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1. 发明专利

JP2011163944A Method for quantifying estrogen 审中-公开
标题翻译：量化雌激素的方法
公开(公告)号：JP2011163944A
公开(公告)日：2011-08-25
申请号：JP2010027305
申请日：2010-02-10
申请人： Kao Corp , 花王株式会社
发明人： SUMIO SHINGO , OGAMI MAMIKO , HONMA SEIJIRO , MAEKUBO HITOE , WATANABE YOKO , SASAMOTO HIDEHIKO
IPC分类号： G01N30/88 , G01N27/62 , G01N30/06 , G01N30/60 , G01N30/72
摘要： PROBLEM TO BE SOLVED: To simply and accurately quantify estrogen in a sample originating from a living body.
SOLUTION: Estrogen is extracted from the sample originating from the living body and converted to pentahalogenated benzyl or pentahalogenated benzoyl derivative and, after the derivative is convertive to a 1-lower alkylpyridinium derivative, this derivative is measured by LC-MS to quantify estrogen in a skin horny layer. In this case, the pentahalogenated benzyl or pentahalogenated benzoyl derivative is purified by a sequential solid phase extraction method to be converted to 1-lower alkylpyridinium derivative.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：简单准确地量化源自活体的样品中的雌激素。解决方案：从源自活体的样品中提取雌激素，并转化为五卤化苄基或五卤代苯甲酰基衍生物，衍生物转化为1-低级烷基吡啶衍生物后，通过LC-MS测定该衍生物雌激素在皮肤角质层。在这种情况下，通过连续的固相萃取法将五卤化苄基或五卤代苯甲酰基衍生物纯化，以转化为1-低级烷基吡啶鎓衍生物。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2005343873A Aromatase activator 有权
公开(公告)号：JP2005343873A
公开(公告)日：2005-12-15
申请号：JP2004169052
申请日：2004-06-07
申请人： Kao Corp , 花王株式会社
发明人： SUMIO SHINGO , MORIWAKI SHIGERU , OUCHI ATSUSHI , KUSUOKU HIROSHI
IPC分类号： A61K8/60 , A61K8/64 , A61K8/72 , A61K8/73 , A61K8/96 , A61K8/97 , A61K8/98 , A61K8/99 , A61K31/7016 , A61K35/64 , A61K35/74 , A61K36/07 , A61K36/18 , A61K36/23 , A61K36/28 , A61K36/48 , A61K36/53 , A61K36/60 , A61K36/73 , A61K36/75 , A61K36/899 , A61K38/17 , A61P3/06 , A61P15/00 , A61P15/08 , A61P15/12 , A61P19/08 , A61P19/10 , A61P43/00 , A61K35/78 , A61K7/00 , A61K35/84
摘要： PROBLEM TO BE SOLVED: To obtain a medicine or a cosmetic that is highly safe and useful for preventing, ameliorating or treating various symptoms caused by estrogen deficiency by promoting estrogen formation in the body. SOLUTION: The subject aromatase activator comprises one or more kinds selected from a plant selected from Iris florentina, Lamium album, Ononis spinosa, Typha angustifolia, Glycyrrhiza glabara, Sophora angustifolia, Citrus paradisi, Cinnamomum cassia, Gentiana lutea, Eugelhardtia chrysolepis, Marsdenia cundurango, Asarum sieboldii, Salvia officinalis, Crataegus cuneata, Dioscorea japonica, Zingiber officinale, Acorus calamus, Betula platyphylla, Lonicera japonica, Crataegus oxyacantha, Achillea millefolum, Morus alba, Thymus serpyllum, Syzygium aromaticum, Citrus unshiu, Citrus aurantium, Astragalus gummifer, Hamamelis virginiana, Angelica dahurica, Ruscus aculeatus, Sinomenium acutum, Imperata cylindrica, Saposhnikovia dibaricata, Humulus lupulus, Ephedra sinica, Lavandura angustifolia, Pyrus malus, Ganoderma lucidum, Lactuca sativa, Citrus limon, Anthemis nobilis and Sanguisorba officinalis, their extracts, yeast essence, silk protein extracts, milk proteins, trehalose, essence of fermented soybeans and royal jelly. COPYRIGHT: (C)2006,JPO&NCIPI

3. 发明专利

JP2012171933A Aromatase activator 审中-公开
标题翻译： AROMATASE激活器
公开(公告)号：JP2012171933A
公开(公告)日：2012-09-10
申请号：JP2011036595
申请日：2011-02-23
申请人： Kao Corp , 花王株式会社
发明人： SUMIO SHINGO , ICHINOSE SUSUMU
IPC分类号： A61K36/00 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide an aromatase activator which reinforces the activity of aromatase.SOLUTION: The aromatase activator comprises basket fern or its extract as an active constituent. Further, the extract is a water extract, an alcohol-water mixture extract or a hexane extract.
摘要翻译：要解决的问题：提供增强芳香酶活性的芳香酶活化剂。解决方案：芳香酶活化剂包括蕨类植物或其提取物作为活性成分。此外，提取物是水提取物，醇 - 水混合物提取物或己烷萃取物。版权所有（C）2012，JPO＆INPIT

4. 发明专利

JP2009085946A Quantification method for steroid hormone 审中-公开
标题翻译：甾体激素的量化方法
公开(公告)号：JP2009085946A
公开(公告)日：2009-04-23
申请号：JP2008229922
申请日：2008-09-08
申请人： Kao Corp , 花王株式会社
发明人： UMODA KIKO , SUMIO SHINGO , HONMA SEIJIRO
IPC分类号： G01N30/88 , G01N1/04 , G01N27/62 , G01N30/04 , G01N30/06 , G01N30/72 , G01N33/48 , G01N33/50 , G01N33/76
CPC分类号： G01N33/743 , G01N33/6848 , G01N2030/8813 , G01N2030/8831 , Y10T436/20
摘要： PROBLEM TO BE SOLVED: To conveniently measure the concentration of steroid hormone inside skin, such as, estrogen having a meaningful function of skin aspects. SOLUTION: The steroid hormone, such as, estrogen within a horny layer of the skin is quantified by carrying out LC-MS analysis of the steroid hormone, obtained from the horny layer of the skin collected by a tape-stripping method. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：方便地测量皮肤内类固醇激素的浓度，例如具有皮肤方面有意义功能的雌激素。解决方案：通过对通过胶带剥离法收集的皮肤角质层获得的类固醇激素进行LC-MS分析来定量类固醇激素，例如皮肤角质层中的雌激素。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2005343872A Aromatase activator 审中-公开
标题翻译： AROMATASE激活器
公开(公告)号：JP2005343872A
公开(公告)日：2005-12-15
申请号：JP2004168996
申请日：2004-06-07
申请人： Kao Corp , 花王株式会社
发明人： SUMIO SHINGO , MORIWAKI SHIGERU , OUCHI ATSUSHI , KUSUOKU HIROSHI
IPC分类号： A61K8/96 , A61K8/97 , A61K36/00 , A61K36/18 , A61K36/23 , A61K36/28 , A61K36/42 , A61K36/48 , A61K36/53 , A61K36/75 , A61K36/81 , A61K36/896 , A61K36/899 , A61P3/06 , A61P5/30 , A61P9/10 , A61P15/12 , A61P19/08 , A61P19/10 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/12 , A61P43/00 , A61K35/78 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To obtain a medicine or a cosmetic that is highly safe and useful for preventing, ameliorating or treating various symptoms caused by estrogen deficiency by promoting estrogen formation in the body. SOLUTION: The subject aromatase activator comprises one or more kinds selected from a plant selected from Hydrangea serrata, Arnica Montana Arnica, Foeniculum vulgare, Curcuma longa, Corydalis turtschaninovii, Isodon japonicus, Scutellaria baicalensis, Curcuma zedoaria, Catalpa ovata, Citrus aurantium, Sasa Veitchii, Schizonepeta tenuifolia, Cassia obatusifolia, Magnolia obovata, Evodia rutaecarpa, Bupleurum falcatum, Asarum sieboldii, Zanthoxylum piperitum, Elettaria cardamomum, Malva sylvestris, Cnidium officinale, Angelica acutiloba, Lycopersicon esculentum, Glehnia littoralis, Atractylodes japonica, Luffa cylindrica, Carthamus tinctorius, Typha latifolia, Lilium candidum, Gentiana scabra and rosin, their extracts, oryza oil, hydrolyzed wheat essence, shea butter and rice fermented essence. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：通过促进体内雌激素形成，获得高度安全和有效的药物或化妆品，用于预防，改善或治疗由雌激素缺乏引起的各种症状。解决方案：本发明的芳香酶活化剂包括选自以下的植物中的一种或多种：选自绣球绣球，山金车花，茯苓，姜黄，紫草，紫草，黄芩，枸杞，枸杞，，Sasa Veitchii，Schizonepeta tenuifolia，Cassia obatusifolia，Magnolia obovata，Evodia rutaecarpa，Bupleurum falcatum，Asarum sieboldii，Zanthoxylum piperitum，Elettaria豆蔻，马鞭草，Cnidium officinale，当归，茄子，白花椒，百合，龙胆，松香，他们的提取物，oryza油，水解小麦精华，乳木果油和米发酵精华。版权所有（C）2006，JPO＆NCIPI

6. 发明专利

JP2012153673A Aromatase activator 有权
标题翻译： AROMATASE激活器
公开(公告)号：JP2012153673A
公开(公告)日：2012-08-16
申请号：JP2011015967
申请日：2011-01-28
申请人： Kao Corp , 花王株式会社
发明人： ICHINOSE SUSUMU , SUMIO SHINGO
IPC分类号： A61K31/11 , A61K8/35 , A61P3/06 , A61P5/30 , A61P9/10 , A61P15/12 , A61P17/14 , A61P17/16 , A61P19/10 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/04 , A61P27/12 , A61P43/00 , A61Q7/00 , A61Q19/00 , A61Q19/08
CPC分类号： A61K31/11 , A61K8/345 , A61K2800/78 , A61Q19/00 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To provide an aromatase activator capable of promoting the production of estrogen in the body safely.SOLUTION: The aromatase activator comprises a compound represented by formula (I) or a salt thereof or a solvate thereof as an active constituent. In the formula (I), the dashed line indicates that the bond may be a double bond. However, a and b in the formula do not simultaneously represent a double bond.
摘要翻译：要解决的问题：提供能够安全地促进体内雌激素生成的芳香酶活化剂。解决方案：芳香族酶活化剂包含由式（I）表示的化合物或其盐或其溶剂合物作为活性成分。在式（I）中，虚线表示键可以是双键。但是，式中的a和b并不表示双键。版权所有（C）2012，JPO＆INPIT

7. 发明专利

JP2011102265A Aromatase activator 审中-公开
标题翻译： AROMATASE激活器
公开(公告)号：JP2011102265A
公开(公告)日：2011-05-26
申请号：JP2009257760
申请日：2009-11-11
申请人： Kao Corp , 花王株式会社
发明人： SUMIO SHINGO , ICHINOSE SUSUMU
IPC分类号： A61K36/18 , A61K36/07 , A61P3/06 , A61P5/30 , A61P9/10 , A61P15/08 , A61P15/10 , A61P15/12 , A61P19/10 , A61P25/02 , A61P25/20 , A61P25/24 , A61P43/00 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide an aromatase activator etc. useful for preventing, ameliorating and treating symptoms of menopausal disorder etc. SOLUTION: The aromatase activator comprises Morchella crassipes, Stemona japonica Miq, Stemona sessilifolia Fr. et Sav., Stemona tuberosa Lour., a related species thereof or an extract thereof as an active ingredient. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供芳香酶活化剂等，其可用于预防，改善和治疗绝经期病症等症状。解决方案：芳香酶活化剂包括禾本科（Morchella crassipes），Stemona japonica Miq，Stemona sessilifolia Fr。等等，Stemona tuberosa Lour。，其相关物质或其提取物作为活性成分。版权所有（C）2011，JPO＆INPIT

8. 发明专利

JP2011102264A Aromatase activator 审中-公开
标题翻译： AROMATASE激活器
公开(公告)号：JP2011102264A
公开(公告)日：2011-05-26
申请号：JP2009257759
申请日：2009-11-11
申请人： Kao Corp , 花王株式会社
发明人： SUMIO SHINGO , ICHINOSE SUSUMU
IPC分类号： A61K36/18 , A61K8/97 , A61P3/06 , A61P15/00 , A61P19/08 , A61P43/00 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide an aromatase activator etc., useful for preventing, ameliorating and treating symptoms of skin troubles etc. SOLUTION: The aromatase activator comprises at least one chosen from Stellera chamaejasme, Euphorbia fischeriana, Euphorbia ebracteolata, Alocasia odora K. Koch, Tinospora capillipes Gagnep., Tinospora sagittata (Oliv.) Gagnep., Cnidium monnieri Cusson, Torilis japonica, Torilis scabra, Peumus boldus, Ricinus communis L., Sassafras officinale Nees, related species thereof or an extract thereof as an active ingredient. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供芳香酶活化剂等，其可用于预防，改善和治疗皮肤问题症状等。解决方案：芳香酶活化剂包括选自Stellera chamaejasme，Euphorbia fischeriana，Euphorbia （ebracteolata），海芋（Alocasia odora K. Koch），T，属（Tinospora capillipes Gagnep。），Tinospora sagitata（Oliv。）Gagnep。，Cnidium monnieri Cusson，Torilis japonica，Torilis scabra，Peumus boldus，Ricinus communis L.，Sassafras officinale Nees，作为活性成分。版权所有（C）2011，JPO＆INPIT

9. 发明专利

JP2012171932A Aromatase activator 审中-公开
标题翻译： AROMATASE激活器
公开(公告)号：JP2012171932A
公开(公告)日：2012-09-10
申请号：JP2011036594
申请日：2011-02-23
申请人： Kao Corp , 花王株式会社
发明人： SUMIO SHINGO , ICHINOSE SUSUMU
IPC分类号： A61K36/18 , A61K8/97 , A61P17/00 , A61P43/00 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To provide an aromatase activator which reinforces the activity of aromatase.SOLUTION: The aromatase activator comprises at least one kind selected from the group consisting of Rhamnus frangula, Castanea dentata, Calluna vulgarris and their extracts as an active constituent(s).

10. 发明专利

JP2012171931A Aromatase activator 审中-公开
标题翻译： AROMATASE激活器
公开(公告)号：JP2012171931A
公开(公告)日：2012-09-10
申请号：JP2011036593
申请日：2011-02-23
申请人： Kao Corp , 花王株式会社
发明人： SUMIO SHINGO , ICHINOSE SUSUMU
IPC分类号： A61K36/18 , A23K1/16 , A23L1/30 , A61K8/97 , A61P3/06 , A61P5/30 , A61P15/12 , A61P17/00 , A61P19/08 , A61P25/24 , A61P43/00 , A61Q1/00 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide an aromatase activator which catalyzes the final stage of a sex steroid hormone biosynthetic route, and biosynthesizes estrogen from androgen.SOLUTION: The aromatase activator comprises Plumpbago zeylanicum being the low tree of evergreen in the Plumbaginaceae or the alcohol-water-mixed liquid extract thereof or the hexane extract thereof as an active ingredient and can improve or treat the symptoms of a menopausal discomfort, hypogonadism, dysautonomia, lipid metabolism abnormality, vasomotor disturbance, osteoporosis or the like, and the symptoms of skin trouble, reduction in skin cell proliferation performance or the like.
摘要翻译：要解决的问题：提供催化性类固醇激素生物合成途径的最后阶段的芳香酶活化剂，并从雄激素生物合成雌激素。解决方案：芳香酶活化剂含有Plumpaginaceae中的常绿矮树，或其醇 - 水混合液体提取物或其己烷提取物作为活性成分，可改善或治疗绝经期不适症状，性腺机能减退，自主神经症，脂代谢异常，血管舒缩障碍，骨质疏松症等，皮肤病症状，皮肤细胞增殖性能降低等。版权所有（C）2012，JPO＆INPIT

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