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1. 发明公开

EP4333852A1 LARGE-CONDUCTANCE POTASSIUM CHANNEL MODULATORS, COMPOSITIONS THEREOF, METHODS OF MANUFACTURING THEREOF, AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：EP4333852A1
公开(公告)日：2024-03-13
申请号：EP22799485.2
申请日：2022-05-04
申请人： Enalare Therapeutics Inc.
发明人： PERGOLIZZI, Joseph V. , RAFFA, Robert B.
IPC分类号： A61K31/53 , C07D251/54 , A61K31/395 , C07D251/40

2. 发明公开

EP4019494A1 METHOD FOR PRODUCING CARBONYL COMPOUND AND FLOW REACTION SYSTEM USED FOR PRODUCTION OF CARBONYL COMPOUND 审中-公开
公开(公告)号：EP4019494A1
公开(公告)日：2022-06-29
申请号：EP20854442.9
申请日：2020-07-28
申请人： FUJIFILM Corporation
发明人： NISHIO, Ryo , WADA, Kenji
IPC分类号： C07C233/00 , C07C233/88 , C07C263/10 , C07C265/04 , C07C265/08 , C07C265/10 , C07C265/12 , C07C265/14 , C07D263/44 , C07D295/108 , C07D251/54 , C07C68/02 , C07C69/96
摘要： There are provided a method of producing a carbonyl compound by a flow type reaction, including introducing a triphosgene solution, a tertiary amine solution, and an active hydrogen-containing compound solution into flow channels different from each other to cause the respective solutions to flow inside the respective flow channels, joining the respective solutions that flow inside the respective flow channels simultaneously or sequentially so that a reaction between phosgene and an active hydrogen-containing compound occurs, and obtaining a carbonyl compound in a joining solution, in which a non-aqueous organic solvent is used as a solvent of each of the respective solutions and a compound having a cyclic structure is used as the tertiary amine; and a flow type reaction system that is suitable for carrying out this production method.

3. 发明授权

EP3191460B1 PROCESS FOR THE PREPARATION OF TRIAZINE CARBAMATES 有权
公开(公告)号：EP3191460B1
公开(公告)日：2020-01-29
申请号：EP15757306.4
申请日：2015-09-07
申请人： Allnex Netherlands B.V.
发明人： FLOOD, Lawrence
IPC分类号： C07D251/70 , C07D251/54 , C07D251/18 , C07D251/24

4. 发明授权

EP3015461B1 Preparation process of a flame redardant composition made from brominated bismuth and/or antimony compounds complexed with melamine and composition obtained thereby 有权
标题翻译：由与三聚氰胺络合的溴化铋和/或锑化合物制成的火焰再生剂组合物的制备方法及由此获得的组合物
公开(公告)号：EP3015461B1
公开(公告)日：2017-08-30
申请号：EP14425136.0
申请日：2014-10-27
申请人： Sichim Alfa S.r.l.
发明人： Castellucci, Anita , Bottoni, Alessandro
IPC分类号： C07D251/54 , C07F9/90 , C07F9/94 , C09K21/10 , C08K5/3477 , C08K5/59
CPC分类号： C09K21/10 , C07D251/54 , C07D251/70 , C07F9/902 , C07F9/94 , C08K3/04 , C08K3/36 , C08K5/34922 , C08K5/34928
摘要： The invention relates to a preparation process of a flame retardant composition made from brominated bismuth and/or antimony compounds complexed with melamine, in which melamine, at least one between the bismuth carbonate and antimony sesquioxide, hydrobromic acid in aqueous solution are placed in contact with each other so as to trigger chemical reactions which lead to the formation of a complex of brominated bismuth or brominated antimony with melamine and melamine bromohydrate. The reagents are placed in contact in the presence of at least one reaction carrier defined by at least one compound chosen from the group consisting of melamine, melamine phosphate, melamine polyphosphate, ammonium phosphate, ammonium polyphosphate, triphenylphosphate,graphite, silica, lignin, coke and compounds containing triazine rings condensed or linked by -NH groups. The reaction carrier is not involved in the reactions. There are no polymeric compounds in quantities such as to create a polymer matrix. The reagents being introduced into the reactor in an amount defined by the stoichiometric ratios of said reactions. The reaction carrier is introduced into the reactor in an amount defined with respect to the total weight of the reagents so that it can perform a modulator function.
摘要翻译：本发明涉及由溴化铋和/或与三聚氰胺络合的锑化合物制成的阻燃剂组合物的制备方法，其中三聚氰胺，碳酸铋和倍半氧化锑之间的至少一种氢溴酸在水溶液中与以引发导致形成溴化铋或溴化锑与三聚氰胺和三聚氰胺溴水合物的复合物的化学反应。在至少一种由至少一种选自三聚氰胺，磷酸三聚氰胺，聚磷酸三聚氰胺，磷酸铵，聚磷酸铵，磷酸三苯酯，石墨，二氧化硅，木质素，焦炭的化合物定义的反应载体存在下使试剂接触和含有三嗪环的化合物通过-NH基团缩合或连接。反应载体不参与反应。没有大量的聚合化合物用于制造聚合物基体。试剂以由所述反应的化学计量比限定的量引入到反应器中。将反应载体以相对于试剂总重量限定的量引入反应器中，以使其可以执行调节剂功能。

5. 发明授权

EP2688952B1 STABILIZER COMPOSITION FOR HALOGEN-CONTAINING POLYMERS 有权
标题翻译：稳定组合物用于含卤素的聚合物
公开(公告)号：EP2688952B1
公开(公告)日：2016-05-18
申请号：EP12710713.4
申请日：2012-03-21
申请人： Chemson Polymer-Additive AG
发明人： CAMPBELL, Colin , PELZL, Bernhard , BUTT, Anthony Stephen
IPC分类号： C08K5/3492 , C07D251/34 , C07D251/38 , C07D251/54 , C08L57/08
CPC分类号： C08K5/34924 , C07D251/34 , C07D251/38 , C08L27/06

6. 发明授权

EP2507217B1 CONCENTRATED STORAGE-STABLE AQUEOUS OPTICAL BRIGHTENING SOLUTIONS 有权
标题翻译：浓缩的储存稳定的水性荧光增白剂SOLUTIONS
公开(公告)号：EP2507217B1
公开(公告)日：2015-03-04
申请号：EP10785354.1
申请日：2010-12-01
申请人： Clariant Finance (BVI) Limited
发明人： KLEIN, Cedric , REVEAUD, Frederic , PUDDIPHATT, David , JACKSON, Andrew, Clive
IPC分类号： C07D251/54
CPC分类号： C07D251/54 , D21H21/30 , Y10T428/249921 , Y10T442/2582 , Y10T442/60
摘要： Concentrated storage stable aqueous solutions (S) comprising components (a), (b) and (c), wherein component (a) is at least one optical brightening agent of formula (1), in which the anionic charge on the brightener is balanced by a cationic charge composed of one or more cations selected from the group consisting of hydrogen, alkali metal cation, alkaline earth metal cation, ammonium, ammonium which is mono-, di- or trisubstituted by a C1-4 linear or branched alkyl radical and ammonium which is mono-, di- or trisubstituted by a C1-4 linear or branched hydroxyalkyl radical, and the concentration of component (a) is 0.08 to 0.3 mol per kg, based on the total weight of the concentrated storage-stable aqueous solutions (S), component (b) is at least one inorganic salt (SA), in a concentration of 2 to 15% by weight, based on the total weight of the concentrated storage-stable aqueous solutions (S), and component (c) is water, in a concentration of 10% to 88% by weight, based on the total weight of the concentrated storage-stable aqueous solutions (S).

7. 发明公开

EP2688875A4 PROCESS FOR THE PREPARATION OF S-TRIAZINE COMPOUNDS 有权
标题翻译：制备S-三嗪化合物的方法
公开(公告)号：EP2688875A4
公开(公告)日：2014-09-17
申请号：EP12759876
申请日：2012-03-21
申请人： BASF SE
发明人： KRÖNER RUDI
IPC分类号： C07D253/06 , C07D251/54
CPC分类号： C07D251/54 , C07D253/06

8. 发明公开

EP2688875A1 PROCESS FOR THE PREPARATION OF S-TRIAZINE COMPOUNDS 有权
标题翻译：用于生产S-三嗪化合物
公开(公告)号：EP2688875A1
公开(公告)日：2014-01-29
申请号：EP12759876.1
申请日：2012-03-21
申请人： BASF SE
发明人： Kröner, Rudi
IPC分类号： C07D251/54
CPC分类号： C07D251/54 , C07D253/06
摘要： A process is described for the preparation of s-triazine derivatives of the formula in which R is a Ci-C12-alkyl radical, by reacting a cyanuric acid halide with a p-aminobenzoic acid ester, which comprises a C6-C12-alkyl radical as radical of the ester alcohol, in a molar ratio of 1:3 to 1:5 in a xylene isomer mixture as solvent. 10 The process is characterized in that the solvent is used in amounts of from 0.6 to 2.1 mol/l.

9. 发明公开

EP2507217A1 CONCENTRATED STORAGE-STABLE AQUEOUS OPTICAL BRIGHTENING SOLUTIONS 有权
标题翻译：浓缩的储存稳定的水性荧光增白剂SOLUTIONS
公开(公告)号：EP2507217A1
公开(公告)日：2012-10-10
申请号：EP10785354.1
申请日：2010-12-01
申请人： Clariant Finance (BVI) Limited
发明人： KLEIN, Cedric , REVEAUD, Frederic , PUDDIPHATT, David , JACKSON, Andrew, Clive
IPC分类号： C07D251/54
CPC分类号： C07D251/54 , D21H21/30 , Y10T428/249921 , Y10T442/2582 , Y10T442/60
摘要： Concentrated storage stable aqueous solutions (S) comprising components (a), (b) and (c), wherein component (a) is at least one optical brightening agent of formula (1), in which the anionic charge on the brightener is balanced by a cationic charge composed of one or more cations selected from the group consisting of hydrogen, alkali metal cation, alkaline earth metal cation, ammonium, ammonium which is mono-, di- or trisubstituted by a C1-4 linear or branched alkyl radical and ammonium which is mono-, di- or trisubstituted by a C1-4 linear or branched hydroxyalkyl radical, and the concentration of component (a) is 0.08 to 0.3 mol per kg, based on the total weight of the concentrated storage-stable aqueous solutions (S), component (b) is at least one inorganic salt (SA), in a concentration of 2 to 15% by weight, based on the total weight of the concentrated storage-stable aqueous solutions (S), and component (c) is water, in a concentration of 10% to 88% by weight, based on the total weight of the concentrated storage-stable aqueous solutions (S).

10. 发明公开

EP2268635A4 HETEROCYCLIC COMPOUNDS 有权
标题翻译：杂环化合物
公开(公告)号：EP2268635A4
公开(公告)日：2012-02-22
申请号：EP08874003
申请日：2008-11-03
申请人： TAIGEN BIOTECHNOLOGY CO LTD
发明人： YEN CHI-FENG , HU CHENG-KUNG , HUANG CHANG-PIN , HUANG YING-HUEY , HAKIMELAHI GHOLAM HOSSEIN , KING CHI-HSIN RICHARD
IPC分类号： C07D239/50 , A61P29/00 , A61P35/00 , C07D251/54 , C07D403/04
CPC分类号： C07D239/50 , C07D251/54 , C07D403/04

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