专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明专利

JP2005154380A Piperidine derivative 审中-公开
标题翻译：哌啶衍生物
公开(公告)号：JP2005154380A
公开(公告)日：2005-06-16
申请号：JP2003398365
申请日：2003-11-28
申请人： Tanabe Seiyaku Co Ltd , 田辺製薬株式会社
发明人： TAKAHASHI MASAMI , YAMANAKA TAKESHI , TERAKAWA YOSHIHIRO , ASAI HIDETOSHI , KOUNO RIKAKO
IPC分类号： C07D211/46 , A61K31/445 , A61K31/4545 , A61P1/02 , A61P1/08 , A61P7/10 , A61P9/00 , A61P9/08 , A61P11/00 , A61P13/02 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P29/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07D211/54 , C07D211/58 , C07D211/62 , C07D401/12
摘要： PROBLEM TO BE SOLVED: To provide a piperidine derivative having excellent tachykinin receptor antagonistic activity. SOLUTION: The invention provides a piperidine derivative expressed by general formula (I) and its pharmacologically permissible salt. In general formula (I), A is a benzene ring which may have a substituent; B 1 is fluorine atom or cyano group; B 2 is a trihalogenoalkyl group, fluorine atom or cyano group or B 1 and B 2 are each an alkoxy group, R 1 is a (substituted) hydroxy group, a substituted thiol group, a substituted sulfonyl group or a group expressed by formula A, R 11 is a substituted carbonyl group or a substituted sulfonyl group, R 12 is hydrogen atom or an alkyl, R 3 is an alkyl, and R 4 is hydrogen atom or an alkyl. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供具有优异的速激肽受体拮抗活性的哌啶衍生物。解决方案：本发明提供由通式（I）表示的哌啶衍生物及其药理学允许的盐。在通式（I）中，A是可以具有取代基的苯环; B 1 是氟原子或氰基; B 2 是三卤代烷基，氟原子或氰基或B 1 和B 2 各自为烷氧基，R 取代的硫醇基，取代的磺酰基或由式A表示的基团，R 11是取代的羰基或取代的磺酰基，R 12 是氢原子或烷基，R 3是烷基，R SP 4是氢原子或烷基。版权所有（C）2005，JPO＆NCIPI

52. 发明专利

JP2004188039A Package body storing container body filled with aqueous formulation comprising vitamin b1s 有权
公开(公告)号：JP2004188039A
公开(公告)日：2004-07-08
申请号：JP2002361533
申请日：2002-12-12
申请人： Tanabe Seiyaku Co Ltd , Terumo Corp , テルモ株式会社 , 田辺製薬株式会社
发明人： UCHIYAMA KANAKO , OSHIMA HIDEHIKO , SAKAGUCHI ITARU , NARISAWA SHINJI , KURUMA CHIE , SONODA TOMOYUKI
IPC分类号： A61J3/00 , A61J1/14
摘要： PROBLEM TO BE SOLVED: To provide a package body storing a container body filled with aqueous formulation comprising vitamin B1s capable of feeding the aqueous formulation comprising vitamin B1s for a long period of time in the stabilized state. SOLUTION: The package body 1 storing the container body filled with the aqueous formulation comprising vitamin B1s comprises a sealed package material 2 made of a shading film hardly permeated by gas, the container body 3 filled with the aqueous formulation comprising vitamin B1s stored inside the package material 2, and a deoxidizer 4 stored in the package material 2. The container body 3 comprises an outlet 32, and a seal part 33 formed at least either in a mixed injection port or in a medical solution container and at an end part of the container body 3. The deoxidizer 4 is stored and fixed inside the package material 2 in such a way that a surface 4a of the deoxidizer 4 on the container body 3 side is in contact with at least one of the outlet 32, the mixed injection port, the medical solution container, or their mounting parts or the seal part 33. COPYRIGHT: (C)2004,JPO&NCIPI

53. 发明专利

JP2004175738A Medicinal composition 审中-公开
公开(公告)号：JP2004175738A
公开(公告)日：2004-06-24
申请号：JP2002345076
申请日：2002-11-28
申请人： Tanabe Seiyaku Co Ltd , 田辺製薬株式会社
发明人： YASUNAKA MASAYUKI , HARADA NAOYUKI , TSUJIJIMA SHUICHI , NAGATA KOICHI , TAKANO MAYUMI
IPC分类号： C07D401/12 , A61K31/454 , A61K31/506 , A61P1/10 , A61P1/18 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P43/00 , C07D403/12
摘要： PROBLEM TO BE SOLVED: To obtain a medicinal composition containing a new phenylcarboxamide derivative having excellent activities for inhibiting the secretion of an apolipoprotein B (ApoB) and for reducing serum lipid, and useful as a medicine as an active ingredient. SOLUTION: This medicinal composition contains the phenylcarboxamide derivative represented by formula [I] [wherein, ring A is a nitrogen-containing aliphatic heterocyclic group which may be substituted; Y is =CH- or =N-; R 2 is a group represented by formula [II] (wherein, (m) is an integer of 0-3; R 6 is an organic group), or the like; and R 3 is hydrogen atom or a halogen atom] or a pharmacologically acceptable salt thereof as an active ingredient. COPYRIGHT: (C)2004,JPO

54. 发明专利

JP2003055197A Functional particle-containing intraoral disintegrative preparation 审中-公开
标题翻译：功能颗粒含有内毒素消毒制剂
公开(公告)号：JP2003055197A
公开(公告)日：2003-02-26
申请号：JP2002158651
申请日：2002-05-31
申请人： Tanabe Seiyaku Co Ltd , 田辺製薬株式会社
发明人： SHIMIZU KOSUKE , NAGAO KEIGO , ISHIBASHI TAKASHI
IPC分类号： A61K9/20 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a functional particle-containing intraoral disintegrative preparation, by which the preparation having a good oral touch, hardly permitting the proliferation of saprophytes and capable of being easily dried is obtained without damaging the functional particles in a compression process and without causing a difference in the contents of the functional particles between the preparations.
SOLUTION: The method for producing the functional particle-containing intraoral disintegrative preparation is characterized by filling a mold with an aqueous dispersion containing (a) a dispersing agent having a dispersion- maintaining factor of ≥75% and a viscosity of ≤100 mPa.s, when homogeneously added to water in a concentration of 1 wt.%, (b) a water-soluble saccharide, and (c) the functional particles, and then removing water.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：提供一种生产含功能性颗粒的口腔内崩解制剂的方法，其中具有良好口腔接触的制剂几乎不允许腐生菌的增殖并且容易干燥，而不会损害功能性颗粒压缩过程，并且不会引起制剂之间的功能性颗粒的含量的差异。解决方案：用于制备含功能颗粒的口腔内崩解制剂的方法的特征在于用含有（a）分散保持因子> = 75％，粘度<= 100mPa s，当以1重量％的浓度均匀加入水中时，（b）水溶性糖类，和（c）功能性颗粒，然后除去水。

55. 发明专利

JP2003048872A Biphenylcarboxamide derivative and method of producing the same 审中-公开
标题翻译：二苯甲酰胺衍生物及其生产方法
公开(公告)号：JP2003048872A
公开(公告)日：2003-02-21
申请号：JP2002155743
申请日：2002-05-29
申请人： Tanabe Seiyaku Co Ltd , 田辺製薬株式会社
发明人： YASUNAKA MASAYUKI , KUSAMA MARI , KAMATANI HIROSHI , TANAKA KEIKO , IGARASHI SHIGEKI
IPC分类号： C07D295/08 , A61K31/167 , A61K31/18 , A61K31/24 , A61K31/245 , A61K31/27 , A61K31/381 , A61K31/402 , A61K31/4402 , A61K31/4439 , A61K31/505 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/664 , A61P1/10 , A61P1/18 , A61P3/04 , A61P3/06 , A61P3/10 , A61P7/02 , A61P9/00 , A61P9/10 , A61P43/00 , C07C269/06 , C07C271/20 , C07C303/38 , C07C311/18 , C07D207/14 , C07D213/40 , C07D239/42 , C07D333/34 , C07D401/04 , C07D401/14 , C07D403/12 , C07F9/24
摘要： PROBLEM TO BE SOLVED: To provide a novel biphenylcarboxamide derivative that has the excellent Apolipo protein B secretion inhibitory action and the serum lipid, and is useful as a medicine and a method of producing the same.
SOLUTION: The biphenylcarboxamide derivative represented by general formula [I] [wherein R
1 is a lower alkyl which may be substituted with halogen atoms; R
2 is H, carboxyl, a lower alkoxycarbonyl, a lower alkoxy; Y is =CH- or =N-; R
3 is the formula (wherein m is an integer of 0-3; R
7 is an organic group); R
4 is H or a halogen atom] and also includes their pharmacologically acceptable salts.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：提供具有优异的阿扑菌蛋白B分泌抑制作用的新型联苯甲酰胺衍生物和血清脂质，并且可用作药物及其制备方法。解决方案：由通式[I]表示的联苯甲酰胺衍生物[其中R 1是可被卤素原子取代的低级烷基; R 2是H，羧基，低级烷氧基羰基，低级烷氧基; Y = CH-或= N-; R 3是式（其中m是0-3的整数; R 7是有机基团）; R 4是H或卤原子]，并且还包括其药理学上可接受的盐。

56. 发明专利

JP2003040781A Food, drink and pharmaceutical preparation 审中-公开
标题翻译：食品，饮料和药物制备
公开(公告)号：JP2003040781A
公开(公告)日：2003-02-13
申请号：JP2001226834
申请日：2001-07-26
申请人： Ezaki Glico Co Ltd , Tanabe Seiyaku Co Ltd , 江崎グリコ株式会社 , 田辺製薬株式会社
发明人： YONETANI TAKASHI , SAKAI KYOKO , TANAKA TAKUJI
IPC分类号： A23G3/34 , A21D13/08 , A23G3/00 , A23L1/187 , A23L1/24 , A23L1/30 , A23L2/02 , A23L2/52 , A61K31/353 , A61K31/7048 , A61P35/00
摘要： PROBLEM TO BE SOLVED: To provide a new carcinostatic agent.
SOLUTION: The carcinostatic agent contains a hesperidin glycoside. The agent is daily takable through the mouth and quickly ameliorates and cures malignant tumors of mammals including human without causing side effects. The carcinostatic agent is effective against colon cancer, oral cavity cancer, esophageal cancer and gastric cancer. A carcinostatic composition is produced by combining the carcinostatic agent with one or more flavonoid compounds such as diosmin, luteolin and quercetin. The carcinostatic agent may be included in foods or drinks.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：提供一种新型的制癌剂。解决方案：制癌剂含有橙皮苷糖苷。该药物通过口服每天可以快速改善并治愈包括人在内的哺乳动物的恶性肿瘤，而不引起副作用。该制癌剂对结肠癌，口腔癌，食道癌和胃癌有效。通过将制癌剂与一种或多种类酮类化合物如二酮，木犀草素和槲皮素组合制备制癌组合物。食品或饮料中可能含有制癌剂。

57. 发明专利

JP2003002834A Pharmaceutical composition 有权
标题翻译：药物组合物
公开(公告)号：JP2003002834A
公开(公告)日：2003-01-08
申请号：JP2002117406
申请日：2002-04-19
申请人： Tanabe Seiyaku Co Ltd , 田辺製薬株式会社
发明人： YLLA SAAKAA , FURTH PAUL , TEEGARDEN BRADLEY R , MORNINGSTAR MARSHALL , SMITH NICHOLAS , GRIFFITH RONALD C
IPC分类号： C07D487/04 , A61K31/407 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61P1/00 , A61P7/00 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/10 , A61P21/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/08 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To obtain a pharmaceutical composition effective for the treatment of inflammatory diseases, and which contains, as an active ingredient, a small molecule of αLβ2 -mediated adhesion inhibitor. SOLUTION: This pharmaceutical composition contains a pharmacologically effective amount of a compound represented by formula (I) or its pharmacologically acceptable salt as an active ingredient, and a pharmacologically acceptable carrier. The pharmaceutical composition is effective for the prevention and treatment of diseases associated with αLβ2 -mediated adhesion.
摘要翻译：要解决的问题：为了获得有效治疗炎性疾病的药物组合物，其含有αLβ2介导的粘附抑制剂的小分子作为活性成分。解决方案：该药物组合物含有药理学有效量的式（I）表示的化合物或其药理学上可接受的盐作为活性成分，以及药理学上可接受的载体。该药物组合物对于预防和治疗与αLβ2介导的粘附相关的疾病是有效的。

58. 发明专利

JPH11276172A Abc transporter gene 失效
标题翻译： ABC运输基因
公开(公告)号：JPH11276172A
公开(公告)日：1999-10-12
申请号：JP8059798
申请日：1998-03-27
申请人： Tanabe Seiyaku Co Ltd , 田辺製薬株式会社
发明人： SHIBATANI TAKEJI , OMORI KENJI , AKATSUKA HIROYUKI , KAWAI ERI , IDEI AKIKO
IPC分类号： C12N15/09 , C12N1/21 , C12N9/20
摘要： PROBLEM TO BE SOLVED: To obtain a new ABC transporter gene encoding a polypeptide constituting an ATP-binding cassette transporter of Pseudomonas fluorescens and capable of efficiently producing useful proteins, e.g. lipase, by microbes.
SOLUTION: This new ABC transporter gene is such one as to encode a polypeptide constituting an ATP-binding cassette transporter of Pseudomonas fluorescens, consisting of e.g. a polypeptide having the amino acid sequence described in formula I to III, or a polypeptide having an amino acid sequence wherein one or several amino acid residue(s) is (are) added, deleted or substituted in the above amino acid sequence and to efficiently produce useful proteins, e.g. lipase through the function of secreting proteins extracellularly. This gene is obtained by separating a chromosomal DNA from the Pseudomonas fluorescens No.33 strain and conducting PCR using a primer consisting of a partial sequence of the ABC transporter gene.
COPYRIGHT: (C)1999,JPO
摘要翻译：要解决的问题：获得编码构成荧光假单胞菌的ATP结合盒转运蛋白的多肽的新的ABC转运蛋白基因，并能够有效地产生有用的蛋白质，例如，脂肪酶，微生物。解决方案：这种新的ABC转运蛋白基因是编码构成荧光假单胞菌（Pseudomonas fluorescens）的ATP结合盒转运蛋白的多肽的一种。具有式I至III中描述的氨基酸序列的多肽或具有氨基酸序列的多肽，其中在上述氨基酸序列中添加，缺失或取代一个或多个氨基酸残基并有效地产生有用的蛋白质，例如脂肪酶通过细胞外分泌蛋白质的功能。通过从荧光假单胞菌No.33菌株中分离染色体DNA并使用由ABC转运蛋白基因的部分序列组成的引物进行PCR获得该基因。

59. 发明专利

JPS6178719A Composite transfusion 失效
标题翻译：复合材料传输
公开(公告)号：JPS6178719A
公开(公告)日：1986-04-22
申请号：JP20106684
申请日：1984-09-25
申请人： Tanabe Seiyaku Co Ltd , Terumo Corp
发明人： SAMEJIMA MASAYOSHI , MATSUDA SABURO , WAKABAYASHI TOSHIO , HAYAKAWA NAOKI
IPC分类号： A61K9/08 , A23L1/304 , A23L1/305 , A61K31/195 , A61K31/40 , A61K31/405 , A61K31/415 , A61K31/70 , A61K33/00 , A61K38/00 , A61K38/01
CPC分类号： A61K33/00 , A23L33/16 , A23L33/175 , A61K38/01 , A61K31/7004 , A61K2300/00
摘要： PURPOSE: To provide a composite transfusion containing a reducing sugar, physiological amino acid and electrolyte at specific balanced ratio, excellent from nutritional viewpoint, and capable of suppressing the browning phenomenon.
CONSTITUTION: The objective composite transfusion essentially resistant to discoloration can be prepared by using a reducing sugar (e.g. glucose, maltose, etc.), physiological amino acids, and electrolytes of the table I at ratios and amounts shown in the table. The concentration product of the reducing sugar and amino acid is preferably 7W25, especially 12W24 to improve the stability of the transfusion. The pH of the transfusion is preferably 4.0W6.0. It can be prepared according to the method used in the preparation of transfusion or injections, and may be sterilized by heating. Since the transfusion can be used as it is without combining with other agent, various problems caused by the combined use, e.g. variation of pH, contamination with microorganisms and foreign materials, etc., can be avoided.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：提供以均衡比例含有还原糖，生理氨基酸和电解质的复合输液，营养观点优良，能抑制褐变现象。构成：可以通过使用表I所示比例和量的表I的还原糖（例如葡萄糖，麦芽糖等），生理氨基酸和电解质来制备基本上抗变色的目的复合输液。还原糖和氨基酸的浓度乘积优选为7-25，特别是12-24，以提高输血的稳定性。输血的pH优选为4.0-6.0。可以根据输血或注射制剂中使用的方法制备，可以通过加热灭菌。由于输液可以原样使用而不与其他药剂组合使用，所以由组合使用引起的各种问题，例如，可以避免pH的变化，微生物和异物的污染等。

60. 发明专利

JPS6170983A Novel microorganism and production of l-threonine therewith 失效
标题翻译：新型微生物及其生产L-螺旋藻
公开(公告)号：JPS6170983A
公开(公告)日：1986-04-11
申请号：JP19356284
申请日：1984-09-14
申请人： Tanabe Seiyaku Co Ltd
发明人： KIZUMI MASAHIKO , KOMATSUBARA SABURO , SUGITA NAOHISA
IPC分类号： C12N15/09 , C12N1/20 , C12N1/21 , C12N15/00 , C12N15/52 , C12P13/08 , C12R1/425
CPC分类号： C12N15/52
摘要： PURPOSE:The DNA coding for L-threonine production is cut off from a microorganism in Serratia and recombined into the vector plasmid and transferred into a Serratia microorganism to prepare a new microorganism with high L- threonine productivity. CONSTITUTION:A chromosome fragment coding for L-threonine production, which is collected from a microorganism in Serratia capable of producing L- thereonine is recombined to form a hybrid plasmid and it is transferred into a microorganism in Serratia. The resultant organism is cultured in a medium to collect the L-threonine accumulated in the medium.
摘要翻译：目的：从沙雷氏菌中的微生物中切下编码L-苏氨酸的DNA，并重组成载体质粒，转入沙雷氏菌属微生物，制备出具有高苏氨酸生产能力的新型微生物。构成：将能够产生L-亮氨酸的沙雷氏菌中的微生物收集的编码L-苏氨酸生成的染色体片段重组以形成杂交质粒，并将其转移到沙雷氏菌属的微生物中。所得生物体在培养基中培养以收集积累在培养基中的L-苏氨酸。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式