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1. 发明专利

JPS6178719A Composite transfusion 失效
标题翻译：复合材料传输
公开(公告)号：JPS6178719A
公开(公告)日：1986-04-22
申请号：JP20106684
申请日：1984-09-25
申请人： Tanabe Seiyaku Co Ltd , Terumo Corp
发明人： SAMEJIMA MASAYOSHI , MATSUDA SABURO , WAKABAYASHI TOSHIO , HAYAKAWA NAOKI
IPC分类号： A61K9/08 , A23L1/304 , A23L1/305 , A61K31/195 , A61K31/40 , A61K31/405 , A61K31/415 , A61K31/70 , A61K33/00 , A61K38/00 , A61K38/01
CPC分类号： A61K33/00 , A23L33/16 , A23L33/175 , A61K38/01 , A61K31/7004 , A61K2300/00
摘要： PURPOSE: To provide a composite transfusion containing a reducing sugar, physiological amino acid and electrolyte at specific balanced ratio, excellent from nutritional viewpoint, and capable of suppressing the browning phenomenon.
CONSTITUTION: The objective composite transfusion essentially resistant to discoloration can be prepared by using a reducing sugar (e.g. glucose, maltose, etc.), physiological amino acids, and electrolytes of the table I at ratios and amounts shown in the table. The concentration product of the reducing sugar and amino acid is preferably 7W25, especially 12W24 to improve the stability of the transfusion. The pH of the transfusion is preferably 4.0W6.0. It can be prepared according to the method used in the preparation of transfusion or injections, and may be sterilized by heating. Since the transfusion can be used as it is without combining with other agent, various problems caused by the combined use, e.g. variation of pH, contamination with microorganisms and foreign materials, etc., can be avoided.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：提供以均衡比例含有还原糖，生理氨基酸和电解质的复合输液，营养观点优良，能抑制褐变现象。构成：可以通过使用表I所示比例和量的表I的还原糖（例如葡萄糖，麦芽糖等），生理氨基酸和电解质来制备基本上抗变色的目的复合输液。还原糖和氨基酸的浓度乘积优选为7-25，特别是12-24，以提高输血的稳定性。输血的pH优选为4.0-6.0。可以根据输血或注射制剂中使用的方法制备，可以通过加热灭菌。由于输液可以原样使用而不与其他药剂组合使用，所以由组合使用引起的各种问题，例如，可以避免pH的变化，微生物和异物的污染等。

2. 发明专利

JPS5916821A Preparation of nonflocculating microcapsule 失效
标题翻译：非结晶微生物的制备
公开(公告)号：JPS5916821A
公开(公告)日：1984-01-28
申请号：JP12482982
申请日：1982-07-16
申请人： Tanabe Seiyaku Co Ltd
发明人： SAMEJIMA MASAYOSHI , HIRATA GOICHI , ISHIBASHI TAKASHI
IPC分类号： A61K9/62 , A61K9/50 , B01J13/02 , B01J13/08 , B01J13/12
CPC分类号： B01J13/08 , A61K9/5047 , A61K9/5089 , B01J13/12 , Y10T428/2984 , Y10T428/2985 , Y10T428/2989
摘要： PURPOSE:To obtain mononuclear microcapsules, having a core material coated with dense and uniform wall membranes, and rich in fluidity, by separating phases from a cyclohexane solution containing ethyl cellulose with a specific hydrocarbon compound as a phase separation inducing agent. CONSTITUTION:0.1-20vol% hydrocarbon compound, having 7-10 (cal/cm ) solubility parameter (delta) and 150-3,000 molecular weight, and soluble in cyclohexane, e.g. liquid paraffin, vaseline, squalane, polybutadiene or polystyrene, as a phase separation inducing agent is added to a solution containing 0.5- 10wt% ethyl cellulose in the cyclohexane, stirring the resultant mixture under heating to prepare a dispersion of the core material, and the resultant dispersion is then cooled under stirring to give the aimed microcapsules.
摘要翻译：目的：通过将含有乙基纤维素的环己烷溶液与作为相分离诱导剂的特定烃化合物分离相，得到具有包覆密实且均匀的壁膜并具有流动性的芯材的单核微胶囊。构成：0.1-20vol％烃化合物，具有7-10（cal / cm 3）1/2溶解度参数（δ）和150-3,000分子量，并且可溶于环己烷，例如将作为相分离诱导剂的液体石蜡，凡士林，角鲨烷，聚丁二烯或聚苯乙烯加入到在环己烷中含有0.5-10wt％乙基纤维素的溶液中，在加热下搅拌所得混合物以制备核心材料的分散体，然后将所得分散体在搅拌下冷却，得到目的微胶囊。

3. 发明专利

JPS57120518A Preparation of microcapsule 失效
标题翻译：微生物的制备
公开(公告)号：JPS57120518A
公开(公告)日：1982-07-27
申请号：JP685981
申请日：1981-01-19
申请人： Tanabe Seiyaku Co Ltd
发明人： SAMEJIMA MASAYOSHI , HIRATA GOICHI
IPC分类号： A61K9/56 , A61K9/16 , B01J13/08
CPC分类号： A61K9/1694 , A61K9/1635 , A61K9/1652 , B01J13/08
摘要： PURPOSE:To obtain uniform microcapsules easily in obtaining the microcapsules by utilizing the phase separation of a polymer soluble in the stomach or intestines or both, by incorporating ethyl cellulose as a flocculation inhibitor in a core substance. CONSTITUTION:A core substance, e.g. a medicine, agricultural chemical, cosmetic or food, is dispersed in a solution containing a polymer soluble in the stomach or intestines or both and ethyl cellulose as a flocculation inhibitor. A film of the polymer is formed on the core substance by the phase separation of the polymeric solution to give the aimed microcapsules soluble in the stomach or intestines or both. The amount of the polymer is about 0.02-10, preferably about 0.1-5 times, that of core substance. Thus, the microcapsules having uniform and relatively narrow distribution of the particle size can be obtained with suppressed coagulation of the polymer or mutual flocculation of microcapsules.
摘要翻译：目的：通过将乙基纤维素作为絮凝抑制剂加入到核心物质中，通过利用可溶于胃或肠内的聚合物的相分离，可以容易地获得均匀的微胶囊。构成：核心物质，例如将药物，农药，化妆品或食品分散在含有可溶于胃或肠或二者的聚合物的溶液中，并将乙基纤维素分散在絮凝抑制剂中。通过聚合物溶液的相分离，在核心物质上形成聚合物膜，得到可溶于胃或肠或两者的目标微胶囊。聚合物的量为核心物质的量的约0.02-10，优选约0.1-5倍。因此，通过抑制凝聚聚合物或微胶囊的相互絮凝，可以获得具有均匀且相对窄的粒径分布的微胶囊。

4. 发明专利

JPS5910512A Microcapsule with sustained release and its preparation 失效
标题翻译： MICROCAPSULE具有持续发布及其准备
公开(公告)号：JPS5910512A
公开(公告)日：1984-01-20
申请号：JP12019382
申请日：1982-07-09
申请人： Tanabe Seiyaku Co Ltd
发明人： SAMEJIMA MASAYOSHI , HIRATA GOICHI , KOIDA YOSHIYUKI , KOBAYASHI YOSHINORI , KIDA AKIRA
IPC分类号： A61K9/62
摘要： PURPOSE: A microcapsule showing sustained release effect of drug in the stomach and the intestine, capable of releasing it securely in these digestive organs, obtained by forming an ethyl cellulose wall film on the core substance of particles which are obtained by granulating a drug substance and an enteric high polymer substance.
CONSTITUTION: An enteric high polymer substance soluble in water at ≥5pH is dissolved or swelled in an inert solvent to give a solution or gel, to which a drug substance suitable for oral medication is added, and the drug is dissolved or dispersed in it. The mixture is granulated, the prepared granules are dried, and the size of the granules anr adjusted to give particles having the desired particle size (preferably 50W500μ particle size). These particles are dispersed into an ethyl cellulose-containing solution, and, an ethyl cellulose wall film is formed on the core substance optionally in the presence an enteric high polymer substance by phase separation. Polysaccharide acetate, alkyl ether of carboxyalkylated polysaccharide, PVA, etc. are used as the enteric high polymer substance.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：显示药物在胃和肠中具有持续释放作用的微胶囊，能够在这些消化器官中牢固地释放，通过在通过制粒药物获得的颗粒的核心物质上形成乙基纤维素壁膜而获得，肠溶高分子物质。构成：可溶于> = 5pH的水中的肠溶性高分子物质在惰性溶剂中溶解或溶胀，得到溶液或凝胶，向其中加入适合于口服药物的药物，并将药物溶解或分散于其中。将混合物造粒，将制备的颗粒干燥，并调节颗粒尺寸以得到具有所需粒度（优选粒径为50-500μm）的颗粒。将这些颗粒分散在含乙基纤维素的溶液中，通过相分离任选地在存在肠溶性高分子物质的情况下在核心物质上形成乙基纤维素壁膜。醋酸多糖，羧烷基化多糖的烷基醚，PVA等用作肠溶性高分子物质。

5. 发明专利

JPS58196842A Preparation of non-coagulable microcapsule 失效
标题翻译：非共混微生物的制备
公开(公告)号：JPS58196842A
公开(公告)日：1983-11-16
申请号：JP8102582
申请日：1982-05-13
申请人： Tanabe Seiyaku Co Ltd
发明人： SAMEJIMA MASAYOSHI , HIRATA GOICHI , ISHIBASHI TAKASHI
IPC分类号： A61K9/50 , A61K9/62 , B01J13/08
CPC分类号： B01J13/08
摘要： PURPOSE:To obtain a cimcrocapsule having a dense wall film, free from coagulation and rich in flowability, in preparing the microcapsule due to the phase separation of ethyl cellulose, by using a certain kind of an org. solvent as a coagulation preventing agent. CONSTITUTION:In preparing a microcapsule by forming a ethyl cellulose wall film on a core substance by the phase separation of ethyl cellulose, as a coagulation preventing agent in the phase separation of ethyl cellulose, an org. solvent of which the hydrogen bonding component deltah of a dissolving parameter is 3.5- 11.0 [(Cal/cm )1/2] and which is dissolved or partially dissolved in cyclohexane, for example, mathanol or ethanol is used. By this method, a microcapsule having a dense wall film, free from coagulation and rich in flowability can be prepared.
摘要翻译：目的：通过使用某种组织，获得具有致密壁膜的电泳胶囊，其没有凝结并且具有丰富的流动性，在由于乙基纤维素的相分离制备微胶囊时。溶剂作为凝固防止剂。构成：在通过乙基纤维素的相分离在核心物质上形成乙基纤维素壁膜来制备微胶囊时，作为乙基纤维素的相分离中的凝固防止剂。使用其溶解参数的氢键成分deltah为3.5-11.0 [（Cal / cm 2）1/2]并溶解或部分溶解在环己烷中的溶剂，例如甲醇或乙醇。通过该方法，可以制备具有不凝结，流动性丰富的致密壁膜的微胶囊。

6. 发明专利

JPS62221621A COMPLEX TRANSFUSION SOLUTION 失效
公开(公告)号：JPS62221621A
公开(公告)日：1987-09-29
申请号：JP6649686
申请日：1986-03-24
申请人： TANABE SEIYAKU CO , TERUMO CORP
发明人： SAMEJIMA MASAYOSHI , MATSUDA SABURO , WAKABAYASHI TOSHIO , HAYAKAWA NAOKI
IPC分类号： A61K31/165 , A61K9/08 , A61K31/195 , A61K31/198 , A61K31/40 , A61K31/405 , A61K31/415 , A61K38/00 , A61P3/00 , A61P3/12
摘要： PURPOSE:A complex transfusion solution, containing a reducing sugar, physiological amino acids and electrolytes at composition ratios balanced within specific ranges and capable of exhibiting nutritionally improved effect and suppressing the browning phenomenon by the Maillard reaction. CONSTITUTION:A complex transfusion solution obtained by blending a reducing sugar, preferably glucose or maltose which is a physiological caloric source with an amino acid mixture which is a nitrogen source and electrolytes in amounts blended shown in the table. Cysteine and/or cystine in the amino acid mixture may be partially or wholly replaced by methionine and tyrosine may be partially or wholly replaced by phenylalanine. The concentration of the reducing sugar is preferably within the range of 6-8wt/vol% and the concentration of the total amino acids is preferably within the range of 2.5-3.5wt/vol%. From the viewpoint of the stabilization of the pharmaceutical, the respective concentrations are preferably adjusted to give 7-25, particularly 17-23 product of the concentrations of both the reducing sugar and total amino acid.

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