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1. 发明授权

EP2414342B1 OXADIAZOLE DERIVATIVES 有权
标题翻译：恶二唑衍生物
公开(公告)号：EP2414342B1
公开(公告)日：2017-05-31
申请号：EP10713159.1
申请日：2010-03-29
申请人： Merck Serono S.A.
发明人： QUATTROPANI, Anna , MONTAGNE, Cyril , SAUER, Wolfgang , CROSIGNANI, Stefano , BOMBRUN, Agnes
IPC分类号： C07D271/06 , A61K31/4245 , A61P37/00
CPC分类号： A61K31/4245 , A61K31/192 , A61K31/197 , C07C57/30 , C07D271/06

2. 发明公开

EP3079818A1 KATALYSATORSYSTEM BASIEREND AUF KUGELFÖRMIGER AKTIVKOHLE ALS TRÄGER UND DESSEN VERWENDUNG 审中-公开
标题翻译：催化剂系统中基于球形活性炭为载体，及其使用
公开(公告)号：EP3079818A1
公开(公告)日：2016-10-19
申请号：EP14824359.5
申请日：2014-11-25
申请人： Blücher GmbH
发明人： BÖHRINGER, Bertram , FICHTNER, Sven , SCHRAGE, Christian , GIEBELHAUSEN, Jann-Michael , WASSERSCHEIDT, Peter , ETZOLD, Bastian , KLEFER, Heiko
IPC分类号： B01J37/12 , B01J21/18 , B01J23/40 , B01J35/00 , B01J35/08 , B01J35/10 , B01J37/02 , C07C29/17 , C07C57/30 , C07C29/141 , C07C51/36
CPC分类号： B01J23/462 , A62D5/00 , A62D9/00 , B01D39/2058 , B01J20/0225 , B01J20/20 , B01J20/28019 , B01J20/28076 , B01J20/3078 , B01J20/3085 , B01J20/3204 , B01J20/3236 , B01J20/3293 , B01J21/18 , B01J23/16 , B01J23/40 , B01J23/42 , B01J23/44 , B01J23/48 , B01J23/70 , B01J35/0006 , B01J35/0026 , B01J35/0093 , B01J35/023 , B01J35/08 , B01J35/10 , B01J35/1023 , B01J35/1028 , B01J35/1042 , B01J35/1047 , B01J35/1061 , B01J35/108 , B01J37/0207 , B01J37/0221 , B01J37/12 , B01J37/16 , B01J37/18 , C01B32/354 , C07C29/141 , C07C51/36 , C07C57/30 , H01M4/9083
摘要： The invention relates to a method for producing a catalyst system having at least one catalytically active component, wherein the catalytically active component comprises at least one metal, wherein first a spherical activated carbon used as a catalyst carrier is subjected to an oxidation. Subsequently, the catalytically active component is applied, optionally followed by a reduction of the catalyst system obtained in said manner.

3. 发明公开

EP2970089A4 SUBSTITUTED AROMATIC COMPOUNDS AND RELATED METHOD FOR THE TREATMENT OF FIBROSIS 有权转让
标题翻译：取代的芳香族化合物和相应的用于纤维化的治疗
公开(公告)号：EP2970089A4
公开(公告)日：2016-10-12
申请号：EP14764458
申请日：2014-03-14
申请人： PROMETIC PHARMA SMT LTD
发明人： ZACHARIE BOULOS , ABBOTT SHAUN , GAGNON LYNE , LAURIN PIERRE , GROUIX BRIGITTE
IPC分类号： C07C57/30 , A61K31/192 , A61P19/04 , C07C57/58 , C07C59/52
CPC分类号： C07C53/134 , A61K31/192 , C07C57/30 , C07C57/58 , C07C59/52
摘要： The present invention relates to compounds of: or a pharmaceutically acceptable salt thereof, wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)—(CH2)n-CH3 wherein n is 3 or 4; R1 is H, F or OH; R2 is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)—(CH2)n-CH3 wherein n is 3 or 4; R3 is H, F, OH or CH2Ph; R4 is H, F or OH; Q is 1) (CH2)mC(0)OH wherein m is 1 or 2, 2) CH(CH3)C(0)OH, 3) C(CH3)2C(0)OH, 4) CH(F)—C(0)OH, 5) CF2-C(0)OH, or 6) C(0)-C(0)OH; and compositions comprising the same and the method using the same for the prevention or treatment of various fibrotic diseases and conditions in subjects, including pulmonary fibrosis, liver fibrosis, skin fibrosis, renal fibrosis, pancreas fibrosis, systemic sclerosis, cardiac fibrosis or macular degeneration.

4. 发明授权

EP2427416B1 SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF 有权转让
标题翻译：取代芳烃化合物和药物它们的应用
公开(公告)号：EP2427416B1
公开(公告)日：2016-03-09
申请号：EP10771933.8
申请日：2010-05-03
申请人： PROMETIC PHARMA SMT LIMITED
发明人： ZACHARIE, Boulos , PENNEY, Christopher , GAGNON, Lyne , BIENVENU, Jean-François , PERRON, Valérie , GROUIX, Brigitte
IPC分类号： C07C57/30 , A61K31/192 , A61K31/41 , A61K31/44 , A61P13/12 , A61P29/00 , C07C57/58 , C07C59/48 , C07C59/52 , C07C61/39 , C07D213/55 , C07D257/04
CPC分类号： C07C57/58 , A61K31/19 , A61K31/192 , C07C57/30 , C07C57/42 , C07C59/48 , C07C59/52 , C07C61/39 , C07D213/55 , C07D257/04
摘要： The present invention relates to substituted aromatic compounds of Formula I and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds in the prevention and/or treatment of various diseases and conditions in subjects, including the prevention or treatment of (i) blood disorders, (ii) renal disorders, a nephropathies, or renal disorder complications; (iii) inflammatory-related diseases; and/or (iv) oxidative stress related disorders.

5. 发明公开

EP2970089A1 SUBSTITUTED AROMATIC COMPOUNDS AND RELATED METHOD FOR THE TREATMENT OF FIBROSIS 有权转让
标题翻译：取代芳香族化合物及其治疗纤维化的相关方法
公开(公告)号：EP2970089A1
公开(公告)日：2016-01-20
申请号：EP14764458.7
申请日：2014-03-14
申请人： ProMetic BioSciences Inc.
发明人： ZACHARIE, Boulos , ABBOTT, Shaun , GAGNON, Lyne , LAURIN, Pierre , GROUIX, Brigitte
IPC分类号： C07C59/52 , A61K31/192 , A61P19/04 , C07C57/32
CPC分类号： C07C53/134 , A61K31/192 , C07C57/30 , C07C57/58 , C07C59/52 , Y02A50/423
摘要： The present invention relates to compounds of: or a pharmaceutically acceptable salt thereof, wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)—(CH2)n-CH3 wherein n is 3 or 4; R1 is H, F or OH; R2 is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)—(CH2)n-CH3 wherein n is 3 or 4; R3 is H, F, OH or CH2Ph; R4 is H, F or OH; Q is 1) (CH2)mC(0)OH wherein m is 1 or 2, 2) CH(CH3)C(0)OH, 3) C(CH3)2C(0)OH, 4) CH(F)—C(0)OH, 5) CF2-C(0)OH, or 6) C(0)-C(0)OH; and compositions comprising the same and the method using the same for the prevention or treatment of various fibrotic diseases and conditions in subjects, including pulmonary fibrosis, liver fibrosis, skin fibrosis, renal fibrosis, pancreas fibrosis, systemic sclerosis, cardiac fibrosis or macular degeneration.
摘要翻译：本发明涉及以下化合物或其药学上可接受的盐，其中A为C 5烷基，C 6烷基，C 5烯基，C 6烯基，C（O） - （CH 2）n -CH 3或CH（ OH） - （CH 2）n -CH 3其中n是3或4; R 1是H，F或OH; R 2是C 5烷基，C 6烷基，C 5烯基，C 6烯基，C（O） - （CH 2）n -CH 3或CH（OH） - （CH 2）n -CH 3，其中n是3 或4; R 3是H，F，OH或CH 2 Ph; R 4是H，F或OH; Q是1）（CH 2）mC（O）OH，其中m是1或2,2,2）CH（CH 3）C（O）OH，3）C（CH 3）2 C（O）OH，4）CH F）-C（O）OH，5）CF 2 -C（O）OH，或6）C（O）-C（O）OH; 和组合物，其包括相同的，并且使用用于各种纤维变性疾病和病症的受试者，包括肺纤维化，肝纤维化，皮肤纤维化，肾纤维化，胰纤维化，系统性硬化症，心脏纤维化或黄斑变性的预防或治疗的相同的方法。

6. 发明公开

EP2737900A4 NDM INHIBITOR 审中-公开
标题翻译： NDM-抑制剂
公开(公告)号：EP2737900A4
公开(公告)日：2015-03-11
申请号：EP12817790
申请日：2012-07-26
申请人： MEIJI SEIKA PHARMA CO LTD
发明人： MORINAKA AKIHIRO , MAEBASHI KAZUNORI , IDA TAKASHI , HIKIDA MUNEO , YAMADA MOTOTSUGU , ABE TAKAO
IPC分类号： A61K31/194 , A61K31/351 , A61K31/40 , A61K31/407 , A61K31/4164 , A61K31/4406 , A61K31/445 , A61K31/5375 , A61K45/00 , A61P31/04 , A61P43/00 , C07C57/26 , C07C57/48 , C07C59/46 , C07C217/22 , C07D309/06
CPC分类号： C07C69/593 , A61K31/194 , A61K31/216 , A61K31/225 , A61K31/351 , A61K31/40 , A61K31/4015 , A61K31/407 , A61K31/4164 , A61K31/4174 , A61K31/4406 , A61K31/45 , A61K31/5375 , A61K45/06 , C07C57/13 , C07C57/26 , C07C57/30 , C07C57/42 , C07C57/48 , C07C57/50 , C07C59/46 , C07C59/64 , C07C63/66 , C07C69/608 , C07C69/612 , C07C69/618 , C07C69/732 , C07C217/18 , C07C233/65 , C07C235/20 , C07C237/22 , C07C279/08 , C07D207/12 , C07D211/46 , C07D213/55 , C07D233/64 , C07D295/108 , C07D309/06 , A61K2300/00
摘要： An objective of the present invention is to provide a novel NDM (New Delhi metallo-²-lactamase) inhibitor that functions as a drug for restoring the antibacterial activity of ²-lactam antibiotics that have been inactivated as a result of decomposition by NDM. According to the present invention, there is provided an NDM inhibitor contains a compound represented by general formula (I):
摘要翻译：本发明的目的是提供一种新的NDM（新德里金属 - 内酰胺酶）抑制剂，其作为恢复由NDM分解而灭活的β-内酰胺抗生素的抗菌活性的药物。根据本发明，提供了含有通式（I）表示的化合物的NDM抑制剂：

7. 发明授权

EP2027134B1 CHIRAL LIGANDS USED IN TRANSITION METAL CATALYSTS FOR ASYMMETRIC ADDITION REACTIONS ESPECIALLY HYDROGENATION 有权转让
标题翻译：过渡金属催化剂上的不对称加成反应，尤其是加氢，二手手性配体
公开(公告)号：EP2027134B1
公开(公告)日：2014-07-16
申请号：EP07729459.3
申请日：2007-05-23
申请人： Solvias AG
发明人： PFALTZ, Andreas , RIBOURDOUILLE, Yann , FENG, Xiangdong , RAMALINGAM, Balamurugan , PUGIN, Benoît , SPINDLER, Felix
IPC分类号： C07F9/46 , C07C51/36 , C07C67/28 , C07C67/283 , C07C213/02 , C07C221/00 , C07F15/00 , C07F17/02 , B01J31/18 , B01J31/24 , C07C67/303 , C07F9/50 , C07C231/12
CPC分类号： C07F9/5022 , B01J31/1875 , B01J31/2495 , B01J2231/643 , B01J2231/645 , B01J2531/821 , B01J2531/822 , B01J2531/827 , C07B2200/07 , C07C51/36 , C07C67/303 , C07C213/02 , C07C231/12 , C07F15/008 , C07F17/02 , C07C57/30 , C07C69/675 , C07C69/732 , C07C69/34 , C07C217/08 , C07C233/47

8. 发明授权

EP2463263B1 ISOTOPE LABELED 2-ARYLPROPIONIC ACID COMPOUNDS AND PROCESS FOR PRODUCTION OF SAME, AND MOLECULAR PROBE FOR POSITRON EMISSION TOMOGRAPHY AND METHOD FOR IMAGING OF CYCLOOXYGENASE AND THE LIKE USING SAME 有权
标题翻译：具有显着的同位素2ARYLPROPIONSÄUREVERBINDUNGEN和生产性分子探针用于成像过程中发射正电子的方法和环氧合酶和类似设备的图片，以便
公开(公告)号：EP2463263B1
公开(公告)日：2014-04-23
申请号：EP10806375.1
申请日：2010-07-29
申请人： Riken
发明人： TAKASHIMA, Misato , SHUKURI, Miho , GOTO, Miki , DOI, Hisashi , ONOE, Hirotaka , SUZUKI, Masaaki , WATANABE, Yasuyoshi
IPC分类号： C07C57/30 , A61K51/00 , C07C51/353 , C07C57/58 , C07C59/64 , C07C59/68 , C07C59/84 , C07C59/86 , C07C67/333 , C07C69/612 , C07C69/65 , C07C69/734 , C07C69/736 , C07C69/738 , G01T1/161
CPC分类号： A61K31/192 , A61K49/0433 , A61K51/04 , A61K51/0402 , C07B59/001 , C07B2200/05 , C07B2200/07 , C07C57/30 , C07C57/58 , C07C59/64 , C07C59/68 , C07C59/84 , C07C59/86 , C07C69/612 , C07C69/65 , C07C69/734 , C07C69/736 , C07C69/738 , C07C2601/08

9. 发明公开

EP2696864A1 THERAPEUTIC COMPOUNDS 审中-公开
标题翻译：治疗性化合物
公开(公告)号：EP2696864A1
公开(公告)日：2014-02-19
申请号：EP12723902.8
申请日：2012-04-11
申请人： Akthelia Pharmaceuticals
发明人： RAQIB, Rubhana , AGERBERTH, Birgitta , GUDMUNDSSON, Gudmundur, Hrafn , STROMBERG, Roger
IPC分类号： A61K31/192 , A61K31/198 , A61P31/04 , A61P31/00 , A61P31/06
CPC分类号： A61K31/192 , A61K31/19 , A61K31/22 , A61K31/59 , A61K31/592 , A61K31/593 , A61K45/06 , C07C57/30 , Y02A50/471 , Y02A50/475 , A61K2300/00
摘要： The invention relates to compounds which are active as drugs for stimulating the innate antimicrobial peptide system and can be used as antimicrobial drugs. Preferred targets are infections selected from infection of the lung, trachea, urinary tract or kidney, upper GI tract and\or blood. Preferred target pathogens are selected from: Mycobacterium tuberculosis; Pseudomonas bacteria; Haemophilus influenzae; Moraxella catarrhalis. “Preferred” compounds of the invention are. Preferred compounds include 4-phenylbutyric acid or a salt of 4-phenylbutyrate, such as sodium 4-phenylbutyrate, Butyric acid or a salt of butyrate, such as sodium butyrate, or gyceryl tributyrate.
摘要翻译：本发明涉及作为刺激先天抗微生物肽系统的药物具有活性并可用作抗微生物药物的化合物。优选的靶标是选自感染肺，气管，尿道或肾，上GI道和/或血液的感染。优选的靶病原体选自：结核分枝杆菌; 假单胞菌; 嗜血杆菌流感; 粘膜炎莫拉菌（Moraxella catarrhalis）。本发明的“优选”化合物是。优选的化合物包括4-苯基丁酸或4-苯基丁酸盐如4-苯基丁酸钠，丁酸或丁酸盐如丁酸钠或三丁酸三烯丙酯。

10. 发明公开

EP2463263A4 ISOTOPE LABELED 2-ARYLPROPIONIC ACID COMPOUNDS AND PROCESS FOR PRODUCTION OF SAME, AND MOLECULAR PROBE FOR POSITRON EMISSION TOMOGRAPHY AND METHOD FOR IMAGING OF CYCLOOXYGENASE AND THE LIKE USING SAME 有权
标题翻译：具有显着的同位素2ARYLPROPIONSÄUREVERBINDUNGEN和生产性分子探针用于成像过程中发射正电子的方法和环氧合酶和类似设备的图片，以便
公开(公告)号：EP2463263A4
公开(公告)日：2013-01-23
申请号：EP10806375
申请日：2010-07-29
申请人： RIKEN
发明人： TAKASHIMA MISATO , SHUKURI MIHO , GOTO MIKI , DOI HISASHI , ONOE HIROTAKA , SUZUKI MASAAKI , WATANABE YASUYOSHI
IPC分类号： C07C57/30 , A61K51/00 , C07C51/353 , C07C57/58 , C07C59/64 , C07C59/68 , C07C59/84 , C07C59/86 , C07C67/333 , C07C69/612 , C07C69/65 , C07C69/734 , C07C69/736 , C07C69/738 , G01T1/161
CPC分类号： A61K31/192 , A61K49/0433 , A61K51/04 , A61K51/0402 , C07B59/001 , C07B2200/05 , C07B2200/07 , C07C57/30 , C07C57/58 , C07C59/64 , C07C59/68 , C07C59/84 , C07C59/86 , C07C69/612 , C07C69/65 , C07C69/734 , C07C69/736 , C07C69/738 , C07C2601/08

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