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1. 发明专利

JP2013238541A Optical waveguide type measurement system and measurement method for glycosylated hemoglobin 审中-公开
标题翻译：光学波形测量系统及测定糖蛋白HEMOGLOBIN的测量方法
公开(公告)号：JP2013238541A
公开(公告)日：2013-11-28
申请号：JP2012112871
申请日：2012-05-16
申请人： Toshiba Corp , 株式会社東芝
发明人： KASAI SHINGO , TONO ICHIRO
IPC分类号： G01N33/53 , G01N21/27 , G01N33/543
CPC分类号： G01N33/54373 , G01N33/54333 , G01N33/723
摘要： PROBLEM TO BE SOLVED: To easily and accurately measure HbA1c.SOLUTION: An optical waveguide type measurement system includes: a first optical waveguide; a first substance that is fixed on the first optical waveguide and can be specifically bound to glycosylated hemoglobin; and a plurality of first magnetic fine particles fixed with a second substance that can be specifically bound to the glycosylated hemoglobin in places different from places where the first substance capable of being specifically bound to the glycosylated hemoglobin. The optical waveguide type measurement system further includes: a first magnetic field application section that is provided above the first optical waveguide and can move at least one of the plurality of first magnetic fine particles by magnetic force; a first light source capable of making light incident to the first optical waveguide; and a first light receiving element capable of light-receiving light emitted from the first optical waveguide.
摘要翻译：要解决的问题：容易且精确地测量HbA1c。解决方案：一种光波导型测量系统，包括：第一光波导; 固定在第一光波导上并能够特异性结合到糖基化血红蛋白上的第一物质; 以及多个与第二物质固定的第一磁性微粒，所述第二物质可以与不同于能够特异性结合到糖基化血红蛋白的第一物质的位置特异性结合到糖基化血红蛋白上。光波导型测量系统还包括：第一磁场施加部分，其设置在第一光波导上方并且可以通过磁力移动多个第一磁性细颗粒中的至少一个; 能够使光入射到第一光波导的第一光源; 以及能够对从第一光波导发射的光进行光接收的第一光接收元件。

2. 发明专利

JP2009240580A Analytical method and device of biogenic substance, and extraction cartridge 有权
标题翻译：分析方法和生物物质和提取盒的装置
公开(公告)号：JP2009240580A
公开(公告)日：2009-10-22
申请号：JP2008091599
申请日：2008-03-31
申请人： Sysmex Corp , Toshiba Corp , シスメックス株式会社 , 株式会社東芝
发明人： KOJIMA JUNKO , MAEKAWA YASUNORI , TAKASE TOMOHIRO , UEMATSU IKUO , HIRAKAWA MASAAKI , NAWATA ISAO , TONO ICHIRO , KASAI SHINGO
IPC分类号： A61B5/157
CPC分类号： A61B5/14514 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150091 , A61B5/150229 , A61B5/150251 , A61B5/150343 , A61B5/150358 , A61B5/150748 , A61B5/150984 , A61B5/15113 , A61B5/15186 , A61B5/1519 , A61B5/157 , A61B5/6824 , A61B5/685 , C12Q1/006
摘要： PROBLEM TO BE SOLVED: To provide analytical method and device of biogenic substance and an extraction cartridge capable of highly precisely analyzing an extract extracted from a subject. SOLUTION: A blood glucose level estimation device (biogenic substance analytical device) 100 includes: an extract medium retention section 53 configured to retain a predetermined amount of extract medium; a reaction section 54 producing a predetermined reaction by glucose; a detection section 40 detecting the glucose from the predetermined reaction generated in the reaction section 54; a liquid storage section 52 storing the glucose by an amount equal to the predetermined amount retained by the extract medium retention section 53; a pump 18 carrying the extract medium stored in the liquid storage section 52 to the extract medium retention section 53 and carrying a part of the extract medium carried to the extract medium retention section 53 and retaining the glucose extracted from the subject, from the extraction medium retention section 53 to the reaction section 54; and a control section 17 analyzing a detection result of the glucose. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供能够高精度地分析从受试者提取的提取物的生物源物质和提取盒的分析方法和装置。解决方案：血糖值估计装置（生物来源物质分析装置）100包括：提取介质保持部53，被配置为保持预定量的提取介质; 由葡萄糖产生预定反应的反应部54; 从反应部54中产生的规定的反应检测葡萄糖的检测部40; 储存葡萄糖量等于由提取介质保留部分53保留的预定量的液体存储部分52; 将存储在液体储存部52中的提取介质携带到提取介质保留部53并将被携带的提取介质的一部分携带到提取介质保留部53并保留从被检体提取的葡萄糖从提取介质保持部53到反应部54; 以及分析葡萄糖的检测结果的控制部17。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2006267052A Inspection apparatus for measuring immune reaction 审中-公开
标题翻译：用于测量免疫反应的检查装置
公开(公告)号：JP2006267052A
公开(公告)日：2006-10-05
申请号：JP2005089453
申请日：2005-03-25
申请人： Toshiba Corp , 株式会社東芝
发明人： UCHIYAMA KENICHI , OOMIYA KAYOKO , KASAI SHINGO , UEMATSU IKUO , TAKASE TOMOHIRO , NAWATA ISAO , TONO ICHIRO
IPC分类号： G01N21/64 , G01N21/78
摘要： PROBLEM TO BE SOLVED: To provide an inspection apparatus for measuring an immune reaction that can excite a labeled coloring matter, after an antigen/antibody reaction in solution in the entire cell, propagates fluorescence radiated by excitation onto a transparent plate for radiating to the outside, and can essentially detect the intensity of only the fluorescence by a light-receiving element.
SOLUTION: The inspection apparatus for measuring an immune reaction comprises the transparent plate; a sensor chip, having a cell that is arranged at least at one location on the surface of the transparent plate and stores the solution of reagents and specimens, a grating that is formed on the transparent plate at the bottom of the cell and allows the fluorescence to enter the transparent plate, and an optical element that is formed on the surface of the transparent plate, separated from the cell and radiates fluorescence propagated to the transparent plate by the grating to the outside; an excitation light irradiation means for irradiating the cell of the sensor chip, with the excitation light along the depth direction of the cell; and a light-receiving means for receiving the fluorescence radiated from the optical element of the sensor chip.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于测量可激发标记色素的免疫反应的检查装置，在整个细胞溶液中的抗原/抗体反应之后，将通过激发辐射的荧光传播到用于辐射的透明板上并且可以基本上通过光接收元件检测仅荧光的强度。解决方案：用于测量免疫反应的检查装置包括透明板; 传感器芯片，具有布置在透明板的表面上的至少一个位置处并存储试剂和试样溶液的电池，形成在电池底部的透明板上的光栅，并允许荧光进入透明板，以及形成在透明板的表面上的与光电元件分离的光学元件，并将通过光栅传播到透明板的荧光发射到外部; 激发光照射装置，用于沿着电池的深度方向照射传感器芯片的电池; 以及用于接收从传感器芯片的光学元件辐射的荧光的光接收装置。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2015025820A 光導波路型測定システムおよび糖化ヘモグロビンの測定方法审中-公开
标题翻译：光学波形测量系统及测定糖蛋白HEMOGLOBIN的测量方法
公开(公告)号：JP2015025820A
公开(公告)日：2015-02-05
申请号：JP2014224498
申请日：2014-11-04
申请人：株式会社東芝 , Toshiba Corp
发明人： KASAI SHINGO , TONO ICHIRO , KANAYAMA SHOICHI
IPC分类号： G01N33/543 , G01N21/17 , G01N33/53 , G01N33/553
摘要：【課題】HbA1cを簡便かつ精度よく測定する。【解決手段】糖化ヘモグロビンと特異的に結合することが可能な第1物質が固定化された第1センシングエリアを有する第1光導波路と、前記第1物質が前記糖化ヘモグロビンと特異的に結合することが可能な箇所とは別の箇所で前記糖化ヘモグロビンと特異的に結合することが可能な第2物質が固定化された超常磁性を有する複数の第1磁性微粒子と、前記第1光導波路の上方に設けられ、前記複数の第1磁性微粒子の少なくとも1つを前記第1センシングエリアから磁力によって移動させることが可能な第1磁場印加部と、前記第1光導波路に光を入射させ前記第1センシングエリアに近接場光を発生させることが可能な第1光源と、前記第1光導波路から出射される光を受光することが可能な第1受光素子と、を有する光導波路型測定システム。【選択図】図1
摘要翻译：要解决的问题：以高精度容易地测量HbA1c。解决方案：一种光波导型测量系统具有：第一光波导，其具有固定有能够与糖基化血红蛋白特异性结合的第一物质的第一感测区域; 多个超顺磁性第一磁性微粒，其固定有能够与第一物质可以特异性结合到糖基化血红蛋白的部分不同的一部分与糖基化血红蛋白特异性结合的第二物质; 第一磁场施加部，设置在第一光波导上方，能够通过磁力从第一感测区域移动多个第一磁性微粒中的至少一个; 第一光源，其使得入射在所述第一光波导上的光能够在所述第一感测区域中产生近场光; 以及能够接收从第一光波导发射的光的第一光接收元件。

5. 发明专利

JP2013195404A Measurement method, sensor chip and measurement device 有权
标题翻译：测量方法，传感器芯片和测量装置
公开(公告)号：JP2013195404A
公开(公告)日：2013-09-30
申请号：JP2012066417
申请日：2012-03-22
申请人： Toshiba Corp , 株式会社東芝
发明人： WADA TAKAKI , TAKASE TOMOHIRO , TONO ICHIRO , NAWATA ISAO , KASAI SHINGO
IPC分类号： G01N33/543 , G01N21/27
摘要： PROBLEM TO BE SOLVED: To provide a measurement method, a sensor chip and a measurement device that can highly accurately measure a plurality of kinds of measurement object substances.SOLUTION: The measurement method according to an embodiment is a measurement method that uses a sensor chip, in which an optical waveguide part has a first area where a first substance reacting to a first measurement object substance is fixed and a second area where a second substance reacting to a second measurement object substance is fixed, and at least any of a third substance reacting to the first substance and a fourth substance reacting to the second substance is fixed on a surface of a base of a particle. The measurement method comprises the steps of: guiding a specimen solution into holding space; calculating absorbance after the specimen solution is guided; inputting at least one particle into the specimen solution guided into the holding space; calculating absorbance after the particle is input; calculating absorbance variation; and calculating an amount of the measurement object substance on the basis of the absorbance variation.
摘要翻译：要解决的问题：提供可以高精度地测量多种测量对象物质的测量方法，传感器芯片和测量装置。解决方案：根据实施例的测量方法是使用传感器芯片的测量方法其中光波导部分具有固定第一物质与第一测量对象物质反应的第一区域和与第二测量对象物质反应的第二物质固定的第二区域，以及至少第三物质与第一物质反应的第四物质和与第二物质反应的第四物质固定在颗粒的基材的表面上。测量方法包括以下步骤：将样品溶液引导到保持空间中; 计算样品溶液引导后的吸光度; 将至少一个颗粒输入到引导到保持空间中的样品溶液中; 计算粒子输入后的吸光度; 计算吸光度变化; 并基于吸光度变化计算测量对象物质的量。

6. 发明专利

JP2012173220A Optical waveguide type biochemical sensor chip, optical waveguide type biosensor, and substance measuring kit 审中-公开
标题翻译：光波导型生物传感器芯片，光波导型生物传感器和物质测量套件
公开(公告)号：JP2012173220A
公开(公告)日：2012-09-10
申请号：JP2011037590
申请日：2011-02-23
申请人： Toshiba Corp , 株式会社東芝
发明人： TONO ICHIRO , KASAI SHINGO
IPC分类号： G01N33/543 , G01N21/78
摘要： PROBLEM TO BE SOLVED: To provide an optical waveguide type biochemical sensor chip which can improve detection sensitivity of a substance to be measured.SOLUTION: An optical waveguide type biochemical sensor chip includes an optical waveguide in which a first substance that specifically reacts with a substance to be measured is fixed to the surface thereof, and fine particles in which a second substance that specifically reacts with the substance to be measured and enzymes for catalyzing coloring reaction are fixed.
摘要翻译：解决的问题：提供能够提高被测定物质的检测灵敏度的光波导型生化传感器芯片。解决方案：光波导型生化传感器芯片包括光波导，其中与待测物质特异性反应的第一物质固定在其表面上，以及细颗粒，其中特定与第要测量的物质和催化着色反应的酶是固定的。版权所有（C）2012，JPO＆INPIT

7. 发明专利

JP2011202997A Optical sensor 有权
标题翻译：光传感器
公开(公告)号：JP2011202997A
公开(公告)日：2011-10-13
申请号：JP2010068426
申请日：2010-03-24
申请人： Toshiba Corp , 株式会社東芝
发明人： UEMATSU IKUO , KASAI SHINGO , TONO ICHIRO , NAWATA ISAO
IPC分类号： G01N21/27
CPC分类号： G01N21/7703 , G01N21/78 , G01N2021/7776 , G01N2021/7786
摘要： PROBLEM TO BE SOLVED: To provide an optical sensor capable of avoiding the influence of a precipitate in a specimen.SOLUTION: The optical sensor 1 includes: an optical waveguide part 12; and a specimen area 20 provided adjacent to the optical waveguide part 12 and configured to hold a specimen, wherein a precipitation surface 21 on which a precipitate 27a of the specimen 27 precipitates is disposed at a position different from a position of a sensing surface 23 on the side of the optical waveguide part 12 where an optical change occurs.
摘要翻译：要解决的问题：提供能够避免样品中沉淀物的影响的光学传感器。解决方案：光学传感器1包括：光波导部分12; 以及与光波导部12相邻并配置为保持试样的试样区域20，其中，试样27的析出物27a析出的析出面21配置在与感测面23的位置不同的位置发生光学变化的光波导部分12的一侧。

8. 发明专利

JP2009133842A Optical-waveguide sensor chip, method of manufacturing same, method of measuring substance, substance-measuring kit and optical-waveguide sensor 有权
标题翻译：光波导传感器芯片，其制造方法，测量物质的方法，物质测量套件和光波导传感器
公开(公告)号：JP2009133842A
公开(公告)日：2009-06-18
申请号：JP2008274708
申请日：2008-10-24
申请人： Morinaga & Co Ltd , Toshiba Corp , 株式会社東芝 , 森永製菓株式会社
发明人： KASAI SHINGO , UEMATSU IKUO , TONO ICHIRO , TAKASE TOMOHIRO , NAWATA ISAO , OMIYA KAYOKO , KOYAMA YURIKO , HONJO TSUTOMU
IPC分类号： G01N33/543 , G01N21/27
摘要： PROBLEM TO BE SOLVED: To provide an optical-waveguide sensor for quantitatively measuring a substance to be measured of an analyte to be measured at a small amount in a short time. SOLUTION: This optical-waveguide sensor includes an optical waveguide having a first substance immobilized on the surface thereof, the first substance being specifically reactive with the substance to be measured, and fine particles dispersed on the optical waveguide and having a second substance immobilized on the surface thereof, the second substance being specifically reactive with the substance to be measured. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种光波导传感器，用于在短时间内以少量定量测量要测量的待分析物质。解决方案：该光波导传感器包括具有固定在其表面上的第一物质的光波导，第一物质与待测物质特异性反应，分散在光波导上并具有第二物质的细颗粒固定在其表面上，第二物质与待测物质特异性反应。版权所有（C）2009，JPO＆INPIT

9. 发明专利

JP2009115665A Material measuring method and material measuring kit 有权
标题翻译：材料测量方法和材料测量工具包
公开(公告)号：JP2009115665A
公开(公告)日：2009-05-28
申请号：JP2007290208
申请日：2007-11-07
申请人： Morinaga & Co Ltd , Toshiba Corp , 株式会社東芝 , 森永製菓株式会社
发明人： TONO ICHIRO , KASAI SHINGO , UEMATSU IKUO , OMIYA KAYOKO , TAKASE TOMOHIRO , KOYAMA YURIKO , HONJO TSUTOMU
IPC分类号： G01N33/543 , G01N21/78 , G01N33/545 , G01N33/553
摘要： PROBLEM TO BE SOLVED: To provide a material measuring method capable of measuring quantitatively a measuring object material in a shorter time.
SOLUTION: This material measuring method includes: a process for immobilizing the first material having an equivalent property to the measuring object material on an optical waveguide surface; and a process wherein specimen solution to be measured and dispersion liquid of particles on which the second materials to be reacted specifically with the measuring object material in a specimen to be measured are immobilized, are dropped onto the optical waveguide surface simultaneously or in the order headed by the specimen solution to be measured, to thereby react specifically the second materials in the particles with the measuring object material in the specimen to be measured, and the first and second materials are reacted specifically together between the optical waveguide and unreacted particles, and an optical change by the particles immobilized on the optical waveguide surface is detected.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供能够在较短时间内定量测量测量对象材料的材料测量方法。解决方案：该材料测量方法包括：将具有等效特性的第一材料固定在光波导表面上的测量对象材料的方法; 以及固定待测试样品的溶液和待测样品中特异性反应的第二材料的颗粒的分散液同时或以顺序的方式滴落到光波导表面上通过待测试样品溶液，从而使颗粒中的第二材料与待测试样品中的测量对象物质特异性地反应，并且第一和第二材料在光波导和未反应颗粒之间特异性地反应，并且检测固定在光波导表面上的颗粒的光学变化。版权所有（C）2009，JPO＆INPIT

10. 发明专利

JP2014163739A Sensor chip 审中-公开
标题翻译：传感器芯片
公开(公告)号：JP2014163739A
公开(公告)日：2014-09-08
申请号：JP2013033198
申请日：2013-02-22
申请人： Toshiba Corp , 株式会社東芝
发明人： WADA TAKAKI , YAMAUCHI TAKEMOTO , TONO ICHIRO , KASAI SHINGO , ISHIDA CHIO
IPC分类号： G01N21/27
摘要： PROBLEM TO BE SOLVED: To provide a sensor chip capable of improving detection sensitivity.SOLUTION: The sensor chip includes: an optical waveguide part; a sensing area provided on the optical waveguide part; a pair of optical element parts provided on the optical waveguide part to sandwich the sensing area between them; a junction part provided on the side where the optical element parts are provided on the optical waveguide part, having first pores where the optical element parts are exposed; and a chamber part provided on the junction part. Gas exists in the first pores.
摘要翻译：要解决的问题：提供能够提高检测灵敏度的传感器芯片。解决方案：传感器芯片包括：光波导部分; 设置在光波导部分上的感测区域; 设置在所述光波导部分上以将感测区域夹在其间的一对光学元件部分; 在所述光波导部分上设置有所述光学元件部分的一侧的接合部分，具有所述光学元件部分露出的第一孔; 以及设置在接合部上的室部。气体存在于第一孔中。

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