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1. 发明公开

EP3480204A1 ORGANIC MAGNESIUM PHOSPHIDE AND METHOD FOR PRODUCING SAME, ORGANIC MAGNESIUM PHOSPHIDE COMPLEX AND METHOD FOR PRODUCING SAME, AND METHOD FOR PRODUCING ORGANIC PHOSPHORUS-CONTAINING COMPOUND USING SAID PHOSPHIDE 有权
公开(公告)号：EP3480204A1
公开(公告)日：2019-05-08
申请号：EP17824115.4
申请日：2017-06-29
申请人： Hokko Chemical Industry Co., Ltd.
发明人： SUZUKI, Kenta , KUMAMOTO, Nobumichi , ITO, Nobuhiro , HATAE, Shinji , SUZUKI, Hiroyuki
IPC分类号： C07F3/02 , C07B49/00 , C07F9/50
摘要： An object is to provide a new organic magnesium phosphide characterized by phosphorus-magnesium bond, and a manufacturing method thereof, as well as a new organic magnesium phosphide complex and a manufacturing method thereof. Another object is to provide a new manufacturing method of organic phosphorus compound using such organic magnesium phosphide or organic magnesium phosphide complex. As a means for solving the problems, an organic magnesium phosphide expressed by Formula (1) below, an organic magnesium phosphide complex expressed by Formula (9) below, and a manufacturing method of organic phosphorus compound characterized in that any such reagent is reacted with an electrophile, are provided:

(In the formula, R 1 and R 2 are each independently an aliphatic group, heteroaliphatic group, alicyclic group, or heterocyclic group, and X is chlorine, bromine, or iodine.)

(In the formula, R 3 and R 4 are each independently an aliphatic group, heteroaliphatic group, aromatic group, alicyclic group, or heterocyclic group, and X and Y are each independently chlorine, bromine, or iodine.)

2. 发明授权

EP2061825B1 UNIVERSAL GRIGNARD METATHESIS POLYMERIZATION 有权
标题翻译： UNIVERSELLE GRIGNARD-METATHESE-POLYMERISATION
公开(公告)号：EP2061825B1
公开(公告)日：2013-05-22
申请号：EP07814646.1
申请日：2007-08-31
申请人： CARNEGIE MELLON UNIVERSITY
发明人： MCCULLOUGH, Richard, D. , IOVU, Mihaela, C. , OSAKA, Itaru
IPC分类号： C08G61/00 , C07B49/00 , C07F3/02
CPC分类号： C08G61/00 , C07B49/00

3. 发明授权

EP1955990B1 PROCESS FOR PRODUCTION OF BIPHENYL DERIVATIVES 有权
标题翻译：方法经营部的联苯衍生物
公开(公告)号：EP1955990B1
公开(公告)日：2012-08-22
申请号：EP06822282.7
申请日：2006-10-25
申请人： Toray Fine Chemicals Co., Ltd.
发明人： HAYASHI, Tamio , NAKATANI, Jiro
IPC分类号： C07C17/26 , C07C22/08 , C07B61/00 , C07C17/263 , C07C25/18 , C07B37/04 , C07B49/00
CPC分类号： C07C17/263 , C07B37/04 , C07B49/00 , C07C17/2632 , C07C22/08 , C07C25/18
摘要： A process for the production of biphenyl derivatives represented by the general formula (1), which is characterized by comprising reacting the chlorine atom of a benzene derivative represented by the general formula (2) with metallic magnesium to form a Grignard reagent and coupling two molecules of the Grignard reagent with each other in the presence of a catalyst and which is excellent in industrial productivity by virtue of its using inexpensive and easily available raw materials. (1) (2) (wherein A’s are at least one member selected from between trifluoromethyl and fluoro; and n is an integer of 1 to 4)

4. 发明公开

EP2014633A1 Process for the production of tertiary alcohols 审中-公开
标题翻译：维尔法赫尔·赫尔斯特隆·阿尔科孔（Alkohole）
公开(公告)号：EP2014633A1
公开(公告)日：2009-01-14
申请号：EP07013809.4
申请日：2007-07-13
申请人： Lonza AG
发明人： McGarrity, John , Djojo, Francis
IPC分类号： C07B49/00 , C07C29/147 , C07D215/18 , C07C31/135 , C07C31/12
CPC分类号： C07B49/00
摘要： Tertiary alcohols are prepared by reacting carboxylic esters with Grignard reagents in ethereal solvents in the presence of lanthanum trichloride and lithium chloride.
The method is particularly suitable for the production of (α S )-α-[3-[(1 E )-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methylethyl)benzenepropanol of formula

which is an intermediate in the production of montelukast.
摘要翻译：在三氯化镧和氯化锂的存在下，在醚溶剂中使羧酸酯与格氏试剂反应制备叔醇。该方法特别适用于制备（±S） - [ - [ - [（1E）-2-（7-氯-2-喹啉基）乙烯基]苯基] -2-（1-羟基-1- 甲基乙基）苯丙醇，其是孟鲁司特生产中的中间体。

5. 发明授权

EP1070070B1 VERFAHREN ZUR HERSTELLUNG VON GRIGNARDVERBINDUNGEN 有权
标题翻译：用于生产的格氏
公开(公告)号：EP1070070B1
公开(公告)日：2008-07-23
申请号：EP99914565.9
申请日：1999-04-01
申请人： BASF SE
发明人： BOYMOND, Laure , ROTTLÄNDER, Mario , CAHIEZ, Gérard , KNOCHEL, Paul
IPC分类号： C07F3/02 , C07B49/00 , C07B61/00
CPC分类号： C07F3/02 , C07B37/04 , C07B49/00 , Y10S585/931
摘要： The invention relates to a method for producing grignard compounds of formula (I). The invention also relates to compounds of formula (I) in polymer bonded compounds of formula (Ia). The invention further relates to the use of the inventive method to produce substance libraries and to the use of compounds of formulae (I) and (Ia) in chemical synthesis.

6. 发明公开

EP1759765A1 Solutions of anhydrous lanthanide salts and its preparation 审中-公开
标题翻译： WasserfreieLösungenvon Seltenerdsalzen und Verfahren zu deren Herstelung
公开(公告)号：EP1759765A1
公开(公告)日：2007-03-07
申请号：EP05019026.3
申请日：2005-09-01
申请人： Ludwig-Maximilians-Universität München
发明人： Knochel, Paul , Krasovskiy, Arkady , Kopp, Felix
IPC分类号： B01J27/10 , B01J27/125 , B01J31/16 , C07B49/00 , C07C29/40 , C07C211/00 , C07F5/00
CPC分类号： C07C29/40 , C01F17/0012 , C01F17/0031 , C07B49/00 , C07C29/143 , C07C67/343 , C07C205/59 , C07C217/84 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2602/10 , C07C2602/42 , C07C69/76 , C07C33/20 , C07C33/24 , C07C35/06 , C07C35/08 , C07C35/18 , C07C35/21 , C07C35/30 , C07C35/36
摘要： The present invention relates to anhydrous solutions of MX 3 •z LiA in a solvent, wherein M is a lanthanide including lanthanum, or yttrium or indium; z > 0; and X and A are independently or both monovalent anions, preferably Cl, Br or I. The solution is readily prepared by dissolving or suspending MX 3 or its hydrate and z equiv LiA in water or hydrophilic solvents, or mixtures thereof, removing the solvent under vacuum and dissolving the resulting powder in another solvent. The solution of MX 3 •z LiA can advantageously be used e.g. in addition reactions of Grignard reagents to ketones and imines. Even the catalytic use of MX 3 •z LiA is possible.
Also claimed are a method for preparing the anhydrous solutions, the use of such solution in a chemical reaction and chemical compositions MX 3 •z LiA, with M, z, X and A as indicated above.
摘要翻译：本发明涉及MX 3镧z LiA在溶剂中的无水溶液，其中M是包含镧或钇或铟的镧系元素; z> 0; 并且X和A独立地是两个一价阴离子，优选Cl，Br或I.通过将MX 3或其水合物和z equiv LiA溶解或悬浮在水或亲水溶剂或其混合物中来容易地制备溶液，除去溶剂真空并将所得粉末溶解在另一种溶剂中。 MX 3¢z LiA的溶液可以有利地例如使用。另外还有格氏试剂对酮和亚胺的反应。即使催化使用MX 3¢z LiA也是可行的。还要求的是制备无水溶液的方法，在化学反应中使用这种溶液以及如上所述的具有M，z，X和A的化学组合物MX 3¢z LiA。

7. 发明公开

EP1405840A4 SOLVENTS CONTAINING CYCLOALKYL ALKYL ETHERS AND PROCESS FOR PRODUCTION OF THE ETHERS 有权
标题翻译： CYCLOALKYL-ALKYL-ETHER ENTHALTENDELÖSUNGSMITTELUND VERFAHREN ZUR HERSTELLUNG DER ETHER
公开(公告)号：EP1405840A4
公开(公告)日：2006-05-17
申请号：EP02738825
申请日：2002-06-27
申请人： ZEON CORP
发明人： KIN IDAN , OHTA GENICHI , TERAISHI KAZUO , WATANABE KIYOSHI
IPC分类号： H04N7/167 , C07B49/00 , C07B61/00 , C07B63/00 , C07C1/32 , C07C13/28 , C07C15/46 , C07C29/40 , C07C29/86 , C07C33/20 , C07C33/34 , C07C41/06 , C07C43/184 , C11D7/26 , C11D7/50 , C11D11/00 , G03G5/00 , G03G5/05 , G11B20/00
CPC分类号： C07C41/06 , C07B49/00 , C07B63/00 , C07C29/40 , C07C43/184 , C07C2601/08 , C11D7/263 , C11D7/5022 , C11D11/0047 , G11B20/00086 , G11B20/0021 , G11B20/00507 , C07C33/20 , C07C35/21
摘要： A solvent containing at least one cycloalkyl alkyl ether (1) represented by the general formula: R1-O-R2 (wherein R1 is cyclopentyl or the like; and R2 is C1-10 alkyl or the like); and a process for the production of the ethers (1), characterized by reacting an alicyclic olefin with an alcohol in the presence of an acid ion-exchange resin having a water content of 5 wt% or below. The solvent is useful as cleaning solvent for electronic components, precision machinery components or the like, reaction solvent for various chemical reactions, extraction solvent for extracting objective organic substances, solvent or remover for electronic and electrical materials, and so on. The process enables industrially advantageous production of the objective cycloalkyl alkyl ethers (1).
摘要翻译：溶剂含有环烷基烷基醚（1）。溶剂含有式（1）的环烷基烷基醚，R 1> -O-R 2>（1）R 1>任选取代的环戊基或环己基; R 2>任选取代的1-10C烷基或3-8C环烷基。（1）含有化合物R 1> -O-R 3>（2）的类似溶剂也包括独立权利要求。和（2）类似的含有化合物R 4> -O-R 3>（3）的溶剂。 R 3> R 2>; R 4>环戊基。

8. 发明授权

EP1246784B9 REAKTION VON CARBONYLVERBINDUNGEN MIT METALLORGANISCHEN REAGENZIEN 无效
标题翻译：反应中与有机金属试剂羰基
公开(公告)号：EP1246784B9
公开(公告)日：2006-01-18
申请号：EP01900150.2
申请日：2001-01-10
申请人： Merck Patent GmbH
发明人： KOOP, Ulrich , KRUMMRADT, Holger , SCHWARZ, Michael , STOLDT, Jöran , ECKSTEIN, Jürgen , ZEHNER, Stefan , MELICHAR, Wolfgang
IPC分类号： C07B49/00 , C07C41/30 , C07C25/13 , C07D495/04
CPC分类号： C07D495/04 , B01F5/0256 , B01F5/064 , B01F13/0059 , B01J19/0093 , B01J19/2415 , B01J2219/00013 , B01J2219/00058 , B01J2219/00065 , B01J2219/00094 , B01J2219/00177 , B01J2219/00889 , B01J2219/00984 , C07B49/00 , C07C41/30 , C07C43/225
摘要： The invention relates to a novel method for carrying out reactions of carbonyl compounds with organometallic reagents, especially grignard reagents. The inventive method is characterised in that the organometallic reagent and the carbonyl compound are provided and tempered separately in a suitable solvent before being pumped into a tempered mini/micromixer.

9. 发明授权

EP1077923B1 AN IMPROVED SYNTHESIS AND PURIFICATION OF (R*,R*)-2- (DIMETHYLAMINO) METHYL]-1-( 3-METHOXYPHENYL) CYCLOHEXANOL HYDROCHLORIDE 有权
标题翻译： EIN VERBESSERTES SYNTHESE- UND REINIGUNGSVERFAHRENFÜR（R *，R *）-2 - [（二甲基氨基）甲基] -1-（3-甲氧基苯基）环己基氢氯酸盐
公开(公告)号：EP1077923B1
公开(公告)日：2004-01-02
申请号：EP99930115.3
申请日：1999-05-20
申请人： Mallinckrodt Inc.
发明人： JARVI, Esa, T. , GRAYSON, Neile, A. , HALVACHS, Robert, E.
IPC分类号： C07C213/02 , C07C213/10 , C07C217/74 , C07B49/00
CPC分类号： C07C213/10 , C07B49/00 , C07C213/02 , C07C2601/14 , C07C217/74
摘要： (R*,R*)-2-[ (dimethylamino) methyl]-1-( 3-methoxyphenyl) cyclohexanol (Tramadol) is synthesized in a Grignard reaction in the presence of an additive resulting in a higher trans:cis ratio of product than is obtained in the absence of the additive. The Grignard reaction between 3 bromoanisole and the appropriate Mannich base in the presence of an amine or ether additive gives the amine product in an improved trans/cis ratio. The base is converted to its hydrochloride and recrystallized from a low molecular weight nitrile such as acetonitrile until a greater than 98 % trans/cis ratio is obtained. Recrystallization from isopropanol gives (R*,R*)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride free of the nitrile solvent. A hydrochloride of Tramadol can be synthesized without increasing a ratio of trans:cis by including a step in which HCl is added to Tramadol base in the presence of toluene.
摘要翻译：（R *，R *）-2 - [（二甲基氨基）甲基] -1-（3-甲氧基苯基）环己醇（曲马多）在Grignard反应中，在添加剂存在下合成，得到较高的反式：顺式比例的产物在不存在添加剂的情况下获得。在胺或醚添加剂存在下，3-溴苯甲醚与合适的曼尼希碱之间的格利雅反应，得到改进的反/顺式比例的胺产物。将碱转化为其盐酸盐并从低分子量腈如乙腈中重结晶，直到获得大于98％的反/顺比。从异丙醇中重结晶得到不含腈溶剂的（R *，R *）2 - [（二甲基氨基）甲基] -1-（3-异丁苯基）环己醇盐酸盐。可以通过包括在甲苯存在下将HCl加入到曲马多碱中的步骤而不增加反式：顺式的比例来合成曲马朵的盐酸盐。

10. 发明授权

EP0415247B1 Verfahren zur Herstellung von etherischen Lösungen von Arylmethylmagnesiumhalogeniden 失效
标题翻译：一种用于Arylmethylmagnesiumhalogeniden的醚溶液的制备方法。
公开(公告)号：EP0415247B1
公开(公告)日：1995-10-25
申请号：EP90116033.3
申请日：1990-08-22
申请人： BASF Aktiengesellschaft
发明人： Kober, Reiner, Dr. , Seele, Rainer, Dr. , Zierke, Thomas, Dr. , Isak, Heinz, Dr. , Karbach, Stefan, Dr. , Wegner, Günter, Dr.
IPC分类号： C07F3/02 , C07B49/00
CPC分类号： C07F3/02 , C07F7/0827

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