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1. 发明专利

JP2006008550A Antiaging agent 审中-公开
标题翻译：抗菌剂
公开(公告)号：JP2006008550A
公开(公告)日：2006-01-12
申请号：JP2004184939
申请日：2004-06-23
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： TSUDA TAKAYA , TAGUCHI ERIKO , KITAMURA KANEMOTO , AMANO SATOSHI , OGURA ARINORI , KOGA NOBUYOSHI
IPC分类号： A61K8/00 , A61K31/16 , A61K31/4965 , A61K33/30 , A61K45/00 , A61K45/06 , A61P17/16 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a novel antiaging agent, in detail, an external preparation for the skin effective for inhibiting the formation of wrinkles by drying and/or ameliorating the formed wrinkles.
SOLUTION: The antiaging agent comprises a prourokinase activation inhibitor and/or a urokinase inhibitor, particularly one or more kinds selected from an amide derivative of tranexamic acid represented by formula (1) [wherein R
1 and R
2 are each independently hydrogen, a 1-18C linear or branched alkyl group, a 5-8C cycloalkyl group, a benzyl group or formula (2) (wherein X is a lower alkyl group, a lower alkoxy group, a hydroxy group, an amino group or a halogen; and n is 0-3)] and its cosmetically acceptable salt.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为了提供一种新颖的抗衰老剂，具体地说，可以通过干燥和/或改善形成的皱纹来有效地抑制皱纹形成的皮肤外用制剂。解决方案：抗衰老剂包括泌尿激酶激活抑制剂和/或尿激酶抑制剂，特别是一种或多种选自式（1）所示的氨甲环酸的酰胺衍生物[其中R SB 1 和R SB 2各自独立地为氢，1-18C直链或支链烷基，5-8C环烷基，苄基或式（2）（其中X为低级烷基，低级烷氧基，羟基，氨基或卤素; n为0-3）]及其化妆品可接受的盐。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP2005139094A Oil-in-water type skin external preparation composition 审中-公开
标题翻译：油包水型皮肤外用制剂组合物
公开(公告)号：JP2005139094A
公开(公告)日：2005-06-02
申请号：JP2003375341
申请日：2003-11-05
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： KIKUCHI AKIO , TSUDA TAKAYA , NISHIDA YOSHIHARU
IPC分类号： A61K8/06 , A61K8/30 , A61K8/34 , A61K8/72 , A61K8/86 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To provide an oil-in-water type skin external preparation composition which excels in long-term storage stability, is not sticky and rich, and has a fresh feeling of use.
SOLUTION: The oil-in-water type skin external preparation composition comprises (a) 5-15 mass% glycerin, (b) 0.5-10 mass% specific alkylene oxide derivative, (c) 0.02-3 mass% batyl alcohol, and (d) 0.02-3 mass% ≥16C saturated aliphatic alcohol (behenyl alcohol or the like).
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：解决问题：提供一种水溶性型的皮肤外用制剂组合物，其长期保存稳定性优异，不粘稠且富有，并且具有清新的使用感。水包油型皮肤外用剂组合物包含（a）5-15质量％的甘油，（b）0.5-10质量％的特定环氧烷衍生物，（c）0.02-3质量％的卤代醇，（d）0.02-3质量％≥16C饱和脂肪族醇（二十二烷醇等）。版权所有（C）2005，JPO＆NCIPI

3. 发明专利

JP2004075661A Skin external agent characterized with epidermis basement membrane care, epidermis basement membrane structure formation-accelerating agent 审中-公开
公开(公告)号：JP2004075661A
公开(公告)日：2004-03-11
申请号：JP2002323030
申请日：2002-11-06
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： AMANO SATOSHI , OGURA ARINORI , MATSUNAGA YUKIKO , TSUDA TAKAYA , AOYAMA YUKARI , KOGA NOBUYOSHI
IPC分类号： A61L27/00 , A61K8/55 , A61K8/64 , A61K8/97 , A61K8/98 , A61K31/661 , A61K36/18 , A61K36/53 , A61K38/00 , A61K38/22 , A61K45/00 , A61K45/06 , A61P17/00 , A61P43/00 , A61Q19/00 , A61Q19/08 , A61K35/78
CPC分类号： A61K8/64 , A61K8/553 , A61K8/97 , A61K8/985 , A61K2800/782 , A61Q1/02 , A61Q19/00 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To provide a new means and skin external agent for accelerating the repair and re-formation of skin basement membrane structure, and a new means for achieving the sufficient formation of the basement membrane in the production of an artificial skin. SOLUTION: This epidermis basement membrane structure formation-accelerating agent consisting of a serineprotease inhibitor and optionally an extracellular matrix protein production-accelerating agent as active ingredients and a skin external agent are provided. Further, the method for producing the artificial skin having sufficiently formed basement membrane is provided by using a medium containing a mixture of the serineprotease inhibitor, optionally the extracellular matrix protein production-accelerating agent of the epidermis basement membrane and a matrix metalloprotease inhibitor, and the method for producing the medium is also provided. COPYRIGHT: (C)2004,JPO

4. 发明专利

JP2003306415A Cosmetic 有权
标题翻译：化妆品
公开(公告)号：JP2003306415A
公开(公告)日：2003-10-28
申请号：JP2003108808
申请日：2003-04-14
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： ISHINO AKIHIRO , YOKOYAMA TOMOKO , TSUDA TAKAYA , HAMADA CHIKA , MIZUMOTO DAIGO , TAJIMA MASAHIRO
IPC分类号： A61K8/00 , A61K36/18 , A61K36/28 , A61K36/53 , A61K36/60 , A61K36/71 , A61K36/73 , A61K36/75 , A61K36/899 , A61P17/00 , A61Q5/00 , A61Q7/02 , A61Q9/02 , A61Q9/04 , A61K7/155 , A61K7/06 , A61K7/15 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a hair growth inhibitor inhibiting growth or development of the hair and highly safe, and to provide a composition for external use, such as a medicament, a quasi drag, and a cosmetic. SOLUTION: This hair growth inhibitor contains at least one kind of galenical selected from Phellodendron amrense, rice bran, Morus bombycis, Coptis japonica, Thymus serpyllum, Prunus persica, Pyrola japonica, Calendula officinalis, Rosa canica, Melissa officinalis, and their extracts as an active ingredient. The active ingredient is mixed with other aqueous-phase and oil-phase components by conventional procedures, so that various compositions applicable to the skin, such as the cosmetic, are prepared. COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供抑制头发生长发育和高度安全的毛发生长抑制剂，并提供外用组合物，例如药物，准阻力和化妆品。解决方案：该毛发生长抑制剂含有至少一种选自黄柏，米糠，桑蚕，黄连，胸腺，紫ica，茯苓，金盏花，玫瑰花，Melissa officinalis中的至少一种，提取物作为活性成分。通过常规方法将活性成分与其它水相和油相组分混合，从而制备适用于皮肤的各种组合物，如化妆品。版权所有（C）2004，JPO

5. 发明专利

JPH07233038A SKIN EXTERNAL PREPARATION 失效
公开(公告)号：JPH07233038A
公开(公告)日：1995-09-05
申请号：JP4641594
申请日：1994-02-21
申请人： SHISEIDO CO LTD
发明人： SUETSUGU MASARU , SHINOJIMA SATORU , ONUMA MASAMI , SHIBATA YUKI , KAKO RUMIKO , TSUDA TAKAYA , MORI MASATERU , KITAMURA KANEMOTO
IPC分类号： C07D295/16 , A61K8/00 , A61K8/30 , A61K8/36 , A61K8/362 , A61K8/42 , A61K8/49 , A61K8/60 , A61K8/67 , A61K8/96 , A61K8/98 , A61P17/16 , A61Q19/00 , A61Q19/02 , C07C237/24 , A61K7/48 , A61K7/00
摘要： PURPOSE:To obtain an external preparation, remarkable in skin beautifying and whitening effects and having high safety by blending L-ascorbic acid (derivative), etc., with a specific amide derivative (salt) of tranexamic acid. CONSTITUTION:This skin external preparation is obtained by blending (A) 0.001-20wt.% one or more selected from among L-ascorbic acid (derivative), a placental extract, kojic acid (derivative), azelaic acid (derivative), glucosamine (derivative) and a glycoside (derivative) of hydroquinone with (B) 0.001-20wt.% (preferably 0.1-7wt.%) amide derivative (salt) of tranexamic acid expressed by the formula (R1 and R2 each is H, a 1-18C alkyl, a 5-8C cycloalkyl, etc., or both combine and, together with N, form a heterocyclic ring). Furthermore, the ingredient (B) is prepared by reacting, e.g. tranexamic acid or its reactive derivative such as an acid chloride with an amine in an inert organic solvent at ambient temperature to the boiling point of the solvent for 1-8hr.

6. 发明专利

JP2002363038A COSMETIC 审中-公开
公开(公告)号：JP2002363038A
公开(公告)日：2002-12-18
申请号：JP2001368909
申请日：2001-12-03
申请人： SHISEIDO CO LTD
发明人： ISHINO AKIHIRO , YOKOYAMA TOMOKO , TSUDA TAKAYA , HAMADA CHIKA , MIZUMOTO DAIGO , TAJIMA MASAHIRO
IPC分类号： A61K8/00 , A61K8/97 , A61K36/00 , A61K36/18 , A61K36/28 , A61K36/53 , A61K36/60 , A61K36/71 , A61K36/73 , A61K36/75 , A61K36/899 , A61P17/14 , A61Q5/00 , A61Q7/02 , A61Q9/02 , A61Q9/04 , A61K7/06 , A61K7/155 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To obtain a highly safe body hair growth inhibitor or a composition for external use such as a medicament, quasi-drug or cosmetic including the inhibitor as active ingredient. SOLUTION: This hair growth inhibitor comprises as the active ingredient a crude drug selected from Phellodendron amrense R., Houttuynia cordata Thumb., rice bran, Morus bombycis KIODZ, Coptis japonic MAKINO, Thymus serpyllum L., Prunus persica B., Pyrola japonica Klenze, Calendula officinalis L., Rose canica L. and Melissa officinalis L. or an extract therefrom. The composition for external use such as a cosmetic is prepared by compounding the above active ingredient with other aqueous phase component and oily phase component according to conventional method.

7. 发明专利

JPH10304880A MEASUREMENT OF NUCLEIC ACID, AND REAGENT THEREFOR 失效
公开(公告)号：JPH10304880A
公开(公告)日：1998-11-17
申请号：JP27758097
申请日：1997-10-09
申请人： SHISEIDO CO LTD
发明人： HATAO MASATO , ICHIKAWA HIDEYUKI , HARIGAI TAKESHI , TSUDA TAKAYA , SHIBATA MICHIO
IPC分类号： G01N33/50 , C07H21/02 , C12N15/09 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To estimate allergic activities of a chemical material by measuring an mRNA or a cDNA by using each specific primer and probe, and carrying out a polymerase chain reaction under a specified condition. SOLUTION: A mRNA or cDNA encoding interleukin-2, interferon-γ, interleukin-10, interleukin-12 p35 subunit and interleukin-12 p40 subunit is measured by carrying out a polymerase chain reaction by a DNA polymerase having 5'→3' exonuclease activities by using a forward primer having a base sequence, etc., of formula I, a reverse primer having a base sequence, etc., of formula II, and a probe having a reporter and a quencher, hybridizing with a template nucleic acid within a region placed between the both primers, and having base sequence, etc., of formula III.

8. 发明专利

JP2002338450A SKIN CARE PREPARATION AND METHOD FOR BEAUTIFICATION USING THE SAME 失效
公开(公告)号：JP2002338450A
公开(公告)日：2002-11-27
申请号：JP2001151118
申请日：2001-05-21
申请人： SHISEIDO CO LTD
发明人： NAKAYAMA TAIICHI , YOSHIKAWA NORINOBU , TSUDA TAKAYA , KUSAKARI TAKESHI , MATSUZAKI FUMIAKI
IPC分类号： A61K9/06 , A61K8/00 , A61K8/06 , A61K8/66 , A61K8/72 , A61K8/73 , A61K8/96 , A61K47/36 , A61P17/16 , A61Q19/00 , A61K7/48 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To obtain a skin care preparation having excellent and stable viscosity, providing comfortableness obtained by a new sense of use, a new value such as information of sign, etc., of completion of massage action obtained by following change in sense and having excellent amelioration and prevention effects on various diseases followed by keratinization abnormality, such as contact dermatitis, psoriasis, pemphigus vulgaris, congential chicken pox, etc., and chapped skin caused by drying, detergent, etc., and to provide a method for beautification using the skin care preparation. SOLUTION: This skin care preparation comprises one or more kinds of polymer thickeners and one or more kinds of splitting enzymes for the polymers with the condition that the enzymes stably exist in the formulation prescription and do not hydrolyze the polymer thickeners in the preparation prescription. The skin care preparation is characterized in that the external preparation comprises a first preparation containing one or more kinds of the polymer thickeners and a second preparation containing one or more kinds of the polymer splitting enzymes and the first preparation is formulated with the second preparation when used. This method for beautification comprises using the skin care preparation.

9. 发明专利

JPH07233043A SKIN EXTERNAL PREPARATION 失效
公开(公告)号：JPH07233043A
公开(公告)日：1995-09-05
申请号：JP4770094
申请日：1994-02-22
申请人： SHISEIDO CO LTD
发明人： SUETSUGU MASARU , SHINOJIMA SATORU , ONUMA MASAMI , SHIBATA YUKI , KAKO RUMIKO , TSUDA TAKAYA , MORI MASATERU , KITAMURA KANEMOTO
IPC分类号： A61K8/30 , A61K8/00 , A61K8/44 , A61K8/49 , A61K8/64 , A61K8/72 , A61Q19/00 , A61K7/48 , A61K7/00
摘要： PURPOSE:To obtain an external preparation, comprising a protein (hydrolyzate) and a specific amide derivative (salt) of tranexamic acid, capable of activating the metabolism of the skin and increasing the elasticity thereof and having excellent effects on properties of protecting the skin and retaining the moisture therein. CONSTITUTION:This skin external preparation is obtained by blending (A) 0.01-20wt.% (preferably 0.01-10wt.%) protein such as collagen, elastin, gelatin or casein and/or protein hydrolyzate with (B) 0.001-20wt.% (preferably 0.1-7wt.%) amide derivative (salt) of tranexamic acid expressed by the formula (R1 is H or a lower alkyl; R2 is an alkyl, a cycloalkyl, an alkenyl, etc.). Furthermore, trans-4-(3',4'-dimethoxycinnamoylaminomethyl) cyclohexanecarboxylic acid, etc., are cited as examples of the ingredient (B).

10. 发明专利

JPH07233024A COSMETIC 失效
公开(公告)号：JPH07233024A
公开(公告)日：1995-09-05
申请号：JP4770194
申请日：1994-02-22
申请人： SHISEIDO CO LTD
发明人： SUETSUGU MASARU , SHINOJIMA SATORU , ONUMA MASAMI , SHIBATA YUKI , KAKO RUMIKO , TSUDA TAKAYA , MORI MASATERU , KITAMURA KANEMOTO
IPC分类号： A61K8/19 , A61K8/00 , A61K8/30 , A61K8/41 , A61K8/44 , A61K8/49 , A61Q1/00 , A61Q1/10 , A61Q1/12 , A61Q19/00 , A61K7/00 , A61K7/48
摘要： PURPOSE:To obtain a cosmetic which contains more than a certain amount of powders where at least one among specific tranexamic acid amides and their salts is added to inhibit skin from becoming dry and gives no greasy and glittering feeling. CONSTITUTION:In a cosmetic containing powders in an amount of 2 or more wt.%, the system is combined with at leasy one from tranexamic acid amides of the formula (R1 is H, a lower alkyl; R2 is an alkyl, a crycloalkyl, an alkenyl, a cycloalkenyl, pyridyl, trifluoromethyl, phenylalkyl, phenyl, styryl and their salts. The amount of the tranexamic acid amide and its salt used is preferably 0.001 to 30wt.%, particularly 0.1 to 20wt.% based on the total weight of the cosmetic. The cosmetic can prevent skin from drying and the addition of an excessive amount of oil or polyhydric alcohol gives humectant feeling to skin with no fear of glittering and greasy feeling and make-up collapse.

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