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    • 3. 发明公开
    • 감수에서 분리된 테르페노이드 또는 이를 포함하는감수추출물을 함유하는 골다공증 예방 및 치료용 약학조성물
    • 用于预防和治愈包含两种泰乐菌素,分离物或提取物的化学成分的组合物
    • KR1020070081294A
    • 2007-08-16
    • KR1020060013167
    • 2006-02-10
    • 동화약품주식회사
    • 유제만임문정노양국오성준이현용장환봉황연하이정욱
    • A61K31/341A61K31/56A61K36/47A61P19/10
    • A composition for preventing and treating osteoporosis comprising terpenoids isolated from Euphorbia kansui or the extracts thereof is provided to inhibit bone absorption of osteoclasts without side effects. The composition for preventing and treating osteoporosis comprises kansuinine A represented by the formula(1) and gamma-euphorbol represented by the formula(2) or the extracts thereof. The kansuinine A represented by the formula(1) and gamma-euphorbol represented by the formula(2) are isolated by extracting and concentrating Euphorbia kansui with methanol, suspending the concentrated extract of Euphorbia kansui in water, and adding nucleic acid into the suspension to separate a nucleic acid layer, adding methylene chloride into a water layer obtained by separating the nucleic acid layer to obtain a methylene chloride fraction, and subjecting the methylene chloride fraction to chromatography.
    • 提供了用于预防和治疗包括从大戟属分离的萜类化合物或其提取物的骨质疏松症的组合物,以抑制破骨细胞的骨吸收而没有副作用。 用于预防和治疗骨质疏松症的组合物包括由式(1)表示的苦参碱A和由式(2)表示的γ-高效药或其提取物。 由式(1)表示的甘露宁A和由式(2)表示的γ-高效酚通过用甲醇萃取浓缩大戟甘油,将浓缩的大戟属浓缩提取物悬浮于水中,并将核酸加入到悬浮液中 分离核酸层,将二氯甲烷加入到通过分离核酸层获得的水层中,得到二氯甲烷部分,并将二氯甲烷部分进行色谱分离。