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1. 发明公开

EP3255413A4 MEASUREMENT DEVICE 审中-公开
公开(公告)号：EP3255413A4
公开(公告)日：2018-08-01
申请号：EP16746527
申请日：2016-01-29
申请人： NITTO DENKO CORP
发明人： IHARA TERUKAZU , NISHIO HAJIME , HATAKEYAMA YOSHIHARU , YANO CHIHARU , NAKANO JUNKO
IPC分类号： G01N21/41 , G01N21/552 , G01N33/543 , G01N33/573
CPC分类号： G01N21/554 , C12Y304/22065 , G01N21/41 , G01N33/54373 , G01N33/573 , G01N2333/96413
摘要： The present invention provides a measurement device which is compact and portable and is simply operated, and which is capable of quantifying the amount of an object to be inspected with high sensitivity and high accuracy. A measurement device of the present invention includes an SPR sensor cell, a light source, and a light receiving element. The SPR sensor cell includes a plurality of optical waveguides. At least one of the plurality of optical waveguides forms a detection unit together with a metal layer onto which a recognition substance for an object to be inspected is fixed, and at least another one of the plurality of optical waveguides forms a reference unit together with a metal layer free of the recognition substance.

2. 发明公开

EP2247953A2 CHK1 SUPPRESSES A CASPASE-2 APOPTOTIC RESPONSE TO DNA DAMAGE THAT BYPASSES P53, BCL-2 AND CASPASE-3 审中-公开
标题翻译： CHK1抑制型胱天蛋白酶凋亡-2-RESPONSE TO P53，BCL-2和胱天蛋白酶-3立即DNA损伤
公开(公告)号：EP2247953A2
公开(公告)日：2010-11-10
申请号：EP09708478.4
申请日：2009-02-04
申请人： Dana-farber Cancer Institute, Inc.
发明人： LOOK, A., Thomas , SIDI, Samuel
IPC分类号： G01N33/574
CPC分类号： G01N33/574 , A61K49/0008 , G01N2333/4704 , G01N2333/96413 , G01N2800/52
摘要： The invention describes methods that are useful for treating cancer by administering a Chk1 inhibitor which can induce apoptosis in p53-defective cells when combined with a chemotherapy and/or radiotherapy. Methods for screening candidates for a Chk1 inhibitor- based cancer treatment regimen are also described.

3. 发明授权

EP0948639B1 IDENTIFICATION OF BLAST CELLS IN A LEUKOCYTE CELL PREPARATION 失效
标题翻译：细胞在急LEUKOZYTENZUBEREITUNG鉴定
公开(公告)号：EP0948639B1
公开(公告)日：2005-08-10
申请号：EP97913899.7
申请日：1997-10-29
申请人： Coulter International Corp.
发明人： KUYLEN, Nazle , CREWS, Harold, R. , JAFFE, Gerald, E. , BARCELON, Maria , LUCAS, Francis, J. , GARCIA, Nancy, M.
IPC分类号： C12Q1/00 , C12Q1/04 , C12Q1/26 , C12Q1/37 , C12Q1/44 , C12Q1/42 , C12Q1/34 , G01N15/14 , G01N33/50 , G01N21/64
CPC分类号： C12Q1/34 , C12Q1/26 , C12Q1/37 , G01N33/574 , G01N33/582 , G01N2333/95 , G01N2333/96413 , G01N2333/96466 , G01N2333/96469 , G01N2800/52

4. 发明公开

EP2977760A1 BIOMARKER FOR DIAGNOSING LIVER CANCER 有权
标题翻译：生物标记ZUR DIAGNOSE VON LEBERKREBS
公开(公告)号：EP2977760A1
公开(公告)日：2016-01-27
申请号：EP14767707.4
申请日：2014-03-17
申请人： Seoul National University R&DB Foundation
发明人： KIM, Youngsoo , YOON, Junghwan , KIM, Hyunsoo , JIN, Jonghwa
IPC分类号： G01N33/574 , G01N33/53 , G01N33/48
CPC分类号： G01N33/57438 , G01N33/5079 , G01N2333/9015 , G01N2333/90206 , G01N2333/96413
摘要： The present invention relates to a biomarker for diagnosis or prognosis of liver cancer which is at least one member selected from the group consisting of ACADVL, ANLN, BASP1, MTHFD1, CAPN1, C4A, FLNB and PABPC1, and a measurement kit, a composition and a method which are for diagnosis or prognosis of liver cancer which include the same. The biomarker according to the present disclosure enables, with high accuracy and sensitivity, an early diagnosis of or monitoring of hepatocellular carcinoma and effective prognosis or assessment of progression of disease. In addition, simple and effective diagnosis of or monitoting of liver cancer is possible by noninvasive tests using blood, urine or the like, and thus the present invention will be very effective in the early detection of liver cancer at home or general clinic through a development of, for example, point of care testing (POCT).
摘要翻译：本发明涉及一种用于肝癌诊断或预后的生物标志物，其为选自ACADVL，ANLN，BASP1，MTHFD1，CAPN1，C4A，FLNB和PABPC1中的至少一种，测定试剂盒，组合物和用于诊断或预后的包括其的肝癌的方法。根据本公开的生物标志物以高精度和灵敏度能够早期诊断或监测肝细胞癌和有效预后或评估疾病进展。此外，通过使用血液，尿液等的非侵入性测试，可以简单有效地诊断或监测肝癌，因此本发明将通过开发在家庭或一般诊所的早期检测中非常有效例如护理点测试（POCT）。

5. 发明公开

EP2496942A4 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 有权
标题翻译：方法和组合物诊断和预后肾损伤和肾功能衰竭的
公开(公告)号：EP2496942A4
公开(公告)日：2013-06-19
申请号：EP10829198
申请日：2010-11-05
申请人： ASTUTE MEDICAL INC
发明人： ANDERBERG JOSEPH , GRAY JEFF , MCPHERSON PAUL , NAKAMURA KEVIN , KAMPF JAMES PATRICK
IPC分类号： G01N33/68
CPC分类号： G01N33/6842 , G01N33/6893 , G01N2333/96413 , G01N2800/347 , G01N2800/56 , Y02A90/26
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Cathepsin B, Renin, Dipeptidyl Peptidase IV, Neprilysin, Beta-2-microglobulin, Carbonic anhydrase IX, and C-X-C motif chemokine 2 as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及一种用于在患有或疑似患有肾损伤的受试者监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及一种使用经配置以检测选自组织蛋白酶B，肾素，二肽基肽酶IV，中性溶酶，β-2微球蛋白，碳酸酐酶IX，和CXC基序的选择的肾损伤标记物的一个或多个测定趋化因子2，如肾损伤的诊断和预后标志物。

6. 发明公开

EP0932668A1 TWO HUMAN CATHEPSIN PROTEINS 失效
标题翻译：两个人组织蛋白酶蛋白质。
公开(公告)号：EP0932668A1
公开(公告)日：1999-08-04
申请号：EP97944435.0
申请日：1997-09-25
申请人： INCYTE PHARMACEUTICALS, INC.
发明人： BANDMAN, Olga , COLEMAN, Roger
IPC分类号： C12N15 , A01K67 , A61K35 , A61K38 , A61P29 , A61P35 , C07H21 , C07K16 , C12N1 , C12N5 , C12N9 , C12P21
CPC分类号： G01N33/573 , A61K38/00 , C12N9/6421 , C12N9/6478 , G01N2333/96413 , G01N2500/02
摘要： The present invention provides two novel human cathepsin proteins (HCPs) and polynucleotides encoding HCPs. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HCPs. The invention also provides for the production and use of antibodies to HCPs in pharmaceutical compositions for the treatment of disease processes that include cancers, inflammation, metastasis and peptide and proenzyme processing. In addition, the invention provides for the production and use of inhibitors of HCPs in pharmaceutical compositions for the treatment of diseases. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the transcripts encoding HCPs. The invention also provides for the use of antisense molecules in pharmaceutical compositions as therapeutics in cancers, inflammation, metastasis and peptide and proenzyme processing.

7. 发明授权

EP2496942B1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 有权
标题翻译：方法和组合物诊断和预后肾损伤和肾功能衰竭的
公开(公告)号：EP2496942B1
公开(公告)日：2017-03-22
申请号：EP10829198.0
申请日：2010-11-05
申请人： Astute Medical, Inc.
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
IPC分类号： G01N33/68
CPC分类号： G01N33/6842 , G01N33/6893 , G01N2333/96413 , G01N2800/347 , G01N2800/56 , Y02A90/26
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Cathepsin B, Renin, Dipeptidyl Peptidase IV, Neprilysin, Beta-2-microglobulin, Carbonic anhydrase IX, and C-X-C motif chemokine 2 as diagnostic and prognostic biomarkers in renal injuries.

8. 发明公开

EP3047280A1 A METHOD FOR ANALYSING A SAMPLE OF IMMUNOGLOBULIN MOLECULES 审中-公开
标题翻译： VERFAHREN ZUR ANALYZE EINER PROBE VON IMMUNGLOBULIN-MOLEKÜLEN
公开(公告)号：EP3047280A1
公开(公告)日：2016-07-27
申请号：EP14772310.0
申请日：2014-09-18
申请人： Genovis Ab
发明人： OLSSON, Fredrik , NORDGREN, Maria , MEJARE, Malin , FREDRIKSSON, Sarah
IPC分类号： G01N33/68 , C12N9/00
CPC分类号： G01N33/6857 , C07K16/00 , C07K2317/53 , C12N9/6472 , C12Y304/2201 , G01N33/6854 , G01N2333/96413
摘要： The inventions provides methods for analysing a sample of immunoglobulins, related peptides, and kits for carrying out such methods.
摘要翻译：本发明提供了用于分析免疫球蛋白样品，相关肽和用于进行这些方法的试剂盒的方法。

9. 发明公开

EP2893032A1 METHODS AND COMPOSITION FOR DETECTING INTESTINAL CELL-BARRIER DYSFUNCTION 有权转让
标题翻译： VERFAHREN UND ZUSAMMENSETZUNG ZUM NACHWEIS EINER DYSFUNKTION DER INTESTINALEN BARRIERE
公开(公告)号：EP2893032A1
公开(公告)日：2015-07-15
申请号：EP13834474.2
申请日：2013-09-05
申请人： Liu, Julia
发明人： IRVIN, Randall, Thomas , LIU, Julia , DAVIS, Elisabeth, Melika
IPC分类号： C12Q1/37
CPC分类号： A61K49/0056 , A61B5/0068 , A61B5/0084 , A61K49/0041 , C07K14/8128 , G01N33/573 , G01N2333/96413 , G01N2333/96469 , G01N2800/065
摘要： Methods for detecting intestinal cell barrier dysfunction in a patient are disclosed. In one method, patient intestinal epithelial cells (lECs), oropharyngeal epithelial cells (OECs) or buccal epithelial cells (BECs) are stained with detectable probes specific against caspase-1 and caspase-3&7, and the cells are viewed for the presence of elevated levels of caspase-1, as evidence by a significantly higher ratio of caspase-1 marker to caspase-3&7, as an indicator of cell barrier dysfunction. In a second method, in situ images of a patient's lEC's, OECs or BECs are obtained by probe-based confocal laser endomicroscopy (pCLE), and images are analyzed for density of cell gaps. Also disclosed is a probe composition for use in detecting intestinal cell barrier dysfunction.
摘要翻译：公开了检测患者肠细胞屏障功能障碍的方法。在一种方法中，患者肠上皮细胞（IEC），口咽上皮细胞（OEC）或颊上皮细胞（BEC））用对caspase-1和caspase-3和7的特异性的可检测的探针进行染色，并观察细胞存在升高的胱天蛋白酶-1的水平，作为caspase-1标记物与半胱天冬酶-3和7的显着较高比例的证据，作为细胞屏障功能障碍的指标。在第二种方法中，通过基于探针的共聚焦激光显微镜（pCLE）获得患者的IEC，OEC或BEC的原位图像，并分析图像的细胞间隙的密度。还公开了用于检测肠细胞屏障功能障碍的探针组合物。

10. 发明公开

EP0948639A1 IDENTIFICATION OF BLAST CELLS IN A LEUKOCYTE CELL PREPARATION 失效
标题翻译：细胞在急LEUKOZYTENZUBEREITUNG鉴定
公开(公告)号：EP0948639A1
公开(公告)日：1999-10-13
申请号：EP97913899.0
申请日：1997-10-29
申请人： Coulter International Corp.
发明人： KUYLEN, Nazle , CREWS, Harold, R. , JAFFE, Gerald, E. , BARCELON, Maria , LUCAS, Francis, J. , GARCIA, Nancy, M.
IPC分类号： G01N33 , C12Q1
CPC分类号： C12Q1/34 , C12Q1/26 , C12Q1/37 , G01N33/574 , G01N33/582 , G01N2333/95 , G01N2333/96413 , G01N2333/96466 , G01N2333/96469 , G01N2800/52
摘要： The necessity to detect blast cells in a patient sample to determine a treatment regime for leukemia has long been desired. The present invention relates to a method and assay reagents for identification of blast cells in a fluid sample. The method further enables the determination of the lineage of the blast cells. The new method provides a determination of blast cells in less time than prior art methods.

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