专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JP2013212109A Examination of schizophrenia 有权
标题翻译：考察瑞典
公开(公告)号：JP2013212109A
公开(公告)日：2013-10-17
申请号：JP2013108428
申请日：2013-05-22
申请人： Tokai Univ , 学校法人東海大学 , Tokyo Metropolitan Institute Of Medical Science , 公益財団法人東京都医学総合研究所 , Rena Science:Kk , 株式会社レナサイエンス , Igaku Seibutsugaku Kenkyusho:Kk , 株式会社医学生物学研究所
发明人： ITOKAWA MASANARI , MIYATA TOSHIO , ARAI MAKOTO
IPC分类号： C12Q1/68 , C12N15/09 , C12Q1/26 , G01N33/53 , G01N33/573 , G01N33/68
摘要： PROBLEM TO BE SOLVED: To provide a method for examining schizophrenia, and a testing reagent or testing equipment for schizophrenia used for the method.SOLUTION: A method for examining schizophrenia, targeting a biological sample of a subject, includes a step of measuring at least one selected from the group consisting of: (1) an amount of a protein modified product of a carbonyl compound (carbonyl protein modified product) in a biological sample; (2) an expression amount or activity of glyoxylase I in a biological sample; (3) an amount of gene abnormality of a glyoxylase I gene; and (4) an amount of pyridoxal in a biological sample.
摘要翻译：要解决的问题：提供一种检查精神分裂症的方法，以及用于该方法的精神分裂症的测试试剂或检测设备。解决方案：一种用于检测受试者生物样品的精神分裂症的方法，包括至少测量的步骤选自：（1）一定量的生物样品中羰基化合物（羰基蛋白质改性产物）的蛋白质改性产物; （2）生物样品中乙醛酸酶I的表达量或活性; （3）乙醛酸酶I基因的基因异常量; 和（4）生物样品中吡哆醛的量。

2. 发明专利

JP2009053204A Method for examining cancer and adenoma 有权
标题翻译：检查癌症和腺癌的方法
公开(公告)号：JP2009053204A
公开(公告)日：2009-03-12
申请号：JP2008263833
申请日：2008-10-10
申请人： Aichi Prefecture , Igaku Seibutsugaku Kenkyusho:Kk , Japan Science & Technology Agency , 愛知県 , 株式会社医学生物学研究所 , 独立行政法人科学技術振興機構
发明人： KANAKI REIJI , IZAWA MINEKO , KIMURA NAOKO , KUREI SHUNSUKE , WATANABE KAZUE
IPC分类号： G01N33/574 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide an examination method and an examination drug for detecting, at a high rate, a cancer patient and a patient having a high degree of risk of cancer.
SOLUTION: It has been found that there is a remarkable difference in distribution of isozyme of a sugar-chain sulfated enzyme GlcNAc-6-sulfuric acid group transferase between non-cancerous tissues and cancerous or adenoma tissues, and it has been made clear that its application makes it possible to specifically detect cancer and adenoma (excluding colon cancer and colon adenoma) by detecting a GlcNAc-6-sulfated sugar chain group in a fixed range from the patient's tissue and fecal matter specimen. Cancer and adenoma can be examined using a MECA-79 antibody (Pharmingen Company catalog No. 09961D) or its equivalent.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种以高速率检测癌症患者和具有高度癌症风险的患者的检查方法和检查药物。解决方案：已发现糖链硫酸化酶GlcNAc-6-硫酸转移酶在非癌组织与癌或腺瘤组织之间的同工酶分布差异显着，已经制成清楚的是，其应用使得可以通过从患者组织和粪便物质样品中检测固定范围内的GlcNAc-6硫酸化糖链基团来特异性检测癌症和腺瘤（不包括结肠癌和结肠腺瘤）。可以使用MECA-79抗体（Pharmingen公司目录号09961D）或其等同物检查癌症和腺瘤。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2008074854A INHIBITOR OF AMYLOID FIBER FORMATION CONTAINING ANTIBODY RECOGNIZING GM1 GANGLIOSIDE-BOUND AMYLOID β-PROTEIN 有权
标题翻译：包含抗体识别GM1抗坏血酸酯结合蛋白β蛋白的淀粉纤维形成抑制剂
公开(公告)号：JP2008074854A
公开(公告)日：2008-04-03
申请号：JP2007258842
申请日：2007-10-02
申请人： Igaku Seibutsugaku Kenkyusho:Kk , National Center For Geriatrics & Gerontology , Katsuhiko Yanagisawa , 国立長寿医療センター総長 , 勝彦柳澤 , 株式会社医学生物学研究所
发明人： YANAGISAWA KATSUHIKO , SHIBATA MASAO
IPC分类号： A61K39/395 , A61P25/28 , C07K16/18 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide an antibody effective for diagnosing, preventing or treating Alzheimer's disease, DNA encoding the antibody, a method for screening a drug, and drugs. SOLUTION: An amino acid sequence and a gene sequence in a variable region of the antibody specifically recognizing GM1 ganglioside-bound amyloid β-protein formed in the initial stage of amyloid fiber formation are determined. The antibody is designed based on the information of the obtained amino acid sequence and the gene sequence. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种对阿尔茨海默氏病的诊断，预防或治疗有效的抗体，编码抗体的DNA，药物筛选方法和药物。确定在淀粉样蛋白纤维形成初期形成的特异性识别GM1神经节苷脂结合的淀粉样β蛋白的抗体的可变区中的氨基酸序列和基因序列。基于获得的氨基酸序列和基因序列的信息设计抗体。版权所有（C）2008，JPO＆INPIT

4. 发明专利

JP2006308568A Analytical method for interaction of proteins using fluorescent protein 有权
标题翻译：使用荧光蛋白相互作用蛋白质的分析方法
公开(公告)号：JP2006308568A
公开(公告)日：2006-11-09
申请号：JP2006084809
申请日：2006-03-27
申请人： Igaku Seibutsugaku Kenkyusho:Kk , Institute Of Physical & Chemical Research , 株式会社医学生物学研究所 , 独立行政法人理化学研究所
发明人： MIYAWAKI ATSUSHI , KARASAWA TOMOJI
IPC分类号： G01N33/542 , C07K14/435 , C07K19/00 , C12N15/09 , G01N21/78
CPC分类号： G01N33/542
摘要： PROBLEM TO BE SOLVED: To provide a method capable of obtaining time information, and capable of tracing migration of a protein, in an analytical method for interaction between the proteins.
SOLUTION: In this analytical method, a fluorescent protein capable of emitting a fluorescence of a color different with the lapse of time is divided into an N-terminal side fragment and a C-terminal side fragment, the first tested protein is made to interacted with the second tested protein, by making a fused protein of the N-terminal side fragment and the first tested protein coexist with a fused protein of the C-terminal side fragment and the second tested protein, and the interaction of the first tested protein with the second tested protein is analyzed by detecting a change of the fluorescence due to the interaction.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供一种能够获得时间信息并能够跟踪蛋白质迁移的方法，用于蛋白质之间相互作用的分析方法。解决方案：在该分析方法中，能够发射随时间推移不同的颜色的荧光的荧光蛋白被分成N-末端侧片段和C-末端侧片段，第一个测试的蛋白质被制成通过使N端侧片段和第一被测试蛋白质的融合蛋白与C端侧片段和第二测试蛋白质的融合蛋白共存，并与第一测试蛋白质的相互作用与第二测试蛋白质相互作用通过检测由于相互作用引起的荧光的变化来分析具有第二测试蛋白质的蛋白质。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2005111471A Heating device utilizing surface acoustic wave 有权
标题翻译：加热装置利用表面声波
公开(公告)号：JP2005111471A
公开(公告)日：2005-04-28
申请号：JP2004009890
申请日：2004-01-16
申请人： Igaku Seibutsugaku Kenkyusho:Kk , Sachiko Shiokawa , 祥子塩川 , 株式会社医学生物学研究所
发明人： SHIOKAWA SACHIKO , MATSUI YOSHIKAZU , KONDO ATSUSHI
IPC分类号： B01J19/10 , F24J3/00 , H03H9/25 , H04R1/00 , H05B1/00
CPC分类号： H05B6/686 , A61N7/00
摘要： PROBLEM TO BE SOLVED: To provide new uses for surface acoustic waves such as those regarding a device utilizing surface acoustic waves, to be more precisely, a heating device utilizing surface acoustic waves and a heating method using the same.
SOLUTION: This heating device is provided with a surface acoustic wave generator having a piezoelectric substrate and reed-screen-shaped electrodes formed on the substrate where a heating reaction zone is formed on a part of the piezoelectric substrate.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：为了提供诸如关于利用表面声波的装置的表面声波的新用途，更准确地说，使用表面声波的加热装置和使用其的加热方法。解决方案：该加热装置设置有表面声波发生器，其具有压电基板和形成在基板上的簧片状电极，在压电基板的一部分上形成有加热反应区。版权所有（C）2005，JPO＆NCIPI

6. 发明专利

JP2014139139A Monoclonal antibody to human telomerase reverse transcriptase 审中-公开
标题翻译：单克隆抗体针对人类TELOMERASE逆转录酶
公开(公告)号：JP2014139139A
公开(公告)日：2014-07-31
申请号：JP2011101970
申请日：2011-04-28
申请人： Igaku Seibutsugaku Kenkyusho:Kk , 株式会社医学生物学研究所 , National Cancer Center , 独立行政法人国立がん研究センター
发明人： MASUTOMI KENKICHI , YASUKAWA ASAMI , OKAMOTO NAOKO , OOKA SEII , KINOSHITA KEITA
IPC分类号： C07K16/40 , C12N15/09 , C12P21/08
CPC分类号： C07K16/40 , C07K2317/73
摘要： PROBLEM TO BE SOLVED: To provide a monoclonal antibody capable of specifically detecting human telomerase reverse transcriptase (hTERT) protein, in particular, a monoclonal antibody capable of specifically detecting endogenous hTERT protein in a detection method such as a Western blot method, a cell immune dyeing method, an ELISA method, an immunoprecipitation method, a chromatin immunoprecipitation method and an RNA-binding protein immunoprecipitation method.SOLUTION: A monoclonal antibody binds to a polypeptide composed of a specific amino acid sequence. A production method of the monoclonal antibody to hTERT comprises a step of immunizing using the polypeptide.
摘要翻译：要解决的问题：提供能够特异性检测人类端粒酶逆转录酶（hTERT）蛋白质的单克隆抗体，特别是能够在检测方法例如Western印迹法，细胞免疫中特异性检测内源性hTERT蛋白质的单克隆抗体染色方法，ELISA法，免疫沉淀法，染色质免疫沉淀法和RNA结合蛋白免疫沉淀法。解决方案：单克隆抗体结合由特定氨基酸序列组成的多肽。 hTERT的单克隆抗体的制备方法包括使用多肽进行免疫的步骤。

7. 发明专利

JP2013236627A Analysis methods for y chromosome and deletion site of sperm forming area on y chromosome 有权
标题翻译： Y染色体上形成区域的色素沉淀和去除位点的分析方法
公开(公告)号：JP2013236627A
公开(公告)日：2013-11-28
申请号：JP2013089854
申请日：2013-04-22
申请人： Kanazawa Univ , 国立大学法人金沢大学 , Igaku Seibutsugaku Kenkyusho:Kk , 株式会社医学生物学研究所
发明人： KO EITETSU , NAMIKI MIKIO , OKADA HIDEKI , KATO KANA , ABE YUKIKO
IPC分类号： C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide analysis methods which enable a simple speedy and accurate examination of male sterility by analyzing and specifying the Y chromosome and the deletion site of the sperm forming area on the Y chromosome.SOLUTION: There are provided novel analyzing methods for the Y chromosome and the deletion pattern of the sperm forming area on the Y chromosome.
摘要翻译：要解决的问题：提供分析方法，通过分析和确定Y染色体上的Y染色体和精子形成区域的缺失位点，能够简单快速，准确地检测雄性不育。解决方案：提供了新颖的分析方法 Y染色体上的Y染色体和精子形成区域的缺失图案。

8. 发明专利

JP2011234720A Method for measuring kinase activity of cyclin/cdk complex 审中-公开
标题翻译：用于测量CYCLIN / CDK复合物的激酶活性的方法
公开(公告)号：JP2011234720A
公开(公告)日：2011-11-24
申请号：JP2011127868
申请日：2011-06-08
申请人： Igaku Seibutsugaku Kenkyusho:Kk , 株式会社医学生物学研究所
发明人： SUZUKI SUSUMU , TAMAI KATSUYUKI , TAJI SHINGO , OGAWA AKIRA
IPC分类号： C12Q1/48 , C07K14/47 , C07K16/18 , C12N9/12 , C12N9/16 , C12N15/09 , G01N33/15 , G01N33/50 , G01N33/573 , G01N33/68
CPC分类号： G01N33/6842 , C07K16/18 , C12Q1/48 , G01N33/5011 , G01N33/573 , G01N33/68 , G01N2333/912 , G01N2333/9121 , G01N2333/916 , G01N2500/04
摘要： PROBLEM TO BE SOLVED: To provide methods for measuring the kinase activity of a cyclin/CDK complex to a RB protein or its partial peptide in a sample.SOLUTION: The invention provides the methods for measuring the kinase activity of the cyclin/CDK complex to the RB protein by assaying the phosphorylation of the RB protein phosphorylated by the cyclin/CDK complex by an immunoassay method using antibody which can identify a phosphorylation condition, and methods for measuring the dephosphorylation activity to the RB protein phosphorylated by the cyclin/CDK complex. Compounds that regulate the activities of these enzymes can be screened by applying these measuring methods.
摘要翻译：待解决的问题：提供测量细胞周期蛋白/ CDK复合物对样品中RB蛋白或其部分肽的激酶活性的方法。解决方案：本发明提供了通过使用免疫测定方法测定由细胞周期蛋白/ CDK复合物磷酸化的RB蛋白的磷酸化来测定细胞周期蛋白/ CDK复合物对RB蛋白的激酶活性的方法，所述抗体可鉴定磷酸化条件和测量由细胞周期蛋白/ CDK复合物磷酸化的RB蛋白的去磷酸化活性的方法。可以通过应用这些测量方法筛选调节这些酶的活性的化合物。版权所有（C）2012，JPO＆INPIT

9. 发明专利

JP2011042581A ANTIBODY AGAINST OXIDIZED LDL/β2GPI COMPLEX AND USE THEREOF 有权
标题翻译：抗氧化LDL /β2GPI复合物的抗体及其用途
公开(公告)号：JP2011042581A
公开(公告)日：2011-03-03
申请号：JP2009146783
申请日：2009-06-19
申请人： Igaku Seibutsugaku Kenkyusho:Kk , Okayama Univ , 国立大学法人岡山大学 , 株式会社医学生物学研究所
发明人： MATSUURA EIJI , KOJIMA KAZUO
IPC分类号： C07K16/44 , C07K16/46 , C12N15/02 , C12N15/09 , G01N33/15 , G01N33/50 , G01N33/53
CPC分类号： G01N33/6893 , A61K49/0034 , A61K49/0058 , C07K16/18 , C07K2317/56 , C07K2317/565 , G01N33/5088 , G01N2800/323
摘要： PROBLEM TO BE SOLVED: To provide a method for diagnosing non-invasive arteriosclerosis, such as the specifying of a specific atherosclerosis(atheromatosis)-existing site, the monitoring of a therapeutic effect. SOLUTION: In light of the constituents of arteriosclerosis atheromatosis, whether an oxidized LDL/β 2 GPI complex antibody specifically binds to the arteriosclerosis atheromatosis in vivo, and whether the lesion can specifically be detected from the outside of a body has been examined. Namely, the nest of the arteriosclerosis, especially an antibody capable of being applied to the imaging of the existing position of arteriosclerosis atheromatosis and the size thereof, has been specified, and the specificity has been analyzed. Consequently, it has been found that an oxidized LDL/β 2 GPI complex antibody labeled product having specificity to a specific epitope, among the oxidized LDL/β 2 GPI complex antibodies capable of imminostaining arteriosclerotic sections is effective for the specific imaging of the existing site of atherosclerosis. This enables the specific imaging of a lesion which is atheromatosis. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供诊断非侵入性动脉硬化的方法，例如指定特异性动脉粥样硬化（动脉粥样硬化）存在部位，治疗效果的监测。解决方案：鉴于动脉粥样硬化性粥样硬化症的成分，氧化的LDL /β2 SBI复合物抗体是否特异性结合动物硬化性动脉粥样硬化症，以及是否可以从身体外面已经被检查过了。也就是说，已经规定了动脉硬化巢，特别是能够应用于动脉硬化性粥样硬化斑块的现有位置成像的抗体及其大小，并且分析了特异性。因此，已经发现，具有特异性表位特异性的氧化的LDL /βSBB2 GPI复合抗体标记的产物在具有抗氧化能力的氧化型LDL /β 2 动脉硬化切片对于现有动脉粥样硬化部位的特异性成像是有效的。这使得能够进行动脉粥样硬化病变的特异性成像。版权所有（C）2011，JPO＆INPIT

10. 发明专利

JP2009229455A Method for detecting, preparing, and culturing pancreas precursor cell 审中-公开
标题翻译：检测，制备和培养胰蛋白酶前体细胞的方法
公开(公告)号：JP2009229455A
公开(公告)日：2009-10-08
申请号：JP2009043351
申请日：2009-02-26
申请人： Igaku Seibutsugaku Kenkyusho:Kk , Atsushi Miyajima , 篤宮島 , 株式会社医学生物学研究所
发明人： SAITO HIROKI , TAKEUCHI MAKI , MIYAJIMA ATSUSHI
IPC分类号： G01N33/48 , A61L27/00 , A61P3/10 , C12N5/07 , C12N5/074 , C12N5/095 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/74
摘要： PROBLEM TO BE SOLVED: To provide identification of cell membrane antigen which can fractionate pancreatic cells, a method for providing pancreatic cells by using the identified cell membrane antigen, and a method for culturing Langerhans islets and a method for forming and culturing pancreatic ducts using cells fractionated by the cell membrane antigen. SOLUTION: Dlk and PCLPI have been found as an pancreatic surface antigen in developmental process. It has been proved that pancreas precursor cell can easily be fractionated by using these antigens as a marker. In addition, a new cultivation system for utilizing those cells fractionated by this invented method to build three-dimensional structure of Langerhans islets and pancreatic ducts has been developed. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供可分离胰腺细胞的细胞膜抗原的鉴定，通过使用鉴定的细胞膜抗原提供胰腺细胞的方法，以及培养朗格汉斯胰岛的方法和形成和培养胰腺的方法使用由细胞膜抗原分离的细胞的导管。解决方案：在发育过程中，已经发现Dlk和PCLPI是胰腺表面抗原。已经证明，通过使用这些抗原作为标记物，可以容易地将胰腺前体细胞分馏。另外，开发了利用本发明方法分级分离的细胞培养体系，建立了朗格汉斯胰岛和胰管三维结构。版权所有（C）2010，JPO＆INPIT

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式