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1. 发明专利

JP2006129758A Animal model for hypertrophic scar 有权
标题翻译：动物模型为高血压病
公开(公告)号：JP2006129758A
公开(公告)日：2006-05-25
申请号：JP2004321368
申请日：2004-11-05
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： KITAJIMA HIROYUKI , NISHIMORI YASUTOMO , GOMI TAKAMASA , TAKEUCHI HIROTAKA , SHISHIDO MAYUMI
IPC分类号： A01K67/027 , A61K45/00 , A61P17/02 , G01N33/15 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide an animal model for hypertrophic scar when screening medicines for hypertrophic scar.
SOLUTION: The animal model for hypertrophic scar is produced by cutting a part of the skin of a rodent with a depth for cutting cutaneous muscle with a sufficient length to observe and breeding for 100 days. The rodent is preferably a rat and the rat is preferably a SD rat or a HWY hairless rat. The rat is applied to a test as a model after cut the cutaneous muscle and ensured that, monitoring the level of the hyperplasia with a replica of the treated position, the volume of the replica increases about 4 times of that of wound forming stage. The hypertrophic scar medicine can be evaluated by coating a specimen on a hypertrophic scar of a model animal for hypertrophic scar and observing decrease thereof.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为筛选肥厚性瘢痕的药物提供肥大性瘢痕的动物模型。解决方案：肥大性瘢痕的动物模型是通过切割具有足够长度的切割皮肤肌肉的深度的啮齿动物的一部分皮肤来观察和育种100天来产生的。啮齿动物优选为大鼠，大鼠优选为SD大鼠或HWY无毛大鼠。大鼠在剪切皮肤肌肉后作为模型进行试验，确保用处理位置的复制物监测增生水平，复制体积增加约4倍于伤口形成阶段。肥厚性瘢痕药物可以通过在模型动物肥大性瘢痕上涂覆一个标本进行肥大性瘢痕评估，并观察其减少。版权所有（C）2006，JPO＆NCIPI

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