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1. 发明专利

JP2000342296A EVALUATION OF SUBSTANCE ACTING ON TRANSFORMING GROWTH FACTOR-BETA 2 (TGF-BETA 2) 失效
公开(公告)号：JP2000342296A
公开(公告)日：2000-12-12
申请号：JP2000089551
申请日：2000-03-28
申请人： SHISEIDO CO LTD
发明人： SOMA TSUTOMU , HIBINO TOSHIHIKO , TAKAHASHI TADAHITO
IPC分类号： G01N33/50 , A61K8/00 , A61K8/97 , A61K36/00 , A61K36/18 , A61K36/23 , A61K36/28 , A61K36/53 , A61K36/73 , A61K36/75 , A61K45/00 , A61P1/16 , A61P13/12 , A61P17/14 , A61Q5/00 , A61Q7/00 , C12N5/07 , C12N5/09 , C12Q1/02 , C12R1/91 , G01N33/15 , G01N33/53 , A61K7/06 , A61K35/78 , C12N5/06
摘要： PROBLEM TO BE SOLVED: To evaluate the subject action substance by proliferating a cell having an ability for producing a plasminogen activator-inhibiting factor-1(PAI-1) in the presence of a transforming growth factor-β2 and a test substance and then measuring PAI-1. SOLUTION: This method for evaluating a substance acting on a transforming growth factor-β2(TGF-β2) comprises proliferating a cell having an ability for producing a plasminogen activator-inhibiting factor-1(PAI-1), such as human hair papilla cell or human fibroblast, in the presence of the transforming growth factor-β2(TGF-β2) and a test substance and then measuring the plasminogen activator-inhibiting factor-1(PAI-1) contained in the culture medium. Thereby, the substance which acts on TGF-β2 and can be used for screening a TGF-β antagonist can simply be evaluated. The TGF-β antagonist is effective as a hair tonic, an agent for inhibiting the transfer of hair into its involutional period, a hepatocirrhosis medicine, a nephritis medicine and the like.

2. 发明专利

JPH10215881A OLIGONUCLEOTIDE PRIMER AND ITS USE 失效
公开(公告)号：JPH10215881A
公开(公告)日：1998-08-18
申请号：JP4014697
申请日：1997-02-07
申请人： SHISEIDO CO LTD
发明人： TAKEDA ATSUSHI , TAKAHASHI TADAHITO , OGO MASASHI , HIBINO TOSHIHIKO
IPC分类号： C12N15/09 , C07H21/04
摘要： PROBLEM TO BE SOLVED: To obtain a new primer for a polymerase chain reaction(PCR) capable of amplifying and detecting a human squamous cell carcinomarelated antigen gene, comprising an oligonucleotide fragment containing a specific nucleotide sequence at 3' or 5' end. SOLUTION: This new primer for a polymerase chain reaction(PCR) comprises an oligonucleotide fragment containing a nucleotide sequence of the formula GCAC, the formula GTGC, the formula CTGA or the formula TCAG at 3' or 5' end, is capable of amplifying a human squamous cell carcinoma-related antigen(SCCA) gene and distinguishing and detecting two types of squamous cell carcinoma antigens, SCCA1 and SCCA2 and is useful for diagnosing squamous cell carcinomas. The primer is obtained by forming various kinds of primers based on a base sequence encoding the amino acid sequence of squamous cell carcinoma antigen(SCCA), carrying out PCR using the primers and selecting a base sequence capable of selectively amplifying SCCA1 and SCCA2, respectively.

3. 发明专利

JP2002104938A PREVENTING OR TREATING COMPOSITION SUCH AS HAIR GROWING AGENT AND AGENT FOR SUPPRESSING TRANSITION TO HAIR RETREATING PERIOD 失效
公开(公告)号：JP2002104938A
公开(公告)日：2002-04-10
申请号：JP2000299341
申请日：2000-09-29
申请人： SHISEIDO CO LTD
发明人： HIBINO TOSHIHIKO , TSUJI YUMIKO , TAKAHASHI TADAHITO , UMISHIO KENICHI , KOBAYASHI KOJI
IPC分类号： A61K8/00 , A61K8/49 , A61K31/352 , A61P1/16 , A61P13/12 , A61P17/14 , A61Q5/00 , A61Q7/00 , A61K7/06
摘要： PROBLEM TO BE SOLVED: To provide a hair growing agent, an agent for suppressing transition to the hair retreating period, a treating agent for hepatocirrhosis and a treating agent for nephritis, whose activity expressions are confirmed by the screening method found by the inventor of the present invention. SOLUTION: An isocoumarin, especially phyllodulcin (1) which is a component contained in an extract of sweet hydrangea leaf, is contained as an active ingredient.

4. 发明专利

JP2005237273A Method for evaluating hair grower 审中-公开
标题翻译：评估头发花洒的方法
公开(公告)号：JP2005237273A
公开(公告)日：2005-09-08
申请号：JP2004051168
申请日：2004-02-26
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： TAKAHASHI TADAHITO , TAJIMA MASAHIRO , EHAMA RITSUKO
IPC分类号： G01N33/50 , C12N15/09 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a method and a kit for evaluating a hair grower, useful for diagnosing hair diseases, predicting alopecia, diagnosing a hair cycle, or the like. SOLUTION: The hair growth effect is known by using an oligonucleotide having a base sequence 5'-CCAAAACTGA AGCCGAGAAG-3' (sequence number 1) and an oligonucleotide having a base sequence 5'-ATCGATGCGG GTACAATGTG A-3'(sequence number 2) as a primer, amplifying a DNA from an insulin-like growth factor-1 receptor mRNA, assaying an amplification product and examining expression of an insulin-like growth factor-1 receptor gene. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种用于评估头发生长器的方法和试剂盒，其用于诊断头发疾病，预测脱发，诊断毛发循环等。解决方案：通过使用具有碱基序列5'-CCAAAACTGA AGCCGAGAAG-3'（序列号1）的寡核苷酸和具有碱基序列5'-ATCGATGCGG GTACAATGTG A-3'（序列号 2）作为引物，从胰岛素样生长因子-1受体mRNA扩增DNA，测定扩增产物并检查胰岛素样生长因子-1受体基因的表达。版权所有（C）2005，JPO＆NCIPI

5. 发明专利

JP2002322094A NEW HAIR TONIC 失效
公开(公告)号：JP2002322094A
公开(公告)日：2002-11-08
申请号：JP2001124978
申请日：2001-04-23
申请人： SHISEIDO CO LTD
发明人： TAKAHASHI TADAHITO , HAMADA CHIKA , TAJIMA MASAHIRO
IPC分类号： A61K8/00 , A61K45/06 , A61P17/14 , A61Q5/00 , A61Q7/00 , A61K7/06
摘要： PROBLEM TO BE SOLVED: To provide a hair-fostering theory good and effective for male pattern alopecia, and further to prepare a hair tonic based on the theory and having high effects. SOLUTION: The hair-fostering theory for promoting the growth of the hair comprises prolongation of a shortened growth period, inhibition of rapid shift to an involutional period, and derivation of the growth period from a resting stage by allowing a medicine to act on each of the steps (the growth period, the involutional period and the resting stage) to overcome the change in the hair to the downy hair caused by the miniaturization of hair follicle peculiar to the male pattern alopecia. The hair tonic effective for the male pattern alopecia is provided by using the theory.

6. 发明专利

JP2002205922A PROLONGATION AGENT FOR ANAGEN OF HAIR 失效
公开(公告)号：JP2002205922A
公开(公告)日：2002-07-23
申请号：JP2001001544
申请日：2001-01-09
申请人： SHISEIDO CO LTD
发明人： TAKAHASHI TADAHITO , HAMADA CHIKA , SUZUKI JUN , TAJIMA MASAHIRO
IPC分类号： C07D493/04 , A61K8/00 , A61K8/49 , A61K8/97 , A61K31/35 , A61K31/36 , A61K36/48 , A61P17/14 , A61Q5/00 , A61Q7/00 , C07D493/14 , A61K7/06 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To obtain a prolongation agent for anagen of hair comprising a component having a prolonging effect on anagen of hair as an active ingredient. SOLUTION: This prolongation agent for anagen of hair comprises an extract of a plant of the genus Sophora of the family Leguminosae as an active ingredient. The prolongation agent for anagen of hair comprises maackiain and/or medicarpin as an active ingredient.

7. 发明专利

JPH1099075A NEW PROTEIN HAVING ICE-LIKE ACTIVITY 失效
公开(公告)号：JPH1099075A
公开(公告)日：1998-04-21
申请号：JP27681396
申请日：1996-09-30
申请人： SHISEIDO CO LTD
发明人： TAKAHASHI TADAHITO , HIBINO TOSHIHIKO
IPC分类号： C12N9/48 , C12R1/91
摘要： PROBLEM TO BE SOLVED: To obtain a protein having a specific molecular weight, breaking activity on both N-acetyl-YVAD-methylcoumarinamide and N-acetylDEVD- methylcoumarinamide and interleukine-lβ-converting enzymelike activity. SOLUTION: This protein has ECE-like activity obtainable from a human keratinized cell, 80kDa relative molecular weight, breaking activity on both N-acetyl-YVAD-methylcoumarinamide and N-acetyl-DEVD-methylcoumarinamide and the following properties. The optimum pH: 7.5. Inhibition of protease activity: inhibited by both Ac-DEVD-CHO and Ac-YVAD-CHO, by N-ethylmaleimide and iodoacetic acid as a thiol alkylating agent and shows clear resistance up to 5mM concentration.

8. 发明专利

JPH07224094A PROTEIN ORIGINATED FROM SCALE OF PSORIASIS 失效
公开(公告)号：JPH07224094A
公开(公告)日：1995-08-22
申请号：JP3516794
申请日：1994-02-09
申请人： SHISEIDO CO LTD
发明人： HIBINO TOSHIHIKO , TAKAHASHI TADAHITO , HORII IZUMI , SAGAWA KENJI
IPC分类号： A61K38/55 , A61P43/00 , C07K1/20 , C07K7/06 , C07K7/08 , C07K14/435 , C07K14/81
摘要： PURPOSE:To provide a protein originated from human psoriasis scales, having a specific mol. wt. and an amino acid sequence, inhibiting the activity of cathepsin L which is a cysteine protease originated from an animal, and useful for preventing and treating osteoporosis, etc. CONSTITUTION:This new psoriasis scale-originated protein having a mol. wt. of approximately 43 kDa by a SDS-PAGE method, having amino acid sequences of formulas I-V, etc., in the molecule, inhibiting the activity of cathepsin L which is a cysteine protease originated from an animal but not inhibiting the activities of cathepsin B and cathepsin H is obtained by treating scales collected from a psoriasis patient in a buffer solution with a homogenizer for uniformly extracting the scales, centrifuging the extract, collecting the supernatant, concentrating the supernatant with an ultrafiltration membrane, subjecting the concentrated solution to a gel-filtration treatment for obtaining a fraction inhibiting papain and having a mol.wt. of approximately 40000, allowing the fraction to pass through an anion exchange column, applying the passed fraction to a cation exchange column, fractionating the treated fraction by a NaCl gradient method, and subsequently purifying the active fraction by an isoelectric point chromatography.

9. 发明专利

JP2002193753A HAIR TONIC 失效
公开(公告)号：JP2002193753A
公开(公告)日：2002-07-10
申请号：JP2000398274
申请日：2000-12-27
申请人： SHISEIDO CO LTD
发明人： TAKAHASHI TADAHITO , ARAI TAKAYUKI , HAMADA CHIKA , TAJIMA MASAHIRO , TSUJI YOSHIHARU
IPC分类号： A61K8/00 , A61K8/41 , A61K8/97 , A61K31/131 , A61K36/48 , A61P17/14 , A61Q5/00 , A61Q7/00 , A61K7/06 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a hair tonic having excellent hair-restoring effect such as a depilation-preventing effect and hair-growing effect. SOLUTION: This hair tonic contains extracts of one or two or more kinds of plants of the genus Sophora and one or two or more kinds of amine oxides represented by the following formula (1) [wherein R1 is a 2-24C straight-chain or branched chain alkyl group; R2 is methyl group or 2-hydroxyethyl group; (n) is 0-5, with the proviso that when R2 is 2-hydroxyethyl group, (n) is 0].

10. 发明专利

JP2002097116A CELL ACTIVATOR 失效
公开(公告)号：JP2002097116A
公开(公告)日：2002-04-02
申请号：JP2000283069
申请日：2000-09-19
申请人： SHISEIDO CO LTD
发明人： HAMADA CHIKA , TAJIMA MASAHIRO , NAKAMA YASUNARI , TAKAHASHI TADAHITO
IPC分类号： A61K8/00 , A61K8/30 , A61K8/46 , A61K31/145 , A61K31/185 , A61P17/14 , A61P17/16 , A61P43/00 , A61Q5/00 , A61Q5/02 , A61Q7/00 , A61K7/06 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To provide cell activating agents for hair to be compounded to a hair-growing agent. SOLUTION: Following agents containing taurine as an active ingredient: a cell activating agent, a hairy cell controlling agent, a hair growing period extending agent, a hairy cell growth activating agent, a follicular epithelium cell growth activating agent, an outer root sheath cell growth activating agent, and a springiness and stiffness improving agent for hair.

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