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1. 发明公开

EP1360168A4 AMPHIPHILIC DERIVATIVES FOR THE PRODUCTION OF VESICLES, MICELLES AND COMPLEXANTS, AND PRECURSORS THEREOF 审中-公开
标题翻译： “两亲衍生物用于制备囊泡，胶束和络合剂，它们的PRE”
公开(公告)号：EP1360168A4
公开(公告)日：2007-10-31
申请号：EP02716274
申请日：2002-01-16
申请人： UNIV BEN GURION
发明人： GRINBERG SARINA , LINDER CHARLES , WIESMAN ZEEV , HELDMAN ELIAHU , KOLOT VICTORIA
IPC分类号： C07C69/76 , C07D303/42 , A61K9/00 , A61K9/107 , A61K9/127 , A61K47/18 , A61K47/24 , C07C69/675 , C07C69/732 , C07C229/12 , C07C229/16 , C07C229/22 , C07C229/30 , C07C235/28 , C07C247/12 , C07C301/00 , C07C309/70 , C07D213/44 , C07D303/04 , C07D303/46 , C07D303/48 , C07F9/02 , C07F9/655
CPC分类号： C07C247/12 , A61K8/14 , A61K8/41 , A61K8/416 , A61K8/42 , A61K8/46 , A61K8/4926 , A61K8/922 , A61K9/0014 , A61K9/1075 , A61K9/1272 , A61K47/18 , A61K47/24 , A61Q19/00 , C07C69/675 , C07C69/732 , C07C229/12 , C07C229/22 , C07C235/28 , C07C301/00 , C07D213/53 , C07D303/04 , C07D303/48 , C07D407/12 , C07F9/65505
摘要： Amphiphilic derivatives composed of at least one fatty acid chain are derived from natural vegetable oils such as vernonia oil, lesquerella oil and castor oil, in which the several reactive groups such as epoxy, hydroxy and double bonds can be modified to polar and ionic groups. The head group of the amphiphilic derivative may be in the main fatty acid chain or in a side chain. The amphiphiles are useful for the formation of vesicles and micelles and for use as complexants and surfactants.

2. 发明公开

EP3122756A1 ANORGANISCH-ORGANISCHE HYBRIDVERBINDUNG 有权
公开(公告)号：EP3122756A1
公开(公告)日：2017-02-01
申请号：EP15712797.8
申请日：2015-02-26
申请人： Karlsruher Institut für Technologie , Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. , Georg-August-Universität Stiftung öffentlichen Rechts, Universitätsmedizin
发明人： HECK, Joachim , POSS, Marieke , REICHARDT, Holger , NAPP, Joanna , ALVES, Frauke , STÜHMER, Walter , FELDMANN, Claus
IPC分类号： C07F7/00 , C07F9/58 , C07F9/6503 , C07F9/6506 , C07F9/6509 , C07F9/6533 , C07F9/655 , C07F9/6558 , C07F9/6561 , C07F9/6574 , C07C309/47 , C07C309/50 , C07D401/04 , C07D401/10 , C07D403/10 , C07D407/12 , C07D413/04 , C07H19/00 , C07D417/10 , C07D417/12
CPC分类号： A61K49/0041 , A61K31/185 , A61K31/427 , A61K31/519 , A61K31/546 , A61K31/569 , A61K31/65 , A61K31/661 , A61K31/6615 , A61K31/662 , A61K31/663 , A61K31/665 , A61K31/675 , A61K31/683 , A61K31/7008 , A61K31/704 , A61K31/7056 , A61K31/7068 , A61K31/7076 , A61K38/12 , A61K47/02 , A61K49/0021 , A61K49/0032 , A61K49/0034 , A61K49/0036 , C07C237/26 , C07C309/47 , C07C2603/46 , C07D251/50 , C07D401/04 , C07D401/10 , C07D403/10 , C07D407/12 , C07D413/04 , C07D417/10 , C07D417/12 , C07D493/10 , C07F5/069 , C07F7/006 , C07F9/091 , C07F9/117 , C07F9/12 , C07F9/301 , C07F9/3813 , C07F9/3873 , C07F9/582 , C07F9/65033 , C07F9/65061 , C07F9/650958 , C07F9/65335 , C07F9/65505 , C07F9/65515 , C07F9/65517 , C07F9/65522 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07F9/65744 , C07F9/65746 , C07J1/0033 , C07J51/00 , C09B1/02 , C09B1/52 , C09B11/08 , C09B19/00 , C09B23/06 , C09B23/086 , C09B29/16 , C09B31/072 , C09B31/08 , C09B35/023 , C09B55/006 , C09B55/009 , C09B57/00 , C09B57/02 , C09B57/08 , C09B62/085 , C09B63/005 , Y02A50/411
摘要： The invention relates to an inorganic-organic hybrid compound as an ion compound, composed of an inorganic cation and an organic anion active substance and optionally, an organic anion fluorescent dye.
摘要翻译：本发明涉及作为离子性化合物的无机 - 有机杂化化合物，由无机阳离子和有机活性成分阴离子组成，也可任选地由有机荧光染料阴离子组成。

3. 发明公开

EP2845859A1 METHOD FOR PREPARING FOSFOMYCIN AMMONIUM SALT 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG VON FOSFOMYCIN-AMMONIAKSALZ
公开(公告)号：EP2845859A1
公开(公告)日：2015-03-11
申请号：EP12883714.3
申请日：2012-11-09
申请人： Northeast Pharmaceutical Group Co., Ltd.
发明人： CHEN, Fapu
IPC分类号： C07F9/655
CPC分类号： C07F9/65505
摘要： Disclosed in the present invention is a method for preparing fosfomycin ammonium salts, comprising the following steps of: in an organic solvent, reacting fosfomycin phenylethylamine with an isocyanate, an isothiocyanate, a ketene, a dimer of an isocyanate, a dimer of an isothiocyanate, or a dimer of a ketene, and tromethamine; or, in an organic solvent, reacting fosfomycin bis-tromethamine with an isocyanate, an isothiocyanate, a ketene, a dimer of an isocyanate, a dimer of an isothiocyanate, or a dimer of ketene. The preparation method of the present invention can be achieved by only a one-step reaction, does not require a low-temperature ion-exchange column, has a high yield, low costs, fewer three-wastes, mild reaction conditions, and low energy consumption, and is convenient to operate and suitable for industrialization.
摘要翻译：本发明公开了一种磷霉素铵盐的制备方法，包括以下步骤：在有机溶剂中，将磷霉素苯乙胺与异氰酸酯，异硫氰酸酯，乙烯酮，异氰酸酯的二聚体，异硫氰酸酯的二聚体，或乙烯酮的二聚体和氨基丁三醇; 或者在有机溶剂中使磷霉素双 - 氨基丁三醇与异氰酸酯，异硫氰酸酯，乙烯酮，异氰酸酯的二聚体，异硫氰酸酯的二聚体或乙烯酮的二聚体反应。本发明的制备方法只需一步反应即可，不需要低温离子交换柱，产率高，成本低，三废物少，反应条件温和，能量低消耗，操作方便，适合工业化。

4. 发明授权

EP1165573B1 COMPOSES INHIBITANT SELECTIVEMENT LES LYMPHOCYTES T GAMMA 9 DELTA 2 有权
标题翻译： ŤGAMMA DELTA 9 2淋巴细胞的化合物SELEKTIF抑制剂
公开(公告)号：EP1165573B1
公开(公告)日：2004-01-21
申请号：EP00917119.0
申请日：2000-04-04
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , SANGSTAT MEDICAL CORPORATION
发明人： BELMANT, Christian , BONNEVILLE, Marc , PEYRAT, Marc, Alix , FOURNIE, Jean-Jacques , KOZIKOWSKI, Alan, P.
IPC分类号： C07F9/40 , A61K31/66 , C07F9/655 , C12N5/06
CPC分类号： C12N5/0636 , A61K2035/122 , C07F9/4028 , C07F9/4037 , C07F9/4075 , C07F9/65505 , C12N2501/999

5. 发明公开

EP1165573A1 COMPOSES INHIBITANT SELECTIVEMENT LES LYMPHOCYTES T GAMMA 9 DELTA 2 有权
标题翻译： ŤGAMMA DELTA 9 2淋巴细胞的化合物SELEKTIF抑制剂
公开(公告)号：EP1165573A1
公开(公告)日：2002-01-02
申请号：EP00917119.0
申请日：2000-04-04
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (E.P.S.T.) , SANGSTAT MEDICAL CORPORATION
发明人： BELMANT, Christian , BONNEVILLE, Marc , PEYRAT, Marc, Alix , FOURNIE, Jean-Jacques , KOZIKOWSKI, Alan, P.
IPC分类号： C07F9/40 , A61K31/66 , C07F9/655 , C12N5/06
CPC分类号： C12N5/0636 , A61K2035/122 , C07F9/4028 , C07F9/4037 , C07F9/4075 , C07F9/65505 , C12N2501/999
摘要： The invention concerns compounds of formula CH3-R1-(CH2)2-R2 wherein: R1 is selected among a tertiary alcohol; a 1,2-diol; a halohydrine; an epoxide; an alkene; an aldehyde or an α-hydroxyaldehyde; and R2 is selected among a methylenediphosphonate; a difluoromethylenediphosphonate; or a monofluoromethylenediphosphonate. The invention also concerns the uses of said compounds as selective inhibitors of Tη9δ2 lymphocytes, and their uses, in particular for therapeutic purposes.

6. 发明公开

EP0220072A3 Method of improving flame resistance of epoxy resins and resulting compositions 失效
标题翻译：改善环氧树脂和结构组合物的阻燃性的方法
公开(公告)号：EP0220072A3
公开(公告)日：1987-09-16
申请号：EP86308089
申请日：1986-10-17
申请人： THE DOW CHEMICAL COMPANY
发明人： Beck, H. Nelson
IPC分类号： C08G59/14 , C08G59/36
CPC分类号： C07F9/65505 , C08G59/145 , C08G59/36
摘要： Flame resistant epoxy resins are prepared by reaction of a di- or poly- epoxide with an oxirane group containing phosphonate of the formula:
wherein R is hydrogen or lower alkyl, R 1 is a lower alkyl and y is 1 to 3. The backbone of the epoxy resin contains a functional substituent, preferably a hydroxyl substituent, which reacts with the oxirane group of the phosphonate. The cured epoxy resins have improved glass temperatures.

7. 发明公开

EP0213704A3 Mixtures of mono- and disodium salts of fosfomycin 失效
标题翻译： FOSFOMYCIN的单一和二次盐的混合物
公开(公告)号：EP0213704A3
公开(公告)日：1987-09-16
申请号：EP86305378
申请日：1986-07-14
申请人： COMPANIA ESPANOLA DE LA PENICILINA Y ANTIBIOTICOS, S.A
发明人： Torregrosa Higom, Arturo , Fernandez Ibanez, Matilde , Garcia Sanchez, Millan , Prieto Prieto, Agustin
IPC分类号： A61K31/665 , C07F09/38
CPC分类号： C07F9/65505 , A61K31/665 , Y02A50/473 , Y02A50/478
摘要： Mixtures of the mono- and di-sodium salts of fosfomycin and their use by parenteral and oral administration are described.
摘要翻译：磷霉素的单 - 和二 - 钠盐的混合物及其肠胃外和口服施用的描述。

8. 发明授权

EP0027597B1 Mono(2-ammonium-2-hydroxymethyl-1,3-propanediol)(2R-cis)-(3-methyloxiranyl)phosphonate, its preparation and pharmaceutical compositions containing it 失效
标题翻译： MONO（2-氨基-2-羟基甲基-1,3-丙二醇）（2R-CIS） - （3-甲基环戊二烯基）磷酸酯，其制备和含有药物组合物
公开(公告)号：EP0027597B1
公开(公告)日：1982-12-15
申请号：EP80106108.6
申请日：1980-10-08
申请人： ZAMBON S.p.A.
发明人： Chiarino, Dario , Della Bella, Davide , Ferrari, Vittorio
IPC分类号： C07F9/38 , A61K31/685
CPC分类号： C07F9/65505

9. 发明授权

EP2665734B1 METHOD FOR THE MANUFACTURE OF COMPOUNDS CONTAINING AN alpha-OXY PHOSPHORUS GROUP 有权转让
标题翻译： PROCESS FOR化合物与ALPHA OXY-磷集团的制备
公开(公告)号：EP2665734B1
公开(公告)日：2016-06-29
申请号：EP12701856.2
申请日：2012-01-23
申请人： Straitmark Holding AG
发明人： BURCK, Sebastian R., W. , COGELS, Samuel, Corentin , NOTTÉ, Patrick
IPC分类号： C07F9/38 , C07F9/58
CPC分类号： C07F9/65515 , C07F9/3808 , C07F9/5325 , C07F9/5728 , C07F9/65505

10. 发明公开

EP2665734A1 METHOD FOR THE MANUFACTURE OF COMPOUNDS CONTAINING AN alpha-OXY PHOSPHORUS GROUP 有权转让
标题翻译： PROCESS FOR化合物与ALPHA OXY-磷集团的制备
公开(公告)号：EP2665734A1
公开(公告)日：2013-11-27
申请号：EP12701856.2
申请日：2012-01-23
申请人： Straitmark Holding AG
发明人： BURCK, Sebastian R., W. , COGELS, Samuel, Corentin , NOTTÉ, Patrick
IPC分类号： C07F9/38 , C07F9/58
CPC分类号： C07F9/65515 , C07F9/3808 , C07F9/5325 , C07F9/5728 , C07F9/65505
摘要： A method for the manufacture of compounds containing an α-oxy phosphorus group is disclosed. A P-O component having at least one P-O-P moiety, whereby at least one phosphorus has the +3 oxidation state, is added in specific proportions to a compound containing an α-oxy carboxylic acid group, followed by conducting the reaction and adding water subsequently. The compounds containing an α-oxy phosphorus group formed can then be recovered.

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