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1. 发明专利

JP2014159960A Automatic measurement method for spontaneous pain action of chronic pain model animal 审中-公开
标题翻译：慢性疼痛模型动物自发性疼痛的自动测量方法
公开(公告)号：JP2014159960A
公开(公告)日：2014-09-04
申请号：JP2011127801
申请日：2011-06-08
申请人： Astellas Pharma Inc , アステラス製薬株式会社
发明人： YATSUGI SACHIKO , NAGAKURA TOUKI , OGINO SHINICHI , SEKIZAWA TOSHIHIRO , KISO TETSUO
IPC分类号： G01N33/48 , G01N33/15 , G01N33/483 , G01N33/50
CPC分类号： G16H50/50
摘要： PROBLEM TO BE SOLVED: To provide a measurement method for spontaneous pain of a chronic pain model animal, and a screening method for chronic pain therapeutic or preventive agents.SOLUTION: This invention relates to a spontaneous pain measurement method comprising a step of measurements with a device comprising means that detects a magnetic field change according to repetitive actions of a model animal. This invention also relates to a screening method for therapeutic or preventive agents comprising a step of measurements of the number of repetitive actions of a model animal using the method, and selection of a test substance with a reduced number of the repeat actions.
摘要翻译：要解决的问题：提供慢性疼痛模型动物的自发性疼痛的测量方法和慢性疼痛治疗或预防剂的筛选方法。解决方案：本发明涉及一种自发性疼痛测量方法，包括以下步骤：装置，其包括根据模型动物的重复动作来检测磁场变化的装置。本发明还涉及一种用于治疗或预防剂的筛选方法，其包括使用该方法测量模型动物的重复动作次数的步骤，以及选择具有减少的重复动作次数的测试物质。

2. 发明专利

JP2014088326A Polypeptide compound 审中-公开
标题翻译：多肽化合物
公开(公告)号：JP2014088326A
公开(公告)日：2014-05-15
申请号：JP2011035450
申请日：2011-02-22
申请人： Astellas Pharma Inc , アステラス製薬株式会社
发明人： KAYAKIRI NATSUKO , ARAKI TAKANOBU , MAKINO TAKUYA , TOMIJIMA MASANORI , HARAYAMA YU , TANABE DAISUKE , TOJO TAKASHI , NAGAI YASUHITO
IPC分类号： C07K7/64 , A61K38/00 , A61P17/10 , A61P31/10
CPC分类号： C07K7/56 , A61K38/00
摘要： PROBLEM TO BE SOLVED: To provide an antibacterial agent, specifically a new polypeptide compound having antifungal action or the salt thereof.SOLUTION: It has been found that a new antibacterial agent has an excellent antifungal activity when a benzoyl group having a cyclic substituent is introduced in the ortho-position of the carbonyl as a partial structure of a natural polypeptide compound. The polypeptide compound of the present invention has excellent antifungal action and can be used as a preventive and/or therapeutic agent for various fungus infections.
摘要翻译：要解决的问题：提供抗菌剂，特别是提供具有抗真菌作用的新的多肽化合物或其盐。解决方案：已经发现，当引入具有环状取代基的苯甲酰基时，新的抗菌剂具有优异的抗真菌活性在作为天然多肽化合物的部分结构的羰基的邻位。本发明的多肽化合物具有优异的抗真菌作用，可用作各种真菌感染的预防和/或治疗剂。

3. 发明专利

JP2013234194A Method of producing c-glycoside derivative 有权
标题翻译：生产C-谷氨酰胺衍生物的方法
公开(公告)号：JP2013234194A
公开(公告)日：2013-11-21
申请号：JP2013153374
申请日：2013-07-24
申请人： Kotobuki Seiyaku Kk , 壽製薬株式会社 , Astellas Pharma Inc , アステラス製薬株式会社
发明人： TOMIYAMA YASUSHI , YOKOTA MASAYUKI
IPC分类号： C07H15/04
CPC分类号： C07H15/04 , C07H1/00
摘要： PROBLEM TO BE SOLVED: To provide a technology of producing C-glycoside derivatives at high efficiency under industrially advantageous conditions.SOLUTION: C-glycoside derivatives can be produced in a short time and high yield while avoiding an ultra-low temperature reaction when utilizing a coupling reaction using aryl magnesate.
摘要翻译：要解决的问题：提供在工业上有利条件下以高效率生产C-糖苷衍生物的技术。解决方案：可以在短时间和高产量下生产C-糖苷衍生物，同时避免超低温反应使用芳基镁酸酯进行偶联反应。

4. 发明专利

JP2013203415A Packaging box with cushioning function 审中-公开
标题翻译：包装盒具有扣紧功能
公开(公告)号：JP2013203415A
公开(公告)日：2013-10-07
申请号：JP2012072782
申请日：2012-03-28
申请人： Astellas Pharma Inc , アステラス製薬株式会社 , Marukin Insatsu Kk , 丸金印刷株式会社
发明人： TATARA ICHIRO , YOSHIDA SACHIKO , ISHIDA YUU
IPC分类号： B65D5/50
摘要： PROBLEM TO BE SOLVED: To secure stability of a stored object in a partition inside a box, to improve a cushioning function, and to facilitate the assembling of the box and the partition, the work of storing the stored object in the box, and the disposal of the box.SOLUTION: A packaging box integrally includes a partition 2 in front of a box 1, and the partition 2 has a first stored object holding part 22, a coupling part 23, and a second stored object holding part 24, is constituted to be turnable in the box 1 with a center of turning at a folding part between a base part 21 fixed on the front and the first stored object holding part 22 installed consecutively therewith and at a folding part between an attaching piece 26 fixed on the front and the second stored object holding part 24 installed consecutively therewith, and can be folded and assembled on the inside surface on the front.
摘要翻译：要解决的问题：为了确保存储对象在盒子内的分隔件中的稳定性，以改善缓冲功能，并且便于组装盒和分隔件，将存储的对象存储在箱中的工作，以及处理盒子。解决方案：包装盒整体地包括在箱1前面的分隔件2，分隔件2具有第一存储物体保持部分22，联接部分23和第二存储物体保持部分24，是被构造成在盒1中可转动，在固定在前面的基部21和与其连续安装的第一存储物体保持部22之间的折叠部分处转动中心，以及在固定在其上的安装片26之间的折叠部分处前部和第二存储物体保持部分24连续安装，并且可以在前面的内表面上折叠和组装。

5. 发明专利

JP2013184934A Novel salt of oxadiazolidinedione, and crystal thereof 审中-公开
标题翻译：新型盐酸氧化物及其结晶
公开(公告)号：JP2013184934A
公开(公告)日：2013-09-19
申请号：JP2012052161
申请日：2012-03-08
申请人： Astellas Pharma Inc , アステラス製薬株式会社
发明人： NEGORO KENJI , YONETOKU YASUHIRO , YAMAZAKI KOJI , MORINAGA YASUHIRO
IPC分类号： C07D271/06 , A61K31/4245 , A61P3/10
摘要： PROBLEM TO BE SOLVED: To provide a magnesium salt of 2-[(4-{[4'-(2-hydroxyethoxy)-2'-methyl[1,1'-biphenyl]-3-yl]methoxy}phenyl)methyl]-1,2,4-oxadiazolidine-3,5-dione (compound A), more stable, having low moisture absorptivity and excellent in solubility, for using the compound A as a medication or a base thereof; and to provide a crystal of the salt.SOLUTION: It is found as the result of study about various salts of the compound A that the crystal of a specific salt of the compound A is excellent in moisture absorptivity and solubility compared to the crystal of a sodium salt, and besides has excellent physical solid stability and chemical solid stability.
摘要翻译：待解决的问题：提供2 - [（4 - {[4' - （2-羟基乙氧基）-2'-甲基[1,1'-联苯] -3-基]甲氧基}苯基）甲基 ]化合物A作为药物或其碱使用，更稳定，吸湿性低，溶解性好的化合物[1,2] -1,2,4-恶二唑烷-3,5-二酮（化合物A）并提供盐的晶体。解决方案：作为对化合物A的各种盐的研究的结果，发现化合物A的特定盐的结晶与水溶性相比具有优异的吸湿性和溶解性钠盐，此外具有优异的物理固体稳定性和化学固体稳定性。

6. 发明专利

JP2013032291A Fluorescent probe 审中-公开
标题翻译：荧光探针
公开(公告)号：JP2013032291A
公开(公告)日：2013-02-14
申请号：JP2009269447
申请日：2009-11-27
申请人： Kyoto Univ , 国立大学法人京都大学 , Astellas Pharma Inc , アステラス製薬株式会社
发明人： MATSUMOTO KENJI , HIKITA MASAKI , NARUMIYA SHU
IPC分类号： C07D249/16 , C09K11/08 , C09K11/56 , C09K11/88 , G01N33/533
CPC分类号： C07D249/16 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1044 , C09K2211/1059 , C09K2211/1092 , G01N33/582
摘要： PROBLEM TO BE SOLVED: To provide a fluorescent probe capable of being easily synthesized, decreasing nonspecific binding to biological molecule such as cell and being labeled and imaged with good fluorescence intensity, and a method of manufacturing such fluorescent probe.SOLUTION: This fluorescent probe capable of decreasing nonspecific binding to biological molecule such as cell and being labeled and imaged with good fluorescence intensity is obtained by condensing an intermediate obtained by bonding an alkyne derivative of cyclooctane to a fluorescent nano particle such as hydrophilic quantum dot, with a substance which can be bonded to a fluorescently-labeled object introduced with an azide group.
摘要翻译：要解决的问题：提供能够容易合成的荧光探针，降低与生物分子如细胞的非特异性结合，并以良好的荧光强度进行标记和成像，以及制造这种荧光探针的方法。解决方案：通过将通过将环辛烷的炔衍生物键合而获得的中间体与荧光纳米颗粒（例如亲水性）结合，能够降低与生物分子例如细胞的非特异性结合并被标记并具有良好荧光强度成像的荧光探针量子点，可以与可以与引入了叠氮基的荧光标记物接合的物质。版权所有（C）2013，JPO＆INPIT

7. 发明专利

JP2012254939A Oxazole compound 审中-公开
标题翻译：奥沙唑化合物
公开(公告)号：JP2012254939A
公开(公告)日：2012-12-27
申请号：JP2009233048
申请日：2009-10-07
申请人： Astellas Pharma Inc , アステラス製薬株式会社
发明人： INAMI HIROSHI , MIZUTANI TAKESHI , MAEDA JUNKO , USUDA HIROYUKI , NAGASHIMA SHINYA , ITO TOMONORI , AOYAMA NAOHIRO , KONYA TORU , HAYASHIDA HISASHI , TERASAWA TAKESHI , SEO TATSUSHI , AKAMATSU MASAHIKO , ISHIKAWA TAKESHI , HAYASHI KAZUMI
IPC分类号： C07D413/14 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/5377 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/06 , A61P25/00 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D417/14 , C07K14/47 , C12N15/09
CPC分类号： C07D413/14 , C07D417/04 , C07D417/14
摘要： PROBLEM TO BE SOLVED: To provide a new excellent method for prophylaxis and/or treatment of diseases associated with IRAK-4 based on inhibitory effects by interleukin 1 receptor-related kinase 4 (IRAK-4).SOLUTION: It is found that an oxazole carboxylic amide derivative, characterized in that an oxazole, position 2 of which is replaced with a heteroaryl group, is bound to a heteroaryl ring via carboxamide, exhibits strong inhibitory effects for IRAK-4 and thereby is able to be a prophylactic and/or therapeutic agent of diseases associated with IRAK-4 such as inflammatory diseases and autoimmune diseases.
摘要翻译：要解决的问题：基于白细胞介素1受体相关激酶4（IRAK-4）的抑制作用，提供用于预防和/或治疗与IRAK-4相关的疾病的新的优异方法。解决方案：发现恶唑羧酰胺衍生物，其特征在于其2位被杂芳基取代的恶唑通过羧酰胺与杂芳基环结合，对IRAK-4和从而能够成为与IRAK-4相关的疾病如炎性疾病和自身免疫性疾病的预防和/或治疗剂。版权所有（C）2013，JPO＆INPIT

8. 发明专利

JP2012143308A Package for storing one dose of medicine taken on specific day 有权
标题翻译：用于在特定日期存放一次药物的包装
公开(公告)号：JP2012143308A
公开(公告)日：2012-08-02
申请号：JP2011002226
申请日：2011-01-07
申请人： Asahi Printing Co Ltd , Astellas Pharma Inc , アステラス製薬株式会社 , 朝日印刷株式会社
发明人： OIDA TETSUO , HIDAKA TAKASHI , NODA TEPPEI
IPC分类号： A61J7/04 , A61J1/03
摘要： PROBLEM TO BE SOLVED: To provide a package attaining accurate administration management of medicine whose administration date is specified, particularly medicine whose administration interval is long, and enabling a user to easily take out the medicine.SOLUTION: The package P includes a tray 10 holding a PTP sheet 30 having a medicine storage part 32 storing the medicine 31, and an outer case 20 storing the tray 10 and sliding relative to the tray 10. The tray 10 is formed with take-out holes 11a, 12a through which the medicine 31 can be inserted, in a position that overlaps with the medicine storage part 32. The outer case 20 has a window part 21b in a position to allow the medicine storage part 32 to be visually observed, and the medicine 31 taken at a time is stored in the medicine storage part 32.
摘要翻译：要解决的问题：为了提供一种包含给药日期的药物的精确管理的包装，特别是给药间隔长的药物，并且使得使用者能够容易地取出药物。
解决方案：包装P包括托盘10，托盘10保持具有储存药剂31的药物贮存部32的PTP片30，以及存放托盘10并相对于托盘10滑动的外壳20.托架10形成具有可以插入药剂31的取出孔11a，12a与药剂收容部32重叠的位置。外壳20具有窗口部21b，能够使药剂收容部32成为目视观察，一次取药31被储存在药物储存部32中。（C）2012年，JPO＆INPIT

9. 发明专利

JP2012102017A Indole compound 审中-公开
标题翻译： INDOLE化合物
公开(公告)号：JP2012102017A
公开(公告)日：2012-05-31
申请号：JP2009049019
申请日：2009-03-03
申请人： Astellas Pharma Inc , アステラス製薬株式会社
发明人： AZAMI HIDENORI , ABE TOMOAKI , KAKEFUDA AKIO , KONDO YUTAKA , WATANABE KAZUSHI , KAMIKAWA AKIO , YASUDA MINORU
IPC分类号： C07D209/42 , A61K31/404 , A61K31/407 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/55 , A61P13/08 , A61P35/00 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/14 , C07D491/056
CPC分类号： C07D209/42 , C07D401/06 , C07D403/06 , C07D405/14 , C07D491/056
摘要： PROBLEM TO BE SOLVED: To provide a compound for a pharmaceutical composition, useful for example as a therapeutic agent of diseases associated with 17βHSD type 5.SOLUTION: As a result of eager investigation of a compound useful as a therapeutic agent of diseases associated with 17βHSD type 5, it is found that an indole compound having a substituted carbamoyl group at 2-position has a strong inhibitory action on the 17βHSD type 5, and is able to be a therapeutic and/or preventive agent for diseases such as prostatic hypertrophy and prostate cancer associated with the 17βHSD type 5 without accompanied by side effects caused by testosterone reduction.
摘要翻译：待解决的问题：提供用于药物组合物的化合物，其可用作例如与17βHSD型5相关的疾病的治疗剂。解决方案：作为对作为治疗剂有用的化合物的深入研究的结果发现与17βHSD型5相关的疾病药物，发现在2位具有取代的氨基甲酰基的吲哚化合物对17βHSD型5具有很强的抑制作用，并且能够成为疾病的治疗和/或预防剂如与17βHSD5型相关的前列腺肥大和前列腺癌，不伴有由睾酮减少引起的副作用。版权所有（C）2012，JPO＆INPIT

10. 发明专利

JP2011168619A Method for treating cancer by co-administration of anticancer agents 审中-公开
标题翻译：通过联合治疗癌症药物治疗癌症的方法
公开(公告)号：JP2011168619A
公开(公告)日：2011-09-01
申请号：JP2011121330
申请日：2011-05-31
申请人： Astellas Pharma Inc , アステラス製薬株式会社
发明人： NAKAHARA TAKAHITO , YAMANAKA KENTARO , KITA AYA , KAMITOKU HIROSHI
IPC分类号： A61K31/282 , A61K31/497 , A61K31/7068 , A61K33/24 , A61K39/395 , A61P35/00 , A61P43/00
CPC分类号： A61K45/06 , A61K31/337 , A61K31/4745 , A61K31/475 , A61K31/497 , A61K31/655 , A61K31/675 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K33/24 , C07D403/06 , Y10S435/975 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide a companion drug having a good antineoplastic effect.
SOLUTION: The present invention relates to therapeutic compositions containing medicament as an active component, particularly 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazine-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide, and is applied in combination with one or more anticancer agents selected from the group consisting of carboplatin, cisplatin, paclitaxel, vinorelbine, gemcitabine, irinotecan, doxorubicin, and dacarbazine, or a retuximab-containing combination therapy of R-DHAP. The therapeutic compositions are useful for the treatment of cancers, preferably all solid cancers and lymphomas, particularly skin cancer, bladder cancer, breast cancer, uterine cancer, ovary cancer, prostate cancer, lung cancer, colon cancer, pancreas cancer, renal cancer, gastric cancer, and the like. Particularly, they are expected as therapeutic agents for some kinds of cancers which show resistance against other anticancer agents.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供具有良好抗肿瘤效果的伴侣药物。解决方案：本发明涉及含有作为活性成分的药物，特别是1-（2-甲氧基乙基）-2-甲基-4,9-二氧代-3-（吡嗪-2-基甲基）-4， 9-二氢-1H-萘并[2,3-d]咪唑-3-鎓溴化物，并与一种或多种抗癌剂组合使用，所述抗癌剂选自卡铂，顺铂，紫杉醇，长春瑞滨，吉西他滨，伊立替康，多柔比星和达卡巴嗪或含有瑞替西单抗R-DHAP的联合疗法。治疗组合物可用于治疗癌症，优选全部固体癌症和淋巴瘤，特别是皮肤癌，膀胱癌，乳腺癌，子宫癌，卵巢癌，前列腺癌，肺癌，结肠癌，胰腺癌，肾癌，胃癌癌症等。特别地，作为对抗其它抗癌剂的抗性的某些癌症，预期它们是治疗剂。版权所有（C）2011，JPO＆INPIT

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