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1. 发明专利

JPH05246865A 失效
公开(公告)号：JPH05246865A
公开(公告)日：1993-09-24
申请号：JP8139992
申请日：1992-03-04
申请人： KIKKOMAN CORP
发明人： KINOSHITA EMIKO , YAMAKOSHI JUN , KIKUCHI MAMORU
IPC分类号： A61K36/48 , A61K35/78
摘要： PURPOSE:To obtain the subject compound having an angiotensin transferase- inhibiting action by separating and collecting the nicotianamine from the extraction solution of soybean with a synthetic adsorption resin. CONSTITUTION:Soybean capable of being stably supplied as a raw material as such is extracted with water or 45-130 deg.C hot water without crushing the soybean. Nicotianamine in the extraction solution is separated and collected with a synthetic adsorption resin (e.g. DIAON HP.20 resin, produced by Mitsubishi Kasei Co.) to obtain the nicotianamine. Since soybean-boiled waste solutions or soybean-immersed waste aqueous solutions by-produced in a process for producing soybean processed foods can be utilized for the production of the nicotianamine, the nicotianamine can be obtained at a greatly low cost. Since the nicotianamine is further has excellent water solubility, the nicotianamine can be added to various beverages and foods, thereby giving healthy foods having antihypertensive actions and having good tastes.

2. 发明专利

JPH04229189A PRODUCTION OF ENZYMATICALLY DECOMPOSED SOYBEAN PROTEIN CAPABLE OF ACTIVATION OF MACROPHAGE 失效
公开(公告)号：JPH04229189A
公开(公告)日：1992-08-18
申请号：JP41503090
申请日：1990-12-27
申请人： KIKKOMAN CORP
发明人： KOGA TAKUO , MURAKAMI SEIJI , KINOSHITA EMIKO , YAMAKOSHI JUN , NAKAJIMA YASUHIKO , KIKUCHI MAMORU
IPC分类号： A61K36/48 , A61P43/00 , C07K14/415 , C12P21/06
摘要： PURPOSE:To enable efficient production of the subject enzymatically decomposed soybean protein by acting a protease (PTE) on a soybean protein (-containing material). CONSTITUTION:Soybeans are defatted, subjected to water extraction and subsequently subjected to isoelectric point precipitation to obtain an isolated soybean protein (A) from which whey is removed. To the component (A), an aqueous solvent such as water, a buffer solution or a low-concentration alcohol-containing aqueous solution is then added in an amount of 5-20 times (W/W) the amount of (A) and the resultant mixture is sterilized at about 121 deg.C/1atm for 5-20min. pH is then adjusted to a desired value to obtain a substrate solution (B). PTE such as an alkali protease is subsequently added to the solution (B) and the resultant mixture is reacted at 25-40 deg.C for 15-30hr to obtain a reaction product (C). The component (C) is then heat treated at about 100 deg.C for deactivation of PTE and, after adjustment of its pH to a value in the vicinity of neutral pH, decomposition residues are removed by centrifugal separation, etc., thus obtaining the objective enzymatically decomposed soybean protein capable of activation of macrophage.

3. 发明专利

JP2001072563A AGENT FOR PREVENTING BODY ODOR 失效
公开(公告)号：JP2001072563A
公开(公告)日：2001-03-21
申请号：JP25392899
申请日：1999-09-08
申请人： KIKKOMAN CORP
发明人： YAMAKOSHI JUN , TOKUTAKE SHOICHI
IPC分类号： C07D311/62 , A61K8/00 , A61K8/49 , A61K8/97 , A61K31/352 , A61K31/353 , A61K31/765 , A61Q5/02 , A61Q15/00 , A61K7/32
摘要： PROBLEM TO BE SOLVED: To provide a body odor-preventing agent which can reduce the generation of body odors such as aging odors. SOLUTION: This agent for preventing body odors contains proanthocyanin as an active ingredient. Especially, proanthocyanin originated from grapes can be added to obtain a body odor-preventing agent which is safe and effective for preventing aging odors.

4. 发明专利

JPH1036259A PREVENTIVE AND THERAPEUTIC AGENT FOR CATARACT 失效
公开(公告)号：JPH1036259A
公开(公告)日：1998-02-10
申请号：JP10837797
申请日：1997-04-11
申请人： KIKKOMAN CORP
发明人： YAMAKOSHI JUN , SASAKI TSUTOMU , ISHIKAWA HIROHARU , IWAI YUKIHIKO , MATSUDO TAKANAO , MORI KENJI , KIKUCHI MAMORU , SAITO MINORU , KASAI KOICHI
IPC分类号： C07D307/58 , A61K9/08 , A61K31/34 , A61K31/341 , A61P27/02 , A61P27/12 , C07D307/60
摘要： PROBLEM TO BE SOLVED: To obtain the subject medicine capable of preventing and treating cataract, comprising a furanone derivative. SOLUTION: This medicine comprises a furanone derivative of the formula (R1 to R3 are each H, hydroxyl, amino, a halogen, mercapto, carboxyl, carbamoyl, an alkyl, an alkenyl, an aryl, etc.; R4 is H, amino, a halogen, carboxyl, an alkyl, an aryl, an aralkyl, etc.) or its salt as an active ingredient. 2.5-Dimethyl-4-pivaloyloxy-3H(2H)-furanone is preferable as the compound of the formula. A dose is 0.01-1,000mg/time/day/adult in the case of injection. In the case of an internal medicine, the medicine is administered several times per adult daily and a dose is 0.1-1,000mg/time. In the case of an eye drop, one to two drops of 0.01-10% solution are applied once to five times a day drop. Senile cataract based on oxidation disorder can be prevented and treated by instillation or administration.

5. 发明专利

JP2006087328A Low-salt soy sauce 审中-公开
标题翻译：低盐大豆
公开(公告)号：JP2006087328A
公开(公告)日：2006-04-06
申请号：JP2004275040
申请日：2004-09-22
申请人： Kikkoman Corp , キッコーマン株式会社
发明人： YAMAKOSHI JUN , MATSUMOTO HIROSUKE , SAITO MINORU , AOTA HITOMI , NAKAHARA TAKEHARU , FUKUDA MASARU , OGUMA TETSUYA , FUJII NORIKAZU
IPC分类号： A23L1/238 , A23L1/305
CPC分类号： A23L33/185 , A23L27/50 , A23V2002/00 , A23V2200/326 , A23V2250/5488
摘要： PROBLEM TO BE SOLVED: To provide low-salt soy sauce having good flavor, remarkably suppressing the blood pressure elevation, preventing cardiac hypertrophy, and usable as special nutritious food. SOLUTION: The low-salt soy sauce is obtained through adding 1.0-10.0 wt.% of potassium chloride, and 0.1-5.0 wt.% of γ-aminobutyric acid to low-salt soy sauce. Alternatively, KCl-containing low-salt soy sauce is obtained by (1) a method using mixed solution of KCl and salt as mother water in an ordinary soy sauce production process, (2) a method where soy sauce obtained by using salt water as mother water is added to soy sauce obtained by desalinating salt via electrodialysis, membrane treatment or the like, or some other method, and the γ-aminobutyric acid is added to the KCl-containing low-salt soy sauce to obtain the low-salt soy sauce having a salt concentration of 0-10 wt.%, and containing 1.0-10.0 wt.% of potassium chloride and 0.1-5.0 wt.% of the γ-aminobutyric acid. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供具有良好风味的低盐酱油，显着抑制血压升高，预防心脏肥大，并可用作特殊营养食品。
解决方案：通过向低盐酱油中加入1.0-10.0重量％的氯化钾和0.1-5.0重量％的γ-氨基丁酸，可以得到低盐酱油。或者，通过（1）在普通酱油生产方法中使用KCl和盐的混合溶液作为母水的方法获得含KCl的低盐酱油，（2）通过使用盐水获得的酱油将母水加入到通过电渗析，膜处理等进行盐水脱盐获得的酱油中，或者其他方法，将γ-氨基丁酸加入到含有KCl的低盐酱油中以获得低盐大豆盐浓度为0〜10重量％的酱油，含有1.0-10.0重量％的氯化钾和0.1-5.0重量％的γ-氨基丁酸。版权所有（C）2006，JPO＆NCIPI

6. 发明专利

JP2005124517A Antithrombotic food and beverage 审中-公开
标题翻译：抗生素食品和饮料
公开(公告)号：JP2005124517A
公开(公告)日：2005-05-19
申请号：JP2003365414
申请日：2003-10-27
申请人： Kikkoman Corp , キッコーマン株式会社
发明人： YAMAKOSHI JUN , SATO TAKUYA , UCHIDA RIICHIRO , TOKUTAKE SHOICHI , SAITO MINORU , KIKUCHI MAMORU , YODA TAKASHI , ABE KATSUSATO
IPC分类号： C12G3/12 , A23L1/30 , A61K36/899 , A61P7/02 , A61P9/10 , C12F3/10 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide foods and beverages exhibiting antithrombotic effect in antithrombotic foods and beverages effectively utilizing distillation residue which is a waste product for production of Shochu (Japanese distilled spirit). SOLUTION: The antithrombotic food and beverage comprise a distillation residue, obtained as a by-product of Shochu produced by a conventional method by using barley, rye, naked barley, adlay, etc., as a raw material, in which the majority of the residue is treated as an industrial waste, particularly a distillation residue of Shochu using barley as a raw material as an active ingredient. The antithrombotic food and beverage are obtained by adding the distillation residue to various kinds of foods and beverages. The distillation residue is formed in powder, tablet, capsule, etc., to provide a health food or the distillation residue is added to various kinds of beverages, e.g. an alcoholic beverage such as Shochu or a fruit-containing beverage, isotonic beverage, etc. to provide the antithrombotic food and beverage. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供在抗血栓形成食品和饮料中显示抗血栓形成作用的食品和饮料，有效地利用作为生产烧酒（日本蒸馏酒）的废弃产物的蒸馏残渣。解决方案：抗血栓形成的食品和饮料包含蒸馏残渣，作为通过使用大麦，黑麦，裸大麦，adlay等作为原料以常规方法生产的Shochu的副产物获得，其中大部分残留物作为工业废物处理，特别是使用大麦作为原料作为活性成分的Shochu的蒸馏残渣。通过将蒸馏残渣加入到各种食品和饮料中来获得抗血栓形成的食物和饮料。蒸馏残留物以粉末，片剂，胶囊等形成，以提供保健食品，或将蒸馏残余物加入到各种饮料中。诸如烧酒或含果实饮料的酒精饮料，等渗饮料等，以提供抗血栓形式的食物和饮料。版权所有（C）2005，JPO＆NCIPI

7. 发明专利

JP2002029968A PROANTHOCYANIDIN COMPOSITION 失效
公开(公告)号：JP2002029968A
公开(公告)日：2002-01-29
申请号：JP2000211343
申请日：2000-07-12
申请人： KIKKOMAN CORP , TAIYO KAGAKU KK
发明人： TOKUTAKE SHOICHI , YAMAKOSHI JUN , FUJII NORIKAZU , HORIE NORIKO , YAMAGUCHI HIROAKI , NANBU HIRONOBU , REKA RAJU JUNEJA
IPC分类号： A23L1/30 , A61K9/56 , A61K31/352 , A61K36/18 , A61K47/14 , A61K47/34 , A61K47/44 , A61P43/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To effectively provide a proanthocyanidin composition having the reduced bitter taste of the proanthocyanidin at a low cost by a safe method without deteriorating the fecal smell-removing effect of the proanthocyanidin. SOLUTION: This proanthocyanidin composition obtained by coating the proanthocyanidin with an oil or a fat in the presence of a polyhydric alcohol fatty acid ester.

8. 发明专利

JP2001120214A METHOD FOR PRODUCING GARLIC-CONTAINING FOOD 失效
公开(公告)号：JP2001120214A
公开(公告)日：2001-05-08
申请号：JP30927299
申请日：1999-10-29
申请人： KIKKOMAN CORP
发明人： YAMAKOSHI JUN , TOKUTAKE SHOICHI
IPC分类号： A23L19/00 , A23L27/10 , A23L1/212
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a garlic-containing food free from garlic odor after eating. SOLUTION: When producing a garlic-containing food, proanthocyanidin is added in an arbitrary production process. Proanthocyanidin derived from grape is preferably added in a ratio of 0.2-10% based on addition amount of garlic in the garlic-containing food.

9. 发明专利

JPH10262571A FEED FOR ANIMAL 失效
公开(公告)号：JPH10262571A
公开(公告)日：1998-10-06
申请号：JP8560497
申请日：1997-03-21
申请人： KIKKOMAN CORP , NODA SANGYO KAGAKU KENKYUSHO
发明人： YAMAKOSHI JUN , KATAOKA SHIGEHIRO , KOGA TAKUO , HOSOYAMA HIROSHI , ARIGA TOSHIAKI
IPC分类号： A23K1/16
摘要： PROBLEM TO BE SOLVED: To obtain a feed for animals having peroxide-lowering action, etc., in animal bodies, increasing resistance to stress and diseases of livestock, etc., and having meat quality-improving action by adding and including proanthocyanidin. SOLUTION: This feed for animals, e.g. livestock such as cow, horse, pig, sheep or rabbit, poultry such as chicken or duck and pet such as dog, cat or bird is obtained by adding and including proanthocyanidin using grape seed, immature apple fruit, bark, etc., of sea pine as a raw material. An amount of proanthocyanin added is >=0.01 (w/w)%, preferably 0.05-3% (w/w)%, based on the feed.

10. 发明专利

JPH1059846A PREVENTIVE OR REMEDY FOR CARARACTA 失效
公开(公告)号：JPH1059846A
公开(公告)日：1998-03-03
申请号：JP30751496
申请日：1996-11-05
申请人： KIKKOMAN CORP
发明人： YAMAKOSHI JUN , ARIGA TOSHIAKI , ISHIKAWA HIROHARU , IWAI YUKIHIKO , MANAKA TATSUO , KATAOKA SHIGEHIRO , YUASA KATSUMI , KIKUCHI MAMORU
IPC分类号： C07H17/065 , A61K31/35 , A61K31/352 , A61K31/353 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61K36/18 , A61P27/02 , C07D311/30 , C07D311/62 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To prepare a preventive or remedy for cararacta caused by a lesion of oxidation, etc., capable of manifesting a sufficient preventive or curative effect on the cararacta by using a specific oligomer as an active ingredient. SOLUTION: This preventive or remedy for cararacta is prepared by formulating a proanthocyanidin oligomer, especially at least one kind selected from di- to triacontamer having flavan-3,4-diol of the formula (R1 is H or hydroxyl; R2 to R4 are each H, hydroxyl or methoxyl; R5 is H, galloyl or glycopyranosyl) as a constituent unit. An extract obtained by extracting a seed, a pericarp or strained lees of a fruit of a grape is preferably used as the proanthocyanidin oligomer. The oligomer is administered in a daily dose of about 0.01-1,000mg/ adult in one portion in the case of injection and is administered in several portions of about 0.1-4,000mg/adult per day in the case of an oral dose.

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