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    • 8. 发明公开
    • 눈꽃동충하초 자실체로부터 분리한4-아세틸-12,13-에폭실-9-트리코테신-3,15-디올을함유하는 항암제 조성물
    • 含有4-乙酰基-12,13-环氧基-9-三氯苯醚-3,15-二醇的反应物组合物
    • KR1020030016087A
    • 2003-02-26
    • KR1020010050001
    • 2001-08-20
    • 권태오장선일정헌택
    • 권태오홍경환오현철배현옥정헌택장선일
    • A61K31/352
    • PURPOSE: A new anticancer composition containing 4-acetyl-12,13-epoxyl-9-trichothecene-3,15-diol separated from a methanol extract of fruit bodies of Isaria japonica Y ASUDA is provided which induces the death of cancer cells through the apoptosis of various cancer cells containing leukemia, breast cancer, liver cancer, cervical cancer. CONSTITUTION: Fruit bodies of Isaria japonica Y ASUDA are extracted in methanol and subjected to HPLC chromatography to separate -acetyl-12,13-epoxyl-9-trichothecene-3,15-diol(AEDT) of formula(1). The anticancer composition contains an effective amount of the ACDT for treatment of a cancer patient. For an example, I. japonica, coucher No. CHO-6133 is inoculated into a potato glucose culture, cultured at 25d eg.C for 10 days to produce a bacteria colony having a diameter of 5cm. The colony is inoculated into agar plugs, subjected to a second culture after sterilizing at 121 deg.C for 20min and then cultured at 25 deg.C for 8 days to produce fruit bodies.
    • 目的:提供从Isaria japonica Y ASUDA的果实体的甲醇提取物中分离的含有4-乙酰基-12,13-环氧基-9-单端三氢呋喃-3,15-二醇的新的抗癌组合物,其通过以下方法诱导癌细胞的死亡 含有白血病,乳腺癌,肝癌,宫颈癌的各种癌细胞的凋亡。 构成:将Isaria japonica Y ASUDA的果实体在甲醇中萃取,进行HPLC色谱分离,分离式(1)的乙酰基-12,13-环氧基-9-单端三烯-3,15-二醇(AEDT)。 抗癌组合物含有治疗癌症患者的有效量的ACDT。 例如,将粳稻号为CHO-6133的茄子接种到马铃薯葡萄糖培养基中,在25d例如C处培养10天以产生直径为5cm的细菌菌落。 将菌落接种到琼脂塞中,在121℃灭菌20分钟后进行第二次培养,然后在25℃下培养8天以产生果实体。