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1. 发明专利

JP2010254641A Azole carboxamide compound or salt thereof 审中-公开
标题翻译：氨基羧酰胺化合物或其盐
公开(公告)号：JP2010254641A
公开(公告)日：2010-11-11
申请号：JP2009108664
申请日：2009-04-28
申请人： Astellas Pharma Inc , アステラス製薬株式会社
发明人： SUGASAWA KEIZO , KAWAGUCHI KENICHI , MATSUMOTO SHUNICHIRO , NOMURA TAKAO , SHIN TAKASHI , SEO TATSUSHI
IPC分类号： C07D277/20 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61P7/12 , A61P13/02 , A61P13/06 , A61P19/02 , A61P29/00 , A61P43/00 , C07D277/56 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D487/04
摘要： PROBLEM TO BE SOLVED: To provide an agent acting based on an excellent action of inhibiting a trkA receptor and used for treating and/or preventing frequent urination, urinary urgency, and urinary incontinence involved in various lower urinary tract diseases including overactive bladder, various lower-urinary-tract-pain-accompanying lower urinary tract diseases such as interstitial cystitis and chronic prostatitis, and various pain-accompanying diseases. SOLUTION: The present invention has been accomplished as the result of the confirmation that a new azole carboxamide compound in which a thiazole ring or an oxazole ring is bonded to a benzene ring, a pyridine ring, a pyrazole ring, or a like ring through a carboxamide or a salt thereof has potent trkA receptor inhibition activity and of the finding that it has possibility of acting as a highly effective and highly safe agent for treating and/or preventing frequent urination, urinary urgency, and urinary incontinence involved in various lower urinary tract diseases, various lower-urinary-tract-pain-accompanying diseases such as interstitial cystitis and chronic prostatitis, and various pain-accompanying diseases. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种基于抑制trkA受体并用于治疗和/或预防多种下尿路疾病（包括膀胱过度活动症）的尿频，尿急，尿失禁的优异作用的药剂各种下尿路 - 伴有尿道下尿路疾病如间质性膀胱炎和慢性前列腺炎以及各种疼痛伴随疾病。解决方案：作为确认其中噻唑环或恶唑环与苯环，吡啶环，吡唑环等键合的新的唑类甲酰胺化合物，已经证实本发明通过甲酰胺或其盐的环具有有效的trkA受体抑制活性，并且发现其具有作为治疗和/或预防多种参与的尿频，尿急，尿失禁的高度有效和高度安全的作用的可能性下尿路疾病，各种下尿路痛伴随疾病如间质性膀胱炎和慢性前列腺炎，以及各种疼痛伴随疾病。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2012254939A Oxazole compound 审中-公开
标题翻译：奥沙唑化合物
公开(公告)号：JP2012254939A
公开(公告)日：2012-12-27
申请号：JP2009233048
申请日：2009-10-07
申请人： Astellas Pharma Inc , アステラス製薬株式会社
发明人： INAMI HIROSHI , MIZUTANI TAKESHI , MAEDA JUNKO , USUDA HIROYUKI , NAGASHIMA SHINYA , ITO TOMONORI , AOYAMA NAOHIRO , KONYA TORU , HAYASHIDA HISASHI , TERASAWA TAKESHI , SEO TATSUSHI , AKAMATSU MASAHIKO , ISHIKAWA TAKESHI , HAYASHI KAZUMI
IPC分类号： C07D413/14 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/5377 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/06 , A61P25/00 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D417/14 , C07K14/47 , C12N15/09
CPC分类号： C07D413/14 , C07D417/04 , C07D417/14
摘要： PROBLEM TO BE SOLVED: To provide a new excellent method for prophylaxis and/or treatment of diseases associated with IRAK-4 based on inhibitory effects by interleukin 1 receptor-related kinase 4 (IRAK-4).SOLUTION: It is found that an oxazole carboxylic amide derivative, characterized in that an oxazole, position 2 of which is replaced with a heteroaryl group, is bound to a heteroaryl ring via carboxamide, exhibits strong inhibitory effects for IRAK-4 and thereby is able to be a prophylactic and/or therapeutic agent of diseases associated with IRAK-4 such as inflammatory diseases and autoimmune diseases.
摘要翻译：要解决的问题：基于白细胞介素1受体相关激酶4（IRAK-4）的抑制作用，提供用于预防和/或治疗与IRAK-4相关的疾病的新的优异方法。解决方案：发现恶唑羧酰胺衍生物，其特征在于其2位被杂芳基取代的恶唑通过羧酰胺与杂芳基环结合，对IRAK-4和从而能够成为与IRAK-4相关的疾病如炎性疾病和自身免疫性疾病的预防和/或治疗剂。版权所有（C）2013，JPO＆INPIT

3. 发明专利

JP2014122161A Pyrazole compounds 审中-公开
标题翻译：吡咯化合物
公开(公告)号：JP2014122161A
公开(公告)日：2014-07-03
申请号：JP2011077864
申请日：2011-03-31
申请人： Astellas Pharma Inc , アステラス製薬株式会社
发明人： MASUDA NAOYUKI , MIYAMOTO SATOSHI , KIKUCHI SHIGETOSHI , MITSUMIZU KIYOTOMO , SATO FUMIE , SHIINA YASUHIRO , HAMAGUCHI WATARU , SEO TATSUSHI , MIHARA TAKUMA
IPC分类号： C07D401/12 , A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/55 , A61P25/00 , A61P25/14 , A61P25/22 , A61P25/28 , A61P25/30 , A61P43/00 , C07D401/14 , C07D403/14 , C07D405/00 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
CPC分类号： C07D401/12 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/55 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： PROBLEM TO BE SOLVED: To provide compounds useful as prophylactic and/or therapeutic agents for integrated dystonia, anxiety, Huntington's chorea, chemical dependence, and/or Alzheimer's disease.SOLUTION: The present inventors investigated compounds endowed with PDE10A inhibitory effects and have completed the present invention by confirming that pyrazole compounds are endowed with PDE10A inhibitory effects. The pyrazole compounds of the present invention are endowed with PDE10A inhibitory effects and can be used as prophylactic and/or therapeutic agents for integrated dystonia, anxiety, Huntington's chorea, chemical dependence, and/or Alzheimer's disease.
摘要翻译：要解决的问题：提供可用作综合性肌张力障碍，焦虑症，亨廷顿舞蹈病，化学依赖性和/或阿尔茨海默病的预防和/或治疗剂的化合物。解决方案：本发明人研究了具有PDE10A抑制作用的化合物，并完成了本发明通过确认吡唑化合物具有PDE10A抑制作用。本发明的吡唑化合物具有PDE10A抑制作用，可用作综合肌张力障碍，焦虑症，亨廷顿氏舞蹈病，化学依赖性和/或阿尔茨海默病的预防和/或治疗剂。

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