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1. 发明专利

JPH11279042A Skin preparation for external use 失效
标题翻译：外用皮肤制剂
公开(公告)号：JPH11279042A
公开(公告)日：1999-10-12
申请号：JP9983698
申请日：1998-03-30
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： AKIMA KAZUO , MUGIKURA SHIGERU , HORII IZUMI , TANAKA CHIAKI
IPC分类号： A61K8/00 , A61K8/02 , A61K8/72 , A61K8/73 , A61Q1/00 , A61Q1/12 , A61Q19/00 , C08B37/08 , A61K7/48 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To obtain a skin preparation for external use capable of manifesting the same preventing actions on the formation of wrinkcles on skin or suppressing actions on keratinization of the skin as those of a retinoid by a single agent by making the preparation include an oligosulfated hyaluronic acid as an active ingredient therein.
SOLUTION: This skin preparation for external use contains an oligosulfated hyaluronic acid containing, e.g. a recurring unit represented by the formula (R
1 to R
4 are each H or SO
3 H, with the proviso that 10-90% of R
1 to R
4 based on the total number thereof occupy SO
3 H; (n) is an average value so as to provide the viscosity-average molecular weight of 1,000-50,000) as an active ingredient. The oligosulfated hyaluronic acid which is the active ingredient can be obtained by treating a high-molecular weight oligohyaluronic acid prepared from various kinds of natural sources with, e.g. an enzyme (hyaluronidase) and then sulfating the resultant treated substance according to a known sulfating method. Thereby, the resultant preparation for external use is capable of suppressing the keratinization of skin and having suppressing actions on secretin intervening properties in combination and maintaining a healthy skin state.
COPYRIGHT: (C)1999,JPO
摘要翻译：要解决的问题：为了获得能够表现出防止皮肤上皱纹形成的作用的皮肤外用制剂，或通过使制剂包含单一试剂，抑制作为类视黄醇类化合物的皮肤角质化作用低聚硫酸化透明质酸作为活性成分。解决方案：这种外用皮肤制剂含有含硫酸盐的透明质酸。由式（R 1至R 4）表示的重复单元各自为H或SO 3 H，条件是R 1至R 4的10-90％基于其总数占SO 3 H;（n）为平均值，提供1,000-50,000的粘均分子量）作为活性成分。作为活性成分的低聚硫酸化透明质酸可以通过用例如各种天然来源制备的高分子量低聚乙酰丙酸来处理。酶（透明质酸酶），然后根据已知的硫酸化方法硫酸化所得的处理物质。由此，所得到的外用制剂能够抑制皮肤的角质化，并且能够组合抑制对促胰液素干预性的抑制作用，并保持健康的皮肤状态。

2. 发明专利

JPH10195107A SULFATED OLIGOHYALURONIC ACID 失效
公开(公告)号：JPH10195107A
公开(公告)日：1998-07-28
申请号：JP1322397
申请日：1997-01-10
申请人： SHISEIDO CO LTD
发明人： AKIMA KAZUO , YOSHIDA YUZO , KITAMURA KANEMOTO , MUGIKURA SHIGERU , SHIRATORI YASUNARI , TANAKA CHIAKI , HORII IZUMI
IPC分类号： A61K8/72 , A61K8/00 , A61K8/73 , A61K31/715 , A61P29/00 , A61Q19/00 , C08B37/08
摘要： PROBLEM TO BE SOLVED: To obtain a sulfated oligohyaluronic acid which has improved penetrativity into the skin and can advantageously inhibit local skin stratification causing its atrophy and keratinization yet has physiological activity and physicochemical properties inherent in a high-molecular-weight sulfated hyaluronic acid by sulfating an oligohyaluronic acid. SOLUTION: The oligohyaluronic acid can be obtained by treating a high- molecular-weight one (say, 2,000 kDa) obtained from various natural resources under a high shearing stress or treating it with hyaluronidase enzyme. This oligohyaluronic acid is sulfated with a sulfating agent comprising a sulfuric acid/trimethyl complex at 50-60 deg.C for several tens hr to several days in an aprotic polar solvent to obtain a sulfated oligohyaluronic acid (salt) of the formula (wherein R to R are each H or SO3 H;... has repeating units, n is either average to give a viscosity-average molecular weight of 1,000-50,000; and SO3 H groups amount to 10-90% of the total number of R to R groups).

3. 发明专利

JPH10158126A HAIR COSMETIC 失效
公开(公告)号：JPH10158126A
公开(公告)日：1998-06-16
申请号：JP19035997
申请日：1997-06-11
申请人： SHISEIDO CO LTD
发明人： SAKAMOTO TETSUO , IKEDA TAKASHI , UEHARA KEIICHI , KOYAMA JUNICHI , HORII IZUMI
IPC分类号： A61K8/00 , A61K8/33 , A61K8/36 , A61K8/73 , A61Q5/00 , A61Q5/02 , A61K7/06
摘要： PROBLEM TO BE SOLVED: To obtain a hair cosmetic capable of reducing the amount of an antimicrobial agent, excellent in safety, and high in a dandruff-preventing effect. SOLUTION: This hair cosmetic contains one or more kinds of antimicrobial compounds excluding ethyl alcohol in a total amount of 0.00001-0.5wt.% based on the whole amount of the hair cosmetic and one or more kinds of substances selected from among the below-described compounds in a total amount of 0.005-1.0wt.% based on the whole amount of the hair cosmetic as active ingredients. (1) Lecithin, (2) ascorbic acid, (3) erythorbic acid, (4) guaiacum resin, (5) nordihydroguaiaretic acid, (6) gallic acid, (7) an ascorbate salt, (8) an erythorbate salt, and (9) a nordihydroguaiaretate salt.

4. 发明专利

JPH0617293B2 失效
公开(公告)号：JPH0617293B2
公开(公告)日：1994-03-09
申请号：JP8206985
申请日：1985-04-17
申请人： SHISEIDO CO LTD
发明人： SAKAMOTO TETSUO , IKEDA TAKASHI , UEHARA KEIICHI , KOYAMA JUNICHI , HORII IZUMI
IPC分类号： A61K8/00 , A61K8/33 , A61K8/36 , A61K8/365 , A61K8/97 , A61Q5/00 , A61K7/06

5. 发明专利

JPH0563451B2 失效
公开(公告)号：JPH0563451B2
公开(公告)日：1993-09-10
申请号：JP19349485
申请日：1985-09-02
申请人： SHISEIDO CO LTD
发明人： SAKAMOTO TETSUO , KOYAMA JUNICHI , HORII IZUMI , IKEDA TAKASHI , UEHARA KEIICHI
IPC分类号： A61K8/00 , A61K8/49 , A61K8/60 , A61K8/97 , A61Q5/00 , A61Q5/02 , A61Q7/00 , A61K7/06

6. 发明专利

JPS6259913A OBSERVING DEVICE FOR SKIN SURFACE SHAPE 失效
公开(公告)号：JPS6259913A
公开(公告)日：1987-03-16
申请号：JP19857085
申请日：1985-09-10
申请人： SHISEIDO CO LTD , FUJIMITSUKU KK
发明人： KURIHARA TAKEKATSU , KUMAGAI HIROKO , SHIMADA SHIGERU , HORII IZUMI , KUMITA NAMIO , SHIMIZU SHUNICHI , OSAKA TETSUJI
IPC分类号： G02B21/06 , A61B5/103 , A61B5/107 , G01N33/50
摘要： PURPOSE:To observe the fine shape of skin accurately without contacting by providing a lighting device for near ultraviolet rays at the periphery of an objective movably in the direction of the optical axis, and observing the surface of the skin while changing lighting methods. CONSTITUTION:The lighting device 3 composed of the ring-shaped light source 6 for near ultraviolet rays, a reflection mirror 9, and a light shield plate 10 is provided at the periphery of a magnifying lens 1 coupled with a camera 2 incorporating a CCD movably in the direction of the optical axis. Fine projections and recesses of the skin are picked up as a gradational image with vertical lighting normally through the reflection mirror 9. When skin grooves, etc., are observed, the lighting device 3 is put closer to a dotted line 11' and the observation is made with dark visual field lighting using a slanting beams from the light shield plate 10. Consequently, an image with good contrast is obtained by using near ultraviolet rays and the lighting methods are changed to observe the surface of the skin accurately under non-contact state.

7. 发明专利

JPS61238718A HAIR COSMETIC 失效
公开(公告)号：JPS61238718A
公开(公告)日：1986-10-24
申请号：JP8206985
申请日：1985-04-17
申请人： SHISEIDO CO LTD
发明人： SAKAMOTO TETSUO , IKEDA TAKASHI , UEHARA KEIICHI , KOYAMA JUNICHI , HORII IZUMI
IPC分类号： A61K8/00 , A61K8/33 , A61K8/36 , A61K8/365 , A61K8/97 , A61Q5/00
摘要： PURPOSE:A hair cosmetic, obtained by incorporating 1-2 of rosemary, Rumex japonicus Houtt., sesamol, lecithin, gamma-oryzanol, phytic acid, etc., having high safety and very useful for preventing dandruff. CONSTITUTION:An antidandruff hair cosmetic obtained by incorporating one or two or more selected from compounds having germicidal and antimicrobial action, e.g. pyrithione zinc, trichlorocarbanilide and triclosan, with a substance selected from the group of 21 kinds of rosemary, Rumex japonicus Houtt., sesamol, lecithin, gamma-oryzanol, phytic acid, phosphatidyl serine, phosphatidyl ethanolamine, ascorbic acid, butyl hydroxyanisole, citric acid, dibutyl hydroxytoluene, erythorbic acid, guaiac resin and nordihydroguiarectic acid as an active constituent.

8. 发明专利

JPH07258092A AGENT FOR TREATMENT OF DISEASES CAUSING ABNORMAL ACCUMULATION OF COLLAGEN 失效
公开(公告)号：JPH07258092A
公开(公告)日：1995-10-09
申请号：JP7378194
申请日：1994-03-22
申请人： SHISEIDO CO LTD
发明人： NAKAYAMA TAIICHI , HORII IZUMI
IPC分类号： A61K8/60 , A61K8/00 , A61K8/97 , A61K31/70 , A61K36/23 , A61P1/16 , A61P11/00 , A61P17/00 , A61P43/00 , A61Q19/00 , A61K7/00 , A61K7/48 , A61K35/78
摘要： PURPOSE:To prepare a drug or a quasi-drug effective for specifically suppressing abnormal synthesis of collagen without exerting undesirable influence on the synthesis of proteins necessary for the restoration of various organs. CONSTITUTION:This agent for the prevention or treatment of diseases or morbid state caused by the abnormal synthesis of collagen contains at least one kind of substance selected from saikosapopin a, saikosaponin b1, saikosaponin b2, saikosaponin c and saikosaponin d as an active component.

9. 发明专利

JPH07224094A PROTEIN ORIGINATED FROM SCALE OF PSORIASIS 失效
公开(公告)号：JPH07224094A
公开(公告)日：1995-08-22
申请号：JP3516794
申请日：1994-02-09
申请人： SHISEIDO CO LTD
发明人： HIBINO TOSHIHIKO , TAKAHASHI TADAHITO , HORII IZUMI , SAGAWA KENJI
IPC分类号： A61K38/55 , A61P43/00 , C07K1/20 , C07K7/06 , C07K7/08 , C07K14/435 , C07K14/81
摘要： PURPOSE:To provide a protein originated from human psoriasis scales, having a specific mol. wt. and an amino acid sequence, inhibiting the activity of cathepsin L which is a cysteine protease originated from an animal, and useful for preventing and treating osteoporosis, etc. CONSTITUTION:This new psoriasis scale-originated protein having a mol. wt. of approximately 43 kDa by a SDS-PAGE method, having amino acid sequences of formulas I-V, etc., in the molecule, inhibiting the activity of cathepsin L which is a cysteine protease originated from an animal but not inhibiting the activities of cathepsin B and cathepsin H is obtained by treating scales collected from a psoriasis patient in a buffer solution with a homogenizer for uniformly extracting the scales, centrifuging the extract, collecting the supernatant, concentrating the supernatant with an ultrafiltration membrane, subjecting the concentrated solution to a gel-filtration treatment for obtaining a fraction inhibiting papain and having a mol.wt. of approximately 40000, allowing the fraction to pass through an anion exchange column, applying the passed fraction to a cation exchange column, fractionating the treated fraction by a NaCl gradient method, and subsequently purifying the active fraction by an isoelectric point chromatography.

10. 发明专利

JPH07116146A MEASURING CREASE METHOD AND APPARATUS 失效
公开(公告)号：JPH07116146A
公开(公告)日：1995-05-09
申请号：JP26365493
申请日：1993-10-21
申请人： SHISEIDO CO LTD
发明人： TAKASU EMIKO , UMEYA JUNICHIRO , HORII IZUMI
IPC分类号： G01B11/24 , A61B5/107 , G01B11/245 , G06T1/00 , G06T7/00 , G06T7/40
摘要： PURPOSE:To enable a method and an apparatus of quantiative evaluating a condition of creases on a surface skin to abstract creases separately from fine crease for each separate evaluation. CONSTITUTION:A measuring crease method comprises obtaining a three dimentional data by three-dimentional measuring of a surface skin; primary Fourier transforming an appointed section so as to indicate a power spectrum; appointing a ruled line 44 to separate an area of creases from an area of fine creases; inverse Fourier transforming both the area of creases and fine creases so that data on constituents of creases and fine creases of the section can be obtained; and caluculating a width, depth, cross-sectional area of the creases and fine creases into numerical values.

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