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1. 发明授权

EP3329250B1 LASER SENSOR FOR PARTICLE SIZE DETECTION 有权转让
公开(公告)号：EP3329250B1
公开(公告)日：2018-12-26
申请号：EP16754420.4
申请日：2016-08-01
申请人： Koninklijke Philips N.V.
发明人： VAN DER LEE, Alexander Marc , HELLMIG, Joachim Wilhelm , SPRUIT, Johannes Hendrikus Maria
IPC分类号： G01N15/14 , G01S17/58 , G01S17/95 , G01B9/02 , G01N15/02 , G01S7/48 , G01S7/491
CPC分类号： G01N15/1434 , G01N15/0205 , G01N2015/03 , G01N2015/1075 , G01N2015/1438 , G01N2015/1452 , G01N2015/1454 , G01N2015/1493 , G01S7/4802 , G01S7/4817 , G01S7/4916 , G01S17/08 , G01S17/58 , G01S17/87 , G01S17/95 , Y02A90/19
摘要： The invention describes a laser sensor module (100) for particle size detection. The laser sensor module (100) comprises at least one first laser (110), at least one first detector (120), at least one electrical driver (130) and at least one evaluator (140). The first laser (110) is adapted to emit first laser light in reaction to signals provided by the at least one driver (130). The at least one first detector (120) is adapted to determine a first self -mixing interference signal (30) of an optical wave within a first laser cavity of the first laser (110). The first self-mixing interference signal (30) is caused by first reflected laser light reentering the first laser cavity, the first reflected laser light being reflected by a particle receiving at least a part of the first laser light. The evaluator (140) is adapted to determine a size of the particle by determining a first relative distance between the particle and the first laser (110) by means of the first self-mixing interference signal (30) and by determining a first amplitude information by means of the first self-mixing interference signal (30). The invention is further related to a corresponding method of determining a particle size.

2. 发明授权

EP2975380B1 PARTICLE MEASURING APPARATUS 有权
标题翻译：颗粒测量仪器
公开(公告)号：EP2975380B1
公开(公告)日：2017-08-23
申请号：EP15182325.9
申请日：2014-03-25
申请人： SYSMEX CORPORATION
发明人： Yamada, Kazuhiro , Yamamoto, Takeshi
IPC分类号： G01N15/14
CPC分类号： G01N15/1434 , G01N15/1459 , G01N2015/1438 , G01N2015/1452

3. 发明公开

EP2724144A1 CHARACTERIZATION OF MOTION-RELATED ERROR IN A STREAM OF MOVING MICRO-ENTITIES 有权
标题翻译：运动误差的A POWER移动单元MICRO表征
公开(公告)号：EP2724144A1
公开(公告)日：2014-04-30
申请号：EP12826157.5
申请日：2012-08-24
申请人： Sony Corporation , Sony Corporation Of America
发明人： DURACK, Gary , FLEISCHER, Stephen, D. , HATCHER, Jeremy , ROBERTS, David , ZORDAN, Michael
IPC分类号： G01N21/00
CPC分类号： G01N15/1404 , G01N15/1427 , G01N15/1429 , G01N15/1459 , G01N2015/1006 , G01N2015/1075 , G01N2015/1415 , G01N2015/1438 , G01N2015/1477 , G01N2015/149
摘要： Apparatus and methods for detecting, characterizing, and compensating motion-related error of moving micro-entities are described. Motion-related error may occur in streams of moving micro-entities, and may represent a deviation in and expected arrival time or an uncertainty in position of a micro-entity within the stream. Motion-related error of micro-entities is observed in a flow cytometer, e.g., as pulse jitter, and is found to have a functional dependence on a parameter of the system. The pulse jitter can be compensated, according to one embodiment, by adjusting data acquisition observation windows. For the flow cytometer, a reduction of pulse jitter can improve measurement accuracy, resolution of doublets, system throughput, and enable an increase in an interrogation region for probing the micro-entities.

4. 发明公开

EP2316022A1 CELL ANALYSIS APPARATUS AND METHODS 有权转让
标题翻译： ZELLANALYSEVORRICHTUNG以外地区
公开(公告)号：EP2316022A1
公开(公告)日：2011-05-04
申请号：EP08820026.6
申请日：2008-08-21
申请人： XY, LLC
发明人： SHARPE, Johnathan, C. , EVANS, Kenneth, M.
IPC分类号： G01N33/48 , C12M1/34
CPC分类号： G01N15/1459 , G01N15/1404 , G01N15/147 , G01N2015/1438 , G01N2015/149 , G01N2015/1497 , Y10T436/11
摘要： Particular embodiments of the inventive technology relate to 'off-axis detector' technology that employs a third detector 23 exhibiting a flow orthogonal axis 43 as defined by its EMR collection angle, where such axis is from 30 degrees to 60 degrees from an intended, flow orthogonal, cell cross section long axis alignment line 13, in addition to employing a fourth detector 24 exhibiting a flow orthogonal axis 44 as defined by its collection angle, where such axis is orthogonal to the flow orthogonal, third detector axis 43. Particular embodiments of the inventive technology relate to 'axially spaced illumination' technology featuring more than one cell illumination site, where, other than the most upflow illumination site (e.g., 121), all illumination site(s) are downflow of at least one other illumination site. Particular embodiments of the inventive technology may feature aspects of both technologies.
摘要翻译：本发明技术的特定实施例涉及“离轴检测器”技术，其采用表现出由其EMR收集角度定义的流动正交轴线43的第三检测器23，其中该轴线与预期的流动相距30度至60度正交的单元横截面长轴对准线13，除了采用表现出由其收集角度限定的流动正交轴44的第四检测器24，其中该轴线正交于流动正交的第三检测器轴43。本发明技术涉及具有多个单元照明位置的“轴向间隔开的照明”技术，其中除了最上升的照明位置（例如，121）之外，所有的照明位置都是至少一个其他照明位置的下流。本发明技术的特定实施例可以涉及两种技术的特征。

5. 发明公开

EP2201349A1 SYSTEMS, STORAGE MEDIUMS, AND METHODS FOR IDENTIFYING PARTICLES IN FLOW 失效
标题翻译：系统，存储介质和方法，流体流粒子IDENTIFYING
公开(公告)号：EP2201349A1
公开(公告)日：2010-06-30
申请号：EP08832367.0
申请日：2008-09-17
申请人： Luminex Corporation
发明人： SCHILFFARTH, Adam, Richard
IPC分类号： G01N15/10 , G01N15/14
CPC分类号： G01N15/1429 , G01N15/0205 , G01N15/1012 , G01N15/1031 , G01N15/1425 , G01N15/1427 , G01N15/1459 , G01N2015/025 , G01N2015/1018 , G01N2015/1438 , G01N2015/1477
摘要： Methods, storage mediums, and systems for correlating pulses generated from multiple interrogation regions in a flow cytometer to particular particles flowing through the flow cytometer are provided. Embodiments of the methods, storage mediums, and systems include configurations for calibrating a flow cytometer using a calibration particle having a unique signature to determine a time-of-flight for particles flowing through the flow cytometer. Based on the calculated time-of-flight and relative positions of interrogation regions corresponding to collectors of the flow cytometer, the methods, storage mediums, and systems may further include configurations for associating other signal pulses to particles of one or more different particle sets.

6. 发明公开

EP2087337A2 EX VIVO FLOW CYTOMETRY METHOD AND DEVICE 审中-公开
标题翻译：方法和装置EX VIVO流式细胞术
公开(公告)号：EP2087337A2
公开(公告)日：2009-08-12
申请号：EP07867348.0
申请日：2007-11-02
申请人： Purdue Research Foundation
发明人： LOW, Philip S. , HE, Wei , KULARATNE, Sumith, A.
IPC分类号： G01N1/30 , G01N33/49 , G01N33/574
CPC分类号： G01N33/582 , G01N15/1459 , G01N15/1463 , G01N33/5091 , G01N33/574 , G01N33/57434 , G01N2015/1006 , G01N2015/1438 , G01N2015/149 , G01N2458/00
摘要： The invention relates to a method for diagnosing a disease state mediated by pathogenic cells. The method comprises the steps of combining with an ex vivo patient sample a composition comprising a conjugate or complex of the general formula (I) Ab-X wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using flow cytometry.

7. 发明公开

EP1729108A1 Partikelkonzentrations-Messvorrichtung und Messverfahren 有权
标题翻译：弥赛亚 - Messvorrichtung和Messverfahren
公开(公告)号：EP1729108A1
公开(公告)日：2006-12-06
申请号：EP06010094.8
申请日：2006-05-16
申请人： SICK Engineering GmbH
发明人： Schröter, Gerry , Melcher, Uwe
IPC分类号： G01N15/06
CPC分类号： G01N21/532 , G01N15/06 , G01N2015/0693 , G01N2015/1438 , G01N2021/151 , G01N2021/536
摘要： Die Erfindung betrifft eine Partikelkonzentrations-Messvorrichtung zur Bestimmung einer Partikelkonzentration innerhalb eines Messvolumens nach dem Prinzip der Transmissionslichtmessung und der Streulichtmessung, wobei die Messvorrichtung wenigstens einen Lichtsender zum Aussenden von Sendelicht in das Messvolumen und wenigstens einen Lichtempfänger aufweist, wobei mittels des Lichtempfängers ein Anteil des durch Partikel im Messvolumen gedämpften Sendelichts detektierbar ist, und wobei mittels des Lichtempfängers ein Anteil des Sendelichts detektierbar ist, der an Partikeln im Messvolumen gestreut wird. Die Messvorrichtung besitzt innerhalb einer Sendereinheit zumindest einen Transmissionslichtsender zum Aussenden eines Transmissionslicht-Sendestrahls und einen separaten Streulichtsender zum Aussenden eines Streulicht-Sendestrahls, wobei der Transmissionslicht-Sendestrahl und der Streulicht-Sendestrahl innerhalb der Sendereinheit seitlich versetzt zueinander verlaufen und durch ein gemeinsames Lichtaustrittsfenster der Sendereinheit in Richtung des Messvolumens geführt werden. Die Erfindung betrifft ferner ein entsprechendes Messverfahren.
摘要翻译：该装置在用于发射透射光束（22）的发射单元（14）内部具有发射器（15），以及用于发射杂散光透射束（38）的发射器（36）。彼此横向延伸的光束（22,38）在发射单元内是不同相的。光束由发射单元的公共发光窗（24）沿测量体积的方向引导。还包括根据透射光测量和杂散光测量的原理确定测量体积内的颗粒浓度的方法的独立权利要求。

8. 发明公开

EP1117983A1 AN APPARATUS FOR DETERMINING THE POSITION OF AN OBJECT 有权
标题翻译：用于确定位置和后续检查的装置和方法高亮显示的对象
公开(公告)号：EP1117983A1
公开(公告)日：2001-07-25
申请号：EP99945961.3
申请日：1999-09-30
申请人： 2C A/S
发明人： CASPERSEN, Christian
IPC分类号： G01N15/14 , G01N35/00 , G01N21/64
CPC分类号： G01N15/1468 , G01N15/1463 , G01N33/54326 , G01N35/00069 , G01N2015/1438 , G01N2021/6441
摘要： The present invention relates to a method and apparatus which can provide rapid scanning of large specimens (14) to detect and determine positions of objects having specific characteristics. The apparatus may, further, be adapted to store information associated with the positions of the detected objects and to retrieve this position information so that an oparator may locate a particular type of target object or objects in the specimen for detailed inspection and analysis subsequent to the scanning. The position information may be stored in a volatile or non-volatile memory device provided therefore in a preferred embodiment of the invention. The specimen may be provided on a solid support, such as a circular disc (13) which may be rotatably mounted about an axis (17) of a frame of the apparatus. The objects can be cells or microorganisms of a particular rare type, i.e. they may be present in a very low density in the specimen.

9. 发明公开

EP0950890A2 Particle imaging apparatus 有权
标题翻译：粒子成像装置
公开(公告)号：EP0950890A2
公开(公告)日：1999-10-20
申请号：EP99400897.7
申请日：1999-04-13
申请人： Sysmex Corporation
发明人： Kubota, Fumio , Imura, Yasuyuki
IPC分类号： G01N15/14
CPC分类号： G01N15/147 , G01N15/1427 , G01N15/1434 , G01N2015/1438 , G01N2015/144 , G01N2015/1452 , G01N2015/1479
摘要： A particle imaging apparatus includes a flow cell (3) for forming a sample flow by surrounding, with a sheath liquid, a sample liquid containing particles, and a particle imaging system for successively imaging each particle in the sample flow, wherein the particle imaging system includes first (31) and second (32) particle imaging systems, and the first and second particle imaging systems include first (18) and second (2) light sources having different focusing configurations for radiating light to each particle.
摘要翻译：本发明提供一种粒子摄像装置，其特征在于，具备：流动室（3），其用鞘液包围含有粒子的试样液体来形成试样流;以及粒子摄像系统，其依次对试样流中的各粒子进行摄像，其中，包括第一（31）和第二（32）粒子成像系统，并且第一和第二粒子成像系统包括具有不同聚焦配置的第一（18）和第二（2）光源，用于将光辐射到每个粒子。

10. 发明公开

EP0435111A2 Apparatus for optically measuring specimen 失效
标题翻译： Verfahren und Vorrichtung zur optischen Messung einer Probe。
公开(公告)号：EP0435111A2
公开(公告)日：1991-07-03
申请号：EP90124242.0
申请日：1990-12-14
申请人： CANON KABUSHIKI KAISHA
发明人： Itoh, Yuji, c/o Canon Kabushiki Kaisha , Toge, Yoshiyuki c/o Canon Kabushiki Kaisha , Saito, Atsushi c/o Canon Kabushiki Kaisha , Yamazaki, Tatsuya c/o Canon Kabushiki Kaisha
IPC分类号： G01N15/14
CPC分类号： G01N15/1434 , G01N15/1459 , G01N2015/1438 , G01N2021/4792 , G01N2021/6421
摘要： There is disclosed a specimen measurement apparatus including means for sequentially moving individual specimens, radiation means for simultaneously radiating first and second radiation beams on first and second positions spaced apart from each other in a moving direction of the specimens, light detection means for time-serially detecting light components emerging from specimens passing the first and second positions using the same light detector, and optical selection means, arranged in an optical path between the radiation positions and the light detection means, for, when a specimen passes the first position, selectively guiding a light component having a first optical characteristic emerging from the specimen to the light detection means, and for, when the specimen passes the second position, selectively guiding a light component having a second optical characteristic emerging from the specimen to the light detection means.
摘要翻译：公开了一种样本测量装置，包括用于顺序地移动单个样本的装置，用于在沿样本的移动方向彼此间隔开的第一和第二位置上同时辐射第一和第二辐射束的辐射装置，用于时间序列的光检测装置通过使用相同的光检测器检测从穿过第一和第二位置的样品出射的光成分，以及布置在辐射位置和光检测装置之间的光路中的光选择装置，当样品通过第一位置时，选择性地引导具有从样本向光检测装置出射的第一光学特性的光分量，并且当样本通过第二位置时，选择性地将具有从样本出射的第二光学特性的光分量引导到光检测装置。

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