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101. 发明专利

JPH0797371A BENZODIAZEPIN DERIVATIVE HAVING ANTIULCER ACTIVITY 失效
公开(公告)号：JPH0797371A
公开(公告)日：1995-04-11
申请号：JP24271293
申请日：1993-09-29
申请人： SHIONOGI & CO
发明人： HAGISHITA YAMAJI , SENO KAORU , MIYAKOSHI MASANORI , TSUSHIMA TADAHIKO , ISHIHARA YASUNOBU
IPC分类号： C07D243/24 , A61K31/55 , A61K31/551 , A61P1/04 , C07D417/12
摘要： PURPOSE:To obtain a compound having a histamine H2 receptor antagonism and a gastrin receptor antagonism and useful as an antiulcer agent having low relapse rate. CONSTITUTION:A compound of formula I [R and R are H, halogen, a lower alkyl, a lower alkoxy; R is H or a lower alkyl; R is single bond or CO; R is NH, 1,4-piperadinyl, etc.; R is a 1-15C alkylene, etc.; R is 2-[(2-guanidino- thiazol-4-yl)methylthin]-ethylcarbamoyl, etc.], e.g. 1-methyl-3-(N'-(m-tolyl) ureido)5-(3-(2-(2-guanidino-1,3-thiazol-4-yl)methylthio (ethylcarbamoylmethylcarbamoylmethoxy)phenyl)-1,3-dihydro-2H-1,4- benzodiazepin-2-one. The compound of formula I is obtained by subjecting a compound of formula II (R is OCH3, OCH2COOH, etc.) to coupling with a compound of formula III (R is NH2, etc.) by well-known acid-base reaction.

102. 发明专利

JPH0772157A METHOD AND KIT FOR DETERMINATION OF SACCHARIFIED PROTEIN 失效
公开(公告)号：JPH0772157A
公开(公告)日：1995-03-17
申请号：JP21671993
申请日：1993-08-31
申请人： SHIONOGI & CO
发明人： KOBAYASHI KUNIO , YOSHIMOTO KOICHI , HIRAUCHI MITSUMASA , UCHIDA KIYOHISA
IPC分类号： G01N33/66 , G01N33/68
摘要： PURPOSE:To determine saccharified protein in a sample simply, quickly and with high accuracy by a method wherein the sample which contains the saccharified protein and glucose coexisting with the saccharified protein is oxidation- treated, it is reacted with hydrazine, phenylhydrazine and a nonionic surface-active agent are added and a caused change in absorbance is measured. CONSTITUTION:A sample as blood which contains saccharified protein and which is originated from a living body, preferably blood serum, is prepared as a sample to be used. The sample is first oxidation-treated, and glucose which affects the measurement of the saccharified protein is removed. Hydrazine is reacted with the sample, and the saccharified protein in the sample is changed into free 2-ketoglucose. Then, phenylhydrazine is added, glucose diphenylhydrazone (a yellow pigment) is produced, and the precipitation of protein is prevented by a nonionic surface-active agent. The reaction rate of this coloration reaction is nearly definite for five to ten minutes from the start of the reaction, and a standard curve is linear. As a result, when a change in absorbance during this period is measured, the colorimetric determination of the saccharified protein in the sample can be performed with high accuracy.

103. 发明专利

JPH0770032A PRODUCTION OF E-METHOXYIMINOACETAMIDE OR ITS ESTER 失效
公开(公告)号：JPH0770032A
公开(公告)日：1995-03-14
申请号：JP18930094
申请日：1994-08-11
申请人： SHIONOGI & CO
发明人： TAKASE AKIRA , KAI HIROYUKI , NISHIDA KUNIYOSHI , SASAMOTO SHIYOUJI , NAGAI MASAHIKO
IPC分类号： C07B43/00 , C07C249/04 , C07C249/12 , C07C251/48
摘要： PURPOSE:To economically obtain the subject compound as an agricultural germicide or an intermediate thereof with low levels of byproducts by treating the z-modification of a methoxyiminoacetamide or methoxyiminoacetate with an acid in a lower alcohol. CONSTITUTION:The objective E-methoxyiminoacetamide or E- methoxyiminoacetate as an E-modification of formula II is obtained by reaction of (A) a x-modification of formula I [X is H, a lower alkyl, a lower alkoxy or a halogen; A is CONHCH3 or COOR (R is a lower alkyl)] with (B) 0.1-10mol of an acid such as hydrogen chloride, sulfuric acid or toluenesulfonic acid at 20-150 deg.C. The E-methoxyiminoacetamide is the E-modification of a methoxyiminoacetamide compound of formula III (wavy line denotes E- or Z-modification or a mixture thereof) useful as an agricultural germicide. The E-methoxyiminoacetate is an intermediate for this E-modification.

104. 发明专利

JPH0767655A PROMOTER FOR COMBINED POXVIRUS AND RECOMBINENT POXVIRUS HAVING THE SAME 失效
公开(公告)号：JPH0767655A
公开(公告)日：1995-03-14
申请号：JP23895393
申请日：1993-08-30
申请人： NIPPON ZEON CO , SHIONOGI & CO
发明人： YAMAGUCHI TAKESHI , FUKUSHI HIDETO , HIRAI KATSUYA , AOYAMA SHIGEMI , IRITANI KOICHI , HAYASHI YUKIHIRO , OGAWA RYOHEI , TAKAMURA CHIZUKO , KAMOGAWA KOICHI
IPC分类号： A61K39/275 , A61P31/12 , C12N7/00 , C12N15/00 , C12N15/09 , C12R1/92
摘要： PURPOSE:To obtain a new promoter useful for improving manifestation ratio of recombinant poxvirus suitable as a recombinant live vaccine for domestic fowls. CONSTITUTION:This promoter for combined poxvirus is a combined promoter for combined poxvirus obtained by linking four or more DNA fragments (e.g. L promoter having a base sequence of the formula) having promoter activity. For example, plasmid p4LH contains four L promoters.

105. 发明专利

JPH0761968A UREA DERIVATIVE CONTAINING HETERO-RING 失效
公开(公告)号：JPH0761968A
公开(公告)日：1995-03-07
申请号：JP12408794
申请日：1994-06-06
申请人： SHIONOGI & CO
发明人： MATSUMURA HIROSHI , YANO TOSHISADA , HASHIZUME HIROSHI , EIGIYOU MASAMI , OTANI KOICHI , ARIMURA AKINORI
IPC分类号： A61K31/42 , A61K31/421 , A61K31/435 , A61K31/44 , A61K31/4402 , A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/451 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61P37/08 , A61P43/00 , C07D207/26 , C07D207/263 , C07D207/27 , C07D211/14 , C07D211/22 , C07D211/46 , C07D211/70 , C07D213/74 , C07D233/02 , C07D233/38 , C07D239/42 , C07D241/20 , C07D263/22 , C07D265/32 , C07D279/12 , C07D295/20 , C07D295/215 , C07D295/22 , C07D295/26 , C07D317/58 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： PURPOSE:To provide a new compound having strong antihistaminic action and useful as an antiallergic agent free from side action. CONSTITUTION:A compound of the formula I [Z is C or N; m is 0, 1, etc,; A is 0, SO2 or CH2; n is 0-3, etc.; R is condensed aromatic ring, carboxyl, etc.; R and R are H, etc.; k is 2-5; Y is O, S, CH2, etc.; Y is CH2 or CO; Y is (CH2)2 or phenylene; k is 0 or 1], e.g. 3-{4-(diphenylhydroxymethyl)- piperidin-1-yl}-propylcarbamoyl-3-oxothiomorpholine. The compound of the formula I can be produced by reacting a urea derivative of the formula II (Q is halogen) with an amine of the formula III in a solvent (e.g. acetonitrile) at 10-120 deg.C. The compound is useful for the prevention and treatment of allergic diseases such as bronchial asthma, allergic rhinitis and urticaria. It has anti- inflammatory action as well.

106. 发明专利

JPH06312942A CARCINOSTATIC AGENT FOR HUMAN HEPATOMA CELL PRODUCING ALPHA-FETOPROTEIN 失效
公开(公告)号：JPH06312942A
公开(公告)日：1994-11-08
申请号：JP3267394
申请日：1994-03-02
申请人： SHIONOGI & CO
发明人： MASUDA KAZUYOSHI , OSADA TOSHIHARU , HIRANO KOICHIRO , TAKAGISHI YASUSHI
IPC分类号： A61K39/395 , A61P35/00
摘要： PURPOSE:To provide a powerful carcinostatic agent giving specific recognition for ATP on the surface of human hepatoma cell membrane, and to provide a method for purifying the agent. CONSTITUTION:The carcinostatic agent, an immunotoxin prepared by binding a type 1 liposome-deactivated protein to a monoclonal antibody (or its fragment) capable of specifically binding to alpha-fetoprotein(AFP) on the surface of human hepatoma cell membrane. And, the method for purifying the agent, comprising a treatment of the immunotoxin by an affinity chromatography using, as substrate, a cross-linked agarose gel with a chlorotriazine pigment covalently bonded thereto.

107. 发明专利

JPH06239852A ANTI-HIV ACTIVE NIVEFURANONE 失效
公开(公告)号：JPH06239852A
公开(公告)日：1994-08-30
申请号：JP3034293
申请日：1993-02-19
申请人： SHIONOGI & CO
发明人： FUJIWARA TAMIO , SATO AKIHIKO , KAWAMURA YOSHIMI , MATSUMOTO KOICHI , ITAZAKI HIROSHI
IPC分类号： A61K31/34 , A61K31/341 , A61P31/12 , C07D307/68 , C12N1/14 , C12P17/04 , C12R1/66
摘要： PURPOSE:To obtain a new compound useful as a preventive and a therapeutic agent for HIV infectious disease, showing antiretro virus activity. CONSTITUTION:A compound of the formula (R is 1-propenyl, 2-hydroxypropyl or 2-alkoxypropyl) or its alkali metal salt such as 5-(hexane1,3-dienyl)-5-methyl-4- oxo-2-(prop-1-enyl)-4,5-dihydrofuran-3-carboxylic acid. This compound is obtained by culturing a fungus RF-4,984 strain (FERM-BP-4,119) belonging to Aspergillus niveus) in a proper medium and under an adequate condition, purifying nivefuranone from the prepared cultured mixture and optionally chemically modifying.

108. 发明专利

JPH06219963A PHARMACEUTICAL CONTAINING REG PROTEIN AS ACTIVE COMPONENT 失效
公开(公告)号：JPH06219963A
公开(公告)日：1994-08-09
申请号：JP9157693
申请日：1993-04-19
申请人： SHIONOGI & CO
发明人： OKAMOTO HIROSHI
IPC分类号： A61K38/00 , A61P3/08 , A61P3/10 , A61P43/00 , C07K14/00 , C07K14/47 , A61K37/02 , C07K13/00
摘要： PURPOSE:To obtain a cell proliferation agent and an agent for suppressing sugar level in body fluid by using rat or human reg protein as an active component. CONSTITUTION:Rat or human reg protein is useful as a cell proliferation agent since the proliferation rate of cell cultured in a culture liquid incorporated with the reg protein is significantly higher than the proliferation rate of control. The protein is also useful as an agent for suppressing the sugar level in body fluid because the reg protein is effective for proliferating pancreatic islet of Langerhans.

109. 发明专利

JPH06211812A BENZODIAZEPINE DERIVATIVE 失效
公开(公告)号：JPH06211812A
公开(公告)日：1994-08-02
申请号：JP812093
申请日：1993-01-21
申请人： SHIONOGI & CO
发明人： HAGISHITA YAMAJI , SENO KAORU , MIYAKOSHI MASANORI , TSUSHIMA TADAHIKO , ISHIHARA YASUNOBU
IPC分类号： A61K31/55 , A61K31/551 , A61P1/04 , A61P43/00 , C07D243/16 , C07D243/18 , C07D243/24
摘要： PURPOSE:To obtain a benzodiazepine derivative, having excellent selective antagonistic action on gastrin receptor and useful as a therapeutic agent for diseases related to the gastrin such as gastric ulcer without any side effects on the central nervous system. CONSTITUTION:The compound of formula I {R is carboxy or CHR R ; R and R are H, alkoxy, amino, azide, OC(O)NH(CH2)3COOR , SCH2COOR (R is H or lower alkyl) or CONR R [R and R are H, (CH2)3(N-substituted) sulfamoylphenyl or, together with N to which both are bound, may form piperazine substituted with (CH2)5C(CH3)2OR (R is H or C(O)NH(CH2)3COOR )]} or its addition salt, e.g. 1-(carboxymethyl)-3-(N'-(m-toyl)ureido)-5-phenyl-1,3- dihydro-2H-1,4-benzodiazepin-2-one. The compound is produced by using a benzodiazepine compound of formula II as a starting substance.

110. 发明专利

JPH06205695A MONOCLONAL ANTIBODY COMBINING WITH BASOPHIL, SEPARATION OF BASOPHIL, RELEASE OF CHEMICAL MEDIATOR FROM BASOPHIL, AND TEST FOR RELEASING CHEMICAL MEDIATOR ORIGINATED FROM BASOPHIL 失效
公开(公告)号：JPH06205695A
公开(公告)日：1994-07-26
申请号：JP29737993
申请日：1993-11-02
申请人： SHIONOGI & CO
发明人： NISHIMURA SHINJI , NISHI YASUSHI , NISHIMURA SHOJI
IPC分类号： C07K1/22 , C07K16/00 , C07K16/18 , C07K16/28 , C07K17/08 , C07K17/14 , C12N5/08 , C12N5/10 , C12N5/20 , C12N15/02 , C12N15/06 , C12P21/08 , C12R1/91 , G01N33/50 , G01N33/53 , G01N33/569 , G01N33/577 , C07K15/28
摘要： PURPOSE:To obtain the novel antibody useful for separating basophils suitable for the releasing test of a specific chemical mediator through IgE. CONSTITUTION:This monoclonal antibody is e.g. a monoclonal antibody BA 101, recognizing a basophil, holding its activity after immobilized on a carrier, not inhibiting the specific release of histamine through the IgE from the basophil, and not inducing the non-specific release of histamine from the basophil. The exemplified anitibody is produced with a hybridoma BA 101 Shionogi (FERM BP-4004).

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