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1. 发明专利

JP2006141326A Culturing device 审中-公开
标题翻译：文化装置
公开(公告)号：JP2006141326A
公开(公告)日：2006-06-08
申请号：JP2004338037
申请日：2004-11-22
申请人： Hitachi Medical Corp , 株式会社日立メディコ
发明人： KOMORI YOSHIHIRO
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： C12M41/36 , C12M41/14
摘要： PROBLEM TO BE SOLVED: To observe the cultured state on a culturing container from an optional observation position with reproducibility. SOLUTION: On an observation position-designating means, a figure corresponding to the culturing container means is shown in a display picture of its operational terminal, and a mark indicating a current camera position, a mark for indicating a position for wishing to transfer and marks where images are saved in the past are displayed. Also, in addition, on the displaying picture, a controlling button, etc., for receiving an input for transfer-initiating command are arranged. By indicating a position for wishing to transfer (observation position) on the figure of the culturing means by using a mouse or key board, the culturing state-observing means such as a camera, etc., is automatically transferred to an objective observing position by an observing position-setting means. Thereby, it becomes possible to observe the cultured state on the culturing container from optional positions with reproducibility. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：从再现性的任意观察位置观察培养容器的培养状态。解决方案：在观察位置指定装置上，在其操作终端的显示图像中示出与培养容器装置对应的图形，以及指示当前相机位置的标记，用于指示希望的位置的标记显示过去保存图像的传输和标记。此外，另外，在显示图像上设置有用于接收传送开始命令的输入的控制按钮等。通过使用鼠标或键盘表示希望在培养装置的图形上转移（观察位置）的位置，诸如照相机等的培养状态观察装置被自动转移到客观观察位置观察位置设定装置。由此，可以从再现性的任意位置观察培养容器的培养状态。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP2005295818A Device for culturing cell 有权
标题翻译：文化细胞装置
公开(公告)号：JP2005295818A
公开(公告)日：2005-10-27
申请号：JP2004112792
申请日：2004-04-07
申请人： Hitachi Medical Corp , 株式会社日立メディコ
发明人： KOMORI YOSHIHIRO , SUZUKI TSUTOMU
IPC分类号： C12M1/00 , C12M1/34
CPC分类号： C12M41/36
摘要： PROBLEM TO BE SOLVED: To provide a device for culturing cells, capable of minutely observing the cultured state of the cells in an optional colony in performing the cell culture, and also easily recognizing the presence or absence of the colony of the cultured cells and its size by the scanning of a camera and an image-processing by keeping the use of a highly magnifying lens and the camera for observing the details in the cultured state without performing the exchanging work of the lenses.
SOLUTION: This device for culturing cells, having a flat plane-formed culturing container for culturing the cells, an image-taking device having its optical axis in the direction of crossing at right angle with the plane and a narrower sight range than the surface of the culturing device and a driving means for relatively moving at least one of the culturing device surface and the image-taking device while maintaining a state that the culturing device surface crosses the optical axis of the image-taking device at the right angle is provided with that, when the driving means moves relatively to the surface part of the culturing device which is not under the sight range of the image-taking device so as to enter the sight range, the image-taking device takes the photographs of the culturing device surface.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种培养细胞的装置，其能够在进行细胞培养时细小地观察可选菌落中的细胞的培养状态，并且还容易识别培养的菌落的存在或不存在通过使用高度放大的镜头和相机来观察细节，在不执行透镜的交换的情况下，通过相机的扫描和图像处理来进行细胞的尺寸和图像处理。解决方案：这种用于培养细胞的装置，具有用于培养细胞的平面形成培养容器，其光轴在与平面成直角交叉的方向上的摄像装置，并且视线范围比培养装置的表面和用于相对移动培养装置表面和摄像装置中的至少一个的驱动装置，同时保持培养装置表面与摄像装置的光轴成直角的状态设置有，当驱动装置相对于不在摄像装置的视野范围内的培养装置的表面部分移动以进入视线范围时，拍摄装置拍摄照片培养装置表面。版权所有（C）2006，JPO＆NCIPI

3. 发明专利

JP2007110932A Automatic method for culturing and cell culture apparatus 有权
标题翻译：用于培养和细胞培养装置的自动方法
公开(公告)号：JP2007110932A
公开(公告)日：2007-05-10
申请号：JP2005303879
申请日：2005-10-19
申请人： Hitachi Medical Corp , 株式会社日立メディコ
发明人： KOMORI YOSHIHIRO
IPC分类号： C12M3/00 , C12M1/34 , C12M1/36 , C12N5/07 , C12N5/071
CPC分类号： C12M41/14 , C12M41/36 , C12M41/48
摘要： PROBLEM TO BE SOLVED: To assist the control such as a change in a culture schedule in which cells can efficiently be cultured on the basis of an image obtained by photographing the interior of an incubator according to simple image processing.
SOLUTION: The cells in the image obtained by photographing the interior of the incubator for culturing the cells is subjected to thinning and the apparent number of cells is calculated by using each cell subjected to the thinning as one cell, respectively. Thereby, the apparent number of cells is compared with the set value to control the culture schedule. The direction of the thinned cells is especially determined and the angle of the direction of each cell and the frequency of appearance of the cells thinned at each angle are calculated. When the frequency of appearance within the range of the set angle exceeds the set value, the practice of subculture processing is determined.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：根据通过根据简单图像处理拍摄培养箱的内部获得的图像来辅助诸如细胞可以有效培养细胞的变化的控制。解决方案：通过拍摄用于培养细胞的培养箱内部获得的图像中的细胞经受稀释，并且通过使用经过稀化的每个细胞分别作为一个细胞来计算细胞的表观数目。因此，将细胞的表观数与设定值进行比较，以控制培养时间表。特别确定了细胞细胞的方向，并计算每个细胞的方向角度和每个角度变薄的细胞的出现频率。当设定角度范围内出现的频率超过设定值时，确定亚文化处理的做法。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2007020507A Apparatus for culturing cell 有权
标题翻译：用于培养细胞的装置
公开(公告)号：JP2007020507A
公开(公告)日：2007-02-01
申请号：JP2005209495
申请日：2005-07-20
申请人： Hitachi Medical Corp , 株式会社日立メディコ
发明人： KOMORI YOSHIHIRO
IPC分类号： C12M1/00 , C12M1/34
CPC分类号： C12M41/36 , C12M41/14
摘要： PROBLEM TO BE SOLVED: To provide an apparatus for culturing cells designed to judge the timing of completion of subculturing and culturing.
SOLUTION: The apparatus for culturing the cells is equipped with a photographing means 15 for photographing the cells in an incubator 17 during the culturing of the cells and a means for measuring the interval of the adjacent cells on the basis of photographed image information about the cells. The apparatus is further provided with a means for detecting the formation of colonies by density information about the cells obtained during the culturing of the cells.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于培养用于判断传代培养和培养完成时间的细胞的装置。解决方案：用于培养细胞的装置配备有拍摄装置15，用于在培养细胞期间拍摄培养箱17中的细胞，以及用于基于拍摄的图像信息测量相邻细胞的间隔的装置关于细胞。该装置还具有用于通过关于细胞培养期间获得的细胞的密度信息来检测菌落形成的装置。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2006141325A Culturing device 有权
标题翻译：文化装置
公开(公告)号：JP2006141325A
公开(公告)日：2006-06-08
申请号：JP2004338036
申请日：2004-11-22
申请人： Hitachi Medical Corp , 株式会社日立メディコ
发明人： KOMORI YOSHIHIRO
IPC分类号： C12M1/00 , C12M1/04
CPC分类号： C12M41/34 , C12M41/14
摘要： PROBLEM TO BE SOLVED: To provide a culturing device without requiring the selection of an installing place on culturing over several days to several months, without having problems such as dust-forming, vibration, noise, etc., and capable of operating working parts such as an air cylinder, etc., even in the time of power failure. SOLUTION: The gas concentration of the gas fed from a gas cylinder such as a carbon dioxide gas cylinder in a temperature-keeping box means arranged with a culturing container means, is adjusted by a gas concentration-adjusting means. In such the culturing, the use of carbon dioxide gas, etc., is essential. Therefore, the gas pressure of the gas cylinder is used as a power source so as to drive the working parts such as an air cylinder, etc., used for a medicine-feeding means or waste liquid-discharging means. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为了提供一种培养装置，而不需要在几天到几个月的培养中选择安装场所，而没有诸如粉尘形成，振动，噪音等问题，并且能够操作工作部件如气缸等，即使在停电时也是如此。解决方案：通过气体浓度调节装置调节从设置有培养容器装置的保温箱装置中的二氧化碳气瓶等气瓶供给的气体的气体浓度。在这样的培养中，使用二氧化碳气体等是至关重要的。因此，气瓶的气体压力被用作电源，以驱动用于给药装置或废液排放装置的诸如气缸等的工作部件。版权所有（C）2006，JPO＆NCIPI

6. 发明专利

JP2012161354A Magnetic resonance imaging device and nonlinear distortion correction method 有权
标题翻译：磁共振成像装置和非线性失真校正方法
公开(公告)号：JP2012161354A
公开(公告)日：2012-08-30
申请号：JP2011021611
申请日：2011-02-03
申请人： Hitachi Medical Corp , 株式会社日立メディコ
发明人： KOMORI YOSHIHIRO , HAYASHI KOJI
IPC分类号： A61B5/055
摘要： PROBLEM TO BE SOLVED: To provide an MRI (magnetic resonance imaging) device for correcting the distortion in an image due to nonlinearity by calculating the distortion amount on an imaging cross section when the cross section is decided, by using the Bio-Savart law, based on the shape of the gradient magnetic field coil.SOLUTION: The MRI device includes a processing means for generating a reconstitution image in a space for storing a subject, based on a magnetic resonance signal. The processing means calculates gradient magnetic field intensity on an arbitrary imaging cross section in the space, based on a pattern constituting a gradient magnetic field generation means, calculates the distortion amount in the gradient magnetic field on the imaging cross section by using the calculated gradient magnetic field intensity, and acquires the reconstitution image with the distortion of the gradient magnetic field intensity removed therefrom by correcting the distortion amount of the reconstitution image, based on the distortion amount in the gradient magnetic field.
摘要翻译：要解决的问题：提供一种MRI（磁共振成像）装置，用于通过在确定横截面时计算成像截面上的失真量来校正由于非线性造成的图像中的失真，通过使用Bio- 萨伐尔定律，基于梯度磁场线圈的形状。解决方案：MRI装置包括用于基于磁共振信号在用于存储对象的空间中产生重构图像的处理装置。处理装置基于构成梯度磁场产生装置的图案，计算空间中的任意成像截面上的梯度磁场强度，通过使用计算的梯度磁场计算成像截面上的梯度磁场中的失真量场强，并且通过基于梯度磁场中的失真量来校正重构图像的失真量来获取从其去除的梯度磁场强度的失真的重构图像。版权所有（C）2012，JPO＆INPIT

7. 发明专利

JP2009022319A Magnetic resonance imaging device 有权
标题翻译：磁共振成像装置
公开(公告)号：JP2009022319A
公开(公告)日：2009-02-05
申请号：JP2007185279
申请日：2007-07-17
申请人： Hitachi Medical Corp , 株式会社日立メディコ
发明人： KOMORI YOSHIHIRO , NAKAI NORIMASA
IPC分类号： A61B5/055
摘要： PROBLEM TO BE SOLVED: To effectively restrain an artifact even in a low S/N ratio image. SOLUTION: The magnetic resonance imaging device prepares a masking image from an image to which a sensitivity image of a plurality of acquired slices is added by an absolute value. The device obtains sensitivity distribution of a receiving coil having a good S/N ratio and from which a low signal area is efficiently removed by multiplying the masking image obtained by complex addition of acquired slices of the sensitivity image. The device removes reflection from a morphologic image by using the acquired sensitivity distribution. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：即使在低S / N比图像中也能有效地抑制伪影。解决方案：磁共振成像装置从添加了多个获取的切片的灵敏度图像的图像准备掩蔽图像绝对值。该装置获得具有良好S / N比的接收线圈的灵敏度分布，并且通过将通过灵敏度图像的所获取的切片的复数相加获得的掩蔽图像相乘来有效地去除低信号区域。该装置通过使用获取的灵敏度分布从形态图像中去除反射。版权所有（C）2009，JPO＆INPIT

8. 发明专利

JP2007312668A Automatic culture device 有权
标题翻译：自动文化装置
公开(公告)号：JP2007312668A
公开(公告)日：2007-12-06
申请号：JP2006145161
申请日：2006-05-25
申请人： Hitachi Medical Corp , Univ Of Tokyo , 国立大学法人東京大学 , 株式会社日立メディコ
发明人： IESHIMA DAISUKE , SUZUKI TSUTOMU , KOMORI YOSHIHIRO , TACHIKUI HIROSHI , ASAHINA IZUMI , UEDA MINORU
IPC分类号： C12M1/00
CPC分类号： C12M41/48 , C12M23/10 , C12M29/26
摘要： PROBLEM TO BE SOLVED: To safely and automatically perform a culture protocol of the separation of a stem cell from marrow liquid and the proliferation and differentiation induction of the cell while reducing the contamination risk. SOLUTION: The automatic cell culture device is provided with an air-tight cell culture device 2 placed in an incubator 36, a liquid feeding means 34 to pour the liquids selectively from a medium vessel 14, a washing liquid vessel 10 and a marrow liquid vessel 12 through a liquid feeding pipe 4 air-tightly connected to the culture device 2, and a liquid discharging means 42 to discharge the liquid in the culture device through a liquid discharging pipe 8. The marrow liquid is poured into the culture device after pouring the medium, and left at rest for a preset period. The culture device is washed to selectively separate the stem cells adhering to the culture device, the medium is poured into the culture device to culture the stem cell until the cell is proliferated to get sufficient number of cells, a differentiation medium 15 is poured into the culture device to differentiate the cell to the objective tissue cell, and the differentiated tissue cell is extracted from the culture device and recovered to a recovery vessel 48. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：安全和自动地执行干细胞与骨髓液分离的培养方案以及细胞的增殖和分化诱导，同时降低污染风险。解决方案：自动细胞培养装置设置有放置在培养箱36中的气密细胞培养装置2，液体供给装置34，从中等容器14，洗涤液容器10和通过与培养装置2气密连接的液体供给管4的骨髓液容器12，以及通过液体排出管8排出培养装置中的液体的液体排出装置42.将骨髓液倒入培养装置倾倒介质后，静置一段时间。洗涤培养装置以选择性分离附着于培养装置的干细胞，将培养基倒入培养装置中以培养干细胞直到细胞增殖以获得足够数量的细胞，将分化培养基15倒入将细胞分化为目的组织细胞的培养装置，并从培养装置中提取分化的组织细胞并回收至回收容器48.版权所有（C）2008，JPO＆INPIT

9. 发明专利

JP2005295969A Cellular segregation device 审中-公开
标题翻译：细胞分离装置
公开(公告)号：JP2005295969A
公开(公告)日：2005-10-27
申请号：JP2004121250
申请日：2004-04-16
申请人： Hitachi Medical Corp , 株式会社日立メディコ
发明人： TACHIKUI HIROSHI , SUZUKI TSUTOMU , KOMORI YOSHIHIRO , MIYAUCHI AKIHIRO , KUWABARA KOSUKE
IPC分类号： C12M1/00 , B01D43/00
CPC分类号： C12M47/04 , C12M25/00 , C12M33/00
摘要： PROBLEM TO BE SOLVED: To provide a cellular segregation device capable of reducing the occurrence of contamination in the segregation operation to be carried out for several times.
SOLUTION: This cellular segregation device is constituted of two or more cellular segregation chambers 1, 3 for storing a cell-containing liquid containing different two or more kinds of cells, and segregating a target cell from the cells contained in the cell-containing liquid, transfer passages 5 for transferring the cells between two or more cellular segregation chambers, injection passages 7, 17 formed in each of the cellular segregation chambers 1, 3, and for injecting the liquid to the cellular segregation chambers, and deriving passages 9, 19, 21 for deriving the liquid in the cellular segregation chambers 1, 3. The cellular segregation chambers 1, 3 have attaching parts 35, 37 for attaching a cell having an adhesive properties or a cell having the adhesive properties stronger than those of other cells in the cells contained in the stored cell-containing liquid, and the transfer passage 5 is constituted so as to have a transfer passage-opening and closing means 5a for opening and closing the transfer passage 5.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：解决的问题：提供一种能够减少分离操作中污染发生多次的细胞分离装置。解决方案：该细胞分离装置由两个或多个细胞分离室1,3构成，用于储存含有不同的两种或更多种细胞的含细胞液体，并将靶细胞与细胞内含有的细胞分离，用于在两个或多个细胞分离室之间转移细胞的转移通道5，在每个细胞分离室1,3中形成的注射通道7,17和用于将液体注入细胞分离室，以及导出通道9 ，19,21，用于导出细胞分离室1,3中的液体。细胞分离室1,3具有用于附着具有粘合性的细胞的附着部分35,37或具有比其它粘合性更强的粘合性的细胞包含在储存的含细胞液体中的细胞中的细胞，并且传送通道5构成为具有用于打开的传送通道 - 开闭装置5a 并关闭转运通道5.版权所有（C）2006，JPO＆NCIPI

10. 发明专利

JP2000268204A PICTURE DISPLAY DEVICE 失效
公开(公告)号：JP2000268204A
公开(公告)日：2000-09-29
申请号：JP11579899
申请日：1999-04-23
申请人： HITACHI MEDICAL CORP
发明人： INOUE YOSUKE , ITO YUKIO , KOMORI YOSHIHIRO
IPC分类号： A61B5/055 , A61B6/03 , G06T1/00 , G06T15/00 , G06T15/08 , G06T19/20 , G09G5/36 , G06T17/40
摘要： PROBLEM TO BE SOLVED: To provide a picture display device setting a cutting place which always contains a specified notice point. SOLUTION: A notice point 23 is displayed on a line 20 displayed on an MPR picture 15 on an XY plane and rotary operators 21 are dragged by a mouse. Thus, the line 20 rotates with the notice point 23 as a center. The line 20 moves along the line 20 in parallel by dragging the parallel moving operators 22 by the mouse. Thus, an arbitrary plane rotates and moves in parallel by always containing the notice point 23 as it is. Thus, the notice points 23 are always displayed on the MPR picture 15 on the XY plane, an MPR picture 16 on a YZ plane and an MPR picture 17 on a ZX plane.

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