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1. 发明专利

JP2008011994A Spots recurrence discrimination method 审中-公开
标题翻译： SPOTS复现歧视方法
公开(公告)号：JP2008011994A
公开(公告)日：2008-01-24
申请号：JP2006184811
申请日：2006-07-04
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： YAMASHITA TOYONOBU , HARIGAI TAKESHI , YANAI MOTOHIRO , IIKURA TOMIO
IPC分类号： A61B5/00 , A61B5/026 , A61B5/107
摘要： PROBLEM TO BE SOLVED: To provide a method for discriminating a recurrence possibility of spots by an image capturing the skin inside state of a spots portion after a phototherapy such as IPL (Intense Pulsed Light)/laser treatment or the blood flow volume of the spots portion before/after the phototherapy. SOLUTION: The spots recurrence after the phototherapy of the spots portion is evaluated by the presence/absence of melanosome or the blood flow volume in the portion after the phototherapy of the spots portion. The presence/absence of the melanosome is evaluated by an image of the epidermal basal layer captured in an early stage after the therapy by a scanning type confocal microscope or a contact type digital video microscope, and the blood flow volume is evaluated by observing the blood flow volume in the skin of the spots portion after the therapy relative to that before the therapy using a device calculating the blood flow volume from the measurement of the amount of hemoglobins. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种通过在诸如IPL（强脉冲光）/激光治疗或血流量之类的光疗法之后的斑点部分的皮肤内部状态捕获斑点的复发可能性的方法在光疗之前/之后的斑点部分。解决方案：斑点部分的光疗后斑点复发通过黑点的存在/不存在或斑点部分的光疗后部分的血流量进行评估。通过扫描型共聚焦显微镜或接触型数字视频显微镜治疗后的早期阶段捕获的表皮基底层的图像评价黑素体的存在/不存在，通过观察血液来评价血流量治疗后的斑点部分的皮肤中的流动体积相对于治疗前的使用计算血液流量的装置从血红蛋白量的测量中的流量。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JPH11155600A IMPROVEMENT IN DETERMINATION OF EXPRESSION OF CYTOKINE GENE 失效
公开(公告)号：JPH11155600A
公开(公告)日：1999-06-15
申请号：JP32817197
申请日：1997-11-28
申请人： SHISEIDO CO LTD
发明人： SHIBATA MICHIO , HARIGAI TAKESHI , HATAO MASATO , ICHIKAWA HIDEYUKI
IPC分类号： G01N33/50 , C07K14/52 , C07K14/54 , C07K14/55 , C07K14/56 , C07K14/57 , C12N15/09 , C12Q1/68 , C12R1/91
摘要： PROBLEM TO BE SOLVED: To accurately determine the expression of the subject gene by treating a test cell, extracting an mRNA, adding an mRNA which is an external strandard thereto, then synthesizing a cDNA, amplifying and comparing a cytokine DNA and the external standard. SOLUTION: An mRAM as an external standard is added to a test cell population or a treated cell substance or an mRNA extracted therefrom to synthesize a cDNA and the cDNA preparation is then divided to amplify a cytokine DNA from either one of the cDNA preparation. The external standard DNA is amplified from the other DNA preparation to compare both. Thereby, the expression of the objective cytokine gene is accurately determined in a method for crushing or carrying out the lysis treatment of the cell in the test cell population, extracting the mRNA from the treated cell substance, synthesizing the cDNA from the mRNA, amplifying the cDNA and performing the determination when the expression of the specific cytokine gene in a sample cell population is determined.

3. 发明专利

JPH10216106A METHOD FOR EVALUATING SKIN TEXTURE 失效
公开(公告)号：JPH10216106A
公开(公告)日：1998-08-18
申请号：JP4012797
申请日：1997-02-07
申请人： SHISEIDO CO LTD , INST ADVANCED SKIN RES INC
发明人： HARIGAI TAKESHI , ICHIKAWA HIDEYUKI , HIRAO TETSUJI , YOKOYAMA TOMOKO , SATO ETSUHISA
IPC分类号： G01N33/53 , A61B5/107
摘要： PROBLEM TO BE SOLVED: To enable evaluation of a skin texture based on substantially different parameters from those of the conventional method by using as an index of the skin texture the difference in the amount of interleukin 1 and interleukin 1 receptor antagonist existing in a keratin sample derived from skin of a part to be evaluated. SOLUTION: Difference in the amount of interleukin 1 (IL-1) and interleukin 1 receptor antagonist (IL-1ra) existing in a keratin sample derived from skin of a part to be evaluated is used as an index of the skin texture. Now, a keratin sample derived from a part to be evaluated of a subject is prepared and the amount of IL-1 and IL-1ra existing in the keratin sample is measured to calculate the ratio between the IL-1 and the IL-1ra from the amount obtained. The ratio calculated is compared with a ratio obtained through the same process with respect to a corresponding keratin sample of a person other than the subject. The ratio from the corresponding keratin sample of the person other than the subject herein used should be a mean obtained from a plurality of persons having stable skins.

4. 发明专利

JP2009120513A Method for measuring in vivo percutaneous absorption and method for evaluating sensitive skin 审中-公开
标题翻译：用于测量体外吸收的方法和评估敏感性皮肤的方法
公开(公告)号：JP2009120513A
公开(公告)日：2009-06-04
申请号：JP2007294604
申请日：2007-11-13
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： KATSUTA YUJI , HARIGAI TAKESHI
IPC分类号： A61K49/00 , A61B10/00 , G01N21/64 , G01N21/78
摘要： PROBLEM TO BE SOLVED: To provide a method for evaluating sensitive skin by carrying out in vivo and non-invasive measurement of percutaneous absorbency (skin barrier function) of a substance from the external world in the sensitive skin, and to further provide a method for screening a drug for the sensitive skin.
SOLUTION: There is provided a method for judging the in vivo percutaneous absorbency or the skin barrier function which uses an image according to fluorescent video microscope observation of the skin coated with a fluorescent substance.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种通过在敏感皮肤中进行来自外部世界的物质的经皮吸收（皮肤屏障功能）的体内和非侵入性测量来评价敏感皮肤的方法，并且进一步提供用于筛选敏感皮肤的药物的方法。提供了一种用于根据荧光视频显微镜观察涂覆有荧光物质的皮肤来判断使用图像的体内经皮吸收性或皮肤屏障功能的方法。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2006262841A Method for evaluating chemical peeling agent 审中-公开
标题翻译：评估化学发泡剂的方法
公开(公告)号：JP2006262841A
公开(公告)日：2006-10-05
申请号：JP2005088837
申请日：2005-03-25
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： EHAMA RITSUKO , KISHIMOTO JIRO , HIBINO TOSHIHIKO , DENDA MITSUHIRO , HARIGAI TAKESHI , KATAGIRI CHIKA , MATSUNAGA YUKIKO , NAKANISHI JIYOUTAROU , FUDA SUMIKO , YANAI MOTOHIRO , AMANO SATOSHI
IPC分类号： C12Q1/68 , A61K8/00 , A61K45/00 , A61P17/16 , A61Q19/00 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a method for screening a chemical peeling agent, and to provide a method for improving the skin.
SOLUTION: This method for screening the chemical peeling agent effective for being used for chemical peeling is characterized by selecting, as an active chemical peeling agent, a candidate chemical agent for promoting the expression of one or more genes selected from the group consisting of SPRR 2A gene, SPRR 2D gene, SPRR 2H gene, SPRR 2F gene, SPRR 1A gene, SPRR 1B gene, repetin gene, S100 A8 gene, S100 A9 gene, cystatin A gene, CCL2 gene and CEBPD gene.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于筛选化学剥离剂的方法，并提供一种改善皮肤的方法。解决方案：用于筛选有效用于化学剥离的化学剥离剂的方法的特征在于，选择作为活性化学剥离剂的候选化学试剂，用于促进一种或多种选自以下的基因的表达：的SPRR 2A基因，SPRR 2D基因，SPRR 2H基因，SPRR 2F基因，SPRR 1A基因，SPRR 1B基因，重复基因，S100A8基因，S100A9基因，半胱氨酸蛋白酶抑制蛋白A基因，CCL2基因和CEBPD基因。版权所有（C）2007，JPO＆INPIT

6. 发明专利

JP2002186485A METHOD FOR ASSAYING NUCLEIC ACID ENCODING EOTAXIN, RANTES OR BETA-DEFENSIN-2, REAGENT THEREFOR, AND METHOD FOR SCREENING ANTIINFLAMMATORY AGENT 失效
公开(公告)号：JP2002186485A
公开(公告)日：2002-07-02
申请号：JP2000391265
申请日：2000-12-22
申请人： SHISEIDO CO LTD
发明人： SHIBATA MICHIO , HARIGAI TAKESHI , ICHIKAWA HIDEYUKI
IPC分类号： G01N33/50 , A61K45/00 , A61P29/00 , A61P37/08 , C12N15/09 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566
摘要： PROBLEM TO BE SOLVED: To provide a specific combination of primers and a probe effective for assaying a nucleic acid encoding eotaxin, RANTES or β-defensin-2 that are known to promote the short-circuited consumption of energy. SOLUTION: A method for assaying a gene as a template by PCR using a pair of PCR primers and a probe that hybridizes to a site between the primers on a template and is bound to a reporter and a quencher, wherein the method permits assaying a gene, particularly an mRNA, encoding eotaxin, RANTES or β-defensin-2 and a kit therefor are provided. These are useful for evaluating or selecting a substance having an antiinflammatory activity.

7. 发明专利

JP2009106492A Method for identifying and evaluating psychosomatic medical sensitive skin using psychosomatic medical index 审中-公开
标题翻译：使用心理医学指标鉴别和评价心理医学敏感性皮肤的方法
公开(公告)号：JP2009106492A
公开(公告)日：2009-05-21
申请号：JP2007281526
申请日：2007-10-30
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： HARIGAI TAKESHI , KATSUTA YUJI
IPC分类号： A61B5/107
摘要： PROBLEM TO BE SOLVED: To provide a method for identifying the type of sensitive skin which is not clarified before into the sensitive skin having dermatological characteristics or the sensitive skin having psychosomatic medical characteristics.
SOLUTION: By using psychosomatic medical indexes, the presence of the psychosomatic medical sensitive skin presenting the symptom of the sensitive skin though there is no abnormality in a dermatological test is found. Further, it is found that the psychosomatic medical indexes are correlated with the degree of the psychosomatic medical sensitive skin.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于鉴定在具有皮肤病学特征的敏感皮肤之前未被澄清的敏感皮肤的类型或具有心身医学特征的敏感皮肤的方法。
解决方案：通过使用心身医学指标，发现皮肤病学检查中没有异常的身体敏感皮肤呈现敏感皮肤的症状。此外，发现心理医学指标与心理敏感皮肤的程度相关。版权所有（C）2009，JPO＆INPIT

8. 发明专利

JP2002125680A METHOD FOR ASSAYING NUCLEIC ACID ENCODING UNCOUPLING PROTEIN(UCP)-1, -2, OR -3, REAGENT THEREFOR, AND METHOD FOR SCREENING MEDICINE FOR REDUCING WEIGHT 失效
公开(公告)号：JP2002125680A
公开(公告)日：2002-05-08
申请号：JP2000324581
申请日：2000-10-24
申请人： SHISEIDO CO LTD
发明人： HARIGAI TAKESHI , SHIBATA MICHIO , SOMA TSUTOMU , ICHIKAWA HIDEYUKI
IPC分类号： G01N33/53 , A61K45/00 , A61P3/04 , C12N9/02 , C12N15/09 , C12Q1/68 , G01N33/566
摘要： PROBLEM TO BE SOLVED: To provide a new method for assaying a gene encoding uncoupling protein-1, -2, or -3, reagents therefor, and a method for evaluating or screening a medicine having a weight-reducing activity utilizing the method. SOLUTION: A method for assaying a gene as a template by the PCR method using a pair of PCR primers and a reporter- and quencher-bound probe which hybridizes to a site between the primers on the template, wherein the method permits assaying a gene, particularly mRNA, which encodes uncoupling protein-1, -2, or -3 using specific primers and a specific probe, and a kit therefor, are provided. These are useful for evaluating or screening a substance having a weight-reducing activity.

9. 发明专利

JPH07233090A EXTERNAL AGENT FOR SKIN 失效
公开(公告)号：JPH07233090A
公开(公告)日：1995-09-05
申请号：JP4770294
申请日：1994-02-22
申请人： SHISEIDO CO LTD
发明人： SUETSUGU MASARU , SHINOJIMA SATORU , ONUMA MASAMI , SHIBATA YUKI , KAKO RUMIKO , HARIGAI TAKESHI , KOBAYASHI HIROSHI , KITAMURA KANEMOTO
IPC分类号： A61K9/00 , A61K8/00 , A61K8/30 , A61K8/41 , A61K8/44 , A61K8/46 , A61K8/49 , A61K31/19 , A61K31/215 , A61K31/44 , A61K45/08 , A61K47/14 , A61P17/00 , A61Q19/00 , A61K7/00 , A61K7/48
摘要： PURPOSE:To obtain an external agent for skin, containing a specific tranexamic acid amide and plural specific kinds of surfactants and having excellent transcutaneous absorbability, safety and application feeling of tranexamic acid amide. CONSTITUTION:This external agent for skin contains (A) a compound (salt) of formula I [R1 is H or a lower alkyl; R2 is a (cyclo)alkyl, a (cyclo)alkenyl, a pyridyl, trifluoromethyl, a phenyl(1-3C lower alkyl) which may have 1-3 OH, lower alkyl, lower alkoxy, halogen or amino substituents on the phenyl ring or styryl], e.g. trans-4-acetylaminomethylcyclohexanecarboxylic acid, (B) an anionic surfactant such as a fatty acid soap and (C) a surfactant other than the component B and containing N in the molecule, e.g. a compound of formula II (R1, R2 and R3 each is a 1-24C alkyl or alkenyl; at least one of R1 to R3 is a >=8C alkyl or alkenyl).

10. 发明专利

JPH07233042A SKIN EXTERNAL PREPARATION 失效
公开(公告)号：JPH07233042A
公开(公告)日：1995-09-05
申请号：JP4769994
申请日：1994-02-22
申请人： SHISEIDO CO LTD
发明人： SUETSUGU MASARU , SHINOJIMA SATORU , ONUMA MASAMI , SHIBATA YUKI , KAKO RUMIKO , HARIGAI TAKESHI , KOBAYASHI HIROSHI , KITAMURA KANEMOTO
IPC分类号： A61K8/30 , A61K8/00 , A61K8/44 , A61K8/49 , A61K8/72 , A61Q1/00 , A61Q1/12 , A61Q19/00 , A61K7/48 , A61K7/00
摘要： PURPOSE:To obtain an external preparation, excellent in stability, feeling of use and humectant actions on the skin without causing any stickiness or surface slippery feeling and good in safety by blending a water-soluble polymer with a specific amide derivative (salt) of tranexamic acid. CONSTITUTION:This skin external preparation is obtained by blending (A) 0.01-5wt.% (preferably 0.1-1wt.%) water-soluble polymer such as a carboxyvinyl polymer, an extract from a seed of quince (Cydonia oblonga), xanthan gum or collagen with (B) 0.001-20-wt.% (preferably 0.1-7wt.%) amide derivative (salt) of tranexamic acid expressed by the formula (R1 is H or a lower alkyl; R2 is an alkyl, a cycloalkyl, an alkenyl, etc.). Furthermore, trans-4-(3',4'- dimethoxycinnamoylaminomethyl)-cyclohexanecarboxylic acid, etc., are cited as examples of the ingredient (B).

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