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1. 发明专利

JP2006169176A Indolylpentenedione derivative having anti-coronavirus activity 审中-公开
标题翻译：具有抗癌性活性的吲哚美辛衍生物
公开(公告)号：JP2006169176A
公开(公告)日：2006-06-29
申请号：JP2004365430
申请日：2004-12-17
申请人： Shionogi & Co Ltd , 塩野義製薬株式会社
发明人： KOBAYASHI MASANORI , FUJISHITA TOSHIO , SATO AKIHIKO
IPC分类号： C07D209/12 , A61K31/404 , A61P31/12 , C07D209/30
摘要： PROBLEM TO BE SOLVED: To provide a new compound usable as an excellent antivirus agent, especially an anti-coronavirus agent. SOLUTION: The compound represented by formula (I) (wherein, R 1 is hydrogen or a lower alkyl; R 2 is hydrogen, a lower alkyl, a lower alkoxy, hydroxy or a halogen; R 3 s are each independently a lower alkyl, a lower alkoxy, hydroxy or a halogen; R 4 s are each independently a lower alkyl, a lower alkoxy, hydroxy or a halogen; m is an integer of 0-2; and n is 0-4), the pharmacologically acceptable salt thereof or the solvate thereof is provided. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供可用作优异的防病毒剂，特别是抗冠状病毒剂的新化合物。解决方案：由式（I）表示的化合物（其中R 1是H或低级烷基; R 2 SP 2是氢，低级烷基，低级烷氧基，羟基或卤素; R 3是各自独立地是低级烷基，低级烷氧基，羟基或卤素; R 4是各自独立的低级烷基，低级烷氧基，羟基或卤素; m为0-2的整数; n为0-4），其药理学上可接受的盐或其溶剂化物。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JPH06239852A ANTI-HIV ACTIVE NIVEFURANONE 失效
公开(公告)号：JPH06239852A
公开(公告)日：1994-08-30
申请号：JP3034293
申请日：1993-02-19
申请人： SHIONOGI & CO
发明人： FUJIWARA TAMIO , SATO AKIHIKO , KAWAMURA YOSHIMI , MATSUMOTO KOICHI , ITAZAKI HIROSHI
IPC分类号： A61K31/34 , A61K31/341 , A61P31/12 , C07D307/68 , C12N1/14 , C12P17/04 , C12R1/66
摘要： PURPOSE:To obtain a new compound useful as a preventive and a therapeutic agent for HIV infectious disease, showing antiretro virus activity. CONSTITUTION:A compound of the formula (R is 1-propenyl, 2-hydroxypropyl or 2-alkoxypropyl) or its alkali metal salt such as 5-(hexane1,3-dienyl)-5-methyl-4- oxo-2-(prop-1-enyl)-4,5-dihydrofuran-3-carboxylic acid. This compound is obtained by culturing a fungus RF-4,984 strain (FERM-BP-4,119) belonging to Aspergillus niveus) in a proper medium and under an adequate condition, purifying nivefuranone from the prepared cultured mixture and optionally chemically modifying.

3. 发明专利

JPH0491790A TWO STEP PCR METHOD 失效
公开(公告)号：JPH0491790A
公开(公告)日：1992-03-25
申请号：JP20629090
申请日：1990-08-02
申请人： SHIONOGI & CO
发明人： IGARASHI HISANAGA , AONO YUKO , ODA SATOSHI , SATO AKIHIKO
IPC分类号： C12N15/09 , C12Q1/68
摘要： PURPOSE:To readily, safely and economically detect a trace amount of DNA in a short time by making primer concentration in the first step PCR to a specific concentration. CONSTITUTION:Primer concentration in the first step PCR is made to 0.005-0.025muM in a PCR method performing PCR twice. Thereby, detection of the aimed DNA with naked eyes is made possible for existing one or more molecules of the DNA with a high specificity and high accuracy not attainable by any of the previous PCR methods. Furthermore, the detection can be readily, safely and economically performed in a short time without requiring any marker such as plotting, hybridization, RI nor biotin.

4. 发明专利

JPS61155959A IMMUNOLOGICAL DIAGNOSTIC REAGENT 失效
公开(公告)号：JPS61155959A
公开(公告)日：1986-07-15
申请号：JP28004784
申请日：1984-12-28
申请人： SHIONOGI & CO , NITTO ELECTRIC IND CO
发明人： NAKAJIMA KUNIAKI , SATO AKIHIKO , NOTO AKIRA , MINAMIDE WAKIO , TANAKA HITOSHI , KIHARA YASUO , KAWASAKI TAKASHI , MORI KENJIRO , USHIYAMA KEIICHI
IPC分类号： C08F20/00 , A61K39/00 , C08F20/22 , C08F20/26 , C08F20/28 , G01N33/543
摘要： PURPOSE:To obtain an immunological diagnostic reagent having storage stability, by compounding calcium bromide in a monomer mixture consisting of a fluoroalkyl acrylate derivative, an acrylic acid derivative and a polyfunctional internal crosslinking monomer. CONSTITUTION:A mixture, with consists of 60-99.8wt% of a fluoroalkyl acrylate derivative regresented by formula I [wherein R is H or a lower alkyl group, R is a group represented by formula II, herein, (m) is an integer of 0-12, x+y=m-1 and R is H or an acetyl group. A is respectively independently H, F or CF3 and (n) is integer of 0-12], 0.1-20wt% of an acrylic acid derivative represented by formula (wherein R is H, a lower alkyl or a carboxyl group and R is H or a lower alkyl group) and 0.1-20wt% of a polyfunctional internal crosslinking monomer, is stably subjected to emulsion copolymerization and, further, calcium bromide is compounded as an additive.

5. 发明专利

JPS61142466A Stabilization of rubella ha antigen 失效
标题翻译： RUBELLA HA ANTIGEN的稳定性
公开(公告)号：JPS61142466A
公开(公告)日：1986-06-30
申请号：JP26486384
申请日：1984-12-14
申请人： Shionogi & Co Ltd
发明人： SATO AKIHIKO , NOTO AKIRA , MORITA FUMIAKI , NAKAJIMA KUNIAKI
IPC分类号： A61K39/00 , G01N33/556 , G01N33/569
CPC分类号： G01N33/56983 , G01N33/556
摘要： PURPOSE: To obtain an antigen liquid which can be preserved stably for a long time with a synergic effect with pH, by controlling a rubella HA antigen liquid above the characteristic pH to stabilize while sodium azide is added to prevent contamination by microorganism.
CONSTITUTION: The culture of kidney cell of a young hamster is vacinated with rubella virus and after several days, the cultured liquid is subjected to a treatment or the like to obtain a rubella HA angiten liquid. The antigen liquid is controlled above pH 9.6 by NaOH to stabilize the preserved freeze dry for re-using. While the antigen liquid is controlled above pH 9.6, sidium azide is added thereto to reach the concentration of 0.05W10% (W/V) to enable preservation thereof for a long time without lowering the valance thereof. Moreover, the longer time stable preservation is made possible by freezing it dry. Thus, the anti-virus antibody valence is measured accurately with a better reproducibility by a red blood corpuscle agglutination control test using the HA antigen thereby facilitating the diagnosis of the contagion of rubella and existing contagion.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：为了获得能够长时间稳定保存并具有pH的协同作用的抗原液，通过控制高于特征pH的风疹HA抗原液体稳定而稳定，同时加入叠氮化钠以防止微生物污染。构成：将小肠仓鼠的肾细胞培养物用风疹病毒脱落，数天后，对培养液进行处理等，得到风疹HA血管液。将抗原液体通过NaOH控制在pH6.6以上以稳定保存的冷冻干燥以便重新使用。当将抗原液体控制在高于pH9.6时，向其中加入叠氮化钠以达到0.05-10％（W / V）的浓度，以使其长期保存而不降低其价值。此外，通过将其冷冻干燥可以实现更长的时间稳定的保存。因此，通过使用HA抗原的红血球凝集对照试验，以更好的再现性精确测量抗病毒抗体价态，从而便于诊断风疹和现有传染病的传染。

6. 发明专利

JPS61274260A IMMUNOLOGICAL DIAGNOSIS REAGENT 失效
公开(公告)号：JPS61274260A
公开(公告)日：1986-12-04
申请号：JP11858385
申请日：1985-05-30
申请人： SHIONOGI & CO , NITTO ELECTRIC IND CO
发明人： NAKAJIMA KUNIAKI , SATO AKIHIKO , NOTO AKIRA , MINAMIDE WAKIO , TANAKA HITOSHI , KIHARA YASUO , KAWASAKI TAKASHI , MORI KENJIRO , USHIYAMA KEIICHI
IPC分类号： C08K5/17 , A61K39/00 , C08F8/00 , C08L33/00 , C08L33/02 , C08L33/04 , G01N33/531 , G01N33/545
摘要： PURPOSE:To achieve excellent inhibition effect for non-specific agglutination, by dissolving a specified acid or a salt thereof in coexistence. CONSTITUTION:This reagent is a water dispersion type high polymer to be selected from among the following (A), (B) and (C) in which an immuno-active substance is immobilized in covalent bond: A) a polymer mixture which comprises 30-98.8wt% of CH2=CR COOR , 0.1-30wt% of R CH=CR COOH, 0.1-20wt% of a vinyl monomer having a sulfonic group and 1-20wt% of a monomer for multifunctional internal crosslinking, B) a monomer mixture which comprises 60-99.8wt% of CH2=CR COOR (CF2)nCFA2, 0.1-20wt% of R CH=CR COOH, 0.1-20wt% of a monomer for multifunctional internal crosslinking and C) a single mixture which comprises 0.1-20wt% of R CH= CR COOH, 0.001-10wt% of a vinyl monomer having a sulfonic group, 50-99.799wt% of a mixture of CH2=CR COOR (CF2)nCFA2 and fluoroalkyl ester acrylate derivative each at a rate of 1-100wt% and 0.1-20wt% of a monomer for multifunctional internal crosslinking.

7. 发明专利

JPS61155960A IMMUNOLOGICAL DIAGNOSTIC REAGENT 失效
公开(公告)号：JPS61155960A
公开(公告)日：1986-07-15
申请号：JP28004884
申请日：1984-12-28
申请人： SHIONOGI & CO , NITTO ELECTRIC IND CO
发明人： NAKAJIMA KUNIAKI , SATO AKIHIKO , NOTO AKIRA , MINAMIDE WAKIO , TANAKA HITOSHI , KIHARA YASUO , KAWASAKI TAKASHI , MORI KENJIRO , USHIYAMA KEIICHI
IPC分类号： C08F20/00 , A61K39/00 , C08F20/22 , C08F20/26 , C08F220/22 , C08F220/28 , G01N33/543
摘要： PURPOSE:To obtain the titled reagent, by adding a polyfunctional internal crosslinking monomer to a mixture consisting of an acrylic acid derivative, a vinyl monomer having a sulfonic acid group, a fluoroalkyl acrylate derivative and a radical polymerizable vinyl monomer. CONSTITUTION:As monomer components, not only 0.1-20wt% of an acrylic acid derivative represented by a formula I (wherein R is H, a lower alkyl group or a carboxyl group and R is H or a lower alkyl group) and 0.001-10wt% of a vinyl monomer having a sulfonic acid group are used but also 50-99.799wt% of a mixture, which consists of a fluoroalkyl acrylate derivative represented by formula II [wherein R is H or a lower alkyl group and R is a group represented by formula III, herein, (m) and (n) are an integer of 0-12, x+y=m-1 and R is H or an acetyl group. A is respectively independently H, F or CF3] occupying 1-100wt% and a radical copolymerizable vinyl monomer except the former two, and 0.1-20wt% of a polyfunctional internal crosslinking monomer are mixed to form a composition which is, in turn, subjected to emulsion copolymerization and, further, calcium bromide is added to the copolymer solution as an additive to obtain an aqueous dispersion of emulsion copolymer particles excellent in the dispersing stability in an aqueous medium.

8. 发明专利

JPS61155958A IMMUNOLOGICAL DIAGNOSTIC REAGENT 失效
公开(公告)号：JPS61155958A
公开(公告)日：1986-07-15
申请号：JP28004684
申请日：1984-12-28
申请人： SHIONOGI & CO , NITTO ELECTRIC IND CO
发明人： NAKAJIMA KUNIAKI , SATO AKIHIKO , NOTO AKIRA , MINAMIDE WAKIO , TANAKA HITOSHI , KIHARA YASUO , KAWASAKI TAKASHI , MORI KENJIRO , USHIYAMA KEIICHI
IPC分类号： C08F2/00 , A61K39/00 , C08F2/22 , C08F8/00 , C08F220/00 , C08F220/10 , C08L33/00 , C08L33/02 , C08L33/04 , G01N33/543
摘要： PURPOSE:To obtain a reagent having good storage stability, by compounding calcium bromide in a mixture of an alkyl acrylate derivative, an acrylic acid derivative, a vinyl monomer having a sulfonic acid group and a polyfunctional internal crosslinking monomer. CONSTITUTION:As monomer components, not only 0.1-30wt% of an acrylic acid derivative having a carboxyl group represented by R CH=CR COOH [wherein R is H, a lower alkyl group or a carboxyl group, R is H or lower alkyl group and, when R is H or a lower alkyl group, R may be a carbo-(lower) alkoxy group] and 0.1-20wt% of a vinyl monomer having a sulfonic acid group but also 1-20wt% of a polyfunctional internal crosslinking monomer are used in addition to 30-98.9wt% of an alkyl acrylate derivative represented by a general formula CHz=CR COOR (wherein R is H or an alkyl group and R is an 1-8C alkyl group). Further, calcium bromide is compounded as an additive to make it possible to perform stable emulsion copolymerization without generating a floc even if no emulsifier is especially used.

9. 发明专利

JPS61155957A IMMUNOLOGICAL DIAGNOSTIC REAGENT 失效
公开(公告)号：JPS61155957A
公开(公告)日：1986-07-15
申请号：JP28004584
申请日：1984-12-28
申请人： SHIONOGI & CO , NITTO ELECTRIC IND CO
发明人： NAKAJIMA KUNIAKI , SATO AKIHIKO , NOTO AKIRA , MINAMIDE WAKIO , TANAKA HITOSHI , KIHARA YASUO , KAWASAKI TAKASHI , MORI KENJIRO , USHIYAMA KEIICHI
IPC分类号： C08K3/16 , A61K39/00 , C08K3/00 , G01N33/543 , G01N33/545
摘要： PURPOSE:To obtain an immunological diagnostic reagent having good storage stability, by compounding calcium bromide in an aqueous dispersion of water- dispersible macromolecular polymer particles having an immunologically active substance immobilized therewith through a covalent bond. CONSTITUTION:The average particle size of a water-dispersible macromolecular polymer particles being a carrier for immobilizing an immunologically active substance is especially pref. 0.1-1mum and the specific gravity thereof is pref. in a range of 0.9-1.5. The polymer particles have a functional group for bonding the immunologically active substance as an essential condition and, as the functional group, a carboxyl group, an amino group, a hydroxyl group or the like are pref. The aqueous dispersion of the water-dispersible macromolecular polymer particles is obtained by the emulsion copolymerization of a vinyl monomer having a carboxyl group such as a monobasic or polybasic acid such as acrylic acid, methacrylic acid, itaconic acid or crotonic acid. Calcium bromide is compounded in the aqueous dispersion as an additive for suppressing non-specific flocculation of particles.

10. 发明专利

JP2005060362A ANTI-HIV AGENT, ANTI-BVDV AGENT, ANTI-HCV AGENT OR ANTI-CoV AGENT CONTAINING SESQUITERPENE DERIVATIVE 审中-公开
标题翻译：抗艾滋病毒抗体药物，抗BVDV药剂，抗HCV抗体药物或含有SESQUITERPENE衍生物的抗病毒剂
公开(公告)号：JP2005060362A
公开(公告)日：2005-03-10
申请号：JP2004014136
申请日：2004-01-22
申请人： Shionogi & Co Ltd , 塩野義製薬株式会社
发明人： SATO AKIHIKO , KOBAYASHI MASANORI
IPC分类号： C07D491/107 , A61K31/352 , A61K31/4439 , A61P31/12 , A61P31/18 , C07D311/78
摘要： PROBLEM TO BE SOLVED: To provide an anti-HIV agent, anti-BVDV agent, anti-HCV agent or anti-CoV agent.
SOLUTION: The sesquiterpene derivatives of a substance produced by bacteria belonging to the genus Stachybotrys, expressed by formula (I) and its related derivatives are found to have an anti-HIV, anti-BVDV, anti-HCV or anti-CoV activity.
COPYRIGHT: (C)2005,JPO&NCIPI

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