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1. 发明专利

JP2013238541A Optical waveguide type measurement system and measurement method for glycosylated hemoglobin 审中-公开
标题翻译：光学波形测量系统及测定糖蛋白HEMOGLOBIN的测量方法
公开(公告)号：JP2013238541A
公开(公告)日：2013-11-28
申请号：JP2012112871
申请日：2012-05-16
申请人： Toshiba Corp , 株式会社東芝
发明人： KASAI SHINGO , TONO ICHIRO
IPC分类号： G01N33/53 , G01N21/27 , G01N33/543
CPC分类号： G01N33/54373 , G01N33/54333 , G01N33/723
摘要： PROBLEM TO BE SOLVED: To easily and accurately measure HbA1c.SOLUTION: An optical waveguide type measurement system includes: a first optical waveguide; a first substance that is fixed on the first optical waveguide and can be specifically bound to glycosylated hemoglobin; and a plurality of first magnetic fine particles fixed with a second substance that can be specifically bound to the glycosylated hemoglobin in places different from places where the first substance capable of being specifically bound to the glycosylated hemoglobin. The optical waveguide type measurement system further includes: a first magnetic field application section that is provided above the first optical waveguide and can move at least one of the plurality of first magnetic fine particles by magnetic force; a first light source capable of making light incident to the first optical waveguide; and a first light receiving element capable of light-receiving light emitted from the first optical waveguide.
摘要翻译：要解决的问题：容易且精确地测量HbA1c。解决方案：一种光波导型测量系统，包括：第一光波导; 固定在第一光波导上并能够特异性结合到糖基化血红蛋白上的第一物质; 以及多个与第二物质固定的第一磁性微粒，所述第二物质可以与不同于能够特异性结合到糖基化血红蛋白的第一物质的位置特异性结合到糖基化血红蛋白上。光波导型测量系统还包括：第一磁场施加部分，其设置在第一光波导上方并且可以通过磁力移动多个第一磁性细颗粒中的至少一个; 能够使光入射到第一光波导的第一光源; 以及能够对从第一光波导发射的光进行光接收的第一光接收元件。

2. 发明专利

JP2012078185A Optical waveguide type biosensor chip and optical waveguide type biosensor chip manufacturing method 审中-公开
标题翻译：光波导型生物传感器芯片和光波导型生物传感器芯片制造方法
公开(公告)号：JP2012078185A
公开(公告)日：2012-04-19
申请号：JP2010223170
申请日：2010-09-30
申请人： Toshiba Corp , 株式会社東芝
发明人： HIRAKAWA MASAAKI , TONO ICHIRO
IPC分类号： G01N21/78 , G01N21/27 , G02B6/122 , G02B6/13
摘要： PROBLEM TO BE SOLVED: To provide an optical waveguide type biosensor chip enabling light detection measurement with high accuracy while maintaining high sensitivity, and a manufacturing method thereof.SOLUTION: An optical waveguide type biosensor chip comprises: a substrate having light transmissivity; an optical waveguide layer formed on the substrate and having higher refractive index than the substrate; a first grating that makes light enter the optical waveguide layer so as to propagate the light in the optical waveguide layer; a second grating that emits the light propagated in the optical waveguide layer to the outside of the optical waveguide layer; and a metal oxide film formed on the optical waveguide layer; and a sensing film comprising at least a coloring agent fixed on the metal oxide film using a crosslinking agent.
摘要翻译：要解决的问题：提供一种在保持高灵敏度的同时高精度地进行光检测测量的光波导型生物传感器芯片及其制造方法。解决方案：光波导型生物传感器芯片包括：具有透光性的基板; 形成在所述基板上并且具有比所述基板更高的折射率的光波导层; 第一光栅，使光进入光波导层，以便在光波导层中传播光; 第二光栅，其将在所述光波导层中传播的光发射到所述光波导层的外部; 以及形成在所述光波导层上的金属氧化物膜; 以及至少包含使用交联剂固定在金属氧化物膜上的着色剂的感测膜。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2009240580A Analytical method and device of biogenic substance, and extraction cartridge 有权
标题翻译：分析方法和生物物质和提取盒的装置
公开(公告)号：JP2009240580A
公开(公告)日：2009-10-22
申请号：JP2008091599
申请日：2008-03-31
申请人： Sysmex Corp , Toshiba Corp , シスメックス株式会社 , 株式会社東芝
发明人： KOJIMA JUNKO , MAEKAWA YASUNORI , TAKASE TOMOHIRO , UEMATSU IKUO , HIRAKAWA MASAAKI , NAWATA ISAO , TONO ICHIRO , KASAI SHINGO
IPC分类号： A61B5/157
CPC分类号： A61B5/14514 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150091 , A61B5/150229 , A61B5/150251 , A61B5/150343 , A61B5/150358 , A61B5/150748 , A61B5/150984 , A61B5/15113 , A61B5/15186 , A61B5/1519 , A61B5/157 , A61B5/6824 , A61B5/685 , C12Q1/006
摘要： PROBLEM TO BE SOLVED: To provide analytical method and device of biogenic substance and an extraction cartridge capable of highly precisely analyzing an extract extracted from a subject. SOLUTION: A blood glucose level estimation device (biogenic substance analytical device) 100 includes: an extract medium retention section 53 configured to retain a predetermined amount of extract medium; a reaction section 54 producing a predetermined reaction by glucose; a detection section 40 detecting the glucose from the predetermined reaction generated in the reaction section 54; a liquid storage section 52 storing the glucose by an amount equal to the predetermined amount retained by the extract medium retention section 53; a pump 18 carrying the extract medium stored in the liquid storage section 52 to the extract medium retention section 53 and carrying a part of the extract medium carried to the extract medium retention section 53 and retaining the glucose extracted from the subject, from the extraction medium retention section 53 to the reaction section 54; and a control section 17 analyzing a detection result of the glucose. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供能够高精度地分析从受试者提取的提取物的生物源物质和提取盒的分析方法和装置。解决方案：血糖值估计装置（生物来源物质分析装置）100包括：提取介质保持部53，被配置为保持预定量的提取介质; 由葡萄糖产生预定反应的反应部54; 从反应部54中产生的规定的反应检测葡萄糖的检测部40; 储存葡萄糖量等于由提取介质保留部分53保留的预定量的液体存储部分52; 将存储在液体储存部52中的提取介质携带到提取介质保留部53并将被携带的提取介质的一部分携带到提取介质保留部53并保留从被检体提取的葡萄糖从提取介质保持部53到反应部54; 以及分析葡萄糖的检测结果的控制部17。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2009150908A Optical waveguide type biochemical sensor chip, its design method, and method of measuring object to be measured 有权
标题翻译：光波导型生物传感器芯片，其设计方法和测量对象的测量方法
公开(公告)号：JP2009150908A
公开(公告)日：2009-07-09
申请号：JP2009087629
申请日：2009-03-31
申请人： Toshiba Corp , 株式会社東芝
发明人： TONO ICHIRO , OMIYA KAYOKO , TAKASE TOMOHIRO , UEMATSU IKUO
IPC分类号： G01N21/27
摘要： PROBLEM TO BE SOLVED: To provide an optical waveguide type biochemical sensor chip capable of widening an allowed incident angle range, while keeping high sensitivity, and inhibiting decay of light intensity in the optical waveguide. SOLUTION: The optical waveguide type biochemical chip includes an optical waveguide layer of polymer resin material, a coupler for making light incident on the optical waveguide layer, a decoupler for making light translated through the optical waveguide layer exit, and a sensing membrane provided on the optical waveguide layer while generating a reaction product which has absorptivity to the light or to the evanescent wave of the light if an analyte is made to interact. The optical waveguide type biochemical sensor chip is characterized by that the decreasing rate R of the output signal after T hours from being interacted with the analyte can be displayed under the specific condition. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够在保持高灵敏度的同时扩大允许的入射角范围并抑制光波导中的光强度的衰减的光波导型生化传感器芯片。解决方案：光波导型生物化学芯片包括聚合物树脂材料的光波导层，用于使入射在光波导层上的光的耦合器，用于使通过光波导层出口折射的光的解耦器，以及感测膜提供在光波导层上，同时产生如果使分析物相互作用，其具有对光或光的ev逝波的吸收性的反应产物。光波导型生化传感器芯片的特征在于，可以在特定条件下显示出与分析物相互作用的T小时后的输出信号的降低率R. 版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2006267052A Inspection apparatus for measuring immune reaction 审中-公开
标题翻译：用于测量免疫反应的检查装置
公开(公告)号：JP2006267052A
公开(公告)日：2006-10-05
申请号：JP2005089453
申请日：2005-03-25
申请人： Toshiba Corp , 株式会社東芝
发明人： UCHIYAMA KENICHI , OOMIYA KAYOKO , KASAI SHINGO , UEMATSU IKUO , TAKASE TOMOHIRO , NAWATA ISAO , TONO ICHIRO
IPC分类号： G01N21/64 , G01N21/78
摘要： PROBLEM TO BE SOLVED: To provide an inspection apparatus for measuring an immune reaction that can excite a labeled coloring matter, after an antigen/antibody reaction in solution in the entire cell, propagates fluorescence radiated by excitation onto a transparent plate for radiating to the outside, and can essentially detect the intensity of only the fluorescence by a light-receiving element.
SOLUTION: The inspection apparatus for measuring an immune reaction comprises the transparent plate; a sensor chip, having a cell that is arranged at least at one location on the surface of the transparent plate and stores the solution of reagents and specimens, a grating that is formed on the transparent plate at the bottom of the cell and allows the fluorescence to enter the transparent plate, and an optical element that is formed on the surface of the transparent plate, separated from the cell and radiates fluorescence propagated to the transparent plate by the grating to the outside; an excitation light irradiation means for irradiating the cell of the sensor chip, with the excitation light along the depth direction of the cell; and a light-receiving means for receiving the fluorescence radiated from the optical element of the sensor chip.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于测量可激发标记色素的免疫反应的检查装置，在整个细胞溶液中的抗原/抗体反应之后，将通过激发辐射的荧光传播到用于辐射的透明板上并且可以基本上通过光接收元件检测仅荧光的强度。解决方案：用于测量免疫反应的检查装置包括透明板; 传感器芯片，具有布置在透明板的表面上的至少一个位置处并存储试剂和试样溶液的电池，形成在电池底部的透明板上的光栅，并允许荧光进入透明板，以及形成在透明板的表面上的与光电元件分离的光学元件，并将通过光栅传播到透明板的荧光发射到外部; 激发光照射装置，用于沿着电池的深度方向照射传感器芯片的电池; 以及用于接收从传感器芯片的光学元件辐射的荧光的光接收装置。版权所有（C）2007，JPO＆INPIT

6. 发明专利

JP2004357721A Optical waveguide type invasion device, invasion induction device and optical waveguide type invasion system 审中-公开
公开(公告)号：JP2004357721A
公开(公告)日：2004-12-24
申请号：JP2003145295
申请日：2003-05-22
申请人： Toshiba Corp , 株式会社東芝
发明人： UCHIYAMA KENICHI , UEMATSU IKUO , OOMIYA KAYOKO , TONO ICHIRO , ETO HIDEO , KISHIMOTO ISAO , OKADA NAOTADA , HIRATA MASAMI , KASHIMA NORIYASU
IPC分类号： G01N21/27 , A61B5/00 , G02B6/122
摘要： PROBLEM TO BE SOLVED: To provide an optical waveguide type invasion device which analyzes a specified substance in body fluid without damaging a living body and without being limited by dissolved oxygen in the body fluid. SOLUTION: The optical waveguide type invasion device comprises: a sensor part 18 provided with a gel layer 12, a negative electrode plate 17 in contact with the gel layer 12 and an optical waveguide plate 15; and a circuit part 20 provided with a light emitting circuit 21 for making light be incident on the optical waveguide plate 15, a light receiving circuit 22 for receiving the light emitted from the optical waveguide plate 15, a control circuit 23 connected to the light emitting circuit 21 and the light receiving circuit 22 for generating measured result data corresponding to the change of the light received in the light receiving circuit 22 and an output circuit 25 for outputting the measured result data. COPYRIGHT: (C)2005,JPO&NCIPI

7. 发明专利

JP2003287536A Optical waveguide type protein chip and protein detecting apparatus 有权
标题翻译：光波导型蛋白芯片和蛋白质检测仪器
公开(公告)号：JP2003287536A
公开(公告)日：2003-10-10
申请号：JP2002089768
申请日：2002-03-27
申请人： Toshiba Corp , 株式会社東芝
发明人： UCHIYAMA KENICHI , ETO HIDEO , TONO ICHIRO
IPC分类号： G01N33/53 , G01N21/77 , G01N27/327 , G01N37/00 , G02B6/122
摘要： PROBLEM TO BE SOLVED: To provide an optical waveguide type protein chip capable of both shortening a reaction time between proteins in a specimen solution such as blood and an antibody and highly sensitively detecting protein molecules even through the use of the specimen solution of a very small quantity. SOLUTION: The optical waveguide type protein chip is provided with a substrate, a first optical waveguide layer formed on the surface of the substrate, gratings each formed on the surfaces of both end parts of the first optical waveguide layer, a second optical waveguide layer made of a transparent conductive material having a refractive index higher than that of the first optical waveguide layer and formed on the first, optical waveguide layer located between the gratings, an antibody fixing film formed on the second optical waveguide layer, a first insulating member formed on the substrate containing the first optical waveguide layer and having a recessed well at a part at which the antibody immobilizing film is located, and an electrode membrane formed in such a way that its part is close to the well on the first insulating member for generating electric charge in-between the second optical waveguide layer. COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供一种光波导型蛋白质芯片，其能够缩短样品溶液如血液和抗体之间的蛋白质之间的反应时间，并且即使通过使用样品溶液也能高灵敏度地检测蛋白质分子数量很少。解决方案：光波导型蛋白芯片设置有基板，形成在基板表面上的第一光波导层，形成在第一光波导层的两端部的表面上的光栅，第二光波导波导层，其由折射率高于第一光波导层的透明导电材料制成，并形成在位于光栅之间的第一光波导层上，形成在第二光波导层上的抗体定影膜，第一绝缘层在包含所述第一光波导层并且在所述抗体固定膜所位于的部分处具有凹槽的所述基板上形成的部件，以及其部分靠近所述第一绝缘构件上的阱的方式形成的电极膜用于在第二光波导层之间产生电荷。版权所有（C）2004，JPO

8. 发明专利

JP2014163739A Sensor chip 审中-公开
标题翻译：传感器芯片
公开(公告)号：JP2014163739A
公开(公告)日：2014-09-08
申请号：JP2013033198
申请日：2013-02-22
申请人： Toshiba Corp , 株式会社東芝
发明人： WADA TAKAKI , YAMAUCHI TAKEMOTO , TONO ICHIRO , KASAI SHINGO , ISHIDA CHIO
IPC分类号： G01N21/27
摘要： PROBLEM TO BE SOLVED: To provide a sensor chip capable of improving detection sensitivity.SOLUTION: The sensor chip includes: an optical waveguide part; a sensing area provided on the optical waveguide part; a pair of optical element parts provided on the optical waveguide part to sandwich the sensing area between them; a junction part provided on the side where the optical element parts are provided on the optical waveguide part, having first pores where the optical element parts are exposed; and a chamber part provided on the junction part. Gas exists in the first pores.
摘要翻译：要解决的问题：提供能够提高检测灵敏度的传感器芯片。解决方案：传感器芯片包括：光波导部分; 设置在光波导部分上的感测区域; 设置在所述光波导部分上以将感测区域夹在其间的一对光学元件部分; 在所述光波导部分上设置有所述光学元件部分的一侧的接合部分，具有所述光学元件部分露出的第一孔; 以及设置在接合部上的室部。气体存在于第一孔中。

9. 发明专利

JP2012078183A Sensor system 审中-公开
标题翻译：传感器系统
公开(公告)号：JP2012078183A
公开(公告)日：2012-04-19
申请号：JP2010223166
申请日：2010-09-30
申请人： Toshiba Corp , 株式会社東芝
发明人： UEMATSU IKUO , TONO ICHIRO , KASAI SHINGO , TAKASE TOMOHIRO , NAWATA ISAO
IPC分类号： G01N33/543 , G01N21/27 , G01N35/02 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a system for uniformly agitating antibody label particles and a specimen in the same mechanism and then transferring liquid onto a chip and performing detection.SOLUTION: A sensor system includes a specimen liquid mixing device and an optical waveguide sensor. The specimen liquid mixing device includes: a device body; a specimen liquid storage chamber formed in the body; a mixing chamber formed in the body, connected to the specimen liquid storage chamber through a first flow channel, and containing antibody label particles to which a second substance specifically reacting to a substance to be measured in the specimen is fixed; a minute pump inserted into the body at an lower end thereof so as to communicate with the mixing chamber and capable of performing suction and discharge; and a mixed liquid transfer space formed above the mixing chamber in the body, connected to the mixing chamber at one end thereof through a second flow channel having a cross section larger than that of the first flow channel, and having an opening to the outside at the other end thereof. The optical waveguide sensor includes a sensing unit placed in the mixed liquid transfer space and having a first substance specifically reacting to the substance to be measured fixed on a surface thereof.
摘要翻译：要解决的问题：提供用于以相同的机构均匀搅拌抗体标记颗粒和样品，然后将液体转移到芯片上并进行检测的系统。解决方案：传感器系统包括样品液体混合装置和光波导传感器。试样液体混合装置包括：装置主体; 形成在体内的试样贮液室; 形成在所述体内的混合室，通过第一流路连接到所述检体液体储存室，并且含有固定有与样品中被测定物质特异性反应的第二物质的抗体标签颗粒; 在其下端插入本体的分泵，以便与混合室连通并能够进行抽吸和排出; 以及混合液体传递空间，其形成在所述主体中的所述混合室的上方，其一端通过具有比所述第一流动通道的横截面大的横截面的第二流动通道连接到所述混合室，其另一端。光波导传感器包括置于混合液体转移空间中的感测单元，并且具有与要测量的物质固定在其表面上特异性反应的第一物质。版权所有（C）2012，JPO＆INPIT

10. 发明专利

JP2011196854A Sensor system 审中-公开
标题翻译：传感器系统
公开(公告)号：JP2011196854A
公开(公告)日：2011-10-06
申请号：JP2010064736
申请日：2010-03-19
申请人： Toshiba Corp , 株式会社東芝
发明人： TONO ICHIRO , HIRAKAWA MASAAKI , UEMATSU IKUO , NAWATA ISAO , TAKASE TOMOHIRO
IPC分类号： G01N21/78 , C12M1/34 , C12Q1/26 , G01N21/27 , G01N35/08 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a compact sensor system capable of performing in a short time, without performing isothermal treatment in a prescribed time, when quantitating enzyme activity in specimen liquid via a plurality of reactions.SOLUTION: A specimen liquid reaction device 1 includes: a reaction chamber 4 connected to a specimen liquid storage chamber 7 through a first channel 8, for storing a specimen substrate to be reacted with a component to be measured in specimen liquid; a fine pump 10 inserted so that the lower end is communicated with the reaction chamber 4; a reaction liquid circulation space 12 connected through a second channel 14 having a larger sectional area than the first channel; and a check valve 17. The device 1 further includes a plane type optical waveguide sensor 21 mounted so as to be positioned in the reaction liquid circulation space 12, and including a sensing film containing at least a film-forming component and a redox dye. and also containing a reaction reagent for generating an oxidative material or a reductive material from a reduction product of the component to be measured and the reaction substrate in either or both of the reaction chamber 4 and the sensing film.
摘要翻译：要解决的问题：提供一种能够在短时间内执行的小型传感器系统，而不需要在规定时间内进行等温处理，当通过多个反应定量样品液体中的酶活性时。溶液：试样液体反应装置1包括：通过第一通道8连接到试样储液室7的反应室4，用于储存与被检测液体中的待测部件反应的试样基板; 插入的细小泵10使得下端与反应室4连通; 通过具有比第一通道更大的截面积的第二通道14连接的反应液体循环空间12; 和止回阀17.装置1还包括安装在反应液循环空间12中的平面型光波导传感器21，并且包括至少含有成膜组分和氧化还原染料的感测膜。并且还含有用于在反应室4和感测膜中的任一个或两者中从被测量组分的还原产物和反应基底产生氧化材料或还原材料的反应试剂。

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