2012-05-04
    • 인제대학교 산학협력단이화여자대학교 산학협력단
    • 양영일이승진김종태정순호
    • C12N5/0797C12N11/04
    • C12N5/0623A61K35/00C12N11/04C12N2533/54
    • The present invention relates to a method for culturing peripheral nerve-derived neural crest stem cells; the neural crest stem cells cultured by the method; a differentiation method; and a cell therapeutic agent and a therapeutic agent for treating neurological disorders, containing the neural crest stem cells. The method comprises the steps of: impregnating peripheral nerve tissues into hydrogel and culturing the peripheral nerve tissues; and decomposing the hydrogel and collecting neural crest stem cells transferred and grown in the hydrogel from the peripheral nerve tissues. The neural crest stem cells have in vivo proliferation ability and pluripotency into all cells forming peripheral nervous system and central nervous system, thereby being applied to the production of a novel drug such as a cell therapeutic agent and a tissue engineering therapeutic agent, a cell biological and molecular biological basic study, and a study on novel drug development.
    • 本发明涉及一种培养周围神经来源的神经嵴干细胞的方法, 通过该方法培养的神经嵴干细胞; 分化方法; 以及含有神经嵴干细胞的治疗神经系统疾病的细胞治疗剂和治疗剂。 该方法包括以下步骤:将周围神经组织浸入水凝胶中并培养周围神经组织; 并分解水凝胶并收集从周围神经组织转移和生长在水凝胶中的神经嵴干细胞。 神经嵴干细胞具有体内增殖能力和多能性进入所有形成周围神经系统和中枢神经系统的细胞,从而被用于生产新型药物如细胞治疗剂和组织工程治疗剂,细胞生物学 和分子生物学基础研究,以及新药开发研究。
    • 8. 发明公开
    • 골격근줄기세포의 배양방법 및 그 용도
    • 用于培养骨骼肌细胞的方法及其用途
    • KR1020130124077A
    • 2013-11-13
    • KR1020120047703
    • 2012-05-04
    • 인제대학교 산학협력단이화여자대학교 산학협력단
    • 양영일이승진김형인
    • C12N5/077C12N11/04
    • C12N5/0658C12N11/04C12N2506/1323
    • The present invention relates to a method for culturing skeletal muscle stem cells; the skeletal muscle stem cells cultured by the method; and a cell therapeutic agent and a therapeutic agent for treating musculoskeletal disorders, containing the skeletal muscle stem cells. The method comprises the steps of: impregnating skeletal muscle tissues into hydrogel and culturing the skeletal muscle tissues; and decomposing the hydrogel and collecting skeletal muscle stem cells which are transferred and grown in the hydrogel from the skeletal muscle tissues. The skeletal muscle stem cells cultured by the culture method has superior pluripotency into various body cells such as skeletal muscle cells, osteoblasts, adipocytes, chondrocytes, vascular endothelial cells, or nerve cells and are spontaneously differentiated into skeletal muscle cells without a special differentiation factor, thereby being applied to the production of a novel drug such as a cell therapeutic agent and a tissue engineering therapeutic agent.
    • 本发明涉及一种培养骨骼肌干细胞的方法, 通过该方法培养的骨骼肌干细胞; 以及含有骨骼肌干细胞的细胞治疗剂和治疗肌肉骨骼疾病的治疗剂。 该方法包括以下步骤:将骨骼肌组织浸入水凝胶中并培养骨骼肌组织; 并分解水凝胶并收集从骨骼肌组织转移和生长在水凝胶中的骨骼肌干细胞。 通过培养方法培养的骨骼肌干细胞对骨骼肌细胞,成骨细胞,脂肪细胞,软骨细胞,血管内皮细胞或神经细胞等各种身体细胞具有优异的多能性,并且自发分化为没有特殊分化因子的骨骼肌细胞, 从而适用于细胞治疗剂和组织工程治疗剂等新型药物的制造。