专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP0419905A3 Quinone derivatives and pharmacological use 失效
标题翻译：喹诺酮衍生物和药理学用途
公开(公告)号：EP0419905A3
公开(公告)日：1992-06-24
申请号：EP90117119.9
申请日：1990-09-05
申请人： Eisai Co., Ltd.
发明人： Abe, Shinya , Okamoto, Yasushi , Tagami, Katsuya , Hibi, Shigeki , Nagakawa, Junichi , Hirota, Kazuo , Hishinuma, Ieharu , Miyamoto, Kaname , Yamanaka, Takashi , Yokohama, Hiromitsu , Yoshimura, Tsutomu , Horie, Tohru , Akita, Yasunori , Katayama, Koichi , Yamatsu, Isao
IPC分类号： C07C66/00 , A61K31/19 , C07C59/90 , C07C59/68 , C07C65/21 , C07C69/736 , C07C255/38 , C07D309/00
CPC分类号： C07D295/185 , C07C45/00 , C07C47/575 , C07C50/38 , C07C59/54 , C07C59/68 , C07C59/90 , C07C65/21 , C07C66/00 , C07C69/734 , C07C69/738 , C07C255/31 , C07C255/41 , C07C255/57 , C07C317/46 , C07C323/55 , C07C323/56 , C07C323/62 , C07C2601/14 , C07C2601/16 , C07D211/46 , C07D213/55 , C07D277/30 , C07D277/46 , C07D309/04 , C07D333/24
摘要： The quinone compound is useful to treat hepatic disease and defined by the formula: wherein A is a group represented by the formula:
(wherein R 3 , R 4 and R 5 which may be the same or different from each other are each a hydrogen atom, a lower alkyl group or a lower alkoxy group) or a group represented by the formula:
(wherein R 3 , R 4 and R 5 which may be the same or different from each other are each a hydrogen atom, a lower alkyl group or a lower alkoxy group, X and Y which may be the same or different from each other are each a hydroxyl group, a group represented by the formula
(wherein n is 0 or 1 and R 6 is a lower alkyl group), or an acyl group),
R 1 is an alkyl group having 2 to 20 carbon atoms, a cycloalkyl group, a cycloalkylalkyl group, an alkenyl group, an alkynyl group, an arylalkyl group, a group represented by the formula
(wherein p is an integer of 1 to 10), a heteroarylalkyl group, a group represented by the formula
{wherein q is an integer of 1 to 6 and B is a group represented by the formula:
(wherein r is 0 or an integer of 1 to 2, R 7 is a lower alkyl group, a cycloalkyl group or an aryl group), or a group represented by the formula -O-R 8 (wherein R 8 is a lower alkyl group or an aryl group)}, or a group represented by the formula (wherein s is an integer of 1 to 3), R 2 is a group represented by the formula -OR 8 (wherein R 8 is a hydrogen atom or a lower alkyl group) or a group represented by the formula:
(wherein R 9 and R 10 which may be the same of different from each other are each a hydrogen atom, a lower alkyl group, a hydroxyalkyl group or a heteroaryl group, provided that R 9 and R 10 may be combined with each other to form a ring together with a nitrogen atom bonded thereto, which may further contain a nitrogen atom and/or an oxygen atom and may be substituted).
摘要翻译：醌化合物可用于治疗肝病并由下式定义：其中A是由下式表示的基团：其中R 3，R 4和R 5可以是相同或不同的是氢原子，低级烷基或低级烷氧基）或由下式表示的基团：其中R 3，R 4和R 5如下：可以相同或不同的是氢原子，低级烷基或低级烷氧基，可以相同或不同的X和Y各自为羟基，由（其中n为0或1，R 6为低级烷基）或酰基），R 1为碳原子数2〜20的烷基，芳基环烷基，环烷基烷基，烯基，炔基，芳基烷基，由式表示的基团，其中p为1〜10的整数，杂芳基烷基基团 p为由式＆lparstr＆CH 2＆rparstr＆B B表示的基团，其中q为1〜6的整数，B为下式所示的基团：其中r为0或1〜2的整数，R 或者由式-OR 8表示的基团（其中R 8为低级烷基或芳基）}，或者式由式＆lparstr＆CH2-CH2-O）@ CH3表示的基团（其中s为1至3的整数），R 2为由式-OR 8表示的基团（其中R 8为氢原子或低级烷基）或由下式表示的基团：其中可以彼此不同的（其中R 9和R 1 各自为氢原子，低级烷基，羟基烷基或杂芳基，条件是R 9和R 1可以彼此结合形成与其键合的氮原子一起形成的环，其还可含有氮原子和/或氧原子并且可以被取代）。

2. 发明公开

EP1312602A1 Amidino derivatives, and anticoagulants and thrombosis therapeutic agents containing them 审中-公开
标题翻译： Amidinoderivate und diese enthaltende antikoagulierende und antithrombotische Wirkstoffe
公开(公告)号：EP1312602A1
公开(公告)日：2003-05-21
申请号：EP02025580.8
申请日：2002-11-15
申请人： Eisai Co., Ltd.
发明人： Satoh, Takashi , Okamoto, Yasushi , Asano, Osamu , Watanabe, Nobuhisa , Nagakura, Tadashi , Saeki, Takao , Inoue, Atsushi , Sakurai, Masahiro
IPC分类号： C07C311/29 , C07C311/21 , C07D333/34 , C07C311/08 , C07C311/44 , C07D333/62 , C07D233/84 , C07D217/22 , C07D333/40 , C07D333/38 , C07C257/18 , C07C275/42 , C07D317/68 , A61K31/196 , A61K31/381 , A61K31/4164 , A61K31/245 , A61P7/02
CPC分类号： C07D333/62 , C07C257/18 , C07C275/42 , C07C311/08 , C07C311/21 , C07C311/29 , C07C311/46 , C07C317/14 , C07D217/22 , C07D233/84 , C07D333/22 , C07D333/28 , C07D333/34 , C07D333/38 , C07D333/40
摘要： Amidino derivatives represented by the following general formula (I):
{where X is a group represented by R 1 SO 2 NR 2 - (wherein R 1 represents optionally substituted C 6-14 aryl, etc. and R 2 represents hydrogen atom, etc.), etc., Ar 1 represents 2,6-naphthylene, etc., R 3 represents hydrogen atom, etc. and Y represents carboxyphenyl, etc.}
and their pharmacologically acceptable salts or solvates.
摘要翻译：由以下通式（I）表示的脒基衍生物：其中X是由R 1 SO 2 NR 2 - 表示的基团（其中R 1表示任选取代的C 6-14芳基等， 2'表示氢原子等）等，Ar 1表示2,6-亚萘基等，R 3表示氢原子等，Y表示羧基苯基等。及其药理学上可接受的盐或溶剂化物。

3. 发明公开

EP0503426A1 Quinone derivatives 失效
标题翻译：希农衍。
公开(公告)号：EP0503426A1
公开(公告)日：1992-09-16
申请号：EP92103555.6
申请日：1992-03-02
申请人： Eisai Co., Ltd.
发明人： Okamoto, Yasushi , Tagami, Katsuya , Hibi, Shigeki , Numata, Hirotoshi , Kawahara, Tetsuya , Kobayashi, Naoki , Shinoda, Masanobu , Harada, Koukichi , Miyamoto, Kaname , Abe, Koichi
IPC分类号： C07D213/55 , C07D213/56 , A61K31/44
CPC分类号： C07D213/56 , C07D213/55
摘要： The object of the present invention is to provide a quinone derivative exhibiting an excellent activity as a drug.
The present invention provides a quinone derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof:

wherein A stands for a group represented by the formula:

(wherein R³, R⁴ and R⁵ is the same or different from each other and each stand for a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an alkoxyalkyl group, an alkoxyalkoxy group, a cycloalkylalkoxy group, a thiol group or a thioalkyl group, with the proviso that a case wherein R³ and R⁴ are each a lower alkoxy group simultaneously is excepted) or a group represented by the formula:

(wherein R³, R⁴ and R⁵ is the same or different from each other and each stand for a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an alkoxyalkyl group, an alkoxyalkoxy group, a cycloalkylalkoxy group, a thiol group or a thioalkyl group, with the proviso that a case wherein R³ and R⁴ are each a lower alkoxy group simultaneously is excepted; X and Y is the same or different from each other and each stand for a hydroxyl group or a protected hydroxyl group);
R¹ stands for a heteroarylalkyl group; and
B stands for a carboxyl group or a protected carboxyl group.
摘要翻译：本发明的目的是提供作为药物具有优异活性的醌衍生物。本发明提供由通式（I）表示的醌衍生物或其药理学上可接受的盐：其中A表示由下式表示的基团：其中R 3，R 4， R 5相同或不同，分别表示氢原子，羟基，低级烷基，低级烷氧基，烷氧基烷基，烷氧基烷氧基，环烷基烷氧基，硫醇基或硫代烷基，条件是其中R 3和R 4同时为低级烷氧基的情况除外）或由下式表示的基团：其中R 3，R 4和R 5相同或不同，分别表示氢原子，羟基，低级烷基，低级烷氧基，烷氧基烷基，烷氧基烷氧基，环烷基烷氧基，硫醇基或硫代烷基，条件是其中R 3和R 4各自为低级烷氧基， ;;;; X和Y彼此相同或不同，各自表示羟基或被保护的羟基）; R 1表示杂芳基烷基; B代表羧基或被保护的羧基。

4. 发明授权

EP0419905B1 Quinone derivatives and pharmacological use 失效
标题翻译： Chinonderivate und ihre pharmakologische Verwendung
公开(公告)号：EP0419905B1
公开(公告)日：1996-01-17
申请号：EP90117119.9
申请日：1990-09-05
申请人： Eisai Co., Ltd.
发明人： Abe, Shinya , Okamoto, Yasushi , Tagami, Katsuya , Hibi, Shigeki , Nagakawa, Junichi , Hirota, Kazuo , Hishinuma, Ieharu , Miyamoto, Kaname , Yamanaka, Takashi , Yokohama, Hiromitsu , Yoshimura, Tsutomu , Horie, Tohru , Akita, Yasunori , Katayama, Koichi , Yamatsu, Isao
IPC分类号： C07C66/00
CPC分类号： C07D295/185 , C07C45/00 , C07C47/575 , C07C50/38 , C07C59/54 , C07C59/68 , C07C59/90 , C07C65/21 , C07C66/00 , C07C69/734 , C07C69/738 , C07C255/31 , C07C255/41 , C07C255/57 , C07C317/46 , C07C323/55 , C07C323/56 , C07C323/62 , C07C2601/14 , C07C2601/16 , C07D211/46 , C07D213/55 , C07D277/30 , C07D277/46 , C07D309/04 , C07D333/24

5. 发明授权

EP0507318B1 Benzothiazole derivative 失效
标题翻译：苯并噻唑衍生物
公开(公告)号：EP0507318B1
公开(公告)日：1997-09-10
申请号：EP92105777.4
申请日：1992-04-03
申请人： Eisai Co., Ltd.
发明人： Okamoto, Yasushi , Tagami, Katsuya , Hibi, Shigeki , Numata, Hirotoshi , Kobayashi, Naoki , Shinoda, Masanobu , Kawahara, Tetsuya , Murakami, Manabu , Oketani, Kiyoshi , Inoue, Takashi , Yamanaka, Takashi , Yamatsu, Isao
IPC分类号： C07D417/12 , C07D417/06 , C07D277/82 , C07D277/84 , A61K31/425 , A61K31/44
CPC分类号： C07D417/06 , C07D277/82 , C07D417/12 , Y02P20/55

6. 发明授权

EP0503426B1 Quinone derivatives 失效
标题翻译：希农衍
公开(公告)号：EP0503426B1
公开(公告)日：1996-12-27
申请号：EP92103555.6
申请日：1992-03-02
申请人： Eisai Co., Ltd.
发明人： Okamoto, Yasushi , Tagami, Katsuya , Hibi, Shigeki , Numata, Hirotoshi , Kawahara, Tetsuya , Kobayashi, Naoki , Shinoda, Masanobu , Harada, Koukichi , Miyamoto, Kaname , Abe, Koichi
IPC分类号： C07D213/55 , C07D213/56 , A61K31/44
CPC分类号： C07D213/56 , C07D213/55

8. 发明公开

EP0419905A2 Quinone derivatives and pharmacological use 失效
标题翻译： Chinonderivate und ihre pharmakologische Verwendung。
公开(公告)号：EP0419905A2
公开(公告)日：1991-04-03
申请号：EP90117119.9
申请日：1990-09-05
申请人： Eisai Co., Ltd.
发明人： Abe, Shinya , Okamoto, Yasushi , Tagami, Katsuya , Hibi, Shigeki , Nagakawa, Junichi , Hirota, Kazuo , Hishinuma, Ieharu , Miyamoto, Kaname , Yamanaka, Takashi , Yokohama, Hiromitsu , Yoshimura, Tsutomu , Horie, Tohru , Akita, Yasunori , Katayama, Koichi , Yamatsu, Isao
IPC分类号： C07C66/00 , A61K31/19 , C07C59/90 , C07C59/68 , C07C65/21 , C07C69/736 , C07C255/38 , C07D309/00
CPC分类号： C07D295/185 , C07C45/00 , C07C47/575 , C07C50/38 , C07C59/54 , C07C59/68 , C07C59/90 , C07C65/21 , C07C66/00 , C07C69/734 , C07C69/738 , C07C255/31 , C07C255/41 , C07C255/57 , C07C317/46 , C07C323/55 , C07C323/56 , C07C323/62 , C07C2601/14 , C07C2601/16 , C07D211/46 , C07D213/55 , C07D277/30 , C07D277/46 , C07D309/04 , C07D333/24
摘要： The quinone compound is useful to treat hepatic disease and defined by the formula:
wherein A is a group represented by the formula:
(wherein R 3 , R 4 and R 5 which may be the same or different from each other are each a hydrogen atom, a lower alkyl group or a lower alkoxy group) or a group represented by the formula:
(wherein R 3 , R 4 and R 5 which may be the same or different from each other are each a hydrogen atom, a lower alkyl group or a lower alkoxy group, X and Y which may be the same or different from each other are each a hydroxyl group, a group represented by the formula
(wherein n is 0 or 1 and R 6 is a lower alkyl group), or an acyl group),

R 1 is an alkyl group having 2 to 20 carbon atoms, a cycloalkyl group, a cycloalkylalkyl group, an alkenyl group, an alkynyl group, an arylalkyl group, a group represented by the formula
(wherein p is an integer of 1 to 10), a heteroarylalkyl group, a group represented by the formula
{wherein q is an integer of 1 to 6 and B is a group represented by the formula:
(wherein r is 0 or an integer of 1 to 2, R 7 is a lower alkyl group, a cycloalkyl group or an aryl group), or a group represented by the formula -O-R 8 (wherein R 8 is a lower alkyl group or an aryl group)}, or a group represented by the formula
(wherein s is an integer of 1 to 3),
R 2 is a group represented by the formula -OR 8 (wherein R 8 is a hydrogen atom or a lower alkyl group) or a group represented by the formula:
(wherein R 9 and R 10 which may be the same of different from each other are each a hydrogen atom, a lower alkyl group, a hydroxyalkyl group or a heteroaryl group, provided that R 9 and R 10 may be combined with each other to form a ring together with a nitrogen atom bonded thereto, which may further contain a nitrogen atom and/or an oxygen atom and may be substituted).
摘要翻译：醌化合物可用于治疗肝病并由下式定义：其中A是由下式表示的基团：其中R 3，R 4和R 5可以是相同或不同的是氢原子，低级烷基或低级烷氧基）或由下式表示的基团：其中R 3，R 4和R 5如下：可以相同或不同的是氢原子，低级烷基或低级烷氧基，可以相同或不同的X和Y各自为羟基，由（其中n为0或1，R 6为低级烷基）或酰基），R 1为碳原子数2〜20的烷基，芳基环烷基，环烷基烷基，烯基，炔基，芳基烷基，由式表示的基团，其中p为1〜10的整数，杂芳基烷基基团 p为由式＆lparstr＆CH 2＆rparstr＆B B表示的基团，其中q为1〜6的整数，B为下式所示的基团：其中r为0或1〜2的整数，R 或者由式-OR 8表示的基团（其中R 8为低级烷基或芳基）}，或者式由式＆lparstr＆CH2-CH2-O）@ CH3表示的基团（其中s为1至3的整数），R 2为由式-OR 8表示的基团（其中R 8为氢原子或低级烷基）或由下式表示的基团：其中可以彼此不同的（其中R 9和R 1 各自为氢原子，低级烷基，羟基烷基或杂芳基，条件是R 9和R 1可以彼此结合形成与其键合的氮原子一起形成的环，其还可含有氮原子和/或氧原子并且可以被取代）。

9. 发明公开

EP0376288A1 Naphthalene derivative 失效
标题翻译： Naphthalinderivate。
公开(公告)号：EP0376288A1
公开(公告)日：1990-07-04
申请号：EP89124034.3
申请日：1989-12-28
申请人： Eisai Co., Ltd.
发明人： Okita, Makoto , Shirota, Hiroshi , Tanaka, Masayuki , Kaneko, Toshihiko , Tagami, Katsuya , Hibi, Shigeki , Okamoto, Yasushi , Nomoto, Seiichiro , Suzuki, Takeshi , Chiba, Kenichi , Goto, Masaki , Hashida, Ryoichi , Ono, Hideki , Ohhara, Hideto , Sakurai, Hideki , Souda, Shigeru , Machida, Yoshimasa , Katayama, Kouichi , Yamatsu, Isao
IPC分类号： C07C59/52 , C07C59/64 , C07C69/157 , C07C69/732 , C07C69/734 , C07D295/182 , C07C49/83 , C07C49/84 , C07C47/565 , C07C47/575 , A61K31/19
CPC分类号： C07F7/1852 , C07C39/225 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/313 , C07C43/315 , C07C45/00 , C07C45/298 , C07C45/30 , C07C45/305 , C07C45/513 , C07C45/54 , C07C45/59 , C07C45/63 , C07C45/71 , C07C47/57 , C07C47/575 , C07C49/83 , C07C49/84 , C07C59/68
摘要： A naphthalene derivative having the formula is new and useful for medicine.
[wherein R 1 represents a hydrogen atom, a lower alkyl group or an acyl group;

R 2 independently represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a cycloalkyl group, a cycloalkylalkyl group, a hydroxyl group, an aryl group which may be substituted, an arylalkyl group whose aryl group may be substituted, a heteroaryl group, or a heteroarylalkyl group;
R 3 and R 4 are the same or different and represent a hydrogen atom, a lower alkyl group, a lower alkenyl group, an aryl group which may be substituent, an arylalkyl group whose aryl group may be substituted, an arylalkenyl group whose aryl group may be substituted, a cycloalkyl group, an alkoxyalkyl group, a heteroaryl group, a heteroarylalkyl group, a carboxyl group, a carboxyalkyl group, an aminoalkyl group, or a cyano group;
R 5 represents a group of the formula, -OR?, (wherein R represents a hydrogen atom or a lower alkyl group), or a group of the formula,
(wherein R 8 and R 9 are the same or different and represent a hydrogen atom or alower alkyl group or R 8 and R 9 can form, along with the nitrogen atom bonded with R 8 and R 9 , a ring which may contain an oxygen atom);
R 6 independently represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, an amino group, an arylalkyl group, or an aryl group; and
m is 0 or an integer of from 1 to 2, and n is 0 or an integer of from 1 to 4.]
摘要翻译：具有该式的萘衍生物是新的并且可用于药物。 [其中R 1表示氢原子，低级烷基或酰基; R 2独立地表示氢原子，低级烷基，低级烷氧基，卤素原子，环烷基，环烷基烷基，羟基，可被取代的芳基，芳基可以被取代，杂芳基或杂芳基烷基; R 3和R 4相同或不同，表示氢原子，低级烷基，低级烯基，可以被取代的芳基，芳基可以被取代的芳基烷基，芳基烯基芳基可以被取代的基团，环烷基，烷氧基烷基，杂芳基，杂芳基烷基，羧基，羧基烷基，氨基烷基或氰基; R 5表示下式基团-OR 7（其中R 7表示氢原子或低级烷基）或下式基团（其中R 8为和R 9相同或不同，表示氢原子或低级烷基，或者R 8和R 9可以与与R 8和R 9键合的氮原子一起形成，可能含有氧原子的环）; R 6独立地表示氢原子，卤素原子，低级烷基，低级烷氧基，羟基，氨基，芳基烷基或芳基。 m为0或1〜2的整数，n为0或1〜4的整数。]

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式