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1. 发明专利

JPH08208427A DERMAL PREPARATION FOR EXTERNAL USE 失效
公开(公告)号：JPH08208427A
公开(公告)日：1996-08-13
申请号：JP1763595
申请日：1995-02-06
申请人： NARISU COSMETIC CO LTD , OSAKA CITY
发明人： HAMADA NOBUTAKE , MISAKI HITOSHI , TANAKA HIROSHI
IPC分类号： C12P1/04 , A61K8/00 , A61K8/96 , A61K8/99 , A61Q19/00 , B01F17/00 , C12R1/38 , A61K7/00 , A61K7/48
摘要： PURPOSE: To obtain a dermal preparation for external use, containing a surface- active substance produced from a microorganism of the genus Pseudomonas, having excellent surface-active functions and high humectant effects, excellent in safety and good in feeling of use. CONSTITUTION: This dermal preparation for external use contains a surface-active substance prepared by culturing a strain (e.g. Pseudomonas putida IFO No. 12996), belonging to the genus Pseudomonas and capable of producing the surface-active substance and extracting the resultant culture solution or the microbial cell with water or a solvent. A humectant substance is also produced from the strain belonging to the genus Pseudomonas. The surface-active substance produced by the microorganism of the genus has strong actions on emulsification of various oils and can be converted into a product, excellent in biodegradability and safety and having a good feeling by use thereof as the dermal preparation for external use and high skin conditioning effects.

2. 发明专利

JPH03284612A TYROSINASE ACTIVITY INHIBITOR, ANTIOXIDANT AND ANTIMICROBIAL AGENT 失效
公开(公告)号：JPH03284612A
公开(公告)日：1991-12-16
申请号：JP8673790
申请日：1990-03-30
申请人： NARISU COSMETIC CO LTD
发明人： SHIBATA HISAO , MINOSASA YUUSUKE , MATSUI KYOKO , UEHARA HISAO , TANAKA HIROSHI
IPC分类号： A61K31/05 , A61K8/00 , A61K8/30 , A61K8/33 , A61K31/00 , A61K31/047 , A61P17/00 , A61P31/04 , A61P43/00 , A61Q19/02 , C09K15/08
摘要： PURPOSE:To obtain a tyrosinase activity inhibitor, an antioxidant and an antimicrobial agent having excellent chemical stability, shelf stability and safety, containing orcinol derivatives. CONSTITUTION:A tyrosinase activity inhibitor, an antioxidant and an antimicrobial agent containing orcinol derivatives shown by formula I and formula II [R1 and R2 are group shown by formula III (n is 0, 1, 2 or 4 in the case of R1 and 0-4 in the case of R2)] such as 2-prenylorcinol. The compound is obtained by dissolving 2mol orcinol in 1mol prenyl alcohol while blending, adding 0.7mol condensation agent (e.g. anhydrous cobalt chloride) and reacting at 60-70 deg.C for about 2 hours under heating. The tyrosinase activity inhibitor, an antioxidant and an antimicrobial agent are useful as a cosmetic having excellent beautifying action on skin, useful for prevention of oxidation of foods, cosmetics and drugs, useful for antisepsis of foods, prevention of food poisoning or control of multiplication of skin microorganisms.

3. 发明专利

JPH03109319A TYROSINASE ACTIVITY INHIBITOR 失效
公开(公告)号：JPH03109319A
公开(公告)日：1991-05-09
申请号：JP24772689
申请日：1989-09-23
申请人： NARISU COSMETIC CO LTD
发明人： SHIBATA HISAO , MINOSASA YUUSUKE , MATSUI KYOKO , UEHARA HISAO , TANAKA HIROSHI
IPC分类号： A61K31/05 , A61K8/00 , A61K8/30 , A61K8/96 , A61K31/047 , A61K36/07 , A61P17/00 , A61P35/00 , A61P43/00 , A61Q19/02 , C07C39/19
摘要： PURPOSE:To obtain a tyrosinase activity inhibitor, containing 5-farnesyl-6-methyl- resorcinol as an active ingredient, having a high tyrosinase activity inhibition rate, applicable to beautifying and whitening cosmetics, etc., and having high safety. CONSTITUTION:An inhibitor containing 5-farnesyl-6-methyl-resorcinol (another name; neogrifolin) as an active ingredient. The aforementioned compound is obtained by using a fruit body (mushroom) of 'NINGYO-TAKE' [Polyporus confluens Fr. (hereinafter simply referred to as 'NINGYO-TAKE')] as a natural product for extraction. Although a living body (in an intact raw state) or dried substance of the fruit body can be utilized as raw materials for extracting the 'NINGYO-TAKE', a fruit body dried at ambient temperature or in the sun about 2-10 days and preventing putrefaction is preferably used.

4. 发明专利

JPH01249885A ANTIOXIDANT FOR LIPID 失效
公开(公告)号：JPH01249885A
公开(公告)日：1989-10-05
申请号：JP7768488
申请日：1988-03-30
申请人： NARISU COSMETIC CO LTD
发明人： SUETSUGU KAZUHIRO , TOTORI MIWAKO , TANAKA HIROSHI
IPC分类号： C09K15/08 , A61K47/00 , A61K47/14
摘要： PURPOSE:To provide the above low toxic antioxidant, outstanding in solubility and miscibility in oil-and-fats, organic solvents, etc., having high stability to heat and light, effective to drugs, foodstuff and cosmetics, containing gentisic acid (ester). CONSTITUTION:The objective antioxidant containing, as an effective component, gentisic acid of the formula (R is H or 1-18C saturated hydrocarbon) and/or its ester. This antioxidant is incorporated in a lipid normally in such an amount as to be 0.001-10 (optimally, 0.01-0.5)wt.% based on the whole amount of the lipid. In obtaining said ester by esterification, when gentisic acid is made to react with a 1-4C monohydric alcohol, sulfuric acid is used as a catalyst, while when said acid is made to react with a 5-18C monohydric alcohol, p- toluenesulfonic acid is used as a catalyst.

5. 发明专利

JPS60109509A BEAUTIFYING AND WHITENING COSMETIC 失效
公开(公告)号：JPS60109509A
公开(公告)日：1985-06-15
申请号：JP21681583
申请日：1983-11-16
申请人： NARISU COSMETIC CO LTD
发明人： TANAKA HIROSHI , MATSUBARA NOBUYOSHI
IPC分类号： A61K8/96 , A61K8/00 , A61K8/97 , A61Q17/04 , A61Q19/02 , C12N9/99
摘要： PURPOSE:A beautifying and whitening cosmetic, obtained by incorporating a liquid or powdery extract obtained by extracting Prunus persica with an organic solvent or water, and if necessary purifying the resultant extract in a skin cosmetic, and capable of preventing the blackening of the skin without a bad effect and promoting the beautifying and whitening effect. CONSTITUTION:A beautifying and whitening cosmetic obtained by incorporating a liquid or dried powdery extract obtained by extracting Prunus persica with an organic solvent, e.g. a lower alcohol, or water and if necessary purifying the resultant extract of the Prunus persica with a column packed with activated carbon, polystyrene gel, ''Cephadax'', ''Biogel'', ''Cepharose'', cellulose or an ion exchange resin, etc., and further incorporating the resultant extract in >=0.01wt% concentration with a cosmetic, e.g. makeup cream, milky lotion, lotion or pack. Thus, the aimed cosmetic capable of suppressing the formation of melanine by the inhibitory action thereof on tyrosinase activity, exhibiting improved beautifying and whitening effect, and having high safety due to no irritation and sensitivity thereof is obtained.

6. 发明专利

JPH03206881A CULTURE MEDIUM FOR PIGMENT PRODUCTION BY TISSUE CULTURE OF LAVENDER CELL 失效
公开(公告)号：JPH03206881A
公开(公告)日：1991-09-10
申请号：JP22071090
申请日：1990-08-20
申请人： NARISU COSMETIC CO LTD
发明人： TANAKA HIROSHI
IPC分类号： C12P1/00 , C12N5/04 , C12R1/91
摘要： PURPOSE:To accomplish the mass production in high yield of the title culture medium suitable for the mass production of lavender cells and the pigment therefrom by incorporating a culture medium with 2,4-dichlorophenoxyacetic acid as plant growth regulatory substance. CONSTITUTION:The objective culture medium to be used in making a tissue culture of lavender cells using Murashige-and-Skoog standard medium, incorporated with 2,4-dichlorophenoxyacetic acid (2,4-D) as the essential plant growth regulatory substance in incubating lavender cells in the dark. The culture medium composition for cell proliferation to be applied is effective when the relative molar concentration ratio of the nitrogen in the form of ammonia to that in the form of nitric acid is 0.11-0.40 and the total amount of both the nitrogens is 40-72.5mM. And the culture medium composition for pigment production is effective when the total amount of both the nitrogens is -10 mol/l.

7. 发明专利

JPH02121905A COSMETIC 失效
公开(公告)号：JPH02121905A
公开(公告)日：1990-05-09
申请号：JP27397988
申请日：1988-10-30
申请人： NARISU COSMETIC CO LTD
发明人： MINOSASA YUUSUKE , MATSUI KYOKO , TANAKA HIROSHI
IPC分类号： C12P1/02 , A61K8/00 , A61K8/96 , A61K8/97 , A61K8/99 , A61Q19/00 , A61Q19/02 , C12N9/99 , C12R1/645
摘要： PURPOSE:To obtain a cosmetic having excellent beautifying effects on skin and wetting effects on skin free from irritation and toxicity, containing a product of cell culture of a fungus belonging to the genus Pycnoporus, capable of producing tyrosinase activity suppressing substance in the cell or an extract thereof. CONSTITUTION:A cosmetic containing one or more products of cell culture of one or more fungi selected from genus Pycnoporus, Grifola, Favolus, Porodisculus and Fomes, capable of producing tyrosinase activity suppressing substance and/or an extract thereof. The above-mentioned extract, etc., are safe, have excellent suppressing effects on tyrosinase activity, contain a viscous solution to make skin wet and are suitable for industrial stable production.

8. 发明专利

JPS6342689A PRODUCTION OF PIGMENT BY TISSUE CULTURE OF LAVENDER CELL AND MEDIUM THEREFOR 失效
公开(公告)号：JPS6342689A
公开(公告)日：1988-02-23
申请号：JP18594186
申请日：1986-08-06
申请人： NARISU COSMETIC CO LTD
发明人： TANAKA HIROSHI
IPC分类号： C12N5/04 , C12N5/00 , C12P1/00 , C12R1/91
摘要： PURPOSE:To produce a glue pigment useful as a dye, etc., in high efficiency at a low cost, by carrying out the tissue culture of lavender cell in two steps using two kinds of Murashige and Skoog media having different total nitrogen amounts as standard media. CONSTITUTION:The 1st stage tissue culture of a lavender cell is carried out by using a standard Murashige and Skoog medium containing a nitrogen source having a relative molar concentration ratio of ammonia nitrogen to nitrate nitrogen of 0.11-0.4 and the total nitrogen content of ammonia nitrogen and nitrate nitrogen of 40-72.5mM. The lavender cell proliferated by the 1st stage culture is subjected to the 2nd stage tissue culture in a standard Murashige and Skoog medium containing a nitrogen source having a total nitrogen content of ammonia nitrogen and nitrate nitrogen of

9. 发明专利

JPH09227333A COSMETIC 失效
公开(公告)号：JPH09227333A
公开(公告)日：1997-09-02
申请号：JP4079896
申请日：1996-02-28
申请人： NARISU COSMETIC CO LTD
发明人： SHIBATA HISAO , TANAKA HIROSHI
IPC分类号： A61K8/96 , A61K8/00 , A61K8/99 , A61K36/06 , A61K36/07 , A61P17/00 , A61P17/16 , A61P43/00 , A61Q19/00 , A61Q19/02 , A61K7/00 , A61K7/48 , A61K35/84
摘要： PROBLEM TO BE SOLVED: To obtain a cosmetic having excellent skin-beautifying effect and humectant effect. SOLUTION: The cosmetic contains an extract of a basidiomycete selected from Boletus subvelutipes, Boletus calopus, Boletus pulverulentus, Boletinum asiaticus, Boletus reticulatus, Boletus venenatus, Boletus pseudocalopus, Boletus auripes, Aureoboletus thibetanus, Suillus spectabilis, Suillus grevillei, Suillus luteus, Leccinum extremiorientale, Leccinum scabrum, Tylopilus fellus, Chalciporus piperatus, Xanthoconium affine, Boletellus mirabilis, Aeroboletus thibetanus, Gyrodon lividus, Boletinum cavipes, Phylloporus bellus, Paxillus involutus, etc., belonging to the family Boletaceae. It has excellent skin- beautifying effect and humectant effect.

10. 发明专利

JPH06271851A ANTIOXIDANT AND COSMETIC 失效
公开(公告)号：JPH06271851A
公开(公告)日：1994-09-27
申请号：JP10002893
申请日：1993-03-19
申请人： NARISU COSMETIC CO LTD
发明人： SUETSUGU KAZUHIRO , SHIRAISHI HIDEKO , IZUMI AIKO , SHIBA ATSUSHI , TANAKA HIROSHI
IPC分类号： A23L3/3571 , A61K8/00 , A61K8/96 , A61K8/99 , A61Q19/00 , C09K15/34 , A61K7/00 , A61K7/48
摘要： PURPOSE:To constantly supply a safe and stable antioxidant excellent in antioxidizing effect on natural oxidation, especially on ultraviolet oxidation and widely suitable for a chemical substance, a medicine, a cosmetic, a quasidrug and a food by finding an antioxidative substance existing in a microorganismic cell body, an extract of the cell body or in a microorganismic metabolite and to provide a cosmetic containing this antioxidant. CONSTITUTION:An antioxidant characteristically containing one or more kinds of materials selected from a cell body of an antioxidant-producing mecroorganism belonging to Staphylococcus, an extract of the microorganism and a metabolite of the microorganism cell body cultured in a protein-containing culture medium is provided. A cosmetic containing this antioxidant is also provided.

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