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21. 发明专利

JP2009273377A Method for selecting candidate peptide presented on surface of cancer cell following binding to mhc class i molecule 审中-公开
标题翻译：选择在MHC类I分子结合下的癌细胞表面呈现的候选肽的方法
公开(公告)号：JP2009273377A
公开(公告)日：2009-11-26
申请号：JP2008125248
申请日：2008-05-12
申请人： Igaku Seibutsugaku Kenkyusho:Kk , Keio Gijuku , 学校法人慶應義塾 , 株式会社医学生物学研究所
发明人： YAHARA ICHIRO , KOYASU SHIGEO , IMAI JUN
IPC分类号： C12Q1/02 , C12N15/09 , G01N33/574
CPC分类号： G01N33/5011 , G01N2333/70539
摘要： PROBLEM TO BE SOLVED: To provide a method for selecting a candidate peptide presented on the surface of a cancer cell following binding to MHC class I molecule, wherein the peptide is involved in the stimulation of T cell immunity (cellular immunity). SOLUTION: A new principle of MHC I-mediated antigen presentation in which a T cell antigen epitope is more efficiently presented on the MHC I molecule when it is positioned at the N-terminal side than when positioned at the C-terminal side even being the same antigen epitope is discovered, and a method for selecting the peptide candidate presented on the surface of the cancer cell is discovered. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种选择在与MHC I类分子结合之后呈现在癌细胞表面上的候选肽的方法，其中所述肽参与T细胞免疫（细胞免疫）的刺激。解决方案：MHC I介导的抗原呈递的新原理，其中当定位在N末端侧时，当位于C末端侧时，T细胞抗原表位在MHC I分子上更有效地呈现发现了甚至是相同的抗原表位，并且发现了选择呈递在癌细胞表面上的候选肽的方法。版权所有（C）2010，JPO＆INPIT

22. 发明专利

JP2006187274A Method for rapidly and histochemically staining acetylcholine esterase 审中-公开
标题翻译：快速和组织化学乙酰胆碱酯酶的方法
公开(公告)号：JP2006187274A
公开(公告)日：2006-07-20
申请号：JP2005257790
申请日：2005-09-06
申请人： Igaku Seibutsugaku Kenkyusho:Kk , Juntendo , 学校法人順天堂 , 株式会社医学生物学研究所
发明人： KOBAYASHI HIROYUKI
IPC分类号： C12Q1/46 , C12Q1/02 , G01N33/48
摘要： PROBLEM TO BE SOLVED: To provide a method for rapidly and histochemically staining acetylcholine esterase.
SOLUTION: The method for rapidly and histochemically staining the acetylcholine esterase comprises adding a solution A containing iodized acetylcholine, a citric acid salt and copper sulfate, and a solution B containing potassium ferricyanide to a frozen tissue fragment having 3-6 μm thickness, incubating the resultant fragment at 10-30°C for 4-6 min, adding a diaminobenzidine salt and hydrogen peroxide to the incubated product, further carrying out the incubation at 10-30°C for 1-2 min, and washing the product with water.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供用于快速和组织化学染色乙酰胆碱酯酶的方法。解决方案：用于快速和组织化学染色乙酰胆碱酯酶的方法包括将含有碘化乙酰胆碱，柠檬酸盐和硫酸铜的溶液A和含有铁氰化钾的溶液B加入到具有3-6μm厚度的冷冻组织片段将所得片段在10-30℃孵育4-6分钟，向培养的产物中加入二氨基联苯胺盐和过氧化氢，进一步在10-30℃孵育1-2分钟，并洗涤产物与水。版权所有（C）2006，JPO＆NCIPI

23. 发明专利

JP2005124505A Nucleic acid encoding antibody of anti-22-1-1 antigen 审中-公开
标题翻译：抗-22-1-1抗原的核酸编码抗体
公开(公告)号：JP2005124505A
公开(公告)日：2005-05-19
申请号：JP2003364814
申请日：2003-10-24
申请人： Igaku Seibutsugaku Kenkyusho:Kk , Manabu Nakajima , Takeshi Watanabe , 学中島 , 株式会社医学生物学研究所 , 武渡邊
发明人： WATANABE TAKESHI , NAKAJIMA MANABU , OIMOMI HIDEKI
IPC分类号： G01N33/574 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08
摘要： PROBLEM TO BE SOLVED: To provide an amino acid sequence of a variable region of an antibody (22-1-1 antibody) of an anti-22-1-1 antigen, and to provide a base sequence thereof. SOLUTION: The nucleic acid has a specific base sequence such as the sequence encoding CDR-H1, the sequence encoding CDR-H2, the sequence encoding CDR-H3, the sequence encoding CDR-L1, the sequence encoding CDR-L2 and the sequence encoding CDR-L3. The antibody of the anti-22-1-1 antigen is constituted based on the sequence. The transformant is obtained by introducing the nucleic acid. The antibody is obtained therefrom. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供抗-22-1-1抗原的抗体（22-1-1抗体）的可变区的氨基酸序列，并提供其碱基序列。解决方案：核酸具有特异性碱基序列，例如编码CDR-H1的序列，编码CDR-H2的序列，编码CDR-H3的序列，编码CDR-L1的序列，编码CDR-L2的序列，以及编码CDR-L3的序列。基于该序列构建抗-22-1-1抗原的抗体。通过引入核酸获得转化体。从其获得抗体。版权所有（C）2005，JPO＆NCIPI

24. 发明专利

JP2017086081A 抗ヒトＣＬＣＰ１抗体とその用途有权
公开(公告)号：JP2017086081A
公开(公告)日：2017-05-25
申请号：JP2016238152
申请日：2016-12-08
申请人：株式会社医学生物学研究所 , Igaku Seibutsugaku Kenkyusho:Kk , 株式会社Oncomics , Oncomics Co Ltd
发明人： ONO KENICHIRO , TAKAHASHI TAKASHI
IPC分类号： C12N15/09 , A61K39/395 , A61P35/00 , A61P35/04 , C07K16/28 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08 , G01N33/53 , G01N33/574
CPC分类号： G01N33/574 , A61K2039/505 , C07K16/3023 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92 , G01N33/5011
摘要：【課題】ヒトCLCP1抗原の細胞外ドメインを認識する抗体及びその用途の提供。【解決手段】CLCP1を発現する、腎がん、膀胱腫瘍、前立腺がん、膵臓がん、胃がん、大腸がん、乳がん又は肺がん細胞の遊走阻害活性、浸潤阻害活性、増殖阻害活性、転移阻害活性、及び細胞障害活性を有する、特定のアミノ酸配列からなるペプチドを認識する抗体、及び該抗体をコードする核酸、該核酸を発現可能に保持するベクター、及び該ベクターを有する形質転換細胞。【選択図】なし

25. 发明专利

JP2011087586A Antibody library 有权
标题翻译：抗体库
公开(公告)号：JP2011087586A
公开(公告)日：2011-05-06
申请号：JP2010261910
申请日：2010-11-25
申请人： Igaku Seibutsugaku Kenkyusho:Kk , 株式会社医学生物学研究所
发明人： KUROSAWA YOSHIKAZU , AKAHORI YASUSHI , IBA YOSHITAKA , MORINO KAZUHIKO , SHINOHARA MIDORI , TAKAHASHI MOTOHIDE , OKUNO YOSHINOBU , SHIRAKI KIMIYASU
IPC分类号： C12N15/09 , C07K16/00 , C12M1/00 , C12N15/10 , C12P21/08 , C12Q1/02 , C12Q1/68 , C40B30/04 , C40B40/08 , C40B40/10 , C40B50/06 , G01N33/53
CPC分类号： C12N15/10 , C07K16/00 , C07K2317/50 , C07K2317/56
摘要： PROBLEM TO BE SOLVED: To provide a gene library composed of a combination of a light chain variable region gene and a heavy chain variable region gene of immunoglobulin. SOLUTION: A light chain variable gene encoding a light chain molecule reconstructing a functional conformation with an expression product of the heavy chain variable region gene is selected as the light chain variable region gene. Thereby, a gene library which is the aggregate of the resultant light chain variable region gene is prepared. The diversity of the heavy chain variable region can be maintained at a high level in vitro by the antibody library. Thereby, the acquisition of antibodies having various binding activities can be expected. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供由轻链可变区基因和免疫球蛋白重链可变区基因组合构成的基因文库。解决方案：选择编码与重链可变区基因的表达产物重建功能构象的轻链分子的轻链可变基因作为轻链可变区基因。由此，制作作为所得轻链可变区基因的聚集体的基因文库。重链可变区的多样性可以通过抗体文库在体外保持在高水平。因此，可以预期获得具有各种结合活性的抗体。版权所有（C）2011，JPO＆INPIT

26. 发明专利

JP2011036262A Fluorescent protein 有权
标题翻译：荧光蛋白
公开(公告)号：JP2011036262A
公开(公告)日：2011-02-24
申请号：JP2010214870
申请日：2010-09-27
申请人： Igaku Seibutsugaku Kenkyusho:Kk , Institute Of Physical & Chemical Research , 株式会社医学生物学研究所 , 独立行政法人理化学研究所
发明人： MIYAWAKI ATSUSHI , KOGURE TAKAKO , HAMA YUTAKA , KANESHIRO MASATAKA , SAITO KENTA , KARASAWA TOMOJI , ARAKI TOSHIO
IPC分类号： C12N15/09 , C07K14/37 , C07K14/435 , C07K14/44 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/02 , C12Q1/66 , G01N33/533
CPC分类号： C07K14/37 , C07K14/43504 , G01N33/533
摘要： PROBLEM TO BE SOLVED: To provide a red- or orange-colored fluorescent protein wherein the maximum fluorescence can be obtained by the maximum excitation by increasing the difference (Stokes shift) between an excitation peak value (maximum absorption wavelength) and fluorescence peak value (maximum fluorescence wavelength). SOLUTION: A new fluorescent protein monomerized by introducing a mutation into a florescent protein derived from Fungia sp., and a new chromoprotein and fluorescent protein derived from Montipora. sp, are provided; and uses of these proteins are also provided. Such a protein as to have an amino acid sequence where one to several amino acids are deleted, substituted and/or added in a specific amino acid sequence, have fluorescent properties, and have a Stokes shift of 100 nm or greater, is also provided. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供红色或橙色荧光蛋白，其中通过增加激发峰值（最大吸收波长）和荧光之间的差异（斯托克斯偏移）可以通过最大激发获得最大荧光峰值（最大荧光波长）。解决方案：通过将突变引入到来自真菌属的荧光蛋白质中的新荧光蛋白和来自Montipora的新的荧光蛋白和荧光蛋白单体化。 sp; 并提供这些蛋白质的用途。具有在特定氨基酸序列中缺失，取代和/或添加一至数个氨基酸的氨基酸序列的蛋白质具有荧光性质，并且还具有100nm以上的斯托克斯位移。版权所有（C）2011，JPO＆INPIT

27. 发明专利

JP2010035559A Chromoprotein and fluorescent protein 有权
标题翻译：染色质和荧光蛋白
公开(公告)号：JP2010035559A
公开(公告)日：2010-02-18
申请号：JP2009231169
申请日：2009-10-05
申请人： Igaku Seibutsugaku Kenkyusho:Kk , Institute Of Physical & Chemical Research , 株式会社医学生物学研究所 , 独立行政法人理化学研究所
发明人： MIYAWAKI ATSUSHI , ANDO RYOKO , KARASAWA TOMOJI , MIZUNO HIDEAKI
IPC分类号： C12N15/09 , C07K14/37 , C07K14/435 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/02 , G01N33/533 , G01N33/542 , G01N33/58
CPC分类号： G01N33/542 , C07K14/37 , C07K2319/00 , G01N33/533 , G01N33/582 , G01N2021/6439 , G01N2500/10
摘要： PROBLEM TO BE SOLVED: To provide a new chromoprotein and a new fluorescent protein. SOLUTION: Provided are chromoproteins derived from Anthopleura inornata, which have certain property, and fluorescent proteins from Trachyphyllia geoffroyi and Scolymia vitiensis, which have certain fluorescent property. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供新的荧光蛋白和新的荧光蛋白。提供了具有一定性质的Anthopleura inornata衍生的色素蛋白，以及具有一定荧光性质的Trachyphyllia geoffroyi和Scolymia vitiensis的荧光蛋白。版权所有（C）2010，JPO＆INPIT

28. 发明专利

JP2009261358A Method for typing allele polymorphism of human gene including hla-drb1 gene, and kit used in the method 审中-公开
标题翻译：用于形成包括HLA-DRB1基因的人基因的ALLELE多态性的方法和方法
公开(公告)号：JP2009261358A
公开(公告)日：2009-11-12
申请号：JP2008116994
申请日：2008-04-28
申请人： Igaku Seibutsugaku Kenkyusho:Kk , 株式会社医学生物学研究所
发明人： AZUMA SHIKEI , ITO SAORI , FUKUSHIMA YOSHIYUKI , KOSHIZAKA TAKUYA , SHIMADA KAZUNORI , HARA HIROTAKA
IPC分类号： C12Q1/68 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a method for typing the allele polymorphism of a human gene, enabling the throughput to be made efficient and its cost to be reduced, and to provide a kit for the typing. SOLUTION: The method for typing the allele polymorphism of a human gene comprises a step of preparing a first receptacle containing a first set of oligonucleotide primers for detecting the allele polymorphism of HLA-DRB1 gene and a set of oligonucleotide primers for detecting the allele polymorphism of another gene different from the HLA-DRB1 gene and a second receptacle containing a second set of gene-amplifying primers for detecting the allele polymorphism of HLA-DRB1 gene and a set of oigonucleotide primers for detecting the allele polymorphism of still another gene different from the HLA-DRB1 gene and the above another gene. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于对人基因的等位基因多态性进行分型的方法，使得能够使吞吐量有效并降低其成本，并提供用于分型的试剂盒。解决方案：人类基因等位基因多态性的分型方法包括制备含有第一组寡核苷酸引物的第一容器的步骤，用于检测HLA-DRB1基因的等位基因多态性和一组寡核苷酸引物，用于检测与HLA-DRB1基因不同的另一个基因的等位基因多态性和含有第二组用于检测HLA-DRB1基因等位基因多态性的基因扩增引物的第二个载体和一组用于检测另一个基因的等位基因多态性的寡核苷酸引物不同于HLA-DRB1基因和上述另一基因。版权所有（C）2010，JPO＆INPIT

29. 发明专利

JP2009095249A Antibody improved in effector function 有权
标题翻译：改善效果的抗体功能
公开(公告)号：JP2009095249A
公开(公告)日：2009-05-07
申请号：JP2007267207
申请日：2007-10-12
申请人： Igaku Seibutsugaku Kenkyusho:Kk , Otsuka Chemical Co Ltd , 大塚化学株式会社 , 株式会社医学生物学研究所
发明人： TSUJI TAKASHI , KAJIWARA YASUHIRO , TEZUKA KATSUNARI , NANBU YURI , FUKAE KAZUHIRO , ASAI HIROAKI , KITA SHOICHI , SETO MINAE , MURAKAMI AKIHIRO
IPC分类号： C12N15/09 , A61K31/7088 , A61K35/76 , A61K39/395 , A61K48/00 , A61P1/04 , A61P19/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/06 , C07K16/18 , C07K16/46 , C12N5/10
摘要： PROBLEM TO BE SOLVED: To provide an antibody improved in an effector function, a method for simply producing the antibody, a method for improving the effector function of an antibody, and a therapeutic composition which contains the antibody, has a high pharmacological activity, can reduce dosages with less side effects, and can be used for wide-ranging uses. SOLUTION: This antibody whose 295-amino acid in the EU index number of Kabat is replaced with a cysteine residue comprises (1) a mutein antibody whose amino acids at specific positions are replaced by other amino acids, and/or (2) an antibody in which the fucose molecules of sugar chains bound to the antibody are reduced. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：为了提供改善效应子功能的抗体，简单生产抗体的方法，改善抗体的效应子功能的方法和含有该抗体的治疗组合物具有高的药理学活性，可以减少副作用较少的剂量，可用于广泛用途。解决方案：在EU指数Kabat中295个氨基酸被半胱氨酸残基取代的该抗体包含（1）特定位置的氨基酸被其它氨基酸替代的突变蛋白抗体，和/或（2 ）抗体，其中与抗体结合的糖链的岩藻糖分子被还原。版权所有（C）2009，JPO＆INPIT

30. 发明专利

JP2008278814A Release of immunoregulation by agonistic anti-human gitr antibody, and application thereof 审中-公开
标题翻译：通过激素反人类GITR抗体释放免疫调节因子及其应用
公开(公告)号：JP2008278814A
公开(公告)日：2008-11-20
申请号：JP2007126815
申请日：2007-05-11
申请人： Igaku Seibutsugaku Kenkyusho:Kk , Kyoto Univ , 国立大学法人京都大学 , 株式会社医学生物学研究所
发明人： KAJSA WING , NOMURA HISAFUMI , SAKAGUCHI YUKIFUMI , HASEGAWA HIRONORI , SHIN KAZUYUKI , KISHI YOSHIRO , YAHARA ICHIRO
IPC分类号： C12N15/09 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/07 , C12N5/0783 , C12N5/09 , C12N5/10 , C12P21/08
摘要： PROBLEM TO BE SOLVED: To provide a means useful for regulating immunoresponse. SOLUTION: The isolated antibody or antibody fragment recognizes a human GITR antigen and exhibits amplification-promoting activity on a human CD4 + T cell. COPYRIGHT: (C)2009,JPO&INPIT

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