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1. 发明授权

EP3590073B1 CODED POLYMER SUBSTRATES FOR BANKNOTE AUTHENTICATION 有权转让
公开(公告)号：EP3590073B1
公开(公告)日：2024-10-16
申请号：EP18760973.0
申请日：2018-03-01
IPC分类号： G06K19/02 , G07D7/1205
CPC分类号： G01N21/554 , G07D7/10 , G07D7/12 , G07D7/205 , G07D7/1205 , G07D2207/0020130101 , B42D25/36

2. 发明授权

EP2972337B1 NANOPLASMONIC IMAGING TECHNIQUE FOR THE SPATIO-TEMPORAL MAPPING OF SINGLE CELL SECRETIONS IN REAL TIME 有权
公开(公告)号：EP2972337B1
公开(公告)日：2018-11-21
申请号：EP14775318.0
申请日：2014-03-13
申请人： The Government of the United States of America, as represented by the Secretary of the Navy
发明人： RAPHAEL, Marc, P. , CHRISTODOULIDES, Joseph, A. , BYERS, Jeff, M. , DELEHANTY, James, B.
IPC分类号： G01N21/552 , G01N21/59 , G01N21/64 , G01N33/543 , G01N21/27
CPC分类号： G01N21/554 , G01N21/274 , G01N21/59 , G01N21/6458 , G01N21/648 , G01N33/54373 , G01N2021/6491
摘要： A label-free method for the spatio-temporal mapping of protein secretions from individual cells in real time by using a chip for localized surface plasmon resonance (LSPR) imaging. The chip is a glass coverslip compatible for use in a standard microscope having at least one array of functionalized plasmonic nanostructures patterned onto it. After placing a cell on the chip, the secretions from the cell are spatially and temporally mapped using LSPR imaging. Transmitted light imaging and/or fluorescence imaging may be done simultaneously with the LSPR imaging.

3. 发明授权

EP2630468B1 APPARATUS AND METHOD FOR OPTICALLY DETECTING ANALYTES 有权转让
公开(公告)号：EP2630468B1
公开(公告)日：2018-07-11
申请号：EP11833912.6
申请日：2011-08-08
申请人： Nokia Technologies Oy
发明人： NISKANEN, Antti , KIVIOJA, Jani
IPC分类号： G01N21/17 , G01N27/00 , G01N33/50 , H01L31/0232 , G02B5/00 , G01N21/25 , G01N21/552 , G01N21/64 , G01N33/543
CPC分类号： G01N21/554 , G01N21/253 , G01N21/255 , G01N21/553 , G01N21/6428 , G01N21/6452
摘要： An apparatus comprising a processor and memory including computer program code. The memory and computer program code can be configured to, with the processor, cause the apparatus to illuminate one or more sensor elements with electromagnetic radiation emitted from corresponding regions of an electronic display. The one or more sensor elements can be configured to exhibit a specific electrical response to the illumination when a specific set of analytes are bound to the one or more sensor elements, determine the electrical response of the one or more sensor elements, and compare the determined electrical response with one or more predetermined electrical responses to determine a match. Each predetermined electrical response can be associated with the binding of a different set of analytes, wherein determination of a match allows the specific set of analytes bound to the one or more sensor elements to be identified.

4. 发明授权

EP3153844B1 SYSTEM FOR BIODETECTION APPLICATIONS 有权
公开(公告)号：EP3153844B1
公开(公告)日：2018-05-23
申请号：EP15742334.4
申请日：2015-06-02
申请人： Consejo Superior de Investigaciones Científicas (CSIC)
发明人： TAMAYO DE MIGUEL, Francisco Javier , MONTEIRO KOSAKA, Priscila , PINI, Valerio , CALLEJA GOMÉZ, Montserrat , RUZ MARTINEZ, Jose Jaime , RAMOS VEGA, Daniel , GONZALEZ SAGARDOY, Maria Ujue
IPC分类号： G01N21/552 , G01N21/65 , G01N21/77 , G01N33/543 , G01N33/553
CPC分类号： G01N33/54346 , G01N21/47 , G01N21/554 , G01N21/59 , G01N21/658 , G01N21/77 , G01N21/7703 , G01N33/54373 , G01N2021/5903
摘要： The present invention relates to a system for biodetection applications comprising two basic elements, a substrate with a functionalized surface and a nanoparticle, the system being capable of enhancing the plasmonic effect of the nanoparticle. The invention also relates to a biosensor incorporating such system, in addition to the method for detecting and quantifying a target analyte selected in a sample using such system. Finally, the invention relates to a device which can detect the enhanced optoplasmonic effect of the nanoparticles by means of the system of the invention or by combining the detection of such optoplasmonic effect with the analysis of the changes in the mechanical characteristics in the substrate.

5. 发明公开

EP3315970A1 MEASUREMENT METHOD, MEASUREMENT CHIP USED FOR SAME, AND KIT FOR MEASUREMENT 审中-公开
标题翻译：测量方法，用于测量的测量芯片和用于测量的套件
公开(公告)号：EP3315970A1
公开(公告)日：2018-05-02
申请号：EP16814192.7
申请日：2016-06-10
申请人： Konica Minolta, Inc.
发明人： MURAMATSU, Shinichi , TAKANO, Keizou
IPC分类号： G01N33/543 , G01N21/64 , G01N33/553
CPC分类号： G01N21/6428 , G01N21/554 , G01N21/64 , G01N21/645 , G01N33/543 , G01N33/553 , G01N2021/6439 , G01N2021/6463 , G01N2201/0635 , G01N2333/8139
摘要： Provided is a measurement method with which an analyte in a sample containing a high concentration of the analyte can be measured with high accuracy without diluting the sample in multiple stages. An embodiment of the present invention relates to a measurement method for measuring an amount of an analyte in a sample, the method including: a binding step of providing the sample to a containing part of a measuring chip including the containing part for containing liquid, and a first capture body immobilized inside the containing part and having a recognition site that specifically binds to the analyte so as to bind the analyte contained in the sample to the first capture body; and a measurement step of measuring an amount of the analyte bound to the first capture body. The measurement method includes an adjustment step in which a second capture body having a recognition site that specifically binds to the analyte is bound to a part of the analyte in the sample in parallel with the binding step or before the binding step so as to reduce the amount of the analyte capable of binding to the first capture body.
摘要翻译：本发明提供一种测定方法，能够高精度地测定含有高浓度分析对象的试样中的分析物，而不会多次稀释试样。本发明的一个实施方式涉及用于测量样品中分析物的量的测量方法，所述方法包括：结合步骤，将样品提供给包括用于容纳液体的容纳部分的测量芯片的容纳部分，以及第一捕获体，所述第一捕获体被固定在所述容纳部分内并且具有识别位点，所述识别位点与所述分析物特异性结合以便将所述样品中包含的所述分析物结合到所述第一捕获体; 以及测量结合到第一捕获体的分析物的量的测量步骤。测量方法包括调整步骤，其中具有与分析物特异性结合的识别位点的第二捕获体在结合步骤的同时或在结合步骤之前与样品中的分析物的一部分结合，从而减少能够结合第一捕获体的分析物的量。

6. 发明公开

EP3298386A1 AN OPTICAL FIBRE FOR USE IN A SYSTEM FOR DETECTION OF ONE OR MORE COMPOUNDS IN A FLUID 审中-公开
标题翻译：用于检测流体中一种或多种化合物的系统中使用的光纤
公开(公告)号：EP3298386A1
公开(公告)日：2018-03-28
申请号：EP16722681.0
申请日：2016-05-16
申请人： INL - International Iberian Nanotechnology Laboratory
发明人： VIEGAS, Diana , QUEIRÓS, Raquel , NIEDER, Jana , FÉRNANDEZ, Maria Teresa , ESPIÑA, Begoña , FREITAS, Paolo , MONTELIUS, Lars
IPC分类号： G01N21/552 , G01N21/65 , G01N21/77 , G01N33/543
CPC分类号： G01N21/554 , G01N21/553 , G01N21/658 , G01N21/7703 , G01N2021/7716 , G01N2201/088 , G01N2201/0886
摘要： The present invention relates to an optical fibre for use in a system for detection of one or more compounds in a fluid. The optical fibre (100, 101, 202) comprising at least two binding portions (102, 104, 118, 210, 211, 212) separated from each other along the longitudinal direction (106) of the optical fibre (100, 101, 202), wherein each of the at least two binding portions (102, 104, 118, 210, 211, 212) comprises a plasmonic structure (120) and/or a SERS structure (121), and a binding material (126) for binding of one or more compounds, wherein the optical fibre (100, 101, 202) is arranged for receiving light and transmitting light to each of the at least two binding portions, wherein each of the at least two binding portions (102, 104, 118, 210, 211, 212) is arranged such that light transmitted through that binding portion (102, 104, 118, 210, 211, 212) without bound compound is different compared to light transmitted through that binding portion (102, 104, 118, 210, 211, 212) with bound compound, or light reflected back from that binding portion (102, 104, 118, 210, 211, 212) without bound compound is different compared to light reflected back from that binding portion (102, 104, 118, 210, 211, 212) with bound compound. The present invention further relates to a system (200) for detection of one or more compounds in a fluid (103) and an optical fibre (100, 101, 202) for use in such a system (200) and a method (400) using the system (200).

7. 发明授权

EP2988114B1 GAS DETECTION DEVICE 有权
标题翻译：气体检测装置
公开(公告)号：EP2988114B1
公开(公告)日：2018-02-28
申请号：EP14784955.8
申请日：2014-04-08
申请人： National University Corporation Yokohama National University
发明人： NISHIJIMA,Yoshiaki , ADACHI,Yuta
IPC分类号： G01N21/552 , G01N21/3504 , G01N21/359
CPC分类号： G01N21/3504 , G01N21/359 , G01N21/553 , G01N21/554 , G01N2201/061 , G01N2201/0635
摘要： A gas detector (10) includes a cell internal space (130) into which a target gas is supplied, the target gas exhibiting an absorption peak in an absorption spectrum; a light source (410) configured to generate light having at least a wavelength belonging to the absorption peak; and a photodetector (420) configured to detect the light that has emitted from the light source (410) and has propagated through the cell internal space (130). The gas detector (10) further includes a conductive thin film (220) in which a plurality of optical apertures(222) are regularly arranged such that a transmission peak in a transmission spectrum is superimposed over the absorption peak in the absorption spectrum along a wavelength axis. The conductive thin film (220) is provided on an optical path extending from the light source (410) to the photodetector (420), and is provided so as to be contactable with the target gas within the cell internal space (130).

8. 发明公开

EP3268724A1 MICROARRAY SLIDES THAT ENHANCE FLUORESCENT SIGNALS VIA PLASMONIC INTERACTION 审中-公开
标题翻译：微阵列通过平稳相互作用增强荧光信号
公开(公告)号：EP3268724A1
公开(公告)日：2018-01-17
申请号：EP16710598.0
申请日：2016-03-07
申请人： Plasmonix, Inc.
发明人： BAUMGOLD, Jesse
IPC分类号： G01N21/552 , B82Y15/00 , B82Y20/00 , G01N21/64 , G01N21/77 , G01N33/543 , G01N33/553
CPC分类号： G01N21/648 , B82Y20/00 , G01N21/553 , G01N21/554 , G01N21/6428 , G01N21/7703 , G01N33/54373 , G01N33/553 , G01N2021/6439 , G01N2201/06113 , G02B21/34
摘要： The invention describes generating and use of a multi-layer plasmonic slide, wherein the plasmonic slide comprises at least 6 layers of metallic nanoparticles that can enhance the detection of fluorescent signals and wherein the plasmonic slide can be printed as a microarray of any size. The microarray containing the plasmonic slide can further be printed with a protein, a glycan, or an antibody. The multi-layer plasmonic slide is capable of detecting proteins, polynucleotides, and/or glycans at orders of magnitude lower concentration than non-plasmonic substrates.

9. 发明授权

EP2024488B1 METAL-ENHANCED CHEMILUMINESCENCE (MEC) 有权
标题翻译：金属增强化学发光（MEC）
公开(公告)号：EP2024488B1
公开(公告)日：2018-01-17
申请号：EP07756908.5
申请日：2007-02-13
申请人： Geddes, Chris
发明人： Geddes, Chris
IPC分类号： G01N21/76 , G01N21/55 , G01N33/553 , G01N21/552
CPC分类号： G01N21/76 , G01N21/553 , G01N21/554 , G01N33/553
摘要： The present invention relates to a method of imaging structures and features using plasmonic emissions from metallic surfaces, such as natiostructures, caused by chemiluminescence based reactions. Importantly, these plasmonic emissions emitted from metallic surface are generated without an external excitation but instead from chemically induced electronically excited states.

10. 发明公开

EP3255413A1 MEASUREMENT DEVICE 审中-公开
标题翻译：测量装置
公开(公告)号：EP3255413A1
公开(公告)日：2017-12-13
申请号：EP16746527.7
申请日：2016-01-29
申请人： Nitto Denko Corporation
发明人： IHARA, Terukazu , NISHIO, Hajime , HATAKEYAMA, Yoshiharu , YANO, Chiharu , NAKANO, Junko
IPC分类号： G01N21/41
CPC分类号： G01N21/554 , C12Y304/22065 , G01N21/41 , G01N33/54373 , G01N33/573 , G01N2333/96413
摘要： The present invention provides a measurement device which is compact and portable and is simply operated, and which is capable of quantifying the amount of an object to be inspected with high sensitivity and high accuracy. A measurement device of the present invention includes an SPR sensor cell, a light source, and a light receiving element. The SPR sensor cell includes a plurality of optical waveguides. At least one of the plurality of optical waveguides forms a detection unit together with a metal layer onto which a recognition substance for an object to be inspected is fixed, and at least another one of the plurality of optical waveguides forms a reference unit together with a metal layer free of the recognition substance.
摘要翻译：本发明提供一种小型且便携且操作简单，且能够高灵敏度且高精度地量化被检查物的量的测量装置。本发明的测量装置包括SPR传感器单元，光源和光接收元件。 SPR传感器单元包括多个光波导。多个光波导中的至少一个光波导与金属层一起形成检测单元，在该金属层上固定有用于被检查对象的识别物质，并且多个光波导中的至少另一个与参考单元一起形成参考单元不含识别物质的金属层。

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