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1. 发明专利

JP2014214139A ＮＡＤＨ産生促進剤审中-公开
标题翻译： NADH生产促销
公开(公告)号：JP2014214139A
公开(公告)日：2014-11-17
申请号：JP2013094671
申请日：2013-04-26
申请人：ポーラ化成工業株式会社 , Pola Chem Ind Inc , 株式会社キルトプランニングオフィス , Kiruto Planning Office:Kk
发明人： TASHIRO KANAE , SHISHIDO MAYUMI , GOMI TAKAMASA , TADA AKIHIRO , TOYOHISA SHOZO , KITAHATA MANA
IPC分类号： A61K8/97 , A61K36/18 , A61P17/00 , A61Q19/00
CPC分类号： A61K8/97 , A61Q19/00
摘要：【課題】皮膚外用剤として好適な、優れたNADH産生促進剤を提供することを課題とする。【解決手段】ユキノシタ科アジサイ属アマチャの抽出物を、NADH産生促進剤の有効成分とする。【選択図】図4
摘要翻译：要解决的问题：提供适合于皮肤外用制剂的优异的NADH生产促进剂。解决方案：NADH生产促进剂包括甜花生叶，绣球花，八卦科的提取物作为活性成分。

2. 发明专利

JP2004089617A Distinguishing method for turbulence of corium collagen fiber bundle 审中-公开
公开(公告)号：JP2004089617A
公开(公告)日：2004-03-25
申请号：JP2002258736
申请日：2002-09-04
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： OBA AI , NISHIMORI YASUTOMO , GOMI TAKAMASA
IPC分类号： A61B5/00
摘要： PROBLEM TO BE SOLVED: To provide a means to non-invasively distinguish a corium collagen fiber bundle in real time.
SOLUTION: A corium collagen fiber bundle structure is distinguished using characteristics of stress variation of the skin surface against compression by external force, such as a pattern of stress variation from the maximum stress at the compression finishing to stress at relaxation finishing in processes of compressing and relaxing the skin surface, as an index. As characteristics of stress variation, a stress relaxation time in characteristics of a pattern of stress variation from the maximum stress at compression finishing to stress at relaxation finishing in processes to compress and to relax the skin surface is used. In such a measurement, a resiliometer is used.
COPYRIGHT: (C)2004,JPO

3. 发明专利

JP2006129758A Animal model for hypertrophic scar 有权
标题翻译：动物模型为高血压病
公开(公告)号：JP2006129758A
公开(公告)日：2006-05-25
申请号：JP2004321368
申请日：2004-11-05
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： KITAJIMA HIROYUKI , NISHIMORI YASUTOMO , GOMI TAKAMASA , TAKEUCHI HIROTAKA , SHISHIDO MAYUMI
IPC分类号： A01K67/027 , A61K45/00 , A61P17/02 , G01N33/15 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide an animal model for hypertrophic scar when screening medicines for hypertrophic scar.
SOLUTION: The animal model for hypertrophic scar is produced by cutting a part of the skin of a rodent with a depth for cutting cutaneous muscle with a sufficient length to observe and breeding for 100 days. The rodent is preferably a rat and the rat is preferably a SD rat or a HWY hairless rat. The rat is applied to a test as a model after cut the cutaneous muscle and ensured that, monitoring the level of the hyperplasia with a replica of the treated position, the volume of the replica increases about 4 times of that of wound forming stage. The hypertrophic scar medicine can be evaluated by coating a specimen on a hypertrophic scar of a model animal for hypertrophic scar and observing decrease thereof.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为筛选肥厚性瘢痕的药物提供肥大性瘢痕的动物模型。解决方案：肥大性瘢痕的动物模型是通过切割具有足够长度的切割皮肤肌肉的深度的啮齿动物的一部分皮肤来观察和育种100天来产生的。啮齿动物优选为大鼠，大鼠优选为SD大鼠或HWY无毛大鼠。大鼠在剪切皮肤肌肉后作为模型进行试验，确保用处理位置的复制物监测增生水平，复制体积增加约4倍于伤口形成阶段。肥厚性瘢痕药物可以通过在模型动物肥大性瘢痕上涂覆一个标本进行肥大性瘢痕评估，并观察其减少。版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2014171441A Screening method of wrinkle formation inhibitor and/or anti-inflammatory agent 有权
标题翻译：皱纹形成抑制剂和/或抗炎剂的筛选方法
公开(公告)号：JP2014171441A
公开(公告)日：2014-09-22
申请号：JP2013047508
申请日：2013-03-11
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： GOMI TAKAMASA , YO KAZUYUKI , SHISHIDO MAYUMI
IPC分类号： C12Q1/02 , A61K8/96 , A61Q19/00 , A61Q19/08 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a screening method for searching for a novel active ingredient toward a development of a cosmetic which inhibit the forming of wrinkles/sags by a novel mechanism which provides a high efficacy.SOLUTION: A method comprises a step for applying loading pressure to epidermal cells from the side face direction, and screens a wrinkle formation inhibitor and/or an anti-inflammatory agent by making activity of an inflammatory factor released from the epidermal cells into an index. The activity of the inflammatory factor is shown by an expression amount of encoded protein, which constitutes the inflammatory factor in cells to which a test substance is added, and is compared with one in cells to which a test substance is not added.
摘要翻译：要解决的问题：提供一种筛选方法，用于通过提供高效率的新颖机制来抑制皱纹/松弛形成的化妆品发展中寻找新的活性成分。解决方案：一种方法包括施加步骤从侧面方向对表皮细胞施加压力，通过使表皮细胞释放的炎性因子的活性成为指标，筛选皱纹形成抑制剂和/或抗炎剂。炎症因子的活性由编码的蛋白质的表达量表示，其构成添加了被测物质的细胞中的炎症因子，并与未添加测试物质的细胞中的炎症因子进行比较。

5. 发明专利

JP2010271163A Method of evaluating skin condition 有权
标题翻译：评估皮肤状况的方法
公开(公告)号：JP2010271163A
公开(公告)日：2010-12-02
申请号：JP2009122819
申请日：2009-05-21
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： TADA AKIHIRO , NISHIKAWA KAZUKO , GOMI TAKAMASA
IPC分类号： G01N33/50 , A61K8/97 , A61Q19/08 , G01N33/52 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide a method of evaluating a skin condition easily and quantitatively so that the method is applied to cosmetics, or the like, and to provide a method of selecting cosmetics using the evaluation method. SOLUTION: The method of evaluating a skin condition, such as epidermal elasticity and/or a skin surface form (average roughness: Ra), easily and quantitatively is found by focusing attention on the content of AGEs in a horny layer for applying to the method of selecting cosmetics utilizing the evaluation method, thus solving the problems. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供容易且定量地评价皮肤状况的方法，以便将该方法应用于化妆品等，并提供使用评价方法选择化妆品的方法。解决方案：通过将注意力集中在用于施加的角质层中的AGE的含量上，可以容易地和定量地评估皮肤状况如表皮弹性和/或皮肤表面形式（平均粗糙度：Ra）的方法涉及使用评价方法选择化妆品的方法，从而解决问题。版权所有（C）2011，JPO＆INPIT

6. 发明专利

JP2017112892A 皮膚老化抑制素材のスクリーニング方法审中-公开
公开(公告)号：JP2017112892A
公开(公告)日：2017-06-29
申请号：JP2015251164
申请日：2015-12-24
申请人：ポーラ化成工業株式会社 , Pola Chem Ind Inc
发明人： GOMI TAKAMASA , TAKEUCHI HIROTAKA , OISHI TAKAYA
IPC分类号： C12Q1/68 , C12Q1/02
摘要：【課題】LOC100292680の発現量を指標とした、皮膚老化抑制素材をスクリーニングする新たな方法を提供することを課題とする。【解決手段】加齢に伴い発現量が減少するLOC100292680の発現量が、被験物質を添加しなかった細胞におけるLOC100292680の発現量と、被験物質を添加した細胞におけるLOC100292680の発現量を比較して、発現量が増加した被験物質を選択するステップ、を含む、皮膚老化抑制素材のスクリーニング方法により課題を解決する。【選択図】図1

7. 发明专利

JP2004267244A Evaluation method of wrinkle 审中-公开
标题翻译：皱纹的评价方法
公开(公告)号：JP2004267244A
公开(公告)日：2004-09-30
申请号：JP2003058110
申请日：2003-03-05
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： GOMI TAKAMASA , NISHIMORI YASUTOMO , HIYAMA NAOKI , SHISHIDO MAYUMI
IPC分类号： G01B11/02 , A61B5/107 , A61B5/117 , G01N21/17
摘要： PROBLEM TO BE SOLVED: To provide a quantitative evaluation method of wrinkle by two-dimensionalizing the image of a part formed with the wrinkle, extracting the part of the wrinkle from the two-dimensional image, non-visualizing the image other than the wrinkle, converting the shape of the wrinkle part into a physical quantity and comparing physical quantities for every individual. SOLUTION: This evaluation method of the wrinkle formed on an animal two-dimensionalizes the image of the part formed with the wrinkle, extracts the part of the wrinkle from the two-dimensional image, non-visualizes the image of the part other than the wrinkle, converts the shape of the wrinkle into the physical quantity and compares the physical quantities for every individual. A favorably citable two-dimensionalizing means is photography or the like. A favorably citable means which extracts the wrinkle part, non-visualizes the image other than the part of the wrinkle and converts the shape of the wrinkle into the physical quantity is a method of putting a transparent and/or translucent sheet on a photography, copying the part of the wrinkle on the transparent and/or translucent sheet, and measuring the length of a taken line segment. COPYRIGHT: (C)2004,JPO&NCIPI
摘要翻译：要解决的问题：为了通过对形成有皱纹的部分的图像进行二维化来提供皱纹的定量评估方法，从二维图像中提取部分褶皱，不可视化图像以外的图像皱纹，将皱纹部分的形状转换成物理量，并比较每个人的物理量。解决方案：这种在动物上形成的皱纹的评估方法使形成皱纹的部分的图像二维化，从二维图像中提取部分皱纹，使其他部分的图像不可视化比皱纹，将皱纹的形状转换成物理量，并比较每个人的物理量。有利地可引用的二维化装置是摄影等。有利的可引用方式是提取皱纹部分，除皱部分以外的图像不可视化，并将皱纹的形状转换成物理量是将透明和/或半透明片材放置在摄影，复印透明片和/或半透明片上的部分褶皱，并测量所取线段的长度。版权所有（C）2004，JPO＆NCIPI

8. 发明专利

JP2013099305A Method for screening anti-aging agent 有权
标题翻译：筛选抗老化剂的方法
公开(公告)号：JP2013099305A
公开(公告)日：2013-05-23
申请号：JP2011246023
申请日：2011-11-10
申请人： Pola Chemical Industries Inc , ポーラ化成工業株式会社
发明人： TASHIRO KANAE , GOMI TAKAMASA
IPC分类号： C12Q1/02 , A23L1/30 , A61K8/97 , A61K36/00 , A61K36/18 , A61K36/53 , A61K36/73 , A61K45/00 , A61P43/00 , A61Q19/08 , C12N5/071
摘要： PROBLEM TO BE SOLVED: To discover a superior anti-aging agent, above all, an agent for preventing or improving wrinkle formation, and establish a method capable of efficiently evaluating such anti-aging agent with good accuracy.SOLUTION: A component including an excellent anti-aging agent (preventive or improving agent for wrinkle formation) can be simply selected with good accuracy by bringing an autophagy activation effect, above all, the activation effect of the decomposition process of a cytoplasm component after autophagosome formation to be an index. Furthermore, the composition containing such component expresses an excellent anti-aging effect (preventive or improving effect to wrinkle formation).
摘要翻译：要解决的问题：为了发现优异的抗老化剂，首先是用于防止或改善皱纹形成的试剂，并且建立能够以高精度有效评价这种抗老化剂的方法。解决方案：通过引入自噬激活效应，尤其是细胞质分解过程的活化作用，可以简单地选择包含优异的抗衰老剂（皱纹形成的预防或改善剂）的成分，具有良好的精度。自噬体形成后的成分为指标。此外，含有该组分的组合物表现出优异的抗衰老作用（预防或改善皱纹形成的效果）。版权所有（C）2013，JPO＆INPIT

9. 发明专利

JP2011011981A Cosmetic 审中-公开
标题翻译：化妆品
公开(公告)号：JP2011011981A
公开(公告)日：2011-01-20
申请号：JP2009154495
申请日：2009-06-30
申请人： Pola Chemical Industries Inc , ポーラ化成工業株式会社
发明人： TADA AKIHIRO , NISHIKAWA KAZUKO , GOMI TAKAMASA
IPC分类号： A61K36/48 , A61K8/97 , A61P17/00 , A61P43/00 , A61Q19/00 , A61Q19/02 , A61Q19/08 , G01N33/50 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide an advanced glycation endproducts (AGEs)-degrading agent in new horny layers, which contains a plant extract as an active ingredient and is suitable for preventing or improving skin-aging phenomena such as the collapse of collagen fiber bundle structures, the formation of wrinkles, the formation of skin slacking, the formation of skin drabness, the deterioration of epidermal elasticity, the change of skin surface conditions, and the like.SOLUTION: The AGEs-degrading agent comprises a plant extract obtained from a plant belonging to genus Astragalus in Leguminosae, such as Astragalus sinicus.
摘要翻译：要解决的问题：提供新的角质层中的高级糖基化终产物（AGEs）降解剂，其含有植物提取物作为活性成分，并且适合于预防或改善皮肤老化现象，例如胶原纤维束的塌陷结构，皱纹的形成，皮肤松弛的形成，皮肤涩味的形成，表皮弹性的变差，皮肤表面状况的变化等。解决方案：AGEs降解剂包括从属于豆科的黄芪属植物，如黄芪。

10. 发明专利

JP2011246354A Skin external preparation 审中-公开
标题翻译：皮肤外用制剂
公开(公告)号：JP2011246354A
公开(公告)日：2011-12-08
申请号：JP2010117865
申请日：2010-05-22
申请人： Pola Chemical Industries Inc , ポーラ化成工業株式会社
发明人： GOMI TAKAMASA
IPC分类号： A61K8/97 , A61K8/63 , A61K8/67 , A61Q19/00 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To provide a skin external preparation suitable for cosmetics for skin beautifying.SOLUTION: The skin external preparation comprises: (1) advanced glycation end-products (AGEs) decomposers; and (2) anti-wrinkle agents. For example, the AGEs decomposers are extracts from plants belonging to the Olea genus of the Oleaceae family, the Saxifraga genus of the Saxifragaceae family, the Potentilla genus of the Rosaceae family, the Aspalathus genus of the Fabaceae family, the Filipendula genus of the Rosaceae family, the Artemisia genus of the Asteraceae family, and the Astragalus genus of the Fabaceae family. Suitable examples of the anti-wrinkle agents are Vitamin A, derivatives and/or pharmacologically acceptable salts thereof, triterpenic acid, derivatives and/or pharmacologically acceptable salts thereof, and plant extracts having corium collagen fiber bundle reconstruction effect.
摘要翻译：要解决的问题：提供适于皮肤美化的化妆品的皮肤外用制剂。皮肤外用剂包括：（1）晚期糖基化终产物（AGEs）分解剂; 和（2）抗皱剂。例如，AGEs分解剂是属于Oleaceae家族的Olea属的植物提取物，Saxifragaceae科的Saxifraga属，蔷薇科的Potentilla属，豆科科的Aspalathus属，蔷薇科的Filipendula属家庭，菊科的艾蒿属和豆科科的黄芪属。抗皱剂的合适实例是维生素A，其衍生物和/或其药理学上可接受的盐，三萜酸，其衍生物和/或其药理学上可接受的盐，以及具有corium胶原纤维束重建效果的植物提取物。版权所有（C）2012，JPO＆INPIT

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