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1. 发明专利

JP2017086081A 抗ヒトＣＬＣＰ１抗体とその用途有权
公开(公告)号：JP2017086081A
公开(公告)日：2017-05-25
申请号：JP2016238152
申请日：2016-12-08
申请人：株式会社医学生物学研究所 , Igaku Seibutsugaku Kenkyusho:Kk , 株式会社Oncomics , Oncomics Co Ltd
发明人： ONO KENICHIRO , TAKAHASHI TAKASHI
IPC分类号： C12N15/09 , A61K39/395 , A61P35/00 , A61P35/04 , C07K16/28 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08 , G01N33/53 , G01N33/574
CPC分类号： G01N33/574 , A61K2039/505 , C07K16/3023 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92 , G01N33/5011
摘要：【課題】ヒトCLCP1抗原の細胞外ドメインを認識する抗体及びその用途の提供。【解決手段】CLCP1を発現する、腎がん、膀胱腫瘍、前立腺がん、膵臓がん、胃がん、大腸がん、乳がん又は肺がん細胞の遊走阻害活性、浸潤阻害活性、増殖阻害活性、転移阻害活性、及び細胞障害活性を有する、特定のアミノ酸配列からなるペプチドを認識する抗体、及び該抗体をコードする核酸、該核酸を発現可能に保持するベクター、及び該ベクターを有する形質転換細胞。【選択図】なし

2. 发明专利

JP2014167419A Combination of molecular markers for early detection of pleural mesothelioma patient and method for analyzing expression of molecular markers 审中-公开
标题翻译：分子标记物的组合，用于早期检测平滑肌细胞患者和分析分子标记表达的方法
公开(公告)号：JP2014167419A
公开(公告)日：2014-09-11
申请号：JP2013039022
申请日：2013-02-28
申请人： Nagoya Univ , 国立大学法人名古屋大学 , Igaku Seibutsugaku Kenkyusho:Kk , 株式会社医学生物学研究所 , Oncomics Co Ltd , 株式会社Oncomics
发明人： YANAGISAWA SEI , TAKAHASHI TAKASHI , YOKOI KOHEI , HASEGAWA YOSHINORI , ONO KENICHIRO , YAGI KASUMI , UEHARA RIE , FUJII NORIHIRO , KISHI YOSHIRO , TAKEUCHI TOSHIYUKI
IPC分类号： G01N33/574 , C07K16/18 , C12N15/02 , C12P21/08
摘要： PROBLEM TO BE SOLVED: To develop a convenient, inexpensive and highly reliable method for examining mesothelioma, and a kit used in the examining method.SOLUTION: The present invention provides a method for examining mesothelioma comprising the steps of: measuring human periostin protein concentration in at least one of a blood sample and a pleural effusion sample of a subject; and measuring human MPF protein concentration in the blood sample of the subject. In the step of measuring human periostin protein concentration, an antibody against human periostin protein may be used. The present invention provides a kit for diagnosing mesothelioma comprising an antibody against human periostin protein and an antibody against human MPF protein. In the diagnosis of mesothelioma using the kit for diagnosing mesothelioma of the present invention, it may be determined whether a subject who has a possibility of having mesothelioma is a patient with mesothelioma or a healthy person. In the diagnosis of mesothelioma using the kit for diagnosing mesothelioma of the present invention, it may be determined whether a subject who has a possibility of having mesothelioma is a patient with mesothelioma or a patient with respiratory organ disease other than mesothelioma.
摘要翻译：要解决的问题：开发用于检查间皮瘤的方便，廉价和高可靠性的方法以及用于检查方法的试剂盒。解决方案：本发明提供了一种用于检查间皮瘤的方法，包括以下步骤：测量人骨膜素蛋白浓度受试者的血液样品和胸腔积液样品中的至少一种; 并测量受试者血样中的人MPF蛋白浓度。在测定人骨膜素蛋白浓度的步骤中，可以使用抗人骨膜素蛋白的抗体。本发明提供了一种用于诊断间皮瘤的试剂盒，其包含针对人骨膜素蛋白的抗体和针对人MPF蛋白的抗体。在使用本发明的诊断间皮瘤的试剂盒的间皮瘤的诊断中，可以确定具有间皮瘤的可能性的受试者是否是间皮瘤患者或健康人。在使用本发明的诊断间皮瘤的试剂盒的间皮瘤的诊断中，可以确定具有间皮瘤的可能性的受试者是否是间皮瘤的患者或除了间皮瘤以外的呼吸器官疾病的患者。

3. 发明专利

JP2010066225A Method and biological marker for blood detection of plurality of cancers utilizing mass spectrometry 有权
标题翻译：用于血液检测的方法和生物标志物利用质谱测定的癌症多样性
公开(公告)号：JP2010066225A
公开(公告)日：2010-03-25
申请号：JP2008235216
申请日：2008-09-12
申请人： Aichi Prefecture , Nagoya Univ , Oncomics Co Ltd , 国立大学法人名古屋大学 , 愛知県 , 株式会社Oncomics
发明人： TAKAHASHI TAKASHI , YANAGISAWA SEI , TOMITA HIDETA , TAKEUCHI TOSHIYUKI , KUSUMEGI MIYOKO , MATSUO KEITARO , TAJIMA KAZUO
IPC分类号： G01N27/62 , G01N33/53 , G01N33/574 , G01N33/68 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a method capable of blood detection of a human cancer-carrying patient aiming at a plurality of cancers including pancreatic cancer and ovarian cancer. SOLUTION: The method for detecting and identifying a plurality of cancers by using a single blood sample relative to a human cancer-carrying patient has processes for: (1) acquiring a protein manifestation profile by measuring a mass spectrum of each protein in a blood sample originated in a human cancer-carrying patient carrying each cancer relative to a plurality of kinds of cancers and in a blood sample originated in a non-cancer healthy person; (2) selecting a peak of a mass number (m/z) capable of discriminating each of a specific kind of human cancers from non-cancer, relative to a peak showing the protein manifestation profile in step (1); and (3) measuring a mass spectrum of a protein in a single blood sample originated in the human cancer-carrying patient in which the kind of the cancer is unknown, and detecting and identifying a plurality of human cancers by using a difference of a relative manifestation level with the non-cancer healthy person as an index, relative to the peak of the mass number (m/z) selected in step (2), based on the acquired protein manifestation profile. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供能够针对包括胰腺癌和卵巢癌在内的多种癌症的携带人体的患者的血液检测的方法。解决方案：通过使用单个血液样品相对于携带癌症的患者检测和鉴定多种癌症的方法具有以下过程：（1）通过测量蛋白质表现谱来测量蛋白质的质谱血液样本源自携带癌症的人类携带癌症的患者相对于多种癌症和源自非癌症健康人的血液样品; （2）相对于在步骤（1）中显示出蛋白质表现形态的峰值，选择能够区分特定种类的人类癌症中的每一种与非癌症的质量数（m / z）的峰值。以及（3）测定来源于癌症的种类未知的携带人体的患者的单一血液样品中的蛋白质的质谱，以及通过使用相对的差异来检测并识别多种人类癌症基于获得的蛋白质表现谱，相对于步骤（2）中选择的质量数（m / z）的峰值，非癌症健康人的表现水平为指标。版权所有（C）2010，JPO＆INPIT

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