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1. 发明专利

JP2017112918A 皮下組織構造の改善成分のスクリーニング方法审中-公开
公开(公告)号：JP2017112918A
公开(公告)日：2017-06-29
申请号：JP2015252345
申请日：2015-12-24
申请人：ポーラ化成工業株式会社 , Pola Chem Ind Inc
发明人： SAKATA AYA , SHISHIDO MAYUMI , HARADA YASUKO
IPC分类号： C12Q1/68 , C12Q1/02
摘要：【課題】皮下組織構造の改善成分の新規なスクリーニング方法を提供する。【解決手段】細胞における皮膚支帯成分の発現量を指標として、皮下組織構造の改善成分をスクリーニングする。【選択図】なし

2. 发明专利

JP2014171441A Screening method of wrinkle formation inhibitor and/or anti-inflammatory agent 有权
标题翻译：皱纹形成抑制剂和/或抗炎剂的筛选方法
公开(公告)号：JP2014171441A
公开(公告)日：2014-09-22
申请号：JP2013047508
申请日：2013-03-11
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： GOMI TAKAMASA , YO KAZUYUKI , SHISHIDO MAYUMI
IPC分类号： C12Q1/02 , A61K8/96 , A61Q19/00 , A61Q19/08 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a screening method for searching for a novel active ingredient toward a development of a cosmetic which inhibit the forming of wrinkles/sags by a novel mechanism which provides a high efficacy.SOLUTION: A method comprises a step for applying loading pressure to epidermal cells from the side face direction, and screens a wrinkle formation inhibitor and/or an anti-inflammatory agent by making activity of an inflammatory factor released from the epidermal cells into an index. The activity of the inflammatory factor is shown by an expression amount of encoded protein, which constitutes the inflammatory factor in cells to which a test substance is added, and is compared with one in cells to which a test substance is not added.
摘要翻译：要解决的问题：提供一种筛选方法，用于通过提供高效率的新颖机制来抑制皱纹/松弛形成的化妆品发展中寻找新的活性成分。解决方案：一种方法包括施加步骤从侧面方向对表皮细胞施加压力，通过使表皮细胞释放的炎性因子的活性成为指标，筛选皱纹形成抑制剂和/或抗炎剂。炎症因子的活性由编码的蛋白质的表达量表示，其构成添加了被测物质的细胞中的炎症因子，并与未添加测试物质的细胞中的炎症因子进行比较。

3. 发明专利

JP2010195723A Skin condition restoration promoter 审中-公开
标题翻译：皮肤状态恢复促销
公开(公告)号：JP2010195723A
公开(公告)日：2010-09-09
申请号：JP2009043505
申请日：2009-02-26
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： KONDO CHIHIRO , SUENOBE NORIKO , SHISHIDO MAYUMI , OIKAWA MIDORI , SAKATA AYA
IPC分类号： A61K8/97 , A61K36/18 , A61P17/02 , A61P17/16 , A61P43/00 , A61Q1/00 , A61Q17/00 , A61Q19/00 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To provide a skin condition restoration promoter containing as an active ingredient a plant essential oil component desirable as an ingredient of a dermatological preparation for external use.
SOLUTION: The skin condition restoration promoter which is a dermatological preparation for external use for skin condition restoration promotion contains as an active ingredient a plant essential oil obtained from a plant belonging to the family Burseraceae and having an acetylcholinesterase inhibiting action and ameliorates morphological changes such as wrinkles and wounds in the skin.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供含有作为外用皮肤病学制剂的成分所需的植物精油成分作为活性成分的皮肤状态恢复促进剂。皮肤状态恢复促进剂作为外用皮肤病恢复促进剂的皮肤病恢复促进剂含有作为活性成分的植物精油，其由属于禾本科植物科的植物获得并具有乙酰胆碱酯酶抑制作用并改善形态学改变如皮肤上的皱纹和伤口。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2005003506A Method for judging influence of object on hair 有权
标题翻译：评估对象对头发的影响的方法
公开(公告)号：JP2005003506A
公开(公告)日：2005-01-06
申请号：JP2003167210
申请日：2003-06-12
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： YAMAMOTO TAKUYA , SHISHIDO MAYUMI
IPC分类号： G01N33/50 , C12Q1/02 , G01N33/15
摘要： PROBLEM TO BE SOLVED: To provide a means properly judging a corresponding mechanism in judgment of thin hair or unhairing due to mechanisms other than testosterone and taking a countermeasure for it.
SOLUTION: The action to the hair of the test object is judged by using a cell cycle of a hair related cell with or without existence of the test object as an index. The cell cycle is discriminated according to a discovery condition of cyclins. As the cyclins, it is preferable to use cyclin A and/or cyclin D1. The expression conditions of the cyclins can be discriminated by using immunocytodyeing or flow cytometry.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种手段，适当地判断由于除了睾酮以外的机制而对细头发进行判断或脱毛的相应机制，并采取对策。解决方案：通过使用具有或不存在测试对象的毛发相关单元的细胞周期作为指标来判断对测试对象的毛发的作用。根据细胞周期蛋白的发现情况区分细胞周期。作为细胞周期蛋白，优选使用细胞周期蛋白A和/或细胞周期蛋白D1。细胞周期蛋白的表达条件可以通过使用免疫细胞染色或流式细胞术来鉴别。版权所有（C）2005，JPO＆NCIPI

5. 发明专利

JP2014214139A ＮＡＤＨ産生促進剤审中-公开
标题翻译： NADH生产促销
公开(公告)号：JP2014214139A
公开(公告)日：2014-11-17
申请号：JP2013094671
申请日：2013-04-26
申请人：ポーラ化成工業株式会社 , Pola Chem Ind Inc , 株式会社キルトプランニングオフィス , Kiruto Planning Office:Kk
发明人： TASHIRO KANAE , SHISHIDO MAYUMI , GOMI TAKAMASA , TADA AKIHIRO , TOYOHISA SHOZO , KITAHATA MANA
IPC分类号： A61K8/97 , A61K36/18 , A61P17/00 , A61Q19/00
CPC分类号： A61K8/97 , A61Q19/00
摘要：【課題】皮膚外用剤として好適な、優れたNADH産生促進剤を提供することを課題とする。【解決手段】ユキノシタ科アジサイ属アマチャの抽出物を、NADH産生促進剤の有効成分とする。【選択図】図4
摘要翻译：要解决的问题：提供适合于皮肤外用制剂的优异的NADH生产促进剂。解决方案：NADH生产促进剂包括甜花生叶，绣球花，八卦科的提取物作为活性成分。

6. 发明专利

JP2013257347A Screening method and antiaging composition 审中-公开
标题翻译：筛选方法和抗菌组合物
公开(公告)号：JP2013257347A
公开(公告)日：2013-12-26
申请号：JP2013201619
申请日：2013-09-27
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： TAKEUCHI HIROTAKA , YO KAZUYUKI , TASHIRO KANAE , SHISHIDO MAYUMI
IPC分类号： G01N33/53 , A61K8/96 , A61K8/97 , A61K45/00 , A61P17/00 , A61P43/00 , A61Q19/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/48 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a screening method capable of accurately and simply selecting an ingredient excellent as a cosmetic basic ingredient (including a quasi-drug), especially an ingredient having an antiaging action based on a new action mechanism.SOLUTION: An ingredient having an antiaging action can be accurately and simply selected by evaluating abnormal conditions of nuclear membranes of a cell being in contact with a material to be inspected and of a cell being in noncontact with the material to be inspected and using a difference between the abnormal conditions of the nuclear membranes of these cells as an index.
摘要翻译：要解决的问题：提供能够准确且简单地选择作为化妆品基础成分（包括准药物）优异成分的筛选方法，特别是基于新的作用机制具有抗衰老作用的成分。解决方案：成分可以通过评价与被检查材料接触的细胞的核膜的异常状态和与待检查材料非接触的细胞的异常情况，并使用异常条件之间的差异，可以准确且简单地选择具有抗衰老作用的抗衰老作用的这些细胞的核膜作为指标。

7. 发明专利

JP2006129758A Animal model for hypertrophic scar 有权
标题翻译：动物模型为高血压病
公开(公告)号：JP2006129758A
公开(公告)日：2006-05-25
申请号：JP2004321368
申请日：2004-11-05
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： KITAJIMA HIROYUKI , NISHIMORI YASUTOMO , GOMI TAKAMASA , TAKEUCHI HIROTAKA , SHISHIDO MAYUMI
IPC分类号： A01K67/027 , A61K45/00 , A61P17/02 , G01N33/15 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide an animal model for hypertrophic scar when screening medicines for hypertrophic scar.
SOLUTION: The animal model for hypertrophic scar is produced by cutting a part of the skin of a rodent with a depth for cutting cutaneous muscle with a sufficient length to observe and breeding for 100 days. The rodent is preferably a rat and the rat is preferably a SD rat or a HWY hairless rat. The rat is applied to a test as a model after cut the cutaneous muscle and ensured that, monitoring the level of the hyperplasia with a replica of the treated position, the volume of the replica increases about 4 times of that of wound forming stage. The hypertrophic scar medicine can be evaluated by coating a specimen on a hypertrophic scar of a model animal for hypertrophic scar and observing decrease thereof.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为筛选肥厚性瘢痕的药物提供肥大性瘢痕的动物模型。解决方案：肥大性瘢痕的动物模型是通过切割具有足够长度的切割皮肤肌肉的深度的啮齿动物的一部分皮肤来观察和育种100天来产生的。啮齿动物优选为大鼠，大鼠优选为SD大鼠或HWY无毛大鼠。大鼠在剪切皮肤肌肉后作为模型进行试验，确保用处理位置的复制物监测增生水平，复制体积增加约4倍于伤口形成阶段。肥厚性瘢痕药物可以通过在模型动物肥大性瘢痕上涂覆一个标本进行肥大性瘢痕评估，并观察其减少。版权所有（C）2006，JPO＆NCIPI

8. 发明专利

JP2010195724A Skin condition restoration promoter 审中-公开
标题翻译：皮肤状态恢复促销
公开(公告)号：JP2010195724A
公开(公告)日：2010-09-09
申请号：JP2009043506
申请日：2009-02-26
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： KONDO CHIHIRO , SUENOBE NORIKO , TAKEUCHI HIROTAKA , SHISHIDO MAYUMI , OIKAWA MIDORI
IPC分类号： A61K36/53 , A61K8/97 , A61P17/00 , A61P17/02 , A61P17/16 , A61P43/00 , A61Q19/00 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To provide a skin condition restoration promoter containing as an active ingredient a plant essential oil component desirable as an ingredient of a dermatological preparation for external use.
SOLUTION: What is provided is a dermatological preparation for external use for skin condition restoration promotion for ameliorating morphological changes such as wrinkles and wounds in the skin which contains as an active ingredient a plant essential oil having both an acetylcholinesterase inhibiting activity and a matrix metalloprotease (MMP) mRNA expression enhancement activity and obtained from one or more plants selected from the plants belonging to the family Lamiaceae.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供含有作为外用皮肤病学制剂的成分所需的植物精油成分作为活性成分的皮肤状态恢复促进剂。解决方案：提供了用于皮肤恢复促进的外用皮肤病学制剂，用于改善皮肤中的形状变化，例如皱纹和伤口，其含有作为活性成分的具有乙酰胆碱酯酶抑制活性的植物精油和基质金属蛋白酶（MMP）mRNA表达增强活性，并且获自一种或多种选自属于家族科植物的植物的植物。版权所有（C）2010，JPO＆INPIT

9. 发明专利

JP2009221153A Complexion improving agent 审中-公开
标题翻译：复合改进剂
公开(公告)号：JP2009221153A
公开(公告)日：2009-10-01
申请号：JP2008067622
申请日：2008-03-17
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： SHISHIDO MAYUMI , SUENOBE NORIKO
IPC分类号： A61K31/437 , A61K8/49 , A61P9/14 , A61P17/00 , A61Q19/00 , C07D471/04
摘要： PROBLEM TO BE SOLVED: To provide a nitrogen monoxide production inhibitor for preventing or improving complexion deterioration caused by nitrogen monoxide production and a skin care preparation that contains the nitrogen monoxide production inhibitor and is suitable for improving complexion.
SOLUTION: The nitrogen monoxide production inhibitor comprises a pyrroloquinoline quinone derivative represented by general formula (1) [wherein R
1 , R
2 and R
3 are each independently a short-chain-length alkyl group, alkenyl group, aralkyl group, alaryl group, phenyl group or a hydrogen atom] and/or its pharmacologically acceptable salt as an active ingredient.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：解决的问题：提供一氧化氮生成抑制剂，用于预防或改善由一氧化氮生成引起的肤色恶化和含有一氧化氮生成抑制剂的皮肤护理制剂，并且适于改善肤色。解决方案：一氧化氮生成抑制剂包括由通式（1）表示的吡咯并喹啉醌衍生物[其中R 1，R 2，R 2和R 3均为氢， / SP>各自独立地为短链长度的烷基，烯基，芳烷基，芳基，苯基或氢原子）和/或其药理学上可接受的盐作为活性成分。版权所有（C）2010，JPO＆INPIT

10. 发明专利

JP2005010089A Method for discriminating hair growth tonic 有权
标题翻译：用于鉴定头发生长的方法
公开(公告)号：JP2005010089A
公开(公告)日：2005-01-13
申请号：JP2003176693
申请日：2003-06-20
申请人： Pola Chem Ind Inc , ポーラ化成工業株式会社
发明人： YAMAMOTO TAKUYA , SHISHIDO MAYUMI
IPC分类号： G01N33/50 , A61K8/00 , A61Q5/00 , A61Q7/00 , G01N33/15 , A61K7/06
摘要： PROBLEM TO BE SOLVED: To accurately discriminate a mechanism in a discrimination of thinning hair and dehairing due to the mechanism except testosterone.
SOLUTION: A manifestation state of cycline T1 in a hair-related cell under the presence and the absence of a specimen, is used for an index, and an influence on the hair due to the specimen is discriminated. The specimen, a hair papilla cell and/or a combined tissue sheath cell coexist on a specimen plate. A vehicle coexists on a control plate. They are synchronously cultured and discriminated by using a compared result of the manifestation state of the cycline T1 as the index.
COPYRIGHT: (C)2005,JPO&NCIPI

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