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1. 发明专利

JP2010119606A Extraction medium filling method and biogenic substance analyzer 审中-公开
标题翻译：萃取介质填充方法和生物物质分析仪
公开(公告)号：JP2010119606A
公开(公告)日：2010-06-03
申请号：JP2008296123
申请日：2008-11-19
申请人： Sysmex Corp , Toshiba Corp , シスメックス株式会社 , 株式会社東芝
发明人： TAKASE TOMOHIRO , NAWATA ISAO , ASAKURA YOSHIHIRO
IPC分类号： A61B5/1459 , A61B5/151
摘要： PROBLEM TO BE SOLVED: To provide an extraction medium filling method capable of accurately filling an extraction medium holder part with a prescribed quantity of an extraction medium.
SOLUTION: According to the method, the extraction medium stored in a liquid storage part is transferred to the extraction medium holder part, and the extract extracted from the skin of a subject is held by the extraction medium held in the extraction medium holder part. Then, the extraction medium holder part of a biogenic substance analyzer for analyzing substances included in the extract held in the extraction medium is filled with the extraction medium. The method of extraction medium filling method includes: a transfer step of transferring the extraction medium from the liquid storage part to the extraction medium holder part; a step of detecting the variation or the quantity of variation of resistance in the extraction medium holder part; and a stopping step of stopping the transfer of the extraction medium based on the detection of the variation or quantity of variation of resistance.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够用规定量的提取介质精确地填充提取介质保持器部分的提取介质填充方法。解决方案：根据该方法，将存储在液体储存部分中的提取介质转移到提取介质保持器部分，并且从被检体皮肤提取的提取物由保持在提取介质保持器中的提取介质保持部分。然后，用提取介质填充用于分析保存在提取介质中的提取物中包含的物质的生物来源物质分析装置的提取介质保持体部。提取介质填充方法包括：将萃取介质从液体储存部分转移到萃取介质保持器部分的转移步骤; 检测提取介质保持器部分中的电阻变化或变化量的步骤; 以及基于对电阻变化的变化或量的检测来停止提取介质的转移的停止步骤。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2009240580A Analytical method and device of biogenic substance, and extraction cartridge 有权
标题翻译：分析方法和生物物质和提取盒的装置
公开(公告)号：JP2009240580A
公开(公告)日：2009-10-22
申请号：JP2008091599
申请日：2008-03-31
申请人： Sysmex Corp , Toshiba Corp , シスメックス株式会社 , 株式会社東芝
发明人： KOJIMA JUNKO , MAEKAWA YASUNORI , TAKASE TOMOHIRO , UEMATSU IKUO , HIRAKAWA MASAAKI , NAWATA ISAO , TONO ICHIRO , KASAI SHINGO
IPC分类号： A61B5/157
CPC分类号： A61B5/14514 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150091 , A61B5/150229 , A61B5/150251 , A61B5/150343 , A61B5/150358 , A61B5/150748 , A61B5/150984 , A61B5/15113 , A61B5/15186 , A61B5/1519 , A61B5/157 , A61B5/6824 , A61B5/685 , C12Q1/006
摘要： PROBLEM TO BE SOLVED: To provide analytical method and device of biogenic substance and an extraction cartridge capable of highly precisely analyzing an extract extracted from a subject. SOLUTION: A blood glucose level estimation device (biogenic substance analytical device) 100 includes: an extract medium retention section 53 configured to retain a predetermined amount of extract medium; a reaction section 54 producing a predetermined reaction by glucose; a detection section 40 detecting the glucose from the predetermined reaction generated in the reaction section 54; a liquid storage section 52 storing the glucose by an amount equal to the predetermined amount retained by the extract medium retention section 53; a pump 18 carrying the extract medium stored in the liquid storage section 52 to the extract medium retention section 53 and carrying a part of the extract medium carried to the extract medium retention section 53 and retaining the glucose extracted from the subject, from the extraction medium retention section 53 to the reaction section 54; and a control section 17 analyzing a detection result of the glucose. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供能够高精度地分析从受试者提取的提取物的生物源物质和提取盒的分析方法和装置。解决方案：血糖值估计装置（生物来源物质分析装置）100包括：提取介质保持部53，被配置为保持预定量的提取介质; 由葡萄糖产生预定反应的反应部54; 从反应部54中产生的规定的反应检测葡萄糖的检测部40; 储存葡萄糖量等于由提取介质保留部分53保留的预定量的液体存储部分52; 将存储在液体储存部52中的提取介质携带到提取介质保留部53并将被携带的提取介质的一部分携带到提取介质保留部53并保留从被检体提取的葡萄糖从提取介质保持部53到反应部54; 以及分析葡萄糖的检测结果的控制部17。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2008122265A Color development reaction detection device and its manufacturing method 审中-公开
标题翻译：颜色发展反应检测装置及其制造方法
公开(公告)号：JP2008122265A
公开(公告)日：2008-05-29
申请号：JP2006307457
申请日：2006-11-14
申请人： Toshiba Corp , 株式会社東芝
发明人： TAKASE TOMOHIRO , NAWATA ISAO , UEMATSU IKUO , HIRAKAWA MASAAKI
IPC分类号： G01N21/78
摘要： PROBLEM TO BE SOLVED: To provide a color development reaction detection device capable of stably measuring the mass of a sensing target even in a case that a temperature change occurs, and to provide its manufacturing method.
SOLUTION: The color development reaction detection device is equipped with a light source 11 coming into contact with a specimen to emit the light guided through the light guide film 14b provided to a biosensor 14 for acquiring the physiological data of the specimen, a first measuring means 11a for measuring the temperature of the light source 11, a second measuring means 15 for detecting the light guided through the light guide film 14b to measure a light detection signal value and a correction means 16b for correcting a reference value when the attenuation of a light detection signal is calculated from the temperature measured by the first measuring means 11a and calculating the attenuation rate of the light detection signal on the basis of the corrected reference value and the light detection signal value measured by the second measuring means 15.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供即使在发生温度变化的情况下也能够稳定地测量感测对象的质量并提供其制造方法的显色反应检测装置。解决方案：显色反应检测装置配备有与试样接触的光源11，以发射通过设置在用于获取试样的生理数据的生物传感器14的导光膜14b所引导的光，用于测量光源11的温度的第一测量装置11a，用于检测通过导光膜14b引导的光以测量光检测信号值的第二测量装置15;以及用于在衰减时校正参考值的校正装置16b 根据由第一测量装置11a测量的温度计算光检测信号，并且基于校正的参考值和由第二测量装置15测量的光检测信号值来计算光检测信号的衰减率。 P>版权所有（C）2008，JPO＆INPIT

4. 发明专利

JP2006267052A Inspection apparatus for measuring immune reaction 审中-公开
标题翻译：用于测量免疫反应的检查装置
公开(公告)号：JP2006267052A
公开(公告)日：2006-10-05
申请号：JP2005089453
申请日：2005-03-25
申请人： Toshiba Corp , 株式会社東芝
发明人： UCHIYAMA KENICHI , OOMIYA KAYOKO , KASAI SHINGO , UEMATSU IKUO , TAKASE TOMOHIRO , NAWATA ISAO , TONO ICHIRO
IPC分类号： G01N21/64 , G01N21/78
摘要： PROBLEM TO BE SOLVED: To provide an inspection apparatus for measuring an immune reaction that can excite a labeled coloring matter, after an antigen/antibody reaction in solution in the entire cell, propagates fluorescence radiated by excitation onto a transparent plate for radiating to the outside, and can essentially detect the intensity of only the fluorescence by a light-receiving element.
SOLUTION: The inspection apparatus for measuring an immune reaction comprises the transparent plate; a sensor chip, having a cell that is arranged at least at one location on the surface of the transparent plate and stores the solution of reagents and specimens, a grating that is formed on the transparent plate at the bottom of the cell and allows the fluorescence to enter the transparent plate, and an optical element that is formed on the surface of the transparent plate, separated from the cell and radiates fluorescence propagated to the transparent plate by the grating to the outside; an excitation light irradiation means for irradiating the cell of the sensor chip, with the excitation light along the depth direction of the cell; and a light-receiving means for receiving the fluorescence radiated from the optical element of the sensor chip.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于测量可激发标记色素的免疫反应的检查装置，在整个细胞溶液中的抗原/抗体反应之后，将通过激发辐射的荧光传播到用于辐射的透明板上并且可以基本上通过光接收元件检测仅荧光的强度。解决方案：用于测量免疫反应的检查装置包括透明板; 传感器芯片，具有布置在透明板的表面上的至少一个位置处并存储试剂和试样溶液的电池，形成在电池底部的透明板上的光栅，并允许荧光进入透明板，以及形成在透明板的表面上的与光电元件分离的光学元件，并将通过光栅传播到透明板的荧光发射到外部; 激发光照射装置，用于沿着电池的深度方向照射传感器芯片的电池; 以及用于接收从传感器芯片的光学元件辐射的荧光的光接收装置。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2014194435A Optical waveguide type biochemical sensor chip 审中-公开
标题翻译：光波导型生化传感器芯片
公开(公告)号：JP2014194435A
公开(公告)日：2014-10-09
申请号：JP2014136219
申请日：2014-07-01
申请人： Toshiba Corp , 株式会社東芝
发明人： UEMATSU IKUO , NAWATA ISAO , TONO ICHIRO , TAKASE TOMOHIRO
IPC分类号： G01N21/552 , G02B6/122
摘要： PROBLEM TO BE SOLVED: To provide an optical waveguide type sensor chip which can improve measurement accuracy by removing a substrate propagating component.SOLUTION: An optical waveguide type sensor chip comprises: a substrate 11; an optical waveguide layer 13 formed in a first principal surface 11a of the substrate 11 and having a refractive index higher than that of the substrate 11; a pair of gratings 12 for making light incident into and emitted from the optical guide waveguide layer 13; a sensing film 15 formed on the optical waveguide layer 13 and provided across the pair of gratings 12 for changing strength of the light propagating through the optical guide layer 13 according to the amount or concentration of an introduced object to be measured; and a substrate propagating component removal part 20 formed in a second principal surface 11b of the substrate 11 and arranged at a position opposed to the sensing film 15 for removing a substrate propagating component Q reflected and reflected/diffracted by the gratings 12 and propagating through the substrate 11.
摘要翻译：要解决的问题：提供一种通过去除衬底传播部件来提高测量精度的光波导型传感器芯片。解决方案：一种光波导型传感器芯片，包括：基板11; 形成在基板11的第一主表面11a中并具有比基板11的折射率高的折射率的光波导层13; 一对光栅12，用于使光入射到光导波导层13中并从光导波导层13射出; 形成在光波导层13上并设置在该对光栅12两侧的感测膜15，用于根据待测量的被引入物体的量或浓度来改变通过导光层13传播的光的强度; 以及基板传播元件去除部分20，其形成在基板11的第二主表面11b中并且布置在与感测膜15相对的位置处，用于去除由光栅12反射和反射/衍射的基板传播分量Q，并传播通过基板11。

6. 发明专利

JP2012215553A Optical waveguide type measurement system, measurement method, and optical waveguide type sensor chip 有权
标题翻译：光波导型测量系统，测量方法和光波导型传感器芯片
公开(公告)号：JP2012215553A
公开(公告)日：2012-11-08
申请号：JP2012011456
申请日：2012-01-23
申请人： Toshiba Corp , 株式会社東芝
发明人： TONO ICHIRO , KASAI SHINGO , WADA TAKAKI , NAWATA ISAO , HIRAKAWA MASAAKI , TAKASE TOMOHIRO , OMIYA KAYOKO , YAMAUCHI TAKEMOTO , NAKAYAMA TADAHIRO , NITTA ISAMU
IPC分类号： G01N33/543 , G01N21/27 , G01N33/553
摘要： PROBLEM TO BE SOLVED: To provide an optical waveguide type measurement system in which detection sensitivity of a measurement object material is more improved to higher accuracy, and a measurement method and an optical waveguide type sensor chip thereof.SOLUTION: The optical waveguide type measurement system includes an optical waveguide having a sensing area where first substances that specifically bind to the measurement object material are immobilized; magnetic fine particles in which second substances that specifically bind to the measurement object material are immobilized, and which have magnetism; a magnetic field applying unit for generating a magnetic field that moves the magnetic particles; a light source that makes light incident to the optical waveguide; and a light receiving element for receiving light emitted from the optical waveguide.
摘要翻译：解决的问题：提供一种测量对象材料的检测灵敏度更高精度的光波导型测量系统及其测量方法和光波导型传感器芯片。解决方案：光波导型测量系统包括具有固定有特定结合测量对象材料的第一物质的感测区域的光波导; 具有与测定对象物质特异结合的第二物质固定的具有磁性的磁性微粒; 磁场施加单元，用于产生使磁性颗粒移动的磁场; 使光入射到光波导的光源; 以及用于接收从光波导发射的光的光接收元件。版权所有（C）2013，JPO＆INPIT

7. 发明专利

JP2012068166A Flat type optical waveguide sensor measurement apparatus 审中-公开
标题翻译：平面型光波导传感器测量装置
公开(公告)号：JP2012068166A
公开(公告)日：2012-04-05
申请号：JP2010214353
申请日：2010-09-24
申请人： Toshiba Corp , 株式会社東芝
发明人： NAWATA ISAO
IPC分类号： G01N21/27
摘要： PROBLEM TO BE SOLVED: To automate a series of operations such as assembly of a liquid reservoir component, drop of solvent, disassembly of the liquid reservoir component, discarding of the solvent, in a measurement using a flat type optical waveguide sensor chip.SOLUTION: The flat type optical waveguide sensor measurement apparatus comprises: a support part 22 for supporting a flat type optical waveguide sensor chip S in a direction in which solvent falls by its own weight from a sensor surface Sa of the flat type optical waveguide sensor chip; a reading device 30 which is provided facing a back surface Sb of the flat type optical waveguide sensor chip S supported by the support part 22 and which includes a laser diode 32 for irradiating the flat type optical waveguide sensor chip S with laser light L and a photo diode 33 for measuring intensity of the laser light L propagated through the flat type optical waveguide sensor chip S; a liquid reservoir component supplying mechanism 60 for supplying a well W attachably/detachably to an area including the sensor surface Sa of the flat type optical waveguide sensor chip S supported by the support part 22; and a solvent supplying device 70 for supplying the solvent M to the sensor surface Sa of the flat type optical waveguide sensor chip S.
摘要翻译：要解决的问题：为了使使用平板型光波导传感器芯片的测量中的一系列操作自动化，例如组装液体储存部件，溶剂滴，液体储存部件的拆卸，废弃溶剂。解决方案：平板型光波导传感器测量装置包括：支撑部分22，用于在平坦型光波导传感器芯片S的平面型光波导传感器芯片S的传感器表面Sa上以其自身重量的方向支撑平坦型光波导传感器芯片S 波导传感器芯片; 设置在与由支撑部22支撑的平面型光波导传感器芯片S的背面Sb相对的面上设置的读取装置30，该读取装置30具备激光二极管32，该激光二极管32用激光L照射平面型光波导传感器芯片S，光电二极管33，用于测量通过平板型光波导传感器芯片S传播的激光L的强度; 储液部件供给机构60，用于向包括由支撑部22支撑的平板型光波导传感器芯片S的传感器面Sa的区域连续地或可拆卸地供给井W; 以及用于将溶剂M供应到平板型光波导传感器芯片S的传感器表面Sa的溶剂供应装置70.版权所有（C）2012，JPO＆INPIT

8. 发明专利

JP2007033203A Optical sensor chip 有权
标题翻译：光传感器芯片
公开(公告)号：JP2007033203A
公开(公告)日：2007-02-08
申请号：JP2005216120
申请日：2005-07-26
申请人： Toshiba Corp , 株式会社東芝
发明人： UCHIYAMA KENICHI , OOMIYA KAYOKO , UEMATSU IKUO , TAKASE TOMOHIRO , NAWATA ISAO , KASAI SHINGO , TONO ICHIRO
IPC分类号： G01N21/27 , C12M1/34 , G01N21/78
摘要： PROBLEM TO BE SOLVED: To provide an optical sensor chip with a simple structure, wherein light which has a wide wavelength band in comparison with laser light is easily introduced into a single-mode optical thin waveguide layer. SOLUTION: The optical sensor chip comprises: a substrate; the single-mode optical waveguide layer which is formed on the surface of the substrate and has a refractive index higher than that of the substrate; a self-luminous layer which is formed at a portion of the surface of the optical waveguide layer and which is thinner than the cutoff; and an optical element arranged at a portion of the surface of the optical waveguide layer and emitting light outside which propagates through the optical waveguide layer. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：解决问题：为了提供具有简单结构的光学传感器芯片，其中与激光相比具有宽波段的光容易地被引入到单模光纤薄波导层中。光传感器芯片包括：基板; 所述单模光波导层形成在所述基板的表面上并且具有比所述基板的折射率高的折射率; 自发光层，其形成在所述光波导层的所述表面的一部分并且比所述截止体更薄; 以及光学元件，其布置在光波导层的表面的一部分处，并且发射通过光波导层传播的外部的光。版权所有（C）2007，JPO＆INPIT

9. 发明专利

JP2013195404A Measurement method, sensor chip and measurement device 有权
标题翻译：测量方法，传感器芯片和测量装置
公开(公告)号：JP2013195404A
公开(公告)日：2013-09-30
申请号：JP2012066417
申请日：2012-03-22
申请人： Toshiba Corp , 株式会社東芝
发明人： WADA TAKAKI , TAKASE TOMOHIRO , TONO ICHIRO , NAWATA ISAO , KASAI SHINGO
IPC分类号： G01N33/543 , G01N21/27
摘要： PROBLEM TO BE SOLVED: To provide a measurement method, a sensor chip and a measurement device that can highly accurately measure a plurality of kinds of measurement object substances.SOLUTION: The measurement method according to an embodiment is a measurement method that uses a sensor chip, in which an optical waveguide part has a first area where a first substance reacting to a first measurement object substance is fixed and a second area where a second substance reacting to a second measurement object substance is fixed, and at least any of a third substance reacting to the first substance and a fourth substance reacting to the second substance is fixed on a surface of a base of a particle. The measurement method comprises the steps of: guiding a specimen solution into holding space; calculating absorbance after the specimen solution is guided; inputting at least one particle into the specimen solution guided into the holding space; calculating absorbance after the particle is input; calculating absorbance variation; and calculating an amount of the measurement object substance on the basis of the absorbance variation.
摘要翻译：要解决的问题：提供可以高精度地测量多种测量对象物质的测量方法，传感器芯片和测量装置。解决方案：根据实施例的测量方法是使用传感器芯片的测量方法其中光波导部分具有固定第一物质与第一测量对象物质反应的第一区域和与第二测量对象物质反应的第二物质固定的第二区域，以及至少第三物质与第一物质反应的第四物质和与第二物质反应的第四物质固定在颗粒的基材的表面上。测量方法包括以下步骤：将样品溶液引导到保持空间中; 计算样品溶液引导后的吸光度; 将至少一个颗粒输入到引导到保持空间中的样品溶液中; 计算粒子输入后的吸光度; 计算吸光度变化; 并基于吸光度变化计算测量对象物质的量。

10. 发明专利

JP2011202997A Optical sensor 有权
标题翻译：光传感器
公开(公告)号：JP2011202997A
公开(公告)日：2011-10-13
申请号：JP2010068426
申请日：2010-03-24
申请人： Toshiba Corp , 株式会社東芝
发明人： UEMATSU IKUO , KASAI SHINGO , TONO ICHIRO , NAWATA ISAO
IPC分类号： G01N21/27
CPC分类号： G01N21/7703 , G01N21/78 , G01N2021/7776 , G01N2021/7786
摘要： PROBLEM TO BE SOLVED: To provide an optical sensor capable of avoiding the influence of a precipitate in a specimen.SOLUTION: The optical sensor 1 includes: an optical waveguide part 12; and a specimen area 20 provided adjacent to the optical waveguide part 12 and configured to hold a specimen, wherein a precipitation surface 21 on which a precipitate 27a of the specimen 27 precipitates is disposed at a position different from a position of a sensing surface 23 on the side of the optical waveguide part 12 where an optical change occurs.
摘要翻译：要解决的问题：提供能够避免样品中沉淀物的影响的光学传感器。解决方案：光学传感器1包括：光波导部分12; 以及与光波导部12相邻并配置为保持试样的试样区域20，其中，试样27的析出物27a析出的析出面21配置在与感测面23的位置不同的位置发生光学变化的光波导部分12的一侧。

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