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1. 发明专利

JPS5965035A Preparation of trans-isoeugenol and its derivative 失效
标题翻译：衍生物及其衍生物的制备
公开(公告)号：JPS5965035A
公开(公告)日：1984-04-13
申请号：JP17396782
申请日：1982-10-05
申请人： T Hasegawa Co Ltd
发明人： FURUHATA AKEMICHI , TAKAGI KEIICHI , KOJIYOU KUNIO
IPC分类号： C07C41/32 , B01J27/00 , B01J27/10 , C07B61/00 , C07C41/00 , C07C43/20 , C07C43/215 , C07C43/23 , C07C67/00 , C07C67/293 , C07C69/157 , C07C69/22
CPC分类号： Y02P20/52
摘要： PURPOSE: To prepare the titled compound having excellent fragrance economically, in an improved selectivity, by contacting eugenol or its derivative with an isomerization catalyst comprising iridium tetrachloride or its monohydrate.
CONSTITUTION: The objective compound of formula II can be prepared easily, in a remarkably excellent selectivity (about 97W99%) and high yield (about ≥99%), by contacting the eugenol of formula I (R is H, 1W6C alkyl, ≤8C aralkyl, or 1W6C acyl) or its derivative with the easily available and preparable catalyst of formula IrCl
4 .nH
2 O (n is 0 or 1) in the presence or absence of water. The amount of the catalyst is preferably about 0.001W0.1wt%, especially about 0.01W0.1wt%, based on the compound of formula I . Preferably, the reaction is carried out in the presence of water to attain rapid reaction.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过使丁子香酚或其衍生物与包含四氯化铱或其一水合物的异构化催化剂接触，以经济方式制备具有优异香味的标题化合物，以提高的选择性。结构式：通过使式I的丁子香酚（R为H，1-二甲基甲酰胺）接触，可以以极好的选择性（约97-99％）和高收率（约> = 99％）容易地制备式II的目的化合物， 6C烷基，<= 8C芳烷基或1-6C酰基）或其衍生物与在存在或不存在水的情况下易于获得且可制备的式IrCl 4·nH 2 O（n为0或1）的催化剂。基于式I化合物，催化剂的量优选为约0.001-0.1重量％，特别是约0.01-0.1重量％。优选地，反应在水的存在下进行以实现快速反应。

2. 发明专利

JPS5671085A PRODUCTION OF 22HYDROXYY55ALKYLLTETRAHYDROFURAN AND ITS NOVEL INTERMEDIATE 失效
公开(公告)号：JPS5671085A
公开(公告)日：1981-06-13
申请号：JP14761979
申请日：1979-11-16
申请人： HASEGAWA CO LTD
发明人： TAKAGI KEIICHI , IWAMOTO MINORU , TAKAZAWA OSAMU , KOJIYOU KUNIO
IPC分类号： C07D317/20 , A61K8/49 , A61K47/00 , A61K47/22 , A61Q13/00 , C07D307/20 , C07D319/06 , C11B9/00
摘要： NEW MATERIAL:The titled compound of formula I (R is 1-6C alkyl). EXAMPLE:2-Hydroxy-5-pentyltetrahydrofuran. USE:Flavor and pefume: they have durable smells and are used in wide fields of food, beverage, cosmetics, medicine, sanitary and health products and are used as a perfume, flavor or modifier. Characteristically, they have fresh and sweet green note. PREPARATION:A novel compound, 4-hydroxy-1,1-polymethylenedioxyalkane of formula II (n is 2, 3) is hydrolyzed in the presence of a catalyst such as sulfuric or p-toluenesulfonic acid, preferably in the presence of water in an organic solvent such as diethyl ether, dimethylformamide at 10-50 deg.C for 1-25hr to give the compound of formula I.

3. 发明专利

JPS5455513A MONOTERPENEEEKETOLS* THEIR PREPARATION* AND APPLICATIONS 失效
公开(公告)号：JPS5455513A
公开(公告)日：1979-05-02
申请号：JP11997977
申请日：1977-10-07
申请人： HASEGAWA CO LTD
发明人： MATSUI MASANAO , KITAHARA TAKESHI , TAKAGI KEIICHI , WATANABE ICHIROU , TAMOGAMI SHIGEYUKI
IPC分类号： C07D339/08 , A61K8/35 , A61Q13/00 , C07C45/00 , C07C49/24 , C07C67/00 , C11B9/00
摘要： NEW MATERIAL:Monoterpene-alpha-ketols of formula (1): (the bond of solid and dotted lines in parallel is a double or single bond). EXAMPLE:3,7-dimethyl-1-octene-3-ol-4-one. USE:Flavoring agents, etc. for giving fruit, particularly durable citron-like flavors, and useful for food, cosmetic bases, cosmetics, health, hygienics, medicines, etc. PROCESS:1,3-Dithian of formula (5) is reacted with isoamyl halides of formula (4): (x is halogen) or prenyl halides to give 2=isoamyl-or 2-prenyl-1,3-dithian, a novel intermediate, which is subjected to aldol condensation with methyl vinyl ketone in the presence of an alkali to form a disubstituted dithian, e.g. 3,7-dimethyl-4,4- propanedithio-1-octene-3-ol, etc. of formula (2). The disubstituted dithian thus obtained is hydrolyzed oxidatively to afford monoterpene-alpha-ketols of formula (1).

4. 发明专利

JPS5448765A ACETYLCYCLOHEXENONE KETALS* THEIR PREPARATION AND USE 失效
公开(公告)号：JPS5448765A
公开(公告)日：1979-04-17
申请号：JP11430677
申请日：1977-09-22
申请人： HASEGAWA CO LTD
发明人： MATSUI MASANAO , KITAHARA TAKESHI , TAKAGI KEIICHI
IPC分类号： C07D317/72 , A61K8/49 , A61Q13/00 , C11B9/00
摘要： NER MATERIAL:Acetylcyclohexenone ketals I (R is H, methyl). EXAMPLE:1-Acetyl-6,6-dimethyl-4,4-ethylenedioxy-1-cyclohexene. USE:Intermediate of a component of natural perfume or the like. Aromatic component or modiifer of a lasting perfume having floral fragrance. PROCESS:The objective compound I wherein R is H, is prepared by reacting a compound obtained by the heat reaction of a compound II (R' is 1-5C alkyl) and a compound III, with ethylene glycol in the presence of an acid catalyst. A compound I wherein R is methyl can be prepared from the above compound I by treating with methylating agent, reacting with halogen, and subjecting to de-hydrohalogenation reaction in the presence of a base. The compounds I are converted to compounds IV,V, or the like, which are known fragrant components separated from tobacco leaves, etc.

5. 发明专利

JPS5419962A PREPARATION OF 2*55DIMETHYLL44HYDROXYY2*33DIHYDROFURANN33ONE 失效
公开(公告)号：JPS5419962A
公开(公告)日：1979-02-15
申请号：JP8350777
申请日：1977-07-14
申请人： HASEGAWA CO LTD
发明人： MATSUI MASANAO , OGAWA TOMOYA , TAKAGI KEIICHI
IPC分类号： C07D307/60
摘要： PURPOSE:Title compound useful as a perfume substance having strawberry-like aroma occurring in pineapple is prepared in one step from readily and inexpensively available 6-deoxy-glucose in high selectivity and yield.

6. 发明专利

JPS52102287A PREPARATION OF CYCLIC LACTONES 失效
公开(公告)号：JPS52102287A
公开(公告)日：1977-08-27
申请号：JP1841476
申请日：1976-02-24
申请人： HASEGAWA CO LTD
发明人： MATSUI MASANAO , OGAWA TOMOYA , TAKAGI KEIICHI , YAMATO TAKESHI , HAYASHI KAZUO
IPC分类号： C07D313/00
摘要： PURPOSE:Convenient method for preparing high-purity large-ring lactones useful as an ingredient for musk-, civet-, or amber-like perfumery.

7. 发明专利

JP2004067723A Aroma and flavor imparting agent 有权
公开(公告)号：JP2004067723A
公开(公告)日：2004-03-04
申请号：JP2002224777
申请日：2002-08-01
申请人： T Hasegawa Co Ltd , 長谷川香料株式会社
发明人： TAMURA HIROSHI , AMAIKE MASAYASU , KATSUTA YASUHIRO , ISHIKAWA MASASHI , TAKAGI KEIICHI
IPC分类号： A23L27/00 , A23L27/12 , C11B9/00 , A23L1/22 , A23L1/222
摘要： PROBLEM TO BE SOLVED: To provide an aroma and flavor imparting agent having a natural feeling and imparting a persistent grape fruity aroma and flavor to a food and drink, and the like. SOLUTION: This aroma and flavor imparting agent consists essentially of nootkatone and further comprises a nootkatone mixture containing a valencene epoxide and nootkatol. COPYRIGHT: (C)2004,JPO

8. 发明专利

JPS6160680A 4-hydroxy-7-isopropyl-4-methyl-10-ehylenedioxy-1,5(e)-undecadiene 失效
标题翻译： 4-羟基-7-异丙基-4-甲基-10-乙烯基-1,5-（E） - 二烯
公开(公告)号：JPS6160680A
公开(公告)日：1986-03-28
申请号：JP17939884
申请日：1984-08-30
申请人： Japan Tobacco Inc , T Hasegawa Co Ltd
发明人： FUJIMORI MINE , KATSUTA YASUHIRO , TAKAGI KEIICHI , IWAMOTO MINORU , KOJO KUNIO
IPC分类号： A61K8/49 , A61Q13/00 , C07D317/20 , C11B9/00
摘要： NEW MATERIAL:A compound shown by the formula I.
USE: An intermediate for synthesizing a perfume substance, or a tobacco flavor substance. Obtainable industrially advantageously.
PREPARATION: 1mol 5-isopropl-8-ethylenedioxy-3-nonen-2-one shown by the formula II is reacted with 1W5mol compound (preferably magnesium allyl bro mide, etc.) shown by the formula CH
2 CHCH
2 HgX in an organic solvent (e.g., THF, etc.) at 20W70°C for 1W50 hours.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：新材料：由式I表示的化合物。用途：合成香料或中草药香料的中间体。在工业上有利地获得。制备：式II所示的1摩尔5-异丙基-8-亚乙二氧基-3-壬烯-2-酮与式（CH2CHCH2·2H2O）所示的1-5摩尔化合物（优选镁烯丙基肉胺等）在有机溶剂（例如THF等）在20-70℃下加热1-50小时。

9. 发明专利

JPS5931728A Preparation of nootkatone 失效
标题翻译： NOOTKATONE的制备
公开(公告)号：JPS5931728A
公开(公告)日：1984-02-20
申请号：JP14162782
申请日：1982-08-17
申请人： T Hasegawa Co Ltd
发明人： TAKAGI KEIICHI , MIZUTANI SHINICHI , HAYASHI KAZUO
IPC分类号： C07C45/33 , B01J31/00 , B01J31/12 , B01J31/22 , C07B61/00 , C07C45/00 , C07C49/653 , C07C67/00
CPC分类号： Y02P20/52
摘要： PURPOSE: To obtain nootkatone useful as a perfume industrially advantageously and selectively in high purity and yield in one step, by catalytically oxidizing valencene with oxygen or a gas containg the oxygen in an inert organic solvent in the presence of an organic heavy metallic catalyst.
CONSTITUTION: Valencene of formula 2 is catalytically oxidized with oxyen or a gas containing the oxygen in an inert organic solvent, e.g. benzene, in the presence of an organic heavy metallic catalyst, preferably an organometallic compound of Group VIII, e.g. Fe, Co, Ni, Ru, Rh, Pd or Ir, etc. to give nootkatone of formula 1 having a grapefruitlike fragrance in one step without passing through an intermediate step of hydroperoxide in danger of causing violent explosion by the technique of industrially advantageous catalytic oxidation industrially and easily in high conversion and yield. Compounds of formulas 3 and 4 formed as by-products in the above-mentioned reaction can be easily converted into the compound of formula 1.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过在有机重金属催化剂存在下，通过在氧气或含有惰性有机溶剂中的气体的气体催化氧化戊烯来获得工业上有效和选择性地高效纯化和产率的香精作为香料。构成：式2的戊烯在含有氧气或惰性有机溶剂中的氧的气体中被催化氧化。苯，在有机重金属催化剂存在下，优选第VIII族的有机金属化合物。 Fe，Co，Ni，Ru，Rh，Pd或Ir等，以一步法得到具有葡萄柚状香料的通式1的诺卡酮，而不经过通过工业上有利催化的技术引起剧烈爆炸的危险中的氢过氧化物的中间步骤在高转化率和产率下工业化和易于氧化。在上述反应中作为副产物形成的式3和4的化合物可以容易地转化成式1的化合物。

10. 发明专利

JPS58222050A Novel preparation of 12-hydroxy-cis-9-dodecenoic acid alkyl ester 失效
标题翻译： 12-羟基-C-9-十二烷酸酯的新型制备
公开(公告)号：JPS58222050A
公开(公告)日：1983-12-23
申请号：JP10549682
申请日：1982-06-21
申请人： T Hasegawa Co Ltd
发明人： TAKAGI KEIICHI , IWAMOTO MINORU , KOJIYOU KUNIO
IPC分类号： C07C69/732 , B01J31/00 , B01J31/02 , C07B61/00 , C07C67/30 , C07C67/31
CPC分类号： Y02P20/52
摘要： PURPOSE: To prepare the titled compound having excellent stereospecificity, in high yield, with easy operation and simple apparatus, in short steps, by contacting 12-(2-tetrahydropyranyloxy)-cis-9-dodecenoic acid alkyl ester (novel compound) with an acid catalyst.
CONSTITUTION: The objective compound of formula III having a cis-ratio of ≥93% is prepared in a yield of as high as ≥80%, by contacting 8-formyloctanoic acid alkyl ester of formula I (R is lower alkyl) with 3-tetrahydropyranyl-oxypropylene triphenyl phosphorane in an organic solvent to obtain 12-(2-tetrahydropyranyloxy)-cis-9-dedecenoic acid alkyl ester of formula II (a novel compound) in high yield and purity, and contacting the compound with an acid catalyst at 5W80°C for 0.5W24hr preferably in an alcohol solvent.
USE: Synthetic intermediate for 9-dodecen-12-olide which is known as a perfumery component of citron having a sweet mint-note fruity smell.
COPYRIGHT: (C)1983,JPO&Japio
摘要翻译：目的：通过使12-（2-四氢吡喃氧基） - 顺式-9-十二碳烯酸烷基酯（新化合物）与一种具有极性立体定向性的化合物酸催化剂。构成：通过使式I（R为低级烷基）的8-甲酰辛酸烷基酯与（R 3为低级烷基）的8-甲酸辛酸烷基酯与 3-四氢吡喃基 - 氧代亚丙基三苯基正膦在有机溶剂中，以高产率和纯度得到式II的12-（2-四氢吡喃氧基） - 顺式-9-十一碳烯酸烷基酯（新化合物），并使该化合物与酸催化剂在5-80℃下反应0.5-24小时，优选在醇溶剂中。用途：9-dodecen-12-olide的合成中间体，被称为柚子的香料成分，具有甜美的薄荷味果味。

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