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1. 发明专利

JP2008064514A Electrode catalyst and enzyme electrode 有权
标题翻译：电极催化剂和酶电极
公开(公告)号：JP2008064514A
公开(公告)日：2008-03-21
申请号：JP2006240867
申请日：2006-09-05
申请人： Kanazawa Univ , Kyoto Univ , Toyota Central R&D Labs Inc , Toyota Motor Corp , トヨタ自動車株式会社 , 国立大学法人京都大学 , 国立大学法人金沢大学 , 株式会社豊田中央研究所
发明人： KAJINO TSUTOMU , SETOYAMA NORIHIKO , KAMIMURA KEIKO , KATO HISAO , KANO KENJI , TSUJIMURA SEIYA , SAKURAI TAKESHI , KATAOKA KUNISHIGE
IPC分类号： G01N27/327 , C12N9/00 , C12N9/02 , C12N11/14 , G01N27/30 , H01L21/28 , H01L31/04 , H01M8/16
CPC分类号： C12N11/14 , C12N9/0091 , G01N27/3271 , H01M4/8605 , H01M4/9008 , H01M4/9083 , H01M8/16 , Y02E60/527
摘要： PROBLEM TO BE SOLVED: To provide a novel electrode catalyst comprising oxidase high in electron transmission efficiency, and an enzyme electrode using it.
SOLUTION: The electrode catalyst comprises CueO and the enzyme electrode is equipped with a porous carbon body and the electrode catalyst comprising CueO supported on the surface of the porous carbon body. CueO is preferably CueO originating from a coli. The porous carbon body which constitutes the enzyme electrode is preferably a carbon gel. The enzyme electrode preferably further includes a mediator for accelerating the giving and receiving of the electron between the porous carbon body and CueO.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种包含电子传输效率高的氧化酶的新型电极催化剂和使用它的酶电极。解决方案：电极催化剂包含CueO，酶电极配备有多孔碳体，并且包含支撑在多孔碳体表面上的CueO的电极催化剂。 CueO优选来自大肠杆菌的CueO。构成酶电极的多孔碳体优选为碳凝胶。酶电极优选还包括用于加速在多孔碳体和CueO之间产生和接收电子的介体。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2007112792A Composition for dyeing keratinous fiber and method for dyeing keratinous fiber 审中-公开
标题翻译：用于染色激光纤维的组合物和用于染色卡氏纤维的方法
公开(公告)号：JP2007112792A
公开(公告)日：2007-05-10
申请号：JP2006254635
申请日：2006-09-20
申请人： Kanazawa Univ , Mandom Corp , 国立大学法人金沢大学 , 株式会社マンダム
发明人： SAKURAI TAKESHI , KATAOKA KUNISHIGE , UEKI YUSAKU , TSUJINO YOSHIO , OTSUKA KAORI
IPC分类号： A61K8/64 , A61K8/19 , A61K8/41 , A61Q5/10 , C12N15/09 , D06P3/08
摘要： PROBLEM TO BE SOLVED: To provide a composition for dyeing a keratinous fiber by using oxygen; and to provide a method for dyeing the keratinous fiber.
SOLUTION: The composition for dyeing the keratinous fiber contains CueO, a copper ion and an oxidation dye. The method for dyeing the keratinous fiber involves bringing the keratinous fiber into contact with the oxidation dye in the presence of the CueO and the copper ion in an oxygen-containing atmosphere.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供通过使用氧对角质纤维进行染色的组合物; 并提供染色角质纤维的方法。解决方案：用于染色角质纤维的组合物含有CueO，铜离子和氧化染料。染色角质纤维的方法涉及在含氧气氛中的CueO和铜离子的存在下使角质纤维与氧化染料接触。版权所有（C）2007，JPO＆INPIT

3. 发明专利

JP2010183857A Electrode catalyst, enzyme electrode, fuel cell and biosensor 有权
标题翻译：电极催化剂，酶电极，燃料电池和生物传感器
公开(公告)号：JP2010183857A
公开(公告)日：2010-08-26
申请号：JP2009028988
申请日：2009-02-10
申请人： Kanazawa Univ , 国立大学法人金沢大学
发明人： KATAOKA KUNISHIGE , SAKURAI TAKESHI , MAEDA YASUO , ITO TAKAHIRO
IPC分类号： C12N15/09 , C12N9/02 , G01N27/327 , H01M4/90 , H01M8/16
CPC分类号： Y02E60/527
摘要： PROBLEM TO BE SOLVED: To provide an electrode catalyst comprising a multi-copper oxidase having a small overvoltage and excellent power generating efficiency, an enzyme electrode with the electrode catalyst, as well as a fuel cell and biosensor equipped with the enzyme electrode.
SOLUTION: The electrode catalyst includes a multi-copper oxidase having a plurality of copper atoms including at least type I copper, wherein at least one cysteine residue and two histidine residues are coordinated with the type I copper, and a proline residue which is present between the cysteine residue and a histidine residue forming a ligand loop among the two histidine residues, or a proline residue which adjoins downstream of the histidine residue forming no ligand loop of the two histidine residues is substituted with an amino acid residue except a proline residue, and a hydrogen bond is formed between the amide proton of the substituted amino acid residue and the sulfur atom of the type I copper-coordinated cysteine residue.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种电极催化剂，其包含具有小过电压和优异的发电效率的多铜氧化酶，具有电极催化剂的酶电极，以及配备有酶电极的燃料电池和生物传感器。解决方案：电极催化剂包括具有多个至少I型铜的铜原子的多铜氧化酶，其中至少一个半胱氨酸残基和两个组氨酸残基与I型铜配位，脯氨酸残基存在于两个组氨酸残基之间形成配体环的半胱氨酸残基和组氨酸残基之间，或者不形成两个组氨酸残基的配体环的组氨酸残基下游邻接的脯氨酸残基被除脯氨酸以外的氨基酸残基取代并且在取代的氨基酸残基的酰胺质子与I型铜配位的半胱氨酸残基的硫原子之间形成氢键。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2013179927A Modified multi-copper oxidase, and stain for keratin fiber using the same 有权
标题翻译：修饰的多铜氧化物和使用其的凯尔蛋白纤维的染料
公开(公告)号：JP2013179927A
公开(公告)日：2013-09-12
申请号：JP2012047659
申请日：2012-03-05
申请人： Shisei Chemical Kk , 資生ケミカル株式会社 , Yoshio Tsujino , 義雄辻野 , Kanazawa Univ , 国立大学法人金沢大学
发明人： TSUJINO YOSHIO , OKAMURA AKINORI , YAMADA MINORU , KATAOKA KUNISHIGE , SAKURAI TAKESHI
IPC分类号： C12N9/06 , A61K8/66 , A61Q5/10 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide modified multi-copper oxidase, and stain (a hair dye) for keratin fiber, excelling in dyeing property with less damage and eruption of hair and the scalp using the modified multi-copper oxidase.SOLUTION: Multi-copper oxidase raises an isoelectric point by adding basic amino acid or substituting a specific residue of an amino acid sequence for a basic amino acid, and stain (a hair dye) for keratin fiber uses the multi-copper oxidase.
摘要翻译：要解决的问题：为了提供改性的多铜氧化酶和染色（染发剂）的角蛋白纤维，具有优异的染色性能，较少的损伤和头发的喷发和头皮使用改性的多铜氧化酶。解决方案：铜氧化酶通过添加碱性氨基酸或用氨基酸序列的特定残基代替碱性氨基酸而提高等电点，角蛋白纤维染色（染发剂）使用多铜氧化酶。

5. 发明专利

JP2005073660A Recombinant type bilirubin oxidase and method for producing the same 有权
标题翻译：重组型胆红素氧化酶及其生产方法
公开(公告)号：JP2005073660A
公开(公告)日：2005-03-24
申请号：JP2003310970
申请日：2003-09-03
申请人： Kanazawa Univ Tlo Inc , 有限会社金沢大学ティ・エル・オー
发明人： KATAOKA KUNISHIGE , TANAKA KAZUHIRO , SAKURAI TAKESHI
IPC分类号： G01N33/72 , C12N9/06 , C12N15/09 , C12Q1/26
摘要： PROBLEM TO BE SOLVED: To provide a bilirubin oxidase having a stable catalytic activity and a method for producing the same.
SOLUTION: This method for producing the bilirubin oxidase is provided by introducing a bilirubin oxidase gene originated from an incomplete filamentous fungus, Myrothecium verrucaria MT-1 and encoding the bilirubin oxidase into e.g. yeast belonging to the genus Pichia as a host animal for performing a transformation. Thereby, the recombinant type bilirubin oxidase having the stable catalytic activity can be produced in a large amount. The obtained recombinant type bilirubin oxidase can be used for a quantitative measurement of bilirubin in an aqueous solution, e.g. in blood, blood serum, blood plasma, bile liquid or urine.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供具有稳定催化活性的胆红素氧化酶及其制备方法。产生胆红素氧化酶的方法是通过引入源自不完全丝状真菌的白藜芦醇MT-1的胆红素氧化酶基因，并将胆红素氧化酶编码为例如。属于毕赤酵母属的酵母作为进行转化的宿主动物。由此，可以大量生产具有稳定的催化活性的重组型胆红素氧化酶。获得的重组型胆红素氧化酶可用于水溶液中胆红素的定量测定，例如，血液，血清，血浆，胆汁液或尿液。版权所有（C）2005，JPO＆NCIPI

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