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1. 发明专利

JPH0767655A PROMOTER FOR COMBINED POXVIRUS AND RECOMBINENT POXVIRUS HAVING THE SAME 失效
公开(公告)号：JPH0767655A
公开(公告)日：1995-03-14
申请号：JP23895393
申请日：1993-08-30
申请人： NIPPON ZEON CO , SHIONOGI & CO
发明人： YAMAGUCHI TAKESHI , FUKUSHI HIDETO , HIRAI KATSUYA , AOYAMA SHIGEMI , IRITANI KOICHI , HAYASHI YUKIHIRO , OGAWA RYOHEI , TAKAMURA CHIZUKO , KAMOGAWA KOICHI
IPC分类号： A61K39/275 , A61P31/12 , C12N7/00 , C12N15/00 , C12N15/09 , C12R1/92
摘要： PURPOSE:To obtain a new promoter useful for improving manifestation ratio of recombinant poxvirus suitable as a recombinant live vaccine for domestic fowls. CONSTITUTION:This promoter for combined poxvirus is a combined promoter for combined poxvirus obtained by linking four or more DNA fragments (e.g. L promoter having a base sequence of the formula) having promoter activity. For example, plasmid p4LH contains four L promoters.

2. 发明专利

JPH03148066A MEMBRANE FOR DIAGNOSING VIRUS INFECTIOUS DISEASE AND DIAGNOSTIC METHOD 失效
公开(公告)号：JPH03148066A
公开(公告)日：1991-06-24
申请号：JP28855889
申请日：1989-11-06
申请人： NIPPON ZEON CO
发明人： SATO TAKANORI , TAKAMURA CHIZUKO , KAMOGAWA KOICHI
IPC分类号： G01N33/569 , A61B10/00
摘要： PURPOSE:To make it possible to diagnose the difference between the infections of affinous viruses efficiently and accurately by attaching two or more kinds of specific antigens which have affinous relation on one membrane carrier, and bringing the antigens into contact with the serum of a body under test. CONSTITUTION:With respect to virus which is the object of diagnosis, there is the cross reaction of antibodies between the virus and the antigen of an affinous virus. Serum to be inspected becomes positive by the reaction with a plurality of the virus antigens. When the deterministic judgment is difficult, there is no special restriction. In practical application, epidemic viruses in the same region are combined in response to purposes. The antigen wherein the peculiarity of the virus is maintained is formed. Then, the respective specific antigens are dropped on one membrane carrier without mixing and without loosing pecurialities. The antigens are sucked, and solvent is removed. Then the antigens are attached. The serum is diluted so that the reactivity with the antibody in the serum to be inspected becomes equal. The membrane is immersed into the serum to be inspected which is diluted at a constant temperature, and the virus antigens and the serum are brought into contact. Thus the infected viruses are diagnosed based on the amount of bondings between the antigens and the antibodies in the serum.

3. 发明专利

JPH06181792A PRODUCTION OF NONINFECTIOUS STRUCTURAL PARTICLE CONTAINING SURFACE ANTIGEN PROTEIN OF VIRUS BELONGING TO FLAVIVIRUS FAMILY AND RECOMBINANT VIRUS USING THEREFOR 失效
公开(公告)号：JPH06181792A
公开(公告)日：1994-07-05
申请号：JP14556892
申请日：1992-06-05
申请人： NIPPON ZEON CO , TOKYO METROPOLITAN GOV
发明人： SATO TAKANORI , TAKAMURA CHIZUKO , KAMOGAWA KOICHI , YASUI KOTARO
IPC分类号： A61K39/12 , A61P31/12 , C12N7/00 , C12N7/01 , C12N15/09 , C12N15/40 , C12P21/02 , C12R1/92
摘要： PURPOSE:To provide a method for mass production of SHA-like particles giving properties similar to those of SHA particles highly valuable as a vaccine. CONSTITUTION:A recombinant virus incorporated with the E-protein of flavivirus family and a cDNA coding the protease therefor is produced and then cultured to obtain the objective SHA-like particles.

4. 发明专利

JPS62122583A TRANSFORMATION OF YEAST 失效
公开(公告)号：JPS62122583A
公开(公告)日：1987-06-03
申请号：JP26414985
申请日：1985-11-25
申请人： NIPPON ZEON CO
发明人： TAKAMURA CHIZUKO , SATO TAKANORI
IPC分类号： C12N15/09 , C12N1/16 , C12N15/81
摘要： PURPOSE:To transform the titled plasma easily in high frequency, by treating a yeast cell with an alkali metal ion and contacting the cell with a deoxyribonucelic acid (DNA) to be included in the presence of a nucleic acid as a carrier. CONSTITUTION:A yeast cell of Saccharomyces genus, etc., is added to an aqueous solution or buffer solution containing >=10mM of an alkali metal ion such as an organic acid salt of Na ion, etc., at a cell concentration of 1-15X10 cell/ ml and treated at or below room temperature. After or simultaneous to the treatment, 0.1mol of the treated liquid is added with 0.5-5mug of a DNA to be included (e.g. plasmid DNA:YRp7) including replication initiation point of yeast), 2-20mug of a nucleic acid as a carrier (e.g. bovine thymus treated with ultrasonic wave) and, if necessary, 70% polyethylene glycol. The mixture is agitated at about room temperature for 0.5-2hr and subjected to a heat pulse of about 50 deg.C to effect the transformation of the cell.

5. 发明专利

JPH05301895A 失效
公开(公告)号：JPH05301895A
公开(公告)日：1993-11-16
申请号：JP12798092
申请日：1992-04-22
申请人： NIPPON ZEON CO
发明人： NAGAYA ATSUSHI , TAKAMURA CHIZUKO , KAMOGAWA KOICHI
IPC分类号： A61K39/00 , A61K39/275 , C07K14/005 , C07K14/155 , C07K14/195 , C07K19/00 , C12N7/00 , C12N7/01 , C12N15/09 , C12N15/39 , C12N15/62 , C12N15/86 , C12P21/02 , C12R1/92 , C07K15/04
摘要： PURPOSE:To provide the hybrid antigen protein having a virus-constituting protein and the small peptide epitope of a pathogenic virus and useful as a vaccine or a diagnostic medicine. CONSTITUTION:The hybrid antigen protein having the virus-constituting protein and the small peptide epitope of the pathogenic virus is produced by preparing a recombined virus having the gene of the virus-constituting protein and the gene of the small peptide epitope of the pathogenic virus and subsequently allowing the recombined virus to express in the cultured cell.

6. 发明专利

JPS6379595A MANIFESTATION PLASMID VECTOR 失效
公开(公告)号：JPS6379595A
公开(公告)日：1988-04-09
申请号：JP22479086
申请日：1986-09-25
申请人： NIPPON ZEON CO
发明人： SATO TAKANORI , TAKAMURA CHIZUKO , KAMOGAWA KOICHI
IPC分类号： C12N15/09 , C12N9/38 , C12N15/00 , C12R1/19 , C12R1/865
摘要： PURPOSE:To obtain a manifestation plasmid vector having a structural gene linked to a promoter which has manifestation function in yeast and Escherichia coli and consists of transcription acceleration sequence of yeast, sequence containing TATAA and rich in bases of A and T and transcription initiation sequence in this order. CONSTITUTION:A structural gene is produced with yeast or Escherichia coli by the use of a plasmid vector (shuttle vector obtained by properly processing pJDB219, YEp13, etc.) obtained by linking a structural gene such as insulin, interferon, etc., to a promoter (e.g. sequence shown by the formula) which contains transcription acceleration sequence of yeast [e.g. all or part of base sequence of UAS (Upstream Activating Sequence) of promoter of enolase gene or UAS of promoter of galactokinase gene], TATAA sequence and -35 range and -10 range required for a promoter of Escherichia coli and is constituted in such a way that a sequence having >=70% A and T contents in the sequence is further connected to transcription initiation sequence to function with both yeast and Escherichia coil.

7. 发明专利

JPH06205672A PRODUCTION OF CHIMERAL PROTEIN HAVING ANTIGEN SITE OF SURFACE ANTIGEN PROTEIN OF JAPANESE ENCEPHALITIS VIRUS AND HEPATITIS B VIRUS AND RECOMBINANT BACULOVIRUS THEREFOR 失效
公开(公告)号：JPH06205672A
公开(公告)日：1994-07-26
申请号：JP6369992
申请日：1992-03-19
申请人： NIPPON ZEON CO , TOKYO METROPOLITAN GOV
发明人： SATO TAKANORI , TAKAMURA CHIZUKO , YASUDA ATSUSHI , KAMOGAWA KOICHI , YASUI KOTARO
IPC分类号： A61K39/155 , A61K39/29 , A61K39/295 , A61P31/12 , C12N7/00 , C12N7/01 , C12N15/09 , C12N15/62 , C12N15/86 , C12P21/02 , C12R1/91 , C12R1/92
摘要： PURPOSE:To provide a method for mass production of chimeral protein for polyvalent vaccine for virus, and to provide recombinant baculovirus therefor. CONSTITUTION:Firstly, recombinant baculovirus is produced by incorporating the nonessential domain of the genome of baculovirus with a DNA obtained by fusion between part of the cDNA coding the surface antigen protein of Japanese encephalitis virus and the DNA coding the surface antigen protein of hepatitis B virus. This recombinant baculovirus is then cultured to manifest a polyvalent vaccine. Thus, the objective chimeral protein usable as the polyvalent vaccine can be mass-produced.

8. 发明专利

JPH02303482A JAPANESE ENCEPHALITIS VIRUS NS1 GENE-RECOMBINANT VACCINIA VIRUS 失效
公开(公告)号：JPH02303482A
公开(公告)日：1990-12-17
申请号：JP12589489
申请日：1989-05-19
申请人： TOKYO METROPOLITAN GOV , NIPPON ZEON CO
发明人： YASUI KOTARO , TAKAMURA CHIZUKO , SATO TAKANORI , KAMOGAWA KOICHI
IPC分类号： C12N7/00 , A61K39/12 , C12N7/01 , C12N15/40 , C12N15/86 , C12R1/91
摘要： NEW MATERIAL:The subject virus obtained by integrating the whole cDNA or part of cDNA (e.g. non-constitutional protein-1 of Japanese encephalitis virus) coding non-constitutional protein of Japanese encephalitis virus into a genome region unessential to proliferation of vaccinia virus. USE:Live vaccine against Japanese encephalitis. PREPARATION:cDNA coding non-constitutional protein of Japanese encephalitis virus is prepared and the first recombinant vector into which DNA region unessential to proliferation of vaccinia virus was integrated is prepared. A region coding the nonconstitutional protein of Japanese encephalitis virus is inserted into the downstream side of promoter of the first recombinant vector to prepare the second recombinant vector. The second recombinant vector is transferred into an animal culture cell in which vaccinia virus was previously infected. A homologous recombinant is carried out between vector DNA and virus genome DNA to assemble the recombinant vaccinia virus.

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