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1. 发明授权

EP3331818B1 SIGNAL AMPLIFICATION IN SOLUTION-BASED PLASMONIC SPECIFIC-BINDING PARTNER ASSAYS 有权转让
公开(公告)号：EP3331818B1
公开(公告)日：2024-07-10
申请号：EP16833889.5
申请日：2016-08-04
IPC分类号： B82Y30/00 , B82Y35/00 , G01N21/17 , G01N21/55
CPC分类号： G01N33/54373 , G01N2469/1020130101 , G01N33/553

2. 发明公开

EP3187874A4 REACTION METHOD, DETECTION METHOD, AND DETECTION DEVICE 有权转让
公开(公告)号：EP3187874A4
公开(公告)日：2018-05-23
申请号：EP15836585
申请日：2015-07-14
申请人： KONICA MINOLTA INC
发明人： MURAYAMA TAKANORI
IPC分类号： G01N33/543 , G01N21/03 , G01N21/05 , G01N21/41 , G01N21/552 , G01N21/64 , G01N33/553
CPC分类号： G01N33/6887 , G01N21/05 , G01N21/51 , G01N21/553 , G01N21/6428 , G01N21/648 , G01N33/54306 , G01N33/54366 , G01N33/54373 , G01N33/553 , G01N2021/0346 , G01N2021/058 , G01N2333/4712
摘要： In a first step, by moving a blocking liquid containing a blocking agent in a containing unit for containing a liquid, the inside of the containing unit is subjected to a blocking treatment. In a second step, by supplying a liquid containing a reaction target substance (detection target substance) into the containing unit, a reaction field which is exposed to the containing unit and to which a capturing body is fixed is caused to capture the reaction target substance. The second step is performed following the first step or simultaneously with the first step.

3. 发明公开

EP3315970A4 MEASUREMENT METHOD, MEASUREMENT CHIP USED FOR SAME, AND KIT FOR MEASUREMENT 审中-公开
公开(公告)号：EP3315970A4
公开(公告)日：2018-05-02
申请号：EP16814192
申请日：2016-06-10
申请人： KONICA MINOLTA INC
发明人： MURAMATSU SHINICHI , TAKANO KEIZOU
IPC分类号： G01N33/543 , G01N21/64 , G01N33/553
CPC分类号： G01N21/64 , G01N33/543 , G01N33/553
摘要： Provided is a measurement method with which an analyte in a sample containing a high concentration of the analyte can be measured with high accuracy without diluting the sample in multiple stages. An embodiment of the present invention relates to a measurement method for measuring an amount of an analyte in a sample, the method including: a binding step of providing the sample to a containing part of a measuring chip including the containing part for containing liquid, and a first capture body immobilized inside the containing part and having a recognition site that specifically binds to the analyte so as to bind the analyte contained in the sample to the first capture body; and a measurement step of measuring an amount of the analyte bound to the first capture body. The measurement method includes an adjustment step in which a second capture body having a recognition site that specifically binds to the analyte is bound to a part of the analyte in the sample in parallel with the binding step or before the binding step so as to reduce the amount of the analyte capable of binding to the first capture body.

4. 发明公开

EP3307867A1 IMAGE DIFFRENTIATED MULTIPLEX ASSAYS 有权
标题翻译：图像微分多重分析
公开(公告)号：EP3307867A1
公开(公告)日：2018-04-18
申请号：EP16806958.1
申请日：2016-06-10
申请人： Plexbio Co., Ltd.
发明人： TSAO, Dean , HUANG, Chin-Shiou , CHUNG, Yao-Kuang
IPC分类号： C12M1/34 , G01N33/543
CPC分类号： G01N33/545 , C12Q1/6813 , C12Q1/6816 , C12Q1/6834 , G01N33/54326 , G01N33/54393 , G01N33/553 , C12Q2563/149 , C12Q2565/501
摘要： Provided herein are encoded microcarriers for analyte detection in multiplex assays. The microcarriers are encoded with an analog code for identification and include a capture agent for analyte detection. Also provided are methods of making the encoded microcarriers disclosed herein. Further provided are methods and kits for conducting a multiplex assay using the microcarriers described herein.

5. 发明公开

EP3165923A4 MARKER, IMMUNOASSAY METHOD, IMMUNOASSAY REAGENT, METHOD FOR ASSAYING ANALYTE, KIT FOR ASSAYING ANALYTE, AND TEST STRIP FOR LATERAL FLOW CHROMATOGRAPHY 有权转让
公开(公告)号：EP3165923A4
公开(公告)日：2017-11-29
申请号：EP15814054
申请日：2015-06-30
申请人： NIPPON STEEL & SUMIKIN CHEM CO
发明人： MATSUMURA YASUFUMI , ENOMOTO YASUSHI , SHINTA RYUZO
IPC分类号： G01N33/553 , G01N33/543 , G01N33/558
CPC分类号： G01N33/558 , G01N33/54346 , G01N33/553
摘要： A resin-metal composite 100 to be used as a marker in an immunoassay, said resin-metal composite 100 comprising a resin particle 10 and metal particles 20 and having the following constitution (A) or constitution (B): (A) the average particle size of the resin-metal composite exceeding 300nm; or (B) the average particle size of the metal particles being in the range of more than 20nm and less than 70nm . It is preferred that a part of the metal particles 20 are two- or three-dimensionally distributed in the surface layer part 60 of the resin particle 10, a part of the three-dimensionally distributed metal particles 20 are partly exposed to the outside of the resin particle 10, and a part of the remainder particles are enclosed in the resin particle 10.

6. 发明公开

EP3112847A4 MEASUREMENT METHOD AND MEASUREMENT DEVICE 审中-公开
标题翻译： MESSVERFAHREN UND MESSVORICHHTUNG
公开(公告)号：EP3112847A4
公开(公告)日：2017-10-04
申请号：EP15755571
申请日：2015-02-23
申请人： KONICA MINOLTA INC
发明人： TAMURA TSURUKI , OOTANI MAKIKO , AOKI YOUICHI
IPC分类号： G01N21/64 , G01N21/552 , G01N33/543 , G01N33/553
CPC分类号： G01N21/554 , G01N21/553 , G01N21/6428 , G01N21/648 , G01N33/54373 , G01N33/553 , G01N2021/6439
摘要： With a blood-derived specimen on top of a metal film on a measurement chip, the intensity of reflected excitation light, the resonance angle of excitation light, the intensity of plasmon-scattered light, or the enhancement angle of excitation light is measured, and the acquired measurement is used to obtain a whole-blood hematocrit value. Using the obtained whole-blood hematocrit value, a first signal value that indicates how much of an analyte the specimen contains is converted to a second signal value that indicates how much of said analyte the liquid part of the specimen contains.
摘要翻译：在测量芯片上的金属膜顶部的血液来源的样本中，测量反射激发光的强度，激发光的共振角，等离子体激元散射光的强度或激发光的增强角，并且采集的测量结果用于获得全血细胞比容值。使用获得的全血细胞比容值，指示试样含有多少分析物的第一信号值被转换成第二信号值，该第二信号值指示试样的液体部分含有多少所述分析物。

7. 发明公开

EP3155406A1 OPTICAL BIOSENSOR 有权
标题翻译： OPTISCHER生物传感器
公开(公告)号：EP3155406A1
公开(公告)日：2017-04-19
申请号：EP15805743.0
申请日：2015-03-03
申请人： University Of South Australia
发明人： VOELCKER, Nico , KRISMASTUTI, Fransiska Sri Herwahyu , PRIETO SIMON, Beatriz
IPC分类号： G01N21/76 , C09K11/00
CPC分类号： G01N21/6428 , G01N33/551 , G01N33/552 , G01N33/553 , G01N33/573 , G01N2021/6432 , G01N2201/068 , G01N2333/95
摘要： Provided herein is an optical biosensor for detecting a target bioanalyte in a sample. The biosensor includes: a porous silicon or alumina substrate having a surface and a detection agent immobilised on the surface. The detection agent includes a sensing domain and a signaling domain, the sensing domain having a linker capable of interacting with the target bioanalyte and the signaling domain having a luminescence donor and a luminescence acceptor wherein the luminescence donor and the luminescence acceptor are connected by the linker and are optically coupled in the absence of the target bioanalyte. Emission of light from the luminescence donor is substantially quenched by the luminescence acceptor, and interaction of the target bioanalyte with the linker results in optical un-coupling of the luminescence donor and the luminescence acceptor to thereby result in light emission from the luminescence donor.
摘要翻译：本文提供了用于检测样品中的目标生物分析物的光学生物传感器。生物传感器包括：具有固定在表面上的表面和检测剂的多孔硅或氧化铝基底。检测剂包括感测区域和信号区域，感测区域具有能够与靶生物分子相互作用的接头和具有发光供体和发光受体的信号区域，其中发光供体和发光受体通过连接体连接并且在不存在目标生物分析物的情况下光学耦合。来自发光供体的光的发射基本上被发光受体猝灭，并且目标生物分子与接头的相互作用导致发光供体和发光受体的光学非偶联，从而导致发光供体的光发射。

8. 发明公开

EP2823308A4 METHODS AND COMPOSITIONS FOR DETECTING MULTIPLE ANALYTES WITH A SINGLE SIGNAL 有权
标题翻译：方法和组合物用于识别多种分析物与一个信号
公开(公告)号：EP2823308A4
公开(公告)日：2016-04-20
申请号：EP13758127
申请日：2013-03-07
申请人： INVISIBLE SENTINEL INC
发明人： SICILIANO NICHOLAS , LEONG LOUIS , KEOUGH MARTIN PATRICK , BROWN ASHLEY SHANIECE
IPC分类号： G01N33/543
CPC分类号： G01N33/54306 , B01L3/5023 , B01L2300/0627 , B01L2300/069 , C12Q1/6804 , C12Q1/686 , G01N33/543 , G01N33/54353 , G01N33/54366 , G01N33/553
摘要： Compositions, methods, and devices for the detection of multiple analytes with a single signal are provided.

9. 发明公开

EP2894475A4 SUBSTANCE MEASUREMENT SENSOR 有权
标题翻译：物质检测传感器
公开(公告)号：EP2894475A4
公开(公告)日：2016-04-13
申请号：EP13834846
申请日：2013-09-04
申请人： JNC CORP
发明人： UEHARA NOBUO
IPC分类号： G01N33/553 , G01N33/543 , G01N33/58
CPC分类号： G01N33/545 , G01N33/532 , G01N33/54326 , G01N33/54333 , G01N33/54393 , G01N33/553 , G01N33/587
摘要： An object of the present invention is to provide an analyte-measuring sensor using a thermoresponsive polymer, which is a novel analyte-measuring sensor capable of quantitatively measuring a target analyte with higher sensitivity. The analyte-measuring sensor of the present invention comprises a labeled particle capable of specifically reacting with a measurement target analyte, a thermoresponsive polymer, a charged substance exhibiting a positive or negative zeta potential in a solution, and a metal particle, and said metal particle is coated with a copolymer of said labeled particle, said charged substance and said thermoresponsive polymer.

10. 发明公开

EP2976644A2 ONE POT PROCESS FOR THE PREPARATION OF GOLD QUANTUM CLUSTERS 失效
标题翻译： EINTOPFVERFAHREN ZUR HERSTELLUNG VON GOLDQUANTENCLUSTERN
公开(公告)号：EP2976644A2
公开(公告)日：2016-01-27
申请号：EP14724519.5
申请日：2014-03-24
申请人： Council Of Scientific & Industrial Research
发明人： KHANDELWAL, Puneet , SINGH, Dheeraj Kumar , PODDAR, Pankaj
IPC分类号： G01N33/553 , G01N33/58
CPC分类号： G01N33/588 , B82Y15/00 , C09K11/06 , C09K2211/10 , G01N33/553
摘要： The invention disclosed herein provides tunable process for the preparation of water dispersive, biocompatible, fluorescent L-cystine labeled gold (Au) quantum clusters without using any toxic reactants. Further the invention discloses application of synthesized fluorescent gold (Au) quantum clusters in the field of nano-medicine, fluorescence imaging and florescence based sensors.
摘要翻译：本文公开的本发明提供了用于制备水分散性，生物相容性，荧光L-胱氨酸标记的金（Au）量子簇的可调节方法，而不使用任何有毒的反应物。此外，本发明公开了在纳米药物，荧光成像和基于荧光的传感器领域中合成的荧光金（Au）量子簇的应用。

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