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1. 发明公开

KR1020030016087A 눈꽃동충하초 자실체로부터 분리한4-아세틸-12,13-에폭실-9-트리코테신-3,15-디올을함유하는 항암제 조성물 无效
标题翻译：含有4-乙酰基-12,13-环氧基-9-三氯苯醚-3,15-二醇的反应物组合物
公开(公告)号：KR1020030016087A
公开(公告)日：2003-02-26
申请号：KR1020010050001
申请日：2001-08-20
申请人： 권태오 , 장선일 , 정헌택
发明人： 권태오 , 홍경환 , 오현철 , 배현옥 , 정헌택 , 장선일
IPC分类号： A61K31/352
摘要： PURPOSE: A new anticancer composition containing 4-acetyl-12,13-epoxyl-9-trichothecene-3,15-diol separated from a methanol extract of fruit bodies of Isaria japonica Y ASUDA is provided which induces the death of cancer cells through the apoptosis of various cancer cells containing leukemia, breast cancer, liver cancer, cervical cancer. CONSTITUTION: Fruit bodies of Isaria japonica Y ASUDA are extracted in methanol and subjected to HPLC chromatography to separate -acetyl-12,13-epoxyl-9-trichothecene-3,15-diol(AEDT) of formula(1). The anticancer composition contains an effective amount of the ACDT for treatment of a cancer patient. For an example, I. japonica, coucher No. CHO-6133 is inoculated into a potato glucose culture, cultured at 25d eg.C for 10 days to produce a bacteria colony having a diameter of 5cm. The colony is inoculated into agar plugs, subjected to a second culture after sterilizing at 121 deg.C for 20min and then cultured at 25 deg.C for 8 days to produce fruit bodies.
摘要翻译：目的：提供从Isaria japonica Y ASUDA的果实体的甲醇提取物中分离的含有4-乙酰基-12,13-环氧基-9-单端三氢呋喃-3,15-二醇的新的抗癌组合物，其通过以下方法诱导癌细胞的死亡含有白血病，乳腺癌，肝癌，宫颈癌的各种癌细胞的凋亡。构成：将Isaria japonica Y ASUDA的果实体在甲醇中萃取，进行HPLC色谱分离，分离式（1）的乙酰基-12,13-环氧基-9-单端三烯-3,15-二醇（AEDT）。抗癌组合物含有治疗癌症患者的有效量的ACDT。例如，将粳稻号为CHO-6133的茄子接种到马铃薯葡萄糖培养基中，在25d例如C处培养10天以产生直径为5cm的细菌菌落。将菌落接种到琼脂塞中，在121℃灭菌20分钟后进行第二次培养，然后在25℃下培养8天以产生果实体。

2. 发明授权

KR100481925B1 가시오갈피로부터 분리된 아세틸렌 계열 화합물들 및 그를함유하는 아폽토시스 유도제 조성물 失效
标题翻译：来自刺五加根的乙炔和含有相同的凋亡诱导组合物
公开(公告)号：KR100481925B1
公开(公告)日：2005-04-11
申请号：KR1020020000241
申请日：2002-01-03
申请人： 권태오 , 윤용갑 , 정헌택
发明人： 오현철 , 배현옥 , 장선일 , 채규윤 , 윤용갑 , 정헌택 , 이호섭 , 권태오
IPC分类号： C07D303/14
摘要： 본 발명은 아폽토시스(apoptosis)를 유도하는 화합물에 관한 것이고, 더욱 상세하게는 헵타데카-1,8-디엔-4,6-디인-3,10-디올, 파낙시돌(panaxydol) 및 8-메톡시-파낙시돌로 구성된 군으로부터 선택된 1종 이상의 화합물을 함유하는 아폽토시스 유도제 조성물에 관한 것이다.

3. 发明授权

KR100443202B1 눈꽃동충하초 자실체로부터 분리한(3Ｒ,6Ｒ)-4-메틸-6-(1-메틸에틸)-3-페닐메틸-1,4-퍼하이드로옥사진-2,5-디온 및 그를 함유하는 아폽토시스 유도제조성물 失效
标题翻译： 눈꽃동충초초자실체由（3R，6R）-4-메틸-6-（1-메틸에틸）-3-페닐메틸-1,4-이이드로로옥사진-2,5-디온및그를함유하는아폽토시스유도제 조성물
公开(公告)号：KR100443202B1
公开(公告)日：2004-08-04
申请号：KR1020020000242
申请日：2002-01-03
申请人： 이호섭 , 권태오 , 정헌택
发明人： 오현철 , 배현옥 , 오기수 , 장선일 , 채규윤 , 정헌택 , 이호섭 , 권태오
IPC分类号： C07D265/32
摘要： PURPOSE: Provided is a novel compound, (3R,6R)-4-methyl-6-(1-methylethyl)-phenylethyl-1,4-perhydroxazine-2,5-dione(MMPP O), separated from fruit body extract of Isaria japonica Yasuda and inducing apoptosis. The compound is represented by the formula 1 and is used as an anti-cancer agent. CONSTITUTION: A composition containing the compound, (3R,6R)-4-methyl-6-(1-methylethyl)-phenylethyl-1,4-perhydroxazine-2,5-dione(MMPP O) characteristically leads to apoptosis in the cancer cell of leukemia, breast cancer, liver cancer, stomach cancer, ovary cancer, urinary bladder cancer, lung cancer and epithelioma cancer.
摘要翻译：本发明提供了一种新型化合物（3R，6R）-4-甲基-6-（1-甲基乙基）苯乙基-1,4-过全鲨嗪-2,5-二酮（MMPP 0） Isaria japonica Yasuda和诱导细胞凋亡。该化合物由式1表示，并用作抗癌剂。组成：含有化合物（3R，6R）-4-甲基-6-（1-甲基乙基）苯乙基-1,4-过全鲨嗪-2,5-二酮（MMPP 0）的组合物特征性地导致癌症中的细胞凋亡白血病细胞，乳腺癌，肝癌，胃癌，卵巢癌，膀胱癌，肺癌和上皮瘤癌。

4. 发明公开

KR1020030059643A 가시오갈피로부터 분리된 아세틸렌 계열 화합물들 및 그를함유하는 아폽토시스 유도제 조성물 失效
标题翻译：从ACANTHOPANAX SENTICOSUS分离的乙烯化合物和含有它们的组合物诱导疫苗
公开(公告)号：KR1020030059643A
公开(公告)日：2003-07-10
申请号：KR1020020000241
申请日：2002-01-03
申请人： 권태오 , 윤용갑 , 정헌택
发明人： 오현철 , 배현옥 , 장선일 , 채규윤 , 윤용갑 , 정헌택 , 이호섭 , 권태오
IPC分类号： C07D303/14
摘要： PURPOSE: Provided is a composition containing acetylene compounds separated from the root of Acanthopanax Senticosus which includes various mechanism in the cell related to apoptosis. The composition is preferably used in treating leukemia. CONSTITUTION: A composition comprises 8-methoxypanaxydol, represented by the formula 3, and more than one compound selected from group of heptadeca-1,8-diene-4,6-diyne-3,10-diol, panaxydol and 8-methoxypanaxydol.
摘要翻译：目的：提供一种从刺五加根分离出的乙炔化合物的组合物，其中包括细胞凋亡相关的各种机制。该组合物优选用于治疗白血病。组成：组合物包含由式3表示的8-甲氧基茴香醚，以及多于一种选自十七碳-1,8-二烯-4,6-二炔-3,10-二醇，双羟萘酸和8-甲氧基茴香醚的化合物。

5. 发明授权

KR100449834B1 프루니오사이드 Ａ 와 그 유도체 및 이를 함유하는 염증치료용 약제 조성물 失效
标题翻译： 프루니오사이드A와그유도체및이를함유하는염증치료용약제제조성물
公开(公告)号：KR100449834B1
公开(公告)日：2004-09-22
申请号：KR1020010078927
申请日：2001-12-13
申请人： 정헌택 , 채규윤 , 권태오
发明人： 오현철 , 오기수 , 배현옥 , 장선일 , 채규윤 , 정헌택 , 이호섭 , 권태오
IPC分类号： C07H15/04
摘要： PURPOSE: Prunioside A, derivatives thereof and a pharmaceutical composition containing the same for the treatment of inflammation are provided, thereby treating the inflammation with less adverse effects. CONSTITUTION: Prunioside A extracted from Spiraceae is represented by formula(1), wherein R is H or acetyl. A pharmaceutical composition for treatment of inflammation contains the prunioside A of formula(1) or derivatives thereof, wherein the daily dose of the prunioside A or derivatives thereof is 0.01 to 100 microgram/kg a day; the pharmaceutical composition is formulated into cream, ointment, injection, granules or liquid; and the prunioside A or derivatives thereof inhibits the formation of nitrogen monoxide.
摘要翻译：目的：提供了Prunioside A及其衍生物和含有它们的药物组合物用于治疗炎症，从而以较少的副作用治疗炎症。构成：从Spiraceae中提取的Prunioside A由式（1）表示，其中R是H或乙酰基。用于治疗炎症的药物组合物含有式（1）的甜菜碱A或其衍生物，其中所述甜菜碱A或其衍生物的日剂量为每天0.01至100微克/ kg; 将药物组合物配制成乳膏，软膏，注射剂，颗粒剂或液体; 并且丙二酰脲A或其衍生物抑制一氧化氮的形成。

6. 发明公开

KR1020030059644A 눈꽃동충하초 자실체로부터 분리한(3Ｒ,6Ｒ)-4-메틸-6-(1-메틸에틸)-3-페닐메틸-1,4-퍼하이드로옥사진-2,5-디온 및 그를 함유하는 아폽토시스 유도제조성물 失效
标题翻译：（3R，6R）-4-甲基-6-（1-甲基乙基） - 苯基-1,2,4-二氢苯并噻唑-2,4-二酮，分离自ISARIA JAPONICA YASUDA的水果及其组合物，诱导宿主
公开(公告)号：KR1020030059644A
公开(公告)日：2003-07-10
申请号：KR1020020000242
申请日：2002-01-03
申请人： 이호섭 , 권태오 , 정헌택
发明人： 오현철 , 배현옥 , 오기수 , 장선일 , 채규윤 , 정헌택 , 이호섭 , 권태오
IPC分类号： C07D265/32
摘要： PURPOSE: Provided is a novel compound, (3R,6R)-4-methyl-6-(1-methylethyl)-phenylethyl-1,4-perhydroxazine-2,5-dione(MMPP O), separated from fruit body extract of Isaria japonica Yasuda and inducing apoptosis. The compound is represented by the formula 1 and is used as an anti-cancer agent. CONSTITUTION: A composition containing the compound, (3R,6R)-4-methyl-6-(1-methylethyl)-phenylethyl-1,4-perhydroxazine-2,5-dione(MMPP O) characteristically leads to apoptosis in the cancer cell of leukemia, breast cancer, liver cancer, stomach cancer, ovary cancer, urinary bladder cancer, lung cancer and epithelioma cancer.
摘要翻译：目的：提供一种新的化合物，（3R，6R）-4-甲基-6-（1-甲基乙基） - 苯乙基-1,4-全羟基嗪-2,5-二酮（MMPP O），从果实提取物 Isaria japonica Yasuda并诱导细胞凋亡。该化合物由式1表示，用作抗癌剂。构成：含有化合物（3R，6R）-4-甲基-6-（1-甲基乙基） - 苯乙基-1,4-全羟基嗪-2,5-二酮（MMPP O）的组合物特征性地导致癌症中的凋亡白血病细胞，乳腺癌，肝癌，胃癌，卵巢癌，膀胱癌，肺癌和上皮瘤癌。

7. 发明公开

KR1020030048880A 프루니오사이드 Ａ 와 그 유도체 및 이를 함유하는 염증치료용 약제 조성물 失效
标题翻译：丙烯酰胺A，其衍生物及其含有相同的药物组合物，用于治疗感染
公开(公告)号：KR1020030048880A
公开(公告)日：2003-06-25
申请号：KR1020010078927
申请日：2001-12-13
申请人： 정헌택 , 채규윤 , 권태오
发明人： 오현철 , 오기수 , 배현옥 , 장선일 , 채규윤 , 정헌택 , 이호섭 , 권태오
IPC分类号： C07H15/04
摘要： PURPOSE: Prunioside A, derivatives thereof and a pharmaceutical composition containing the same for the treatment of inflammation are provided, thereby treating the inflammation with less adverse effects. CONSTITUTION: Prunioside A extracted from Spiraceae is represented by formula(1), wherein R is H or acetyl. A pharmaceutical composition for treatment of inflammation contains the prunioside A of formula(1) or derivatives thereof, wherein the daily dose of the prunioside A or derivatives thereof is 0.01 to 100 microgram/kg a day; the pharmaceutical composition is formulated into cream, ointment, injection, granules or liquid; and the prunioside A or derivatives thereof inhibits the formation of nitrogen monoxide.
摘要翻译：目的：提供二萜A，其衍生物和含有其的用于治疗炎症的药物组合物，从而以较少的副作用治疗炎症。构成：从螺旋体科提取的ios藜A由式（1）表示，其中R为H或乙酰基。用于治疗炎症的药物组合物含有式（1）的藜芦苷A或其衍生物，其中每日剂量为每日0.01至100微克/月的柚苷A或其衍生物的日剂量; 药物组合物配制成霜剂，软膏剂，注射剂，颗粒剂或液体剂; 并且藜芦苷A或其衍生物抑制一氧化氮的形成。

8. 发明授权

KR100421625B1 개오동나무의 표피로부터 분리한 카탈포사이드를유효성분으로서 함유하는 항염증제 조성물 失效
标题翻译：一种消炎剂组合物，其含有从柴火表皮分离的过氧化氢酶作为活性成分
公开(公告)号：KR100421625B1
公开(公告)日：2004-03-11
申请号：KR1020010077053
申请日：2001-12-06
申请人： 정헌택
发明人： 배현옥 , 장선일 , 오현철 , 권태오 , 정헌택
IPC分类号： A61K31/70
CPC分类号： A61K31/7048 , A61K31/00
摘要： There is provided an anti-inflammatory composition containing iridoid glycoside compound, catalposide isolated from stem bark of Catalpa ovata as an active ingredient, for treating inflammatory response by inhibiting inducible nitric oxygen synthase iNOS, NF-κB, TNF-alpha, IL-1beta and IL-6.
摘要翻译： NF-κB，TNF-α和TNF- IL-1β和IL-6。

9. 发明公开

KR1020030046796A 개오동나무의 표피로부터 분리한 카탈포사이드를유효성분으로서 함유하는 항염증제 조성물 失效
标题翻译：含有CATAPPA OVATA作为活性成分的烟碱分离的抗炎药物组合物
公开(公告)号：KR1020030046796A
公开(公告)日：2003-06-18
申请号：KR1020010077053
申请日：2001-12-06
申请人： 정헌택
发明人： 배현옥 , 장선일 , 오현철 , 권태오 , 정헌택
IPC分类号： A61K31/70
CPC分类号： A61K31/7048 , A61K31/00
摘要： PURPOSE: A composition containing cataposide which inhibits activity of NF-κB and gene expression of pro-inflammatory cytokines such as TNF-α, IL-1β and IL-6, and iNOS is provided. Therefore, the composition can be used in treatment of diseases caused by excessive inflammatory responses without causing any adverse effect on the human body. CONSTITUTION: An antiinflammatory agent composition contains cataposide as an active ingredient in a single dose amount of 0.001 to 500mg/kg. The cataposide is isolated from the stem bark of Catalpa ovata G. Don. Diseases caused by excessive inflammatory responses include autoimmune disease and septicemia selected from the group consisting of rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, psoriasis, inflammatory bowel disease autoimmune hepatitis.
摘要翻译：目的：提供一种含有抑制NF-κB活性的氨甲蝶呤和TNF-α，IL-1β，IL-6及iNOS等促炎细胞因子基因表达的组合物。因此，该组合物可用于治疗由过度炎症反应引起的疾病，而不会对人体造成任何不良影响。构成：抗炎药物组合物含有0.001〜500mg / kg的单次剂量的氨甲喋呤作为活性成分。蝎尾草是从梓pa的茎皮中分离出来的。由过度炎症反应引起的疾病包括选自类风湿性关节炎，多发性硬化症，系统性红斑狼疮，牛皮癣，炎症性肠病自身免疫性肝炎的自身免疫疾病和败血症。

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