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1. 发明专利

JP2011196854A Sensor system 审中-公开
标题翻译：传感器系统
公开(公告)号：JP2011196854A
公开(公告)日：2011-10-06
申请号：JP2010064736
申请日：2010-03-19
申请人： Toshiba Corp , 株式会社東芝
发明人： TONO ICHIRO , HIRAKAWA MASAAKI , UEMATSU IKUO , NAWATA ISAO , TAKASE TOMOHIRO
IPC分类号： G01N21/78 , C12M1/34 , C12Q1/26 , G01N21/27 , G01N35/08 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a compact sensor system capable of performing in a short time, without performing isothermal treatment in a prescribed time, when quantitating enzyme activity in specimen liquid via a plurality of reactions.SOLUTION: A specimen liquid reaction device 1 includes: a reaction chamber 4 connected to a specimen liquid storage chamber 7 through a first channel 8, for storing a specimen substrate to be reacted with a component to be measured in specimen liquid; a fine pump 10 inserted so that the lower end is communicated with the reaction chamber 4; a reaction liquid circulation space 12 connected through a second channel 14 having a larger sectional area than the first channel; and a check valve 17. The device 1 further includes a plane type optical waveguide sensor 21 mounted so as to be positioned in the reaction liquid circulation space 12, and including a sensing film containing at least a film-forming component and a redox dye. and also containing a reaction reagent for generating an oxidative material or a reductive material from a reduction product of the component to be measured and the reaction substrate in either or both of the reaction chamber 4 and the sensing film.
摘要翻译：要解决的问题：提供一种能够在短时间内执行的小型传感器系统，而不需要在规定时间内进行等温处理，当通过多个反应定量样品液体中的酶活性时。溶液：试样液体反应装置1包括：通过第一通道8连接到试样储液室7的反应室4，用于储存与被检测液体中的待测部件反应的试样基板; 插入的细小泵10使得下端与反应室4连通; 通过具有比第一通道更大的截面积的第二通道14连接的反应液体循环空间12; 和止回阀17.装置1还包括安装在反应液循环空间12中的平面型光波导传感器21，并且包括至少含有成膜组分和氧化还原染料的感测膜。并且还含有用于在反应室4和感测膜中的任一个或两者中从被测量组分的还原产物和反应基底产生氧化材料或还原材料的反应试剂。

2. 发明专利

JP2011167165A Method for manufacturing optical sensor chip 审中-公开
标题翻译：制造光传感器芯片的方法
公开(公告)号：JP2011167165A
公开(公告)日：2011-09-01
申请号：JP2010036495
申请日：2010-02-22
申请人： Toshiba Corp , 株式会社東芝
发明人： HIRAKAWA MASAAKI , UEMATSU IKUO , OMIYA KAYOKO
IPC分类号： C12M1/34 , C12Q1/26 , C12Q1/28 , C12Q1/54 , G01N21/27
摘要： PROBLEM TO BE SOLVED: To provide a method for manufacturing optical sensor chips which can control permeability change of a sensing film in a retention period by removing bound water contained in the sensing film. SOLUTION: In the method of manufacturing optical sensor chips, at least one enzyme in a first enzyme oxidizing or reducing a measured object and a second enzyme generating a substance of a coloring substance by reacting with the generated product of the first enzyme is coated with an ionic polymer containing a buffer; the first enzyme, the second enzyme, the coloring substance, and a nonionic cellulose derivative are mixed to prepare coating liquid for sensing film formation; and the sensing film is formed by applying the coating liquid for sensing film formation on an optical waveguide layer formed on a substrate and heating and drying the coating liquid. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种制造光学传感器芯片的方法，其可以通过去除感测膜中包含的结合水来控制保持期间的感测膜的透过率变化。解决方案：在制造光学传感器芯片的方法中，通过与第一种酶的产物反应，在第一种酶中氧化或还原被测物体中的至少一种酶和产生着色物质的第二种酶是产生第一种酶的产物，涂覆有含有缓冲液的离子聚合物; 将第一酶，第二酶，着色物质和非离子性纤维素衍生物混合以制备用于感测成膜的涂布液; 并且通过在形成在基板上的光波导层上涂布感光成膜用涂布液，加热干燥涂布液而形成感测膜。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2012078185A Optical waveguide type biosensor chip and optical waveguide type biosensor chip manufacturing method 审中-公开
标题翻译：光波导型生物传感器芯片和光波导型生物传感器芯片制造方法
公开(公告)号：JP2012078185A
公开(公告)日：2012-04-19
申请号：JP2010223170
申请日：2010-09-30
申请人： Toshiba Corp , 株式会社東芝
发明人： HIRAKAWA MASAAKI , TONO ICHIRO
IPC分类号： G01N21/78 , G01N21/27 , G02B6/122 , G02B6/13
摘要： PROBLEM TO BE SOLVED: To provide an optical waveguide type biosensor chip enabling light detection measurement with high accuracy while maintaining high sensitivity, and a manufacturing method thereof.SOLUTION: An optical waveguide type biosensor chip comprises: a substrate having light transmissivity; an optical waveguide layer formed on the substrate and having higher refractive index than the substrate; a first grating that makes light enter the optical waveguide layer so as to propagate the light in the optical waveguide layer; a second grating that emits the light propagated in the optical waveguide layer to the outside of the optical waveguide layer; and a metal oxide film formed on the optical waveguide layer; and a sensing film comprising at least a coloring agent fixed on the metal oxide film using a crosslinking agent.
摘要翻译：要解决的问题：提供一种在保持高灵敏度的同时高精度地进行光检测测量的光波导型生物传感器芯片及其制造方法。解决方案：光波导型生物传感器芯片包括：具有透光性的基板; 形成在所述基板上并且具有比所述基板更高的折射率的光波导层; 第一光栅，使光进入光波导层，以便在光波导层中传播光; 第二光栅，其将在所述光波导层中传播的光发射到所述光波导层的外部; 以及形成在所述光波导层上的金属氧化物膜; 以及至少包含使用交联剂固定在金属氧化物膜上的着色剂的感测膜。版权所有（C）2012，JPO＆INPIT

4. 发明专利

JP2009240580A Analytical method and device of biogenic substance, and extraction cartridge 有权
标题翻译：分析方法和生物物质和提取盒的装置
公开(公告)号：JP2009240580A
公开(公告)日：2009-10-22
申请号：JP2008091599
申请日：2008-03-31
申请人： Sysmex Corp , Toshiba Corp , シスメックス株式会社 , 株式会社東芝
发明人： KOJIMA JUNKO , MAEKAWA YASUNORI , TAKASE TOMOHIRO , UEMATSU IKUO , HIRAKAWA MASAAKI , NAWATA ISAO , TONO ICHIRO , KASAI SHINGO
IPC分类号： A61B5/157
CPC分类号： A61B5/14514 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150091 , A61B5/150229 , A61B5/150251 , A61B5/150343 , A61B5/150358 , A61B5/150748 , A61B5/150984 , A61B5/15113 , A61B5/15186 , A61B5/1519 , A61B5/157 , A61B5/6824 , A61B5/685 , C12Q1/006
摘要： PROBLEM TO BE SOLVED: To provide analytical method and device of biogenic substance and an extraction cartridge capable of highly precisely analyzing an extract extracted from a subject. SOLUTION: A blood glucose level estimation device (biogenic substance analytical device) 100 includes: an extract medium retention section 53 configured to retain a predetermined amount of extract medium; a reaction section 54 producing a predetermined reaction by glucose; a detection section 40 detecting the glucose from the predetermined reaction generated in the reaction section 54; a liquid storage section 52 storing the glucose by an amount equal to the predetermined amount retained by the extract medium retention section 53; a pump 18 carrying the extract medium stored in the liquid storage section 52 to the extract medium retention section 53 and carrying a part of the extract medium carried to the extract medium retention section 53 and retaining the glucose extracted from the subject, from the extraction medium retention section 53 to the reaction section 54; and a control section 17 analyzing a detection result of the glucose. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供能够高精度地分析从受试者提取的提取物的生物源物质和提取盒的分析方法和装置。解决方案：血糖值估计装置（生物来源物质分析装置）100包括：提取介质保持部53，被配置为保持预定量的提取介质; 由葡萄糖产生预定反应的反应部54; 从反应部54中产生的规定的反应检测葡萄糖的检测部40; 储存葡萄糖量等于由提取介质保留部分53保留的预定量的液体存储部分52; 将存储在液体储存部52中的提取介质携带到提取介质保留部53并将被携带的提取介质的一部分携带到提取介质保留部53并保留从被检体提取的葡萄糖从提取介质保持部53到反应部54; 以及分析葡萄糖的检测结果的控制部17。版权所有（C）2010，JPO＆INPIT

5. 发明专利

JP2008122265A Color development reaction detection device and its manufacturing method 审中-公开
标题翻译：颜色发展反应检测装置及其制造方法
公开(公告)号：JP2008122265A
公开(公告)日：2008-05-29
申请号：JP2006307457
申请日：2006-11-14
申请人： Toshiba Corp , 株式会社東芝
发明人： TAKASE TOMOHIRO , NAWATA ISAO , UEMATSU IKUO , HIRAKAWA MASAAKI
IPC分类号： G01N21/78
摘要： PROBLEM TO BE SOLVED: To provide a color development reaction detection device capable of stably measuring the mass of a sensing target even in a case that a temperature change occurs, and to provide its manufacturing method.
SOLUTION: The color development reaction detection device is equipped with a light source 11 coming into contact with a specimen to emit the light guided through the light guide film 14b provided to a biosensor 14 for acquiring the physiological data of the specimen, a first measuring means 11a for measuring the temperature of the light source 11, a second measuring means 15 for detecting the light guided through the light guide film 14b to measure a light detection signal value and a correction means 16b for correcting a reference value when the attenuation of a light detection signal is calculated from the temperature measured by the first measuring means 11a and calculating the attenuation rate of the light detection signal on the basis of the corrected reference value and the light detection signal value measured by the second measuring means 15.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供即使在发生温度变化的情况下也能够稳定地测量感测对象的质量并提供其制造方法的显色反应检测装置。解决方案：显色反应检测装置配备有与试样接触的光源11，以发射通过设置在用于获取试样的生理数据的生物传感器14的导光膜14b所引导的光，用于测量光源11的温度的第一测量装置11a，用于检测通过导光膜14b引导的光以测量光检测信号值的第二测量装置15;以及用于在衰减时校正参考值的校正装置16b 根据由第一测量装置11a测量的温度计算光检测信号，并且基于校正的参考值和由第二测量装置15测量的光检测信号值来计算光检测信号的衰减率。 P>版权所有（C）2008，JPO＆INPIT

6. 发明专利

JP2008022763A Optical glucose sensor chip and method for producing the same 有权
标题翻译：光学葡萄糖传感器芯片及其制造方法
公开(公告)号：JP2008022763A
公开(公告)日：2008-02-07
申请号：JP2006198173
申请日：2006-07-20
申请人： Toshiba Corp , 株式会社東芝
发明人： UEMATSU IKUO , HIRAKAWA MASAAKI , OOMIYA KAYOKO
IPC分类号： C12M1/34 , G01N21/78
CPC分类号： C12Q1/002 , C12Q1/006 , G01N21/552 , G01N21/78
摘要： PROBLEM TO BE SOLVED: To provide an optical glucose sensor chip suppressing or preventing time-lapse deterioration of first and second enzymes in a sensing film.
SOLUTION: The optical glucose sensor chip comprises the following: a base plate; a pair of optical elements formed at the main surface of the base plate, making light incident into the base plate and making the incident light emit out of the base plate; and a glucose sensing film formed at the main surface of the base plate disposed between the optical elements, containing a coloring agent, a first enzyme oxidizing or reducing glucose and a second enzyme generating substance reacting with the generated material of the first enzyme so as to make the coloring agent develop colors, and a nonionic cellulose derivative. The sensing film has a structure that at least one of the first and second enzymes is covered with ionic polymer, where a cushioning agent is taken and the enzymes and the coloring agent are held by the nonionic cellulose derivative.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供抑制或防止感测膜中第一和第二酶的延时劣化的光学葡萄糖传感器芯片。解决方案：光学葡萄糖传感器芯片包括：底板; 形成在所述基板的主表面的一对光学元件，使入射到所述基板中并使所述入射光从所述基板射出的光; 以及葡萄糖感测膜，其形成在设置在所述光学元件之间的所述基板的主表面处，所述葡萄糖感测膜含有着色剂，第一酶氧化还原葡萄糖和与所述第一酶的产生物质反应的第二酶产生物质，以便使着色剂显色，和非离子纤维素衍生物。感测膜具有以下结构：第一和第二酶中的至少一个被离子聚合物覆盖，其中采用缓冲剂，酶和着色剂由非离子纤维素衍生物保持。版权所有（C）2008，JPO＆INPIT

7. 发明专利

JP2012215553A Optical waveguide type measurement system, measurement method, and optical waveguide type sensor chip 有权
标题翻译：光波导型测量系统，测量方法和光波导型传感器芯片
公开(公告)号：JP2012215553A
公开(公告)日：2012-11-08
申请号：JP2012011456
申请日：2012-01-23
申请人： Toshiba Corp , 株式会社東芝
发明人： TONO ICHIRO , KASAI SHINGO , WADA TAKAKI , NAWATA ISAO , HIRAKAWA MASAAKI , TAKASE TOMOHIRO , OMIYA KAYOKO , YAMAUCHI TAKEMOTO , NAKAYAMA TADAHIRO , NITTA ISAMU
IPC分类号： G01N33/543 , G01N21/27 , G01N33/553
摘要： PROBLEM TO BE SOLVED: To provide an optical waveguide type measurement system in which detection sensitivity of a measurement object material is more improved to higher accuracy, and a measurement method and an optical waveguide type sensor chip thereof.SOLUTION: The optical waveguide type measurement system includes an optical waveguide having a sensing area where first substances that specifically bind to the measurement object material are immobilized; magnetic fine particles in which second substances that specifically bind to the measurement object material are immobilized, and which have magnetism; a magnetic field applying unit for generating a magnetic field that moves the magnetic particles; a light source that makes light incident to the optical waveguide; and a light receiving element for receiving light emitted from the optical waveguide.
摘要翻译：解决的问题：提供一种测量对象材料的检测灵敏度更高精度的光波导型测量系统及其测量方法和光波导型传感器芯片。解决方案：光波导型测量系统包括具有固定有特定结合测量对象材料的第一物质的感测区域的光波导; 具有与测定对象物质特异结合的第二物质固定的具有磁性的磁性微粒; 磁场施加单元，用于产生使磁性颗粒移动的磁场; 使光入射到光波导的光源; 以及用于接收从光波导发射的光的光接收元件。版权所有（C）2013，JPO＆INPIT

8. 发明专利

JP2012145348A Optical waveguiding type biochemical sensor chip, biosensor cartridge and biosensor system 审中-公开
标题翻译：光学波形式生物传感器芯片，生物传感器盒和生物传感器系统
公开(公告)号：JP2012145348A
公开(公告)日：2012-08-02
申请号：JP2011001738
申请日：2011-01-07
申请人： Toshiba Corp , 株式会社東芝
发明人： HIRAKAWA MASAAKI , YAMAUCHI TAKEMOTO , TAKASE TOMOHIRO
IPC分类号： G01N21/78
摘要： PROBLEM TO BE SOLVED: To provide an optical waveguiding type biochemical sensor chip capable of repeatedly performing high sensitive measurement, a biosensor cartridge and a biosensor system.SOLUTION: According to an embodiment, the optical waveguiding type biochemical sensor chip includes an optical waveguiding part and a sensing part. The optical waveguiding part includes an optical waveguiding layer for guiding light. The sensing part is in contact with a main surface of the optical waveguiding part and includes a sensing material layer. By one reaction of oxidation and reduction corresponding to a specimen introduced into the sensing material layer, a first change is generated in absorption characteristics of the sensing material layer for infiltration light infiltrated into the sensing material layer. By the other reaction of oxidation and reduction caused by voltage applied to the sensing material layer, a second change reversed to the first change is generated in the absorption characteristics.
摘要翻译：要解决的问题：提供能够重复执行高灵敏度测量的光波导型生化传感器芯片，生物传感器盒和生物传感器系统。解决方案：根据实施例，光波导型生化传感器芯片包括光波导部分和感测部分。光波导部分包括用于引导光的光波导层。感测部分与光波导部分的主表面接触并且包括传感材料层。通过与引入到感测材料层中的试样相对应的氧化和还原的一个反应，在渗透到感测材料层中的渗透光的感测材料层的吸收特性中产生第一变化。通过由施加到感测材料层的电压引起的另一氧化还原反应，在吸收特性中产生与第一变化相反的第二变化。版权所有（C）2012，JPO＆INPIT

9. 发明专利

JP2012055257A Test element, test kit, test device, and test method 有权
标题翻译：测试元件，测试套件，测试设备和测试方法
公开(公告)号：JP2012055257A
公开(公告)日：2012-03-22
申请号：JP2010203118
申请日：2010-09-10
申请人： Toshiba Corp , 株式会社東芝
发明人： TONO ICHIRO , WADA TAKAAKI , OMIYA KAYOKO , KASAI SHINGO , HIRAKAWA MASAAKI
IPC分类号： C12M1/34 , C12Q1/25 , C12Q1/26
CPC分类号： C12Q1/28 , C12Q1/26 , G01N21/7703 , G01N21/78
摘要： PROBLEM TO BE SOLVED: To provide a test element, test kit, test device and method for testing with high measurement accuracy and having a short time for testing.SOLUTION: According to one embodiment, a test element includes: a base having transparency; a pair of optical element parts, an optical waveguide part arranged away from each other on a major surface of the base; a detection part which is provided on a major surface of the opposite side to the side where the base of the optical waveguide part is provided, and is provided between the optical element parts; and a holding part in a frame shape wherein one end is projectingly provided from the major surface of the detection part. The detection part includes a color former and a film-forming body holding the color former.
摘要翻译：要解决的问题：提供测量元件，测试套件，测试装置和测量方法，测量精度高，测试时间短。解决方案：根据一个实施例，测试元件包括：具有透明度的基底; 一对光学元件部分，在所述基座的主表面上彼此远离布置的光波导部分; 检测部，其设置在与设置有所述光波导部的基部的一侧相反的一侧的主表面上，并设置在所述光学元件部之间; 以及框架形状的保持部，其中从所述检测部的主表面突出地设置有一端。检测部分包括着色剂和保持着色剂的成膜体。版权所有（C）2012，JPO＆INPIT

10. 发明专利

JP2011127937A Glucose sensor chip 审中-公开
标题翻译：葡萄糖传感器芯片
公开(公告)号：JP2011127937A
公开(公告)日：2011-06-30
申请号：JP2009284581
申请日：2009-12-15
申请人： Toshiba Corp , 株式会社東芝
发明人： HIRAKAWA MASAAKI , UEMATSU IKUO
IPC分类号： G01N21/27 , C12Q1/26 , C12Q1/28 , C12Q1/32 , C12Q1/48 , C12Q1/54 , G01N21/78
CPC分类号： C12Q1/006 , G01N21/7703
摘要： PROBLEM TO BE SOLVED: To provide a glucose sensor chip having a sensing film with high measuring sensitivity. SOLUTION: The glucose sensor chip includes a light waveguide layer 3 containing a pair of the gratings 4 provided on the main surface of a substrate 2 in a mutually spaced-apart state and the sensing film 5 provided to the part of the light waveguide layer 3 across a pair of the gratings 4. The sensing film 5 is formed of a film forming high-molecular compound a crosslinkable high-molecular compound and a porous low-molecular compound. A colorant, first enzyme for oxidizing or reducing glucose and second enzyme, which reacts with the product of the first enzyme to produce a substance for developing the colorant, are held in the sensing film. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供具有高测量灵敏度的感测膜的葡萄糖传感器芯片。解决方案：葡萄糖传感器芯片包括光波导层3，该光波导层3包含以相互间隔的状态设置在基板2的主表面上的一对光栅4，以及设置在该光的一部分上的感测膜5 波导层3穿过一对光栅4.传感膜5由形成高分子化合物的可交联的高分子化合物和多孔低分子化合物形成。用于氧化或还原葡萄糖的第一种着色剂和与第一种酶的产物反应以产生着色剂显影的物质的第二种酶被保持在感测膜中。版权所有（C）2011，JPO＆INPIT

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