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1. 发明专利

JP2003055197A Functional particle-containing intraoral disintegrative preparation 审中-公开
标题翻译：功能颗粒含有内毒素消毒制剂
公开(公告)号：JP2003055197A
公开(公告)日：2003-02-26
申请号：JP2002158651
申请日：2002-05-31
申请人： Tanabe Seiyaku Co Ltd , 田辺製薬株式会社
发明人： SHIMIZU KOSUKE , NAGAO KEIGO , ISHIBASHI TAKASHI
IPC分类号： A61K9/20 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a functional particle-containing intraoral disintegrative preparation, by which the preparation having a good oral touch, hardly permitting the proliferation of saprophytes and capable of being easily dried is obtained without damaging the functional particles in a compression process and without causing a difference in the contents of the functional particles between the preparations.
SOLUTION: The method for producing the functional particle-containing intraoral disintegrative preparation is characterized by filling a mold with an aqueous dispersion containing (a) a dispersing agent having a dispersion- maintaining factor of ≥75% and a viscosity of ≤100 mPa.s, when homogeneously added to water in a concentration of 1 wt.%, (b) a water-soluble saccharide, and (c) the functional particles, and then removing water.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：提供一种生产含功能性颗粒的口腔内崩解制剂的方法，其中具有良好口腔接触的制剂几乎不允许腐生菌的增殖并且容易干燥，而不会损害功能性颗粒压缩过程，并且不会引起制剂之间的功能性颗粒的含量的差异。解决方案：用于制备含功能颗粒的口腔内崩解制剂的方法的特征在于用含有（a）分散保持因子> = 75％，粘度<= 100mPa s，当以1重量％的浓度均匀加入水中时，（b）水溶性糖类，和（c）功能性颗粒，然后除去水。

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