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1. 发明公开

EP3517530A1 PROCESS FOR THE PREPARATION OF TRIAZINE CARBAMATES 审中-公开
公开(公告)号：EP3517530A1
公开(公告)日：2019-07-31
申请号：EP19157963.0
申请日：2014-02-28
申请人： Allnex Netherlands B.V.
发明人： JACOBS III, William , FLOOD, Lawrence A.
IPC分类号： C07D251/70
摘要： This invention relates to a process for the preparation of triazine carbamates by reacting a mixture of an aminotriazine A having at least two amino groups per molecule, an organic carbonate C which is preferably an acyclic carbonate, and a mixture B of bases comprising at least two basic metal compounds B1 and B2 individually selected from the group consisting of hydrides, amides, alkoxides, and arylalkoxides of metals, wherein the metal in B1 is not the same as the metal in B2.

2. 发明公开

EP3394040A1 CFTR REGULATORS AND METHODS OF USE THEREOF 有权转让
公开(公告)号：EP3394040A1
公开(公告)日：2018-10-31
申请号：EP16880160.3
申请日：2016-12-23
申请人： The Regents of the University of California, A California Corporation
发明人： VERKMAN, Alan , LEVIN, Marc, H. , CIL, Onur , LEE, Sujin
IPC分类号： C07D251/70 , C07D251/50 , C07D251/44
CPC分类号： C07D251/52 , A61K31/496 , A61K31/53 , A61K31/5377 , A61K31/55 , A61K45/06 , A61P1/10 , A61P27/04 , C07D251/46 , C07D403/04 , C07D413/12
摘要： Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders, and other diseases and disorders.

3. 发明公开

EP3327009A1 METHOD FOR ALKYLATING AN AMINO COMPOUND 审中-公开
公开(公告)号：EP3327009A1
公开(公告)日：2018-05-30
申请号：EP16200228.1
申请日：2016-11-23
申请人： Borealis Agrolinz Melamine GmbH
发明人： GABRIEL, Herbert , DICKE, René
IPC分类号： C07D251/70 , C07C275/06
CPC分类号： C07D251/70 , C07C273/1863 , C07C275/06
摘要： The invention relates to a method for alkylating an amino compound, characterized in that at least one triazine derivative of general formula (I)

or at least one urea or urea derivative of the general formula (II)

wherein
• R 4 and R 5 mean independently from each other Q 1 or a moiety of the formula R 6 -N-R 7 or R 8 -N-R 9 bound with its central nitrogen atom to the triazine ring of the structure of formula (I), whereat
- Q 1 means a linear or branched C 1 -C 30 -alkyl or a cyclic substituent in form of a C 5 -C 20 -cycloalkyl, a C 5 -C 20 -aryl, a C 1 -C 20 -alkylsubstituted C 5 -C 20 -aryl or an amide of a cyclic unsaturated carboxylic acid, whereat the C 1 -C 30 -alkyl or the cyclic substituent can be interrupted by one or multiple oxygen atoms, sulphur atoms, substituted nitrogen atoms and/or by one or multiple groups of the type -C(O)O-, -OC(O)-, -C(O)- and/or -OC(O)O-,

• R 1 , R 2 , R 3 , R 6 , R 7 , R 8 and R 9 mean independently from each other H, linear or branched C 1 -C 20 -alkyl, C 5 -C 20 -cyclo alkyl, C 5 -C 20 -aryl, C 1 -C 20 -alkylsubstituted C 5 -C 20 -aryl, which in each case can be interrupted by one or multiple oxygen atoms, sulphur atoms and/or substituted nitrogen atoms and/or by one or multiple groups of the type -C(O)O-, - OC(O)-, -C(O)- and/or -OC(O)O- and/or can be functionalized by one or multiple hydroxyl groups and/or mercapto groups, and
• X means O or S,
is reacted with at least one alcohol of the general formula (III)

R 10 -OH

wherein R 10 means a linear or branched C 1 -C 20 -alkyl, C 5 -C 20 -cycloalkyl, or C 1 -C 20 -alkylsubstituted C 5 -C 20 -aryl, which can be in each case interrupted by one or multiple oxygen atoms, sulphur atoms, substituted nitrogen atoms and/or by one or multiple groups of the type -C(O)O-, -OC(O)-, -C(O)- and/or -OC(O)O- and/or can be functionalized by one or multiple hydroxyl groups and/or mercapto groups, wherein the reaction is carried out in the presence of at least one Ruthenate of the general formula (IV) M n (RuO 4 ) and/or at least one Perruthenate of the general formula (V) M(RuO 4 )n wherein the cation M is selected from a group comprising an alkali, earth alkali or substituted or non-substituted ammonium cation.

4. 发明公开

EP3263561A1 NOVEL TRIAZINE PRECONDENSATE AND METHOD FOR OBTAINING THE SAME 无效
标题翻译：新的三嗪前体及其获得方法
公开(公告)号：EP3263561A1
公开(公告)日：2018-01-03
申请号：EP16176878.3
申请日：2016-06-29
申请人： Borealis Agrolinz Melamine GmbH
发明人： GABRIEL, Herbert , DICKE, René , PUCHINGER, Helmut
IPC分类号： C07D251/70
CPC分类号： C07D251/70
摘要： The present invention relates to a triazine precondensate according to the general formula (I)

wherein R 1 means Q 1 or a moiety of the formula R 3 -N-R 4 connected with the nitrogen atom to the triazine ring of the structure of formula (I), wherein R 9 means Q 1 or a moiety of the formula R 7 -N-R 8 connected with the nitrogen atom to the triazine ring of the structure of formula (I),
wherein R 2 , R 3 , R 4 and R 6 mean independently from each other H, Q1 or R 8 mean independently from each other H, Q 1 ,

R 7 and

or

R 10 and R 11 mean independently from each other R 7 or R 8 ; R 5 means linear or branched C 2 -C 20 -alkyl that can be interrupted by one or more oxygen atoms, sulphur atoms, substituted or non-substituted nitrogen atoms, R x , Ry mean independently from each other H, OH, Q 1 , -[C 1 -C 18 ]-OH or

wherein Q 1 means linear or branched C 1 -C 20 -alkyl, linear or branched C 2 -C 20 -alkenyl, linear or branched C 2 -C 20 -alkinyl, C 3 -C 10 -cycloalkyl, C 5 -C 7 -cycloalkenyl, which in each case can be interrupted by one or more oxygen atoms, sulphur atoms, substituted or non-substituted nitrogen atoms and/or by one or more groups of the type -C(O)O-, -OC(O)-, -C(O)-, -NHC(O)O-, -OC(O)NH- and/or -OC(O)O-; and wherein n = 0-10, preferably 1-8, most preferably 1 - 5, and m = 0-8, preferably 1-7, most preferably 1 - 5 or mixtures thereof.
摘要翻译：本发明涉及根据通式（I）的三嗪预缩合物，其中R 1是指Q1或式R3-N-R4与氮原子连接至式（I）结构的三嗪环的部分，其中 R9是指Q1或式R7-NR8的与氮原子连接的式（I）结构的三嗪环的部分，其中R2，R3，R4和R6彼此独立地表示H，Q1或R8 彼此独立地表示H，Q1，R7和/或R10和R11彼此独立地表示R7或R8; R5是指可被一个或多个氧原子，硫原子，取代或未取代的氮原子间隔的直链或支链C2-C20-烷基，Rx，Ry彼此独立地表示H，OH，Q1， - [C1- C18] -OH或其中Q1表示直链或支链C1-C20-烷基，直链或支链C2-C20-链烯基，直链或支链C2-C20-炔基，C3-C10-环烷基，C5-C7-环烯基，可以被一个或多个氧原子，硫原子，取代或未取代的氮原子和/或一个或多个-C（O）O - ， - OC（O） - ，-C（= O） - ， - NHC（O）O-，-OC（O）NH-和/或-OC（O）O-。并且其中n = 0-10，优选1-8，最优选1-5和m = 0-8，优选1-7，最优选1-5或其混合物。

5. 发明授权

EP2016059B1 TRIAZINE DERIVATIVES 有权转让
标题翻译：三嗪衍生物
公开(公告)号：EP2016059B1
公开(公告)日：2016-12-07
申请号：EP07728693.8
申请日：2007-05-02
申请人： BASF SE
发明人： EHLIS, Thomas , BORSOS, Elek
IPC分类号： C07D251/52 , C07D251/70 , A61Q17/04
CPC分类号： C07D251/52 , C07D251/70

6. 发明授权

EP1885486B1 AFFINITY ADSORBENTS FOR FACTOR VIII AND VON WILLEBRAND'S FACTOR 有权转让
标题翻译：亲和吸附剂因子VIII和血管性血友病因子
公开(公告)号：EP1885486B1
公开(公告)日：2016-03-23
申请号：EP06727055.3
申请日：2006-05-09
申请人： Prometic Biosciences Ltd
发明人： BETLEY, Jason, Richard , BAINES, Baldev, Singh ProMetic BioSciences Ltd.
IPC分类号： B01J20/32 , G01N30/00 , G01N33/86 , C07D251/48 , C07D251/50 , C07D251/70 , C07D403/12 , B01J20/286 , B01J20/289 , C07K14/755
CPC分类号： B01J20/286 , B01J20/289 , B01J20/3212 , B01J20/3219 , B01J20/3242 , B01J20/3244 , B01J20/3251 , B01J20/3253 , B01J20/3255 , B01J2220/54 , B01J2220/58 , C07D251/48 , C07D251/50 , C07D251/70 , C07D403/12 , C07K14/755 , G01N33/86 , G01N2333/755 , Y10T436/25375 , Y10T436/255

7. 发明公开

EP2964619A1 PROCESS FOR THE PREPARATION OF TRIAZINE CARBAMATES 有权转让
标题翻译： VERFAHREN ZUR HERSTELLUNG VON TRIAZINCARBAMATEN
公开(公告)号：EP2964619A1
公开(公告)日：2016-01-13
申请号：EP14707396.9
申请日：2014-02-28
申请人： Allnex IP S.à.r.l.
发明人： JACOBS III, William , FLOOD, Lawrence A.
IPC分类号： C07D251/70
CPC分类号： C07D251/24 , C07D251/18 , C07D251/22 , C07D251/70
摘要： This invention relates to a process for the preparation of triazine carbamates by reacting a mixture of an aminotriazine A having at least two amino groups per molecule, an organic carbonate C which is preferably an acyclic carbonate, and a mixture B of bases comprising at least two basic metal compounds B1 and B2 individually selected from the group consisting of hydrides, amides, alkoxides, and arylalkoxides of metals, wherein the metal in B1 is not the same as the metal in B2.
摘要翻译：本发明涉及通过使每分子具有至少两个氨基的氨基三嗪A，优选无环碳酸酯的有机碳酸酯C和至少包含两个氨基的碱的混合物B反应来制备三嗪氨基甲酸酯的方法碱金属化合物B1和B2分别选自金属的氢化物，酰胺，烷氧化物和芳基烷氧基化物，其中B1中的金属与B2中的金属不同。

8. 发明公开

EP2774922A1 Method for obtaining a functionalized triazine compound and the triazine compound obtained by said method 审中-公开
标题翻译：一种用于获得官能化三嗪类化合物的方法和通过该方法获得的三嗪化合物
公开(公告)号：EP2774922A1
公开(公告)日：2014-09-10
申请号：EP13157609.2
申请日：2013-03-04
申请人： Borealis Agrolinz Melamine GmbH
发明人： Dicke, Rene
IPC分类号： C07D251/70
CPC分类号： C07D251/70
摘要： The present invention relates to a method for obtaining a triazine compound with at least one amino group comprising a an aliphatic moiety with at least two functional groups comprising the steps of
a) providing at least one triazine compound of the general formulae (I)

wherein
- R 1 and R 2 mean independently from each other Q 1 or a moiety of the formula R 3 -N-R 4 or R 5 -N-R 6 bound with its central nitrogen atom to the triazine ring of the structure of formula (I), whereat
- Q 1 means a linear or branched C 1 -C 30 -alkyl or a cyclic substituent in form of a C 5 -C 20 -cycloalkyl, a C 5 -C 20 -aryl, a C 1 -C 20 -alkylsubstituted C 5 -C 20 -aryl or an amide of a cyclic unsaturated carboxylic acid, whereat in each case one or multiple carbon atoms can be substituted by one or multiple oxygen atoms, sulphur atoms, substituted nitrogen atoms and/or by one or multiple groups of the type -C(O)O-,-OC(O)-,-C(O)- and/or -OC(O)O-,

- R 3 , R 4 , R 5 and R 6 mean independently from each other H, linear or branched C 1 -C 20 -alkyl, C 5 -C 20 -cyclo alkyl, C 5 -C 20 -aryl, C 1 -C 20 -alkylsubstituted C 5 -C 20 -aryl,whereat in each case one or multiple carbon atoms can be substituted by one or multiple oxygen atoms, sulphur atoms and/or substituted nitrogen atoms and/or by one or multiple groups of the type -C(O)O-, -OC(O)-, -C(O)- and/or -OC(O) O- and/or can be functionalized by one or multiple hydroxyl groups and/or mercapto groups; and

b) reacting said aminotriazine of the general formulae (I) with at least one primary amine of the general formulae (II)

R 7 NH 2

wherein R 7 is a linear or branched C 3 -C 20 -alkyl, C 5 -C 20 cycloalkyl, C 5 -C 20 aryl substituted C 3 -C 20 -alkyl, or C 5 -C 20 -aryl substituted C 5 -C 20 -cycloalkyl, C 5 -C 20 aryl or C 1 -C 20 alkylsubstituted C 5 -C 20 aryl each comprising at least two functional groups, or a mixture of primary amines of the general formulae (II),
wherein the at least two functional groups are not bound to the carbon atom carrying the primary amino group -NH 2 , and
wherein the at least two functional groups are not bound to the same carbon atom,

c) wherein the reaction takes place in the presence of at least one acidic catalyst.
The present invention relates also to the compounds obtained by this method and their use.
摘要翻译：本发明涉及一种方法，用于获得三嗪化合物与至少一种氨基包括式餐饮脂族部分具有至少两个官能团，其包括a。提供的通用（I）worin中的至少一种三嗪化合物的步骤） - R 1和R 2是指从海誓山盟，Q 1或以其中心氮原子键合到式（I）的结构的三嗪环的式R 3 -NR 4或R 5 -NR 6的基团，在此unabhängig - 的Q 1表示直链或支链的C 1 -C 30烷基或一个C 5 -C 20环烷基，一个C 5 -C 20芳基，一个C的形式的环状取代基1 -C 20 -alkylsubstituted的C 5 - C20芳基或环状不饱和羧酸的酰胺的，在此在每种情况下的一个或多个碳原子可以被一个或多个氧原子，硫原子，氮原子被substituiertem和substituiertem /或由类型的一个或多个组 -C（O）O - ， - OC（O） - ， - C（O） - 和/或-OC（O）O-， - R 3，R 4，R 5和R 6从海誓山盟独立意味着 H，直链或支链C 1 -C 20烷基，C 5 -C 20 - 环烷基，C 5 -C 20芳基，C 1个-C 20 -alkylsubstituted的C 5 -C 20芳基，在此在每种情况下一个或多个碳原子可以被一个或多个氧原子，硫原子和/或氮原子被substituiertem和substituiertem /或由类型的一个或多个基团-C（O）O-，-OC（O） - ，-C （O） - 和/或-OC（O）O-和/或可以由一个或多个羟基基团和/或巯基进行官能化; 和b）使通式所述的氨基三嗪餐饮（I）与一般公式中的至少一个伯胺餐饮（II）€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR7 NH 2 worin R7是直链或支链的C 3 -C 20烷基，C 5 -C 20环烷基，C 5 -C 20芳基取代的C 3 -C 20烷基，或C 5 -C 20芳基取代的C 5 -C 20环烷基，的C 5 -C 20芳基或C 1 -C 20烷基取代的C 5 -C 20芳基每个都包括至少两个官能团，或通式的伯胺的混合物（II），其中所述至少两个官能团是未结合到携带伯氨基-NH 2的碳原子，和worin所述至少两个官能团不键合到相同的碳原子，c）中的worin反应在至少一种酸性催化剂的存在下。本发明即涉及由该方法和它们的使用得到的化合物。

9. 发明授权

EP2562864B1 Proton-conducting polymer 有权
标题翻译：质子聚合物
公开(公告)号：EP2562864B1
公开(公告)日：2014-08-27
申请号：EP12189523.9
申请日：2007-10-30
申请人： NIPPON STEEL & SUMIKIN CHEMICAL CO., LTD.
发明人： Kawada, Atsushi , Tashiro, Aya
IPC分类号： H01M8/10 , C07D251/70 , C08F20/34 , C08G73/06
CPC分类号： C08F20/34 , C07D251/70 , C08G73/0644 , C08G73/065 , C08G73/0655 , C08G73/0661 , H01M8/103 , H01M8/1048 , H01M8/1072 , H01M2300/0082 , H01M2300/0085 , H01M2300/0091 , Y02P70/56

10. 发明授权

EP2197858B1 1,3,5-TRIAZINE-2,4,6-TRIAMINE COMPOUND OR PHARMACEUTICAL ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 有权
标题翻译： 1,3,5-三嗪-2,4,6-三胺或它们的药学上可接受的盐和药物组合物中以
公开(公告)号：EP2197858B1
公开(公告)日：2014-07-02
申请号：EP08793562.3
申请日：2008-08-28
申请人： HanAll Biopharma Co., Ltd. , Korea Research Institute Of Chemical Technology
发明人： CHEON, Hyae Gyeong , KIM, Kwang-Rok , RHEE, Sang Dal , JUNG, Won Hoon , LEE, Jong-Cheol , KIM, Sung Wuk , JUN, Sung Soo
IPC分类号： C07D251/54 , C07D251/70 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , A61K31/53 , A61P3/06 , A61P35/00
CPC分类号： C07D251/70 , A61K31/53 , C07D251/54 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12

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