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1. 发明专利

JP2011011981A Cosmetic 审中-公开
标题翻译：化妆品
公开(公告)号：JP2011011981A
公开(公告)日：2011-01-20
申请号：JP2009154495
申请日：2009-06-30
申请人： Pola Chemical Industries Inc , ポーラ化成工業株式会社
发明人： TADA AKIHIRO , NISHIKAWA KAZUKO , GOMI TAKAMASA
IPC分类号： A61K36/48 , A61K8/97 , A61P17/00 , A61P43/00 , A61Q19/00 , A61Q19/02 , A61Q19/08 , G01N33/50 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide an advanced glycation endproducts (AGEs)-degrading agent in new horny layers, which contains a plant extract as an active ingredient and is suitable for preventing or improving skin-aging phenomena such as the collapse of collagen fiber bundle structures, the formation of wrinkles, the formation of skin slacking, the formation of skin drabness, the deterioration of epidermal elasticity, the change of skin surface conditions, and the like.SOLUTION: The AGEs-degrading agent comprises a plant extract obtained from a plant belonging to genus Astragalus in Leguminosae, such as Astragalus sinicus.
摘要翻译：要解决的问题：提供新的角质层中的高级糖基化终产物（AGEs）降解剂，其含有植物提取物作为活性成分，并且适合于预防或改善皮肤老化现象，例如胶原纤维束的塌陷结构，皱纹的形成，皮肤松弛的形成，皮肤涩味的形成，表皮弹性的变差，皮肤表面状况的变化等。解决方案：AGEs降解剂包括从属于豆科的黄芪属植物，如黄芪。

2. 发明专利

JP2010088654A Method of discrimination among skin type by skin physiological index 审中-公开
标题翻译：通过皮肤生理指标分析皮肤类型的方法
公开(公告)号：JP2010088654A
公开(公告)日：2010-04-22
申请号：JP2008261536
申请日：2008-10-08
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： AKAMATSU TAKASHI , MIZUKOSHI KOJI , NISHIKAWA KAZUKO
IPC分类号： A61B5/00 , A61B5/107
摘要： PROBLEM TO BE SOLVED: To provide a method of accurate discrimination among skin properties or phenomenal characteristics such as skin barrier function, oily skin phenomena, skin care effects, etc., using the skin physiological indexes of sebum volume or the like.
SOLUTION: A skin discrimination method for skin barrier function is characterized by the use of an index of TEWL (Trans Epidermal Water Loss) estimated based on the area and volume of sebum in sampled horny layer cells, a skin discrimination method for skin care execution time is characterized by the use of an index of the shiny face skin area after wash, and a skin discrimination method for skin care effects is characterized by the use of an index of sebum volume sampled from skin. The method of discrimination among skin includes the methods.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供使用皮脂量等的皮肤生理指标来提供皮肤特性或皮肤屏障功能，油性皮肤现象，护肤效果等现象特征之间的准确区别的方法。皮肤屏障功能的皮肤鉴别方法的特征在于使用基于采样角质层细胞中皮脂面积和体积的TEWL（Trans Epidermal Water Loss）指数，皮肤鉴别方法护理执行时间的特征在于使用洗脸后的光泽面部皮肤区域的指标，并且皮肤识别方法的皮肤护理效果的特征在于使用从皮肤采集的皮脂量指数。皮肤鉴别方法包括方法。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2003081747A Extension inhibitor of dendrite of melanocyte and cosmetic containing the same 审中-公开
标题翻译：含有它们的墨西哥渗透剂和化妆品的扩展抑制剂
公开(公告)号：JP2003081747A
公开(公告)日：2003-03-19
申请号：JP2001275851
申请日：2001-09-12
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： SAEKI YUKO , TADA AKIHIRO , KANAMARU AKIKO , NISHIKAWA KAZUKO , SUZUKI SATOSHI , SAITO YUKO
IPC分类号： A61K8/96 , A61K8/00 , A61K8/97 , A61K36/00 , A61P17/16 , A61P43/00 , A61Q19/00 , A61Q19/02 , A61K7/00 , A61K7/48 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a preventing or ameliorating means effective for pigment anomaly accompanying inflammation and pigment anomaly such as freckle.
SOLUTION: An excellent bleaching cosmetic for dealing with skin- melanization phenomena associated with a melanocyte and a macrophage is provided by making a skin care preparation such as the cosmetic contain an essence of Lonicera japonica Thunb or Lonicera confuse DC. of Caprifoliaceae or Loniceraceae, preferably the essence of bubs, leaves and stems, having excellent activities for inhibiting the extension of a dendrite of the melanocyte.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：提供一种有效的色素异常伴随炎症和颜料异常如雀斑的预防或改善手段。解决方案：通过制备皮肤护理制剂如化妆品含有金银花（Lonicera japonica Thunb）或忍冬（Donicera）混淆DC的精华，提供了用于处理与黑素细胞和巨噬细胞相关的皮肤黑化现象的优异的漂白化妆品。（Caprifoliaceae）或忍冬科（Lonicaceae），优选是泡沫，叶子和茎的本质，具有优异的抑制黑素细胞枝晶延伸的活性。

4. 发明专利

JP2003081748A Extension inhibitor of dendrite of melanocyte and cosmetic containing the same 审中-公开
标题翻译：含有它们的墨西哥渗透剂和化妆品的扩展抑制剂
公开(公告)号：JP2003081748A
公开(公告)日：2003-03-19
申请号：JP2001275881
申请日：2001-09-12
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： SAEKI YUKO , TADA AKIHIRO , KANAMARU AKIKO , NISHIKAWA KAZUKO , SUZUKI SATOSHI , SAITO YUKO
IPC分类号： A61K8/96 , A61K8/00 , A61K8/97 , A61K31/56 , A61K36/18 , A61P17/16 , A61Q19/00 , A61K7/00 , A61K7/48 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a preventing or ameliorating means effective for pigment anomaly accompanying inflammation and pigment anomaly such as freckle.
SOLUTION: An excellent bleaching cosmetic for dealing with skin- melanization phenomena associated with a melanocyte and a macrophage is provided by making a skin care preparation such as the cosmetic contain an essence of Forsythia suspensa Thunb. vahl of Oleaceae, preferably the essence of a fruit, having excellent activities for inhibiting the extension of a dendrite of the melanocyte.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：提供一种有效的色素异常伴随炎症和颜料异常如雀斑的预防或改善手段。解决方案：通过使护肤品如化妆品含有连翘的精华，提供了用于处理与黑素细胞和巨噬细胞相关的皮肤黑化现象的优异的漂白化妆品。油菜科的叶子，优选水果的本质，具有极好的抑制黑素细胞枝晶延伸的活性。

5. 发明专利

JP2005306767A Skin care preparation for external use for summer 有权
标题翻译：用于夏季外用的皮肤护理准备
公开(公告)号：JP2005306767A
公开(公告)日：2005-11-04
申请号：JP2004124891
申请日：2004-04-21
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： TADA AKIHIRO , KANAMARU AKIKO , SAEKI YUKO , NISHIKAWA KAZUKO
IPC分类号： A61K8/00 , A61K8/30 , A61K8/96 , A61K8/97 , A61P17/00 , A61Q19/00 , A61K7/48
摘要： PROBLEM TO BE SOLVED: To provide a technique for sufficiently enhancing the melamine production-inhibiting effect of an ascorbic acid compound.
SOLUTION: The subject skin care preparation for external use is characterized by containing (1) ascorbic acid and/or its derivative and (2) centaureidine having a chemical structure of the formula and/or its salt in an amount of 0.001 to 1 mass %. The ascorbic acid and/or its derivative are preferably an ascorbic acid phosphate, ascorbic acid-2-glucoside or its salt. The centaureidine is preferably prepared by subjecting an alcohol extract of a plant in the family Compositae to a solution extraction using ethyl acetate and water, concentrating the ethyl acetate phase, and then subjecting the concentrated phase to a fractional purification with column chromatography using silica gel as a carrier. The plant in the Compositae includes Achilea millefolium, Centaurea cyanus, Tanacetum parthenium, Acroptilon repens, Smallanthus sonchifolius, Lepidium meyenii, and Eupatorium rebaudianum.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供一种充分提高抗坏血酸化合物的三聚氰胺抑制作用的技术。解决方案：外用皮肤护理制剂的特征在于含有（1）抗坏血酸和/或其衍生物，和（2）具有下式化学结构和/或其盐的中心定胺量为0.001至 1质量％。抗坏血酸和/或其衍生物优选为抗坏血酸磷酸酯，抗坏血酸-2-葡萄糖苷或其盐。百里酚胺优选通过使用乙酸乙酯和水进行溶液萃取，使乙酸乙酯相浓缩，然后使用硅胶作为分馏纯化的浓缩相进行部分纯化，制备菊科科植物的醇提取物，承运人菊科植物包括Achilea millefolium，Centaurea cyanus，Tanacetum parthenium，Acroptilon repens，Smallanthus sonchifolius，Lepidium meyenii和Eupatorium rebaudianum。版权所有（C）2006，JPO＆NCIPI

6. 发明专利

JP2005002056A Dendrite growth promoter of melanocyte, and cosmetic containing the same 审中-公开
标题翻译： MENANOCYTE的生长发育促进剂和含有它的化妆品
公开(公告)号：JP2005002056A
公开(公告)日：2005-01-06
申请号：JP2003167909
申请日：2003-06-12
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： KANAMARU AKIKO , TADA AKIHIRO , SAEKI YUKO , NISHIKAWA KAZUKO
IPC分类号： C07D311/86 , A61K8/00 , A61K8/49 , A61K8/96 , A61K8/97 , A61K31/352 , A61K36/18 , A61P17/00 , A61P43/00 , A61Q19/00 , A61K7/00 , A61K7/48 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a means for promoting the growth of a dendrite of a melanocyte, promoting melanin transfer and preventing cell death of the melanocyte. SOLUTION: A skin care preparation for external use such as a cosmetic contains a dendrite growth promoter of the melanocyte, comprising a chitosan derivative represented by formula (1) (wherein, R1, R2, R3, R4 and R5 are each independently hydroxy group in which the hydrogen atom may be substituted with a 1-4C alkyl group, or a hydrogen atom) or a salt thereof. The skin care preparation for external use is useful for preventing the formation of vitiligo caused by the cell death of the melanocyte by transportation insufficiency of a melanin granule from the melanocyte to a keranocyte, or the amelioration of the vitiligo. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供促进黑素细胞枝晶生长的方法，促进黑素转运并预防黑素细胞的细胞死亡。解决方案：用于外用的护肤品例如化妆品含有黑素细胞的枝晶生长促进剂，其包含由式（1）表示的壳聚糖衍生物（其中，R 1，R 2，R 3，R 4和R 5各自独立地为氢原子可被1-4C烷基取代的羟基或氢原子）或其盐。用于外用的皮肤护理制剂可用于防止黑素细胞的细胞死亡引起的白癜风的形成，其由黑素细胞向角质细胞的黑色素颗粒的运输不全，或白癜风的改善。版权所有（C）2005，JPO＆NCIPI

7. 发明专利

JP2003081807A Extension inhibitor of dendrite of melanocyte and cosmetic comprising the same 审中-公开
标题翻译：墨西哥渗透剂的扩散抑制剂和包含其的化妆品
公开(公告)号：JP2003081807A
公开(公告)日：2003-03-19
申请号：JP2001275903
申请日：2001-09-12
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： SAEKI YUKO , TADA AKIHIRO , KANAMARU AKIKO , NISHIKAWA KAZUKO , SUZUKI SATOSHI , SAITO YUKO
IPC分类号： A61K8/00 , A61K8/02 , A61K8/06 , A61K8/96 , A61K8/97 , A61K36/28 , A61P17/00 , A61P43/00 , A61Q19/00 , A61Q19/02 , A61K7/48 , A61K7/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a bleaching cosmetic suitable as a prophylactic or an ameliorating means effective against dyschromia accompanied with inflammation or dyschromia such as ephelides. SOLUTION: This bleaching cosmetic can be obtained by including an essence of Calendula officinalis L. of the family Compositae, preferably an essence of a flower bud, a leaf and a stem having excellent inhibitory actions on extension of dendrites of melanocytes in a skin care preparation such as a cosmetic. The resultant excellent bleaching cosmetic is responsive to skin blackening phenomena associated with the melanocytes and macrophages.
摘要翻译：要解决的问题：提供一种漂白化妆品，其适合作为预防或改善方法，其有效地防止伴有炎症或色素异常的异色性，例如白介素。解决方案：这种漂白化妆品可以通过包括菊科的金盏花精华，优选花芽的精华，叶和茎对皮肤护理制剂中黑素细胞的树突延伸具有优异的抑制作用而获得如化妆品。所得优异的漂白化妆品对与黑素细胞和巨噬细胞相关的皮肤黑化现象有反应。

8. 发明专利

JP2010271163A Method of evaluating skin condition 有权
标题翻译：评估皮肤状况的方法
公开(公告)号：JP2010271163A
公开(公告)日：2010-12-02
申请号：JP2009122819
申请日：2009-05-21
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： TADA AKIHIRO , NISHIKAWA KAZUKO , GOMI TAKAMASA
IPC分类号： G01N33/50 , A61K8/97 , A61Q19/08 , G01N33/52 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide a method of evaluating a skin condition easily and quantitatively so that the method is applied to cosmetics, or the like, and to provide a method of selecting cosmetics using the evaluation method. SOLUTION: The method of evaluating a skin condition, such as epidermal elasticity and/or a skin surface form (average roughness: Ra), easily and quantitatively is found by focusing attention on the content of AGEs in a horny layer for applying to the method of selecting cosmetics utilizing the evaluation method, thus solving the problems. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供容易且定量地评价皮肤状况的方法，以便将该方法应用于化妆品等，并提供使用评价方法选择化妆品的方法。解决方案：通过将注意力集中在用于施加的角质层中的AGE的含量上，可以容易地和定量地评估皮肤状况如表皮弹性和/或皮肤表面形式（平均粗糙度：Ra）的方法涉及使用评价方法选择化妆品的方法，从而解决问题。版权所有（C）2011，JPO＆INPIT

9. 发明专利

JP2005132784A Method for promoting growth of dendrite of melanocyte 有权
标题翻译：促进葡萄球菌生长发育的方法
公开(公告)号：JP2005132784A
公开(公告)日：2005-05-26
申请号：JP2003371621
申请日：2003-10-31
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： KANAMARU AKIKO , TADA AKIHIRO , SAEKI YUKO , NISHIKAWA KAZUKO
IPC分类号： A61K36/18 , A61P43/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a means for promoting the growth of a dendrite of melanocyte. SOLUTION: A composition for promoting the growth of the dendrite of the melanocyte contains an essence of a plant belonging to the genus Symphytum of Boraginaceae as an active ingredient. The composition for promoting the growth of the dendrite of the melanocyte is obtained by extracting the plant body of the genus Symphytum of the Boraginaceae, preferably the terrestrial part thereof with a polar solvent. The culturing dendrite of the melanocyte is elongated and the states of the dendrites are uniformized by adding the composition to a medium for culturing the melanocyte. COPYRIGHT: (C)2005,JPO&NCIPI

10. 发明专利

JP2005075771A Brightening cosmetic 有权
标题翻译：更好的化妆品
公开(公告)号：JP2005075771A
公开(公告)日：2005-03-24
申请号：JP2003308353
申请日：2003-09-01
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： TADA AKIHIRO , KANAMARU AKIKO , SAEKI YUKO , NISHIKAWA KAZUKO
IPC分类号： C07D311/62 , A61K8/00 , A61K8/33 , A61K8/44 , A61K8/49 , A61K31/195 , A61K31/352 , A61K31/366 , A61K31/375 , A61K31/60 , A61K31/7048 , A61K36/28 , A61P17/00 , A61Q19/00 , A61K7/00 , A61K7/48 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To obtain a material for a brightening cosmetic which suppresses excessive melanin production and exhibits whitening actions while retaining a natural feeling, and to prepare a brightening cosmetic. SOLUTION: A compound (1) represented by formula (1) (wherein R1, R2, R3, R4, R5 and R6 are each independently hydrogen atom or a 1-4C alkyl group; and R7, R8 and R9 are each independently hydrogen atom, hydroxy group or a 1-4C alkyloxy group) and/or a salt thereof and one or more (2) selected from among ascorbic acid, its derivatives and salts thereof, glucosides of hydroquinone and salts thereof, 4-methylsalicylic acid and salts thereof, tranexamic acid and salts thereof, and ellagic acid and salts thereof are incorporated into a skin care preparation for external use. As the compound represented by formula (1), centaureidin represented by formula (2) is preferably exemplified. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：获得抑制过量黑色素生成并在保持自然感的同时发挥美白作用并制备增亮化妆品的增白化妆品的材料。解决方案：由式（1）表示的化合物（1）（其中R 1，R 2，R 3，R 4，R 5和R 6各自独立地为氢原子或1-4C烷基;并且R 7，R 8和R 9各自为独立的氢原子，羟基或1-4C烷氧基）和/或其盐和选自抗坏血酸，其衍生物和盐中的一种或多种（2），氢醌的糖苷及其盐，4-甲基水杨酸其盐，氨甲环酸及其盐，鞣花酸及其盐掺入外用皮肤护理制剂中。作为由式（1）表示的化合物，优选举出式（2）表示的代卡毒素。版权所有（C）2005，JPO＆NCIPI

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