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1. 发明专利

JP2020090448A アレルギー性結膜炎予防又は治療剤审中-公开
公开(公告)号：JP2020090448A
公开(公告)日：2020-06-11
申请号：JP2018227519
申请日：2018-12-04
申请人： JUNTENDO
发明人： MATSUDA AKIRA , HIRAKATA TOSHIAKI , YOKOMIZO TAKEHIKO
IPC分类号： A61K31/202 , A23L33/115 , A61K31/232 , A61P27/02 , A61P27/14 , A61P29/00 , A61P37/08 , A61P43/00
摘要：【課題】新たなアレルギー性結膜炎の予防治療剤の提供。【解決手段】オメガ3脂肪酸又はそのエステルを有効成分とするアレルギー性結膜炎予防又は治療剤。【選択図】なし

2. 发明专利

JP2014076009A Method of determining allergic rhinitis 审中-公开
标题翻译：确定过敏性RHINITIS的方法
公开(公告)号：JP2014076009A
公开(公告)日：2014-05-01
申请号：JP2012225608
申请日：2012-10-11
申请人： Juntendo , 学校法人順天堂
发明人： MIWA MASATO
IPC分类号： C12Q1/68 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a method of determining allergic rhinitis in a non-invasive manner.SOLUTION: A method of determining allergic rhinitis is characterized in measuring the expression level of a filaggrin gene in the nasal mucosa of a patient.
摘要翻译：要解决的问题：提供以非侵入性方式确定过敏性鼻炎的方法。解决方案：确定过敏性鼻炎的方法的特征在于测量患者鼻粘膜中丝聚蛋白基因的表达水平。

3. 发明专利

JP2014038087A Diagnostic method of nitric monoxide stress 有权
标题翻译：硝基一氧化氮应变的诊断方法
公开(公告)号：JP2014038087A
公开(公告)日：2014-02-27
申请号：JP2013109299
申请日：2013-05-23
申请人： Juntendo , 学校法人順天堂 , Nikken Seil Co Ltd , 日研ザイル株式会社
发明人： YAMAKURA FUMIYUKI , KAWASAKI HIROAKI , SAKAI KAZUO
IPC分类号： G01N33/53 , G01N27/447 , G01N30/88
摘要： PROBLEM TO BE SOLVED: To provide a nitric monoxide stress diagnostic method of identifying a position where a nitric monoxide stress is generated in a living body, and to provide a method of diagnosing a disease originated from the nitric monoxide stress at the identified position of the living body.SOLUTION: By detecting nitro-tryptophan produced in a protein by nitric monoxide stress, a nitric monoxide stress diagnostic method identifies a position where the nitric monoxide stress is generated in a living body by combining: a specific position (a specific organ, for example) of the living body; and a specific protein related to the specific position of the living body such as produced at the specific position of the living body or originated from the specific position. A diagnostic method that diagnoses a disease originated from the nitric monoxide stress at the position of the specified living body, is provided. Both the methods can be provided.
摘要翻译：要解决的问题：提供一种用于鉴定在生物体中产生一氧化氮应激的位置的一氧化氮应激诊断方法，并且提供一种诊断来源于所识别的位置的一氧化氮应激的疾病的方法生物体。解决方案：通过一氧化氮胁迫检测蛋白质产生的硝基色氨酸，一氧化氮应激诊断方法通过组合确定生物体内产生一氧化氮应激的位置：特定位置（特定器官，例如）生物体; 以及与活体的具体位置相关的特定蛋白质，例如在生物体的特定位置产生或来自特定位置的特定蛋白质。提供诊断来自于特定生物体的位置的一氧化氮应激的疾病的诊断方法。可以提供这两种方法。

4. 发明专利

JP2014023786A Exercise device 有权
标题翻译：锻炼装置
公开(公告)号：JP2014023786A
公开(公告)日：2014-02-06
申请号：JP2012167475
申请日：2012-07-27
申请人： Juntendo , 学校法人順天堂 , Showa Denki Kk , 昭和電機株式会社
发明人： SAWAKI KEISUKE , KAMATANI JUNJI , ARIMOTO KEN , TAKENAKA YUZO , HOTEI TOMOTERU , ADACHI SHINYA
IPC分类号： A63B23/00 , A61H1/02 , A61H3/00 , A63B22/02 , A63B69/00
摘要： PROBLEM TO BE SOLVED: To provide an exercise device capable of setting a load relief ratio or a load relief amount by a simple method.SOLUTION: An exercise device 1 includes a chamber 10 having an opening 12 which allows a user 40 to enter and leave it, a seal member 20 which closes the opening 12 of the chamber 10 airtight, a pressure control unit 30 which pressurizes the inside of the chamber 10, and an exercise apparatus 2 accommodated inside the chamber 10, and relieves a prescribed load from the body weight of the user 40 by pressurizing the inside of the chamber 10 with a prescribed pressure. The size of the seal member 20 can be selected in accordance with the physique of the user 40. The pressure control unit 30 pressurizes the inside of the chamber 10 with a pressure which is calculated from the selected size of the seal member 20 and the set load relief ratio or load relief amount on the basis of the correlation between the load relief ratio or the load relief amount predetermined for each size of the seal member 20 and the pressure.
摘要翻译：要解决的问题：提供一种能够通过简单的方法设定负载减小量或负载释放量的运动装置。解决方案：运动装置1包括具有允许使用者40进入和离开的开口12的室10 封闭室10的开口12的密封构件20，对室10内部进行加压的压力控制单元30和容纳在室10内的运动装置2，并且从身体释放规定的负荷通过以规定的压力对腔室10的内部进行加压来使用者40的重量。密封构件20的尺寸可以根据使用者40的体质来选择。压力控制单元30以从密封构件20和组的选定尺寸计算出的压力对室10的内部加压基于对于密封构件20的每个尺寸预先确定的负载减小量或负载减轻量与压力之间的相关性的负载减小量或负载减轻量。

5. 发明专利

JP2012034898A Underwater sphygmomanometer 有权
标题翻译：水下气泡计
公开(公告)号：JP2012034898A
公开(公告)日：2012-02-23
申请号：JP2010178704
申请日：2010-08-09
申请人： Juntendo , 学校法人順天堂
发明人： KAWAI SACHIO , INOUE HITOSHI , INOUE HIROSHI
IPC分类号： A61B5/022
摘要： PROBLEM TO BE SOLVED: To provide an underwater sphygmomanometer, capable of normally measuring blood pressure in water without being affected by water or hydraulic pressure.SOLUTION: The underwater sphygmomanometer includes a sphygmomanometer body 50 stored and installed within a waterproof case 10; and a sphygmomanometer cuff 70 with a pressurizing bag 80 and a microphone 90 disposed outside the waterproof case 10. The waterproof case 10 includes a regulator 20 connectable to a respiration air tank 100, the regulator equilibrating the internal pressure of the waterproof case 10 with the external pressure of the waterproof case according to increase in external pressure of the waterproof case 10 in going deep underwater by introducing air into the waterproof case 10; an external discharge pipe portion 32 having a discharge valve 33 for discharging the air inside the waterproof case 10 to the outside of the waterproof case 10 according to reduction in external pressure of the waterproof case 10 in floating; and a measurement start lever 40 which operates a measurement start button 51 of the sphygmomanometer body 50.
摘要翻译：要解决的问题：提供一种水下血压计，能够正常地测量水中的血压而不受水或液压的影响。
解决方案：水下血压计包括存储并安装在防水壳10内的血压计主体50; 以及血压计袖带70，其具有设置在防水壳10外部的加压袋80和麦克风90.防水壳10包括可连接到呼吸空气罐100的调节器20，调节器将防水壳10的内部压力与防水外壳的外部压力通过将空气引入防水壳10中，防水外壳10的外部压力在深水下进行; 外部排出管部32，具有排水阀33，用于根据防水壳10的外部压力的浮动将防水壳10内的空气排出到防水壳10的外部; 以及测量启动杆40，其操作血压计主体50的测量开始按钮51.版权所有：（C）2012，JPO＆INPIT

6. 发明专利

JP2011152324A Electrode for intracerebral substance measurement 审中-公开
标题翻译：用于内窥镜物质测量的电极
公开(公告)号：JP2011152324A
公开(公告)日：2011-08-11
申请号：JP2010016619
申请日：2010-01-28
申请人： Juntendo , Keio Gijuku , 学校法人慶應義塾 , 学校法人順天堂
发明人： EINAGA YASUAKI , MITANI NAOKO , YOSHIMI KENJI
IPC分类号： A61B5/00 , A61B10/00 , G01N27/30 , G01N27/416 , G01N27/48 , G01N33/483
摘要： PROBLEM TO BE SOLVED: To provide a micro-electrode which has such sufficient strength as to prevent bending of the micro-electrode even when inserted into the brain of a large animals including a human being and which enables intracerebral substances to be measured at high sensitivity.
SOLUTION: An electrode for intracerebral substance measurement has a micro-needle-shaped electrode part which is obtained by vapor-depositing diamond including 3-8% boron raw material on the surface of high-strength metal needle and which has a diameter of 0.01-0.3 mm and a length of 0.02-2.0 mm.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种微电极，其具有足够的强度，即使当插入到包括人的大型动物的脑中并且能够测量大脑内物质时，也能够防止微电极的弯曲灵敏度高。解决方案：用于脑内物质测量的电极具有微针状电极部，其通过在高强度金属针的表面上气相沉积含有3-8％硼原料的金刚石而获得，并且具有直径为0.01-0.3mm，长度为0.02-2.0mm。版权所有（C）2011，JPO＆INPIT

7. 发明专利

JP2011141177A Method for diagnosing chronic kidney disease 审中-公开
标题翻译：用于诊断慢性病毒性疾病的方法
公开(公告)号：JP2011141177A
公开(公告)日：2011-07-21
申请号：JP2010001638
申请日：2010-01-07
申请人： Juntendo , 学校法人順天堂
发明人： MURAKOSHI MAKI , TANIMOTO MITSUO , AIDA TOMOHITO , HAGIWARA SHINJI , TOMINO YASUHIKO
IPC分类号： G01N33/53 , C12Q1/02 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a novel diagnostic drug for a chronic kidney disease.
SOLUTION: This method for judging the chronic kidney disease is characterized by measuring the expression amount of mindin in a sample originating from an examination target or the gene thereof.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于慢性肾脏疾病的新型诊断药物。解决方案：用于判断慢性肾脏疾病的方法的特征在于测量源自检查对象或其基因的样品中的思维肽的表达量。版权所有（C）2011，JPO＆INPIT

8. 发明专利

JP2010197175A X-ray analyzer and x-ray analysis method 审中-公开
标题翻译： X射线分析仪和X射线分析方法
公开(公告)号：JP2010197175A
公开(公告)日：2010-09-09
申请号：JP2009041520
申请日：2009-02-24
申请人： Japan Synchrotron Radiation Research Inst , Juntendo , 学校法人順天堂 , 財団法人高輝度光科学研究センター
发明人： IWAMOTO HIROYUKI , MURAYAMA TAKASHI
IPC分类号： G01N23/04
摘要： PROBLEM TO BE SOLVED: To solve various technical problems at once which have been difficult to solve by a containerless method or a container method in an X-ray analyzer which irradiates a very small target particle, such as, a single molecule of protein with an X-ray beam.
SOLUTION: An X-ray analyzer includes a probe-type measuring means 2 for measuring the position and shape of a target particle P held in a holding substrate 1; a moving mechanism 3 for holding a probe 2a of the probe-type measuring means 2, in such a way as to move between a measuring position capable of measuring the target particle P and a retracted position, a position which does not interfere with the irradiation of the target particle with an X-ray beam by an X-ray irradiation mechanism; and a position adjusting mechanism 5 for adjusting the relative position of the holding substrate 1 and the X-ray irradiation mechanism. The relative position of the holding substrate 1 and the X-ray irradiation mechanism is adjusted to the target particle P, of which the position is predetermined by the probe-type measuring means 2 so as to enable it to irradiate X-ray beam.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：为了解决在X射线分析装置中难以解决的各种技术问题，该X射线分析仪照射非常小的目标颗粒，例如单分子蛋白质与X射线束。解决方案：X射线分析仪包括用于测量保持在保持基板1中的目标颗粒P的位置和形状的探针型测量装置2; 用于保持探针型测量装置2的探针2a的移动机构3以能够测量目标颗粒P的测量位置和缩回位置之间移动，不干扰照射的位置的X射线束的X射线照射机构; 以及用于调整保持基板1和X射线照射机构的相对位置的位置调整机构5。将保持基板1和X射线照射机构的相对位置通过探针型测定单元2调整到预定位置的目标粒子P，使其能够照射X射线束。版权所有（C）2010，JPO＆INPIT

9. 发明专利

JP2010105925A Skin keratinization-promoting agent 审中-公开
标题翻译：皮肤促进促进剂
公开(公告)号：JP2010105925A
公开(公告)日：2010-05-13
申请号：JP2008276990
申请日：2008-10-28
申请人： Juntendo , Mikimoto Pharmaceut Co Ltd , 学校法人順天堂 , 御木本製薬株式会社
发明人： NIYONSABA FRANCOIS , OGAWA HIDEOKI , OKAMOTO KIKUHIKO , MAEYAMA KAORU , HATTORI FUMIHIRO
IPC分类号： A61K8/98 , A61K8/64 , A61K35/56 , A61K38/00 , A61P17/16 , A61Q19/00 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To provide a new skin keratinization-promoting agent useful for improvement of barrier functions of the skin and prevention of skin ageing.
SOLUTION: The skin keratinization-promoting agent comprises hydrolyzed conchiolin. Thus, the skin keratinization-promoting agent exhibits effects for preventing skin ageing and for improving skin troubles.
COPYRIGHT: (C)2010,JPO&INPIT

10. 发明专利

JP2010105924A Skin keratinization-promoting agent 有权
标题翻译：皮肤促进促进剂
公开(公告)号：JP2010105924A
公开(公告)日：2010-05-13
申请号：JP2008276989
申请日：2008-10-28
申请人： Juntendo , Mikimoto Pharmaceut Co Ltd , 学校法人順天堂 , 御木本製薬株式会社
发明人： NIYONSABA FRANCOIS , OGAWA HIDEOKI , OKAMOTO KIKUHIKO , HATTORI FUMIHIRO , SAKAIDA KAZUNORI
IPC分类号： A61K8/19 , A61K8/98 , A61K33/00 , A61K35/56 , A61Q19/00 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To provide a new skin keratinization-promoting agent useful for improvement of barrier functions of the skin and prevention of skin ageing. SOLUTION: The skin keratinization-promoting agent comprises mineral components derived from a pearl layer. The mineral components derived from a pearl layer is obtained by calcining a pearl layer, obtained by denucleation of a pearl, or a pearl layer of a shell, then dissolving the mineral components in an acid or purified water followed by filtration and neutralization. The mineral components derived from the pearl layer contain calcium, sodium, magnesium, iron, zinc and a trace amount of other minerals. The compositional ratio of the main mineral components based on the dried matter is 50-99 mass%, preferably 70-95 mass%, of calcium, 0-40 mass%, preferably 1-15 mass%, of sodium, 0-5 mass%, preferably 0.01-1 mass%, of magnesium, 0-10 mass%, preferably 0.5-5 mass%, of iron and 0-5 mass%, preferably 0.01-1 mass%, of zinc. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供可用于改善皮肤屏障功能并防止皮肤老化的新型皮肤角质化促进剂。皮肤角质化促进剂包含衍生自珍珠层的矿物成分。来自珍珠层的矿物组分是通过煅烧通过脱壳珍珠获得的珍珠层或壳的珍珠层获得的，然后将矿物组分溶解在酸或纯净水中，然后过滤和中和。来自珍珠层的矿物成分含有钙，钠，镁，铁，锌和其他矿物质。基于干物质的主要矿物成分的组成比为50〜99质量％，优选为70〜95质量％的钙，0〜40质量％，优选为1-15质量％的钠，0〜5质量％％，优选0.01〜1质量％的镁，0〜10质量％，优选0.5〜5质量％的铁和0〜5质量％，优选0.01〜1质量％的锌。版权所有（C）2010，JPO＆INPIT

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